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May play a role in autophagy (By similarity).. Additionally we are shipping ATG16L2 Proteins (2) and many more products for this protein.
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IKKalpha, which may control autophagic protein degradation through its interaction with ATG16L2, plays a critical role in maintaining pancreatic acinar cell homeostasis, whose dysregulation promotes pancreatitis through p62 aggregate accumulation
Despite forming the Atg12-Atg5-Atg16L2 complex, Atg16L2 is not recruited to phagophores and is mostly present in the cytosol.
ATG16L2 is a susceptibility gene for Crohn's disease in the Chinese population. The rs11235604 single nucleotide polymorphism is remarkably associated with downregulation of the expression of ATG16L2.
A novel SNP-systemic lupus erythematosus association was identified between FCHSD2 and P2RY2, peaking at rs11235667 on a 33-kb haplotype upstream of ATG16L2.
Atg16L2 may play an important role in autophagy of T cells and serve as a potential biomarker to predict clinical relapse of Multiple sclerosis
Three novel risk loci including ATG16L2 were discovered by genome-wide association study in the Korean Crohn's disease population, of which two showed patterns of association in the International Inflammatory Bowel Disease Genetics Consortium dataset.
May play a role in autophagy (By similarity).
ATG16 autophagy related 16-like 2
, autophagy-related protein 16-2
, APG16-like 2
, Atg16L2 alpha
, Atg16L2 beta
, autophagy related 16 like 2
, autophagy-related 16-like 2 alpha
, autophagy-related 16-like 2 beta
, mFLJ00012 protein
, WD repeat-containing protein 80