BPI Fold Containing Family A, Member 1 Proteins (BPIFA1)

BPIFA1 is the human homolog of murine plunc, and like the mouse gene, is specifically expressed in the upper airways and nasopharyngeal regions. Additionally we are shipping BPIFA1 Antibodies (62) and BPIFA1 Kits (19) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
BPIFA1 51297 Q9NP55
BPIFA1 18843 P97361
BPIFA1 246238 Q8K4I4
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Top BPIFA1 Proteins at antibodies-online.com

Showing 9 out of 11 products:

Catalog No. Origin Source Conjugate Images Quantity Delivery Price Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 30 to 35 Days
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 50 Days
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg 11 Days
Wheat germ Human GST tag 10 μg 11 to 12 Days
Escherichia coli (E. coli) Human His tag 100 μg 15 to 19 Days
Yeast Cow His tag   1 mg 60 to 71 Days
Yeast Rat His tag   1 mg 60 to 71 Days
Escherichia coli (E. coli) Human GST tag,S tag,His tag 100 μg 15 to 18 Days
Escherichia coli (E. coli) Mouse Un-conjugated   1 mg 11 to 18 Days

BPIFA1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, , ,
Mouse (Murine) ,

Rat (Rattus)

Top referenced BPIFA1 Proteins

  1. Human BPIFA1 Protein expressed in Wheat germ - ABIN1315483 : Nicholas, Skipp, Barton, Singh, Bagmane, Mould, Angco, Ward, Guha-Niyogi, Wilson, Howarth, Davies, Rennard, OConnor, Djukanovic: Identification of lipocalin and apolipoprotein A1 as biomarkers of chronic obstructive pulmonary disease. in American journal of respiratory and critical care medicine 2010 (PubMed)

  2. Human BPIFA1 Protein expressed in HEK-293 Cells - ABIN2729200 : Budding, van de Graaf, Hoefnagel, Hack, Otten: Anti-BPIFA1/SPLUNC1: a new autoantibody prevalent in patients with endstage cystic fibrosis. in Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society 2014 (PubMed)

More Proteins for BPI Fold Containing Family A, Member 1 (BPIFA1) Interaction Partners

Human BPI Fold Containing Family A, Member 1 (BPIFA1) interaction partners

  1. The study found reduced endogenous SPLUNC1 in cystic fibrosis (CF) secretions, and rapid degradation of recombinant SPLUNC1 (rSPLUNC1) by CF secretions. