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ASPN encodes a cartilage extracellular protein that is member of the small leucine-rich proteoglycan family. Additionally we are shipping Asporin Antibodies (49) and Asporin Kits (39) and many more products for this protein.
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ASPN D15 (show MRPL16 Proteins) is associated with increased risk of symmetrical hand osteoarthritis particularly in individuals with low variation in work tasks.
we found that asporin can be downregulated by bone morphogenetic protein 4 (show BMP4 Proteins) in Hs578T cells and its upregulation may be facilited by serum-free cultivation or by three dimensional growth
Asporin promotes epithelial mesenchymal transformation, invasion, and migration of pancreatic cancer cellss by activating CD44 (show CD44 Proteins)-AKT (show AKT1 Proteins)/ERK (show EPHB2 Proteins)-NF-kappaB (show NFKB1 Proteins) pathway in paracrine and autocrine manner.
High ASPN expression in stroma is associated with prostate cancer progression.
To test the associations of ASPN variations with risk of subsequent oncologic outcomes.
Collectively, our findings indicate that ASPN is upregulated and plays an oncogenic role in gastric cancer progression and metastasis by influencing the EGFR (show EGFR Proteins) signaling pathway.
Our results showed that ASPN rs13301537 T to C change and variant C genotype may contribute to knee OA risk in a Chinese Han population.
this is the first case-control study in Mexican women that suggests that menopause and the D-repeat polymorphism in the ASPN gene are associated with knee OA
Osteomodulin (show OMD Proteins), osteoglycin (show OGN Proteins), and asporin appear to be distinctly regulated in osteoarthritis labrum compared to OA cartilage.
Asporin may represent a new therapeutic target molecule for the development of drugs aimed at manipulating the cancer microenvironment.
Asporin deficiency changes skin glycosaminoglycan composition, and decorin (show DCN Proteins) and biglycan (show BGN Proteins) content, which may explain the changes in skin mechanical properties.
inhibition of TLR2- and TLR4 (show TLR4 Proteins)-induced inflammatory responses and binding abilities to TLR2 and TLR4 (show TLR4 Proteins)
positively regulates FGF-2 (show FGF2 Proteins) activity through a direct interaction
Findings suggest that asporin is one of the important cartilage matrix proteins that binds to the ECM (show MMRN1 Proteins) and TGF-beta1 (show TGFB1 Proteins) and thereby modulates interactions between TGF-beta (show TGFB1 Proteins) and its signaling receptors.
PLAP-1/asporin plays a specific role in the periodontal ligament as a negative regulator of cytodifferentiation and mineralization by regulating BMP-2 (show BMP2 Proteins) activity to prevent the periodontal ligament from developing non-physiological mineralization
The findings indicate that TGF-beta1 (show TGFB1 Proteins) induces ASPN through Smad3 (show SMAD3 Proteins) but that this induction is indirect.
Leucine-rich repeat motif 5 (LRR5) of PLAP-1/asporin, plays an important role in the PLAP-1/asporin-BMP-2 (show BMP2 Proteins) interaction.
The small leucine-rich repeat secreted protein Asporin induces eyes in Xenopus embryos through the IGF signalling pathway.
Mapping of the OGN (show OGN Proteins) and ASPN genes and association with growth and carcass traits.
This gene encodes a cartilage extracellular protein that is member of the small leucine-rich proteoglycan family. The encoded protein may regulate chondrogenesis by inhibiting transforming growth factor-beta 1-induced gene expression in cartilage. This protein also binds collagen and calcium and may induce collagen mineralization. Polymorphisms in the aspartic acid repeat region of this gene are associated with a susceptibility to osteoarthritis. Alternate splicing results in multiple transcript variants.
asporin (LRR class 1)
, asporin proteoglycan
, periodontal ligament associated protein 1
, small leucine-rich protein 1C
, biglycan-like protein 3
, periodontal ligament-associated protein 1