Asporin Proteins (ASPN)

ASPN encodes a cartilage extracellular protein that is member of the small leucine-rich proteoglycan family. Additionally we are shipping Asporin Antibodies (49) and Asporin Kits (39) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ASPN 54829 Q9BXN1
ASPN 66695 Q99MQ4
Rat ASPN ASPN 306805  
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Top Asporin Proteins at

Showing 5 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
Yeast Cow His tag   1 mg Log in to see 60 to 71 Days
Escherichia coli (E. coli) Mouse GST tag,His tag 100 μg Log in to see 15 to 18 Days

ASPN Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
Mouse (Murine) ,

More Proteins for Asporin (ASPN) Interaction Partners

Human Asporin (ASPN) interaction partners

  1. ASPN D15 (show MRPL16 Proteins) is associated with increased risk of symmetrical hand osteoarthritis particularly in individuals with low variation in work tasks.

  2. we found that asporin can be downregulated by bone morphogenetic protein 4 (show BMP4 Proteins) in Hs578T cells and its upregulation may be facilited by serum-free cultivation or by three dimensional growth

  3. Asporin promotes epithelial mesenchymal transformation, invasion, and migration of pancreatic cancer cellss by activating CD44 (show CD44 Proteins)-AKT (show AKT1 Proteins)/ERK (show EPHB2 Proteins)-NF-kappaB (show NFKB1 Proteins) pathway in paracrine and autocrine manner.

  4. High ASPN expression in stroma is associated with prostate cancer progression.

  5. To test the associations of ASPN variations with risk of subsequent oncologic outcomes.

  6. Collectively, our findings indicate that ASPN is upregulated and plays an oncogenic role in gastric cancer progression and metastasis by influencing the EGFR (show EGFR Proteins) signaling pathway.

  7. Our results showed that ASPN rs13301537 T to C change and variant C genotype may contribute to knee OA risk in a Chinese Han population.

  8. this is the first case-control study in Mexican women that suggests that menopause and the D-repeat polymorphism in the ASPN gene are associated with knee OA

  9. Osteomodulin (show OMD Proteins), osteoglycin (show OGN Proteins), and asporin appear to be distinctly regulated in osteoarthritis labrum compared to OA cartilage.

  10. Asporin may represent a new therapeutic target molecule for the development of drugs aimed at manipulating the cancer microenvironment.

Mouse (Murine) Asporin (ASPN) interaction partners

  1. Asporin deficiency changes skin glycosaminoglycan composition, and decorin (show DCN Proteins) and biglycan (show BGN Proteins) content, which may explain the changes in skin mechanical properties.

  2. inhibition of TLR2- and TLR4 (show TLR4 Proteins)-induced inflammatory responses and binding abilities to TLR2 and TLR4 (show TLR4 Proteins)

  3. positively regulates FGF-2 (show FGF2 Proteins) activity through a direct interaction

  4. Findings suggest that asporin is one of the important cartilage matrix proteins that binds to the ECM (show MMRN1 Proteins) and TGF-beta1 (show TGFB1 Proteins) and thereby modulates interactions between TGF-beta (show TGFB1 Proteins) and its signaling receptors.

  5. PLAP-1/asporin plays a specific role in the periodontal ligament as a negative regulator of cytodifferentiation and mineralization by regulating BMP-2 (show BMP2 Proteins) activity to prevent the periodontal ligament from developing non-physiological mineralization

  6. The findings indicate that TGF-beta1 (show TGFB1 Proteins) induces ASPN through Smad3 (show SMAD3 Proteins) but that this induction is indirect.

  7. Leucine-rich repeat motif 5 (LRR5) of PLAP-1/asporin, plays an important role in the PLAP-1/asporin-BMP-2 (show BMP2 Proteins) interaction.

Xenopus laevis Asporin (ASPN) interaction partners

  1. The small leucine-rich repeat secreted protein Asporin induces eyes in Xenopus embryos through the IGF signalling pathway.

Pig (Porcine) Asporin (ASPN) interaction partners

  1. Mapping of the OGN (show OGN Proteins) and ASPN genes and association with growth and carcass traits.

Asporin (ASPN) Protein Profile

Protein Summary

This gene encodes a cartilage extracellular protein that is member of the small leucine-rich proteoglycan family. The encoded protein may regulate chondrogenesis by inhibiting transforming growth factor-beta 1-induced gene expression in cartilage. This protein also binds collagen and calcium and may induce collagen mineralization. Polymorphisms in the aspartic acid repeat region of this gene are associated with a susceptibility to osteoarthritis. Alternate splicing results in multiple transcript variants.

Gene names and symbols associated with Asporin Proteins (ASPN)

  • asporin (ASPN)
  • asporin (LRR class 1) (aspn)
  • asporin (Aspn)
  • asporin L homeolog (aspn.L)
  • 4631401G09Rik protein
  • AA986886 protein
  • aspnl protein
  • bgl3 protein
  • os3 protein
  • plap-1 protein
  • plap1 protein
  • slrr1c protein
  • wu:fk08c11 protein
  • zgc:109936 protein

Protein level used designations for Asporin Proteins (ASPN)

asporin (LRR class 1) , asporin proteoglycan , periodontal ligament associated protein 1 , small leucine-rich protein 1C , asporin , biglycan-like protein 3 , periodontal ligament-associated protein 1

54829 Homo sapiens
65228 Danio rerio
66695 Mus musculus
306805 Rattus norvegicus
415954 Gallus gallus
495030 Xenopus laevis
507990 Bos taurus
610685 Canis lupus familiaris
739953 Pan troglodytes
100054817 Equus caballus
100410747 Callithrix jacchus
100446487 Pongo abelii
100600227 Nomascus leucogenys
100732832 Cavia porcellus
100511749 Sus scrofa
101108885 Ovis aries
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