anti-Ataxin 3 (ATXN3) Antibodies

Machado-Joseph disease, also known as spinocerebellar ataxia-3, is an autosomal dominant neurologic disorder. Additionally we are shipping Ataxin 3 Proteins (12) and and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
ATXN3 4287 P54252
ATXN3 110616 Q9CVD2
ATXN3 60331 O35815
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Top anti-Ataxin 3 Antibodies at antibodies-online.com

Showing 10 out of 80 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-ATXN3 Antibody Titration:  0.2-1 ug/ml  Positive Control:  293T cell lysate WB Suggested Anti-ATXN3  Antibody Titration: 0.2-1 µg/mL  Positive Control:.93T cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated IHC (p), WB Anti- Ataxin 3 Picoband antibody, IHC(P) IHC(P): Human Lung Cancer Tissue Flow Cytometry analysis of A549 cells using anti-ATXN3 antibody . Overlay histogram showing A549 cells stained with  (Blue line).The cells were blocked with 10% normal goat serum. And then incubated with rabbit anti-ATXN3 Antibody (,1µg/1x106 cells) for 30 min at 20°C. DyLight®488 conjugated goat anti-rabbit IgG (BA1127, 5-10µg/1x106 cells) was used as secondary antibody for 30 minutes at 20°C. Isotype control antibody (Green line) was rabbit IgG (1µg/1x106) used under the same conditions. Unlabelled sample (Red line) was also used as a control. 100 μg Log in to see 4 to 6 Days
$280.00
Details
Human Rabbit Un-conjugated EIA, FACS, IHC (p), WB ATXN3 Antibody (Center) FC analysis of ZR-75-1 cells (bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. Formalin-fixed and paraffin-embedded human brain tissue reacted with ATXN3 Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated ICC, IF, WB Immunocytochemistry/Immunofluorescence: Ataxin-3 Antibody [NBP1-32083] - 293T cells were fixed in 4% paraformaldehyde at RT for 15 min. Green: Ataxin 3 protein stained by Ataxin 3 antibody diluted at 1:250. Blue: Hoechst 33342 staining. Western Blot: Ataxin-3 Antibody [NBP1-32083] - Ataxin 3 antibody detects Ataxin 3 protein by western blot analysis. 293T mock transfected (-) or transfected with a construct expressing human Ataxin 3. 10 % SDS-PAGE Ataxin 3 antibody dilution: 1:20000 0.1 mL Log in to see 8 to 11 Days
$516.98
Details
Human Rabbit Un-conjugated IF, IHC, WB Western blot analysis of extracts of various cell lines, using ATXN3 antibody. 100 μL Log in to see 16 Days
$366.77
Details
Human Rabbit Un-conjugated FACS, IHC (p), WB Western blot analysis of ATXN3 Antibody (Center) (ABIN653191) in MCF-7 cell line lysates (35 µg/lane). ATXN3 (arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human brain tissue reacted with ATXN3 Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Log in to see 10 to 11 Days
$385.00
Details
Human Rabbit Un-conjugated IHC (p) Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma 400 μL Log in to see 10 to 11 Days
$385.00
Details
Human Rabbit Un-conjugated ELISA, IHC, WB ABIN6271651 at 1/200 staining Human lung cancer tissue sections by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary. ABIN6271651 at 1/200 staining Mouse kidney tissue sections by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary. 100 μL Log in to see 11 to 12 Days
$450.00
Details
Human Rabbit Un-conjugated ELISA, IHC, WB Western blot analysis of MCF-7  lysate using ATXN3 antibody. The lane on the left is treated with the antigen-specific peptide. ABIN6276643 at 1/100 staining Mouse lung tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22¡ãC. An HRP conjugated goat anti-rabbit antibody was used as the secondary 100 μL Log in to see 11 to 12 Days
$390.77
Details

Top referenced anti-Ataxin 3 Antibodies

  1. Human Polyclonal Ataxin 3 Primary Antibody for IHC (p), ELISA - ABIN542748 : Michlewski, Krzyzosiak: Molecular architecture of CAG repeats in human disease related transcripts. in Journal of molecular biology 2004 (PubMed)
    Show all 3 Pubmed References

More Antibodies against Ataxin 3 Interaction Partners

Human Ataxin 3 (ATXN3) interaction partners

  1. Functionally, Ataxin-3 overexpression promoted cell proliferation, and Ataxin-3 knockdown inhibited cell proliferation in testicular cancer cell. In addition, up-regulation of Ataxin-3 inhibited the expression of PTEN and activated the AKT/mTOR pathway.

  2. Studied the role of KPNA3 (karyopherin subunit alpha 3) in nuclear transport of ataxin-3 in spinocerebellar ataxia type 3.

  3. Low exon skipping efficiencies combined with reduction in important ataxin-3 protein functions suggest that skipping of exon 8 and 9 is not a viable therapeutic option for spinocerebellar ataxia type-3. The modified protein was incapable of binding poly-ubiquitin chains, which may interfere with its normal deubiquitinating function.

  4. Data suggest ATXN3 binds with low-micromolar affinity to both wild-type p97/VCP and mutants linked to proteostasis deficiency multisystem proteinopathy 1 (MSP1; also called hereditary inclusion body myopathy); stoichiometry of binding is one ATXN3 molecule per p97/VCP hexamer in presence of ATP; MSP1 mutants of p97/VCP bind ATXN3 irrespective of nucleotide state. (VCP = valosin-containing protein/ATPase; ATXN3 = ataxin-3)

  5. DNA methylation levels in the ATXN3 promoter were significantly higher in SCA3/MJD patients

  6. data elucidate the important role of ataxin-3 proteolysis in the pathogenesis of Machado-Joseph disease.

