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The protein encoded by BCORL1 is a transcriptional corepressor that is found tethered to promoter regions by DNA-binding proteins.
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Either endogenous BCORL1 silencing or ectopic BCORL1(Q1076H) expression mimicked the effects of a CRISPR/Cas9-edited BCORL1(Q1076H) locus.
Studied the clinical significance of BCORL1 and its role in the metastasis of HCC.
BCORL1 knockdown up-regulates E-cadherin expression and subsequently inhibits cell migration and invasion of lung cancer cells.
study concluded that in pediatric acute myeloid leukemia, BCOR and BCORL1 mutations rarely occur
genetic association study in population in Italy: Data suggest BCORL1 mutations/single nucleotide polymorphisms are not associated with leukemic transformation of chronic myeloproliferative neoplasms (MPN) into acute myeloid leukemia (AML). [LETTER]
Data indicate that sequencing of BCOR and related BCORL1 genes in a cohort of 354 myelodysplastic syndromes (MDS) patients identified 4.2% and 0.8% of mutations respectively.
BCORL1 by genetic criteria is a novel candidate tumor suppressor gene, joining the growing list of genes recurrently mutated in acute myelogenous leukemia.
Dysregulated BCoR-L1 expression is associated with breast cancer
The protein encoded by this gene is a transcriptional corepressor that is found tethered to promoter regions by DNA-binding proteins. The encoded protein can interact with several different class II histone deacetylases to repress transcription. Two transcript variants encoding different isoforms have been found for this gene.
BCL6 corepressor-like 1
, BCL6 co-repressor-like 1
, BCL-6 corepressor-like protein 1
, BCoR-like protein 1