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BMX encodes a non-receptor tyrosine kinase belonging to the Tec kinase family. Additionally we are shipping BMX Antibodies (180) and BMX Kits (18) and many more products for this protein.
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These results suggested that BMX can promote cell proliferation through PI3K (show PIK3CA Proteins)/AKT (show AKT1 Proteins)/mTOR (show FRAP1 Proteins) and STAT3 (show STAT3 Proteins) signaling pathways in cervical cancer cells.
results demonstrate that cleaved BMX is a novel N-end rule substrate, and its degradation exhibits a novel interplay between substrate phosphorylation and N-end rule degradation, revealing an increasing complex regulatory network of apoptotic proteolytic signaling cascades.
Data indicate that EPHA3 (show EPHA3 Proteins) is involved in regulating the multidrug resistance (MDR) of small cell lung cancer (SCLC) via PI3K (show PIK3CA Proteins)/BMX/STAT3 (show STAT3 Proteins) signaling and may be a therapeutic target in SCLC.
BMX directly inhibits a core component of the intrinsic apoptosis machinery opens opportunities to improve the efficacy of existing chemotherapy by potentiating BAK (show BAK1 Proteins)-driven cell death in cancer cells.
Report BMX-ARHGAP gene fusion in gastric cardia adenocarcinoma.
These findings suggested that polymorphisms of the BMX gene could be a potential predictor of clinical symptoms following mTBI.
BMX is an antiapoptotic downstream effector of PI3K (show PIK3CA Proteins), independent of AKT (show AKT1 Proteins).
The effects of dietary K(+) on Bmx were more pronounced
Overexpression of ETK is associated with the malignancy and disease progression of renal cell carcinoma (show MOK Proteins).
This review characterizes the role of BMX in inflamamtion, cardiovascular disease and cancer.
results suggest that the endothelial Bmx tyrosine kinase (show TYRO3 Proteins) could provide a target to attenuate the development of cardiac hypertrophy
Btk (show BTK Proteins), Tec (show NR4A3 Proteins), Bmx are required for TLR-dependent signaling in many types of myeloid cells while being tissue-specific.
Tyrosine kinase (show TYRO3 Proteins) BMX phosphorylates phosphotyrosine-primed motif mediating the activation of multiple receptor tyrosine kinases.
Our findings therefore indicate that Bmx activity contributes to tumor angiogenesis and growth.
genetic ablation of BMX conferred protection in arthritis model confirming BMX an essential mediator of inflammation in vivo; conclude BMX an essential component of inflammatory cytokine signaling and catalytic as well noncatalytic functions are involved
Investigate Bmx mediates VEGF (show VEGFA Proteins)-dependent lymphangiogenic signaling.
by preventing binding of Etk/Bmx to PAR(1 (show MARK2 Proteins)) -C-tail, hPar1 oncogenic properties are abrogated
activation of Etk largely co-localizes with TNFR2 (show TNFRSF1B Proteins) in vascular endothelial cells and cardiomyocytes.
Bmx overexpression accelerates keratinocyte proliferation and wound reepithelialization. Bmx expression also induces chronic inflammation and angiogenesis in the skin.
Role of Bmx in ischemia-mediated arteriogenesis/angiogenesis: response to ischemia, reduced in knockout mice and enhanced in transgenic mice.
This gene encodes a non-receptor tyrosine kinase belonging to the Tec kinase family. The protein contains a PH-like domain, which mediates membrane targeting by binding to phosphatidylinositol 3,4,5-triphosphate (PIP3), and a SH2 domain that binds to tyrosine-phosphorylated proteins and functions in signal transduction. The protein is implicated in several signal transduction pathways including the Stat pathway, and regulates differentiation and tumorigenicity of several types of cancer cells. Multiple alternatively spliced variants, encoding the same protein, have been identified.
BMX non-receptor tyrosine kinase
, cytoplasmic tyrosine-protein kinase BMX-like
, BTK-like on X chromosome
, Etk/Bmx cytosolic tyrosine kinase
, NTK38 tyrosine kinase
, bone marrow tyrosine kinase gene in chromosome X protein
, cytoplasmic tyrosine-protein kinase BMX
, epithelial and endothelial tyrosine kinase
, TYRO8 protein tyrosine kinase 8
, bone marrow tyrosine kinase gene in chromosome X protein homolog