  7. The findings reveal ATXN3 to be a novel deubiquitinase of Chk1, providing a new mechanism of Chk1 stabilization in genome integrity maintenance.

  8. Segregation patterns and factors influencing instability of expanded ATXN3 CAG transmissions in Machado-Joseph disease have been analyzed.

  9. Our data reveal a previously unrecognized balance between pathogenic and potentially therapeutic properties of the ataxin-3-Rad23 interaction; they highlight this interaction as critical for the toxicity of the SCA3 protein, and emphasize the importance of considering protein context when pursuing suppressive avenues.

  10. the opposing activities of RNF4 and ataxin-3 consolidate robust MDC1-dependent signaling and repair ofDNA double-strand break.

  11. we demonstrated that neural differentiation in these iPS cells was accompanied by autophagy and that rapamycin promoted autophagy through degradation of mutant ATXN3 proteins in neurally differentiated spinocerebellar ataxia-3 human induced pluripotent stem cells (p < 0.05). In conclusion, patient-derived iPS cells are a good model for studying the mechanisms of SCA3 and may provide a tool for drug discovery in vitro.

  12. South American cohort did not confirm the effect of the four candidate loci as modifier of onset age: mithocondrial A10398G polymorphism and CAGn at RAI1, CACNA1A, ATXN3, and ATXN7 genes

  13. Ataxin-3 phosphorylation decreases neuronal defects in spinocerebellar ataxia type 3 models.

  14. USP19_b up-regulates the protein levels of the polyglutamine (polyQ)-containing proteins, ataxin-3 (Atx3) and huntingtin (Htt), and thus promotes aggregation of their polyQ-expanded species in cell models

  15. Based on these data and other related studies, we presumed that de novo mutations of ATXN3 emerging from large ANs are at least one survival mechanisms of mutational ATXN3 and we can redefine the range of CAG repeats as: ANs/=50

  16. Results suggest that the aggregation of Josephin proceeds from the monomer state to the formation of spheroidal intermediates with a native structure. Only successively, these intermediates evolve into misfolded aggregates and into the final fibrils.

  17. This study did not find relationship between CAG expansion length and psychiatric disorders.

  18. Data show that homozygosity for Machado-Joseph disease (MJD)/SCA3 protein enhances the clinical severity of the disease.

  19. A multistage aggregation mechanism for ataxin-3 is described in which flanking domain self-assembly precedes polyglutamine aggregation yet is influenced by polyglutamine expansion.

  20. Ubiquitination of ataxin-3 is not necessary for its proteasomal degradation.Ataxin-3 is regulated by ubiquitin-binding site 2 on its N terminus.Ubiquitin-binding site 2 of ataxin-3 prevents its proteasomal degradation by interacting with Rad23.

Ataxin 3 (ATXN3) Antigen Profile

Protein Summary

Machado-Joseph disease, also known as spinocerebellar ataxia-3, is an autosomal dominant neurologic disorder. The protein encoded by this gene contains (CAG)n repeats in the coding region, and the expansion of these repeats from the normal 13-36 to 68-79 is one cause of Machado-Joseph disease. There is a negative correlation between the age of onset and CAG repeat numbers. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Gene names and symbols associated with anti-Ataxin 3 (ATXN3) Antibodies

  • ataxin 3 (atxn3) antibody
  • ataxin 3 (ATXN3) antibody
  • ataxin 3 L homeolog (atxn3.L) antibody
  • ataxin-3 (MICPUN_104046) antibody
  • ataxin-3 (MICPUCDRAFT_46658) antibody
  • ataxin 3 (Atxn3) antibody
  • 2210008M02Rik antibody
  • AI463012 antibody
  • AI647473 antibody
  • AT3 antibody
  • ataxin-3 antibody
  • ATX3 antibody
  • ATXN3 antibody
  • JOS antibody
  • MGC83584 antibody
  • MJD antibody
  • MJD1 antibody
  • Rsca3 antibody
  • Sca3 antibody
  • zgc:56323 antibody

Protein level used designations for anti-Ataxin 3 (ATXN3) Antibodies

ataxin-3 , ataxin 3 , ataxin-3-like , Machado-Joseph disease (spinocerebellar ataxia 3, olivopontocerebellar ataxia 3, autosomal dominant, ataxin 3) , Machado-Joseph disease protein 1 , ataxin 3 variant h , ataxin 3 variant m , ataxin 3 variant ref , josephin , olivopontocerebellar ataxia 3 , spinocerebellar ataxia type 3 protein , Machado-Joseph disease (spinocerebellar ataxia 3, olivopontocerebellar ataxia 3, autosomal dominant, ataxin 3) homolog , machado-Joseph disease protein 1 homolog

GENE ID SPECIES
394079 Danio rerio
480229 Canis lupus familiaris
549143 Xenopus (Silurana) tropicalis
738729 Pan troglodytes
790880 Bos taurus
100144422 Sus scrofa
100171397 Ovis aries
444085 Xenopus laevis
100393557 Callithrix jacchus
8249057 Micromonas sp. RCC299
9682664 Micromonas pusilla CCMP1545
4287 Homo sapiens
110616 Mus musculus
60331 Rattus norvegicus
378424 Gallus gallus
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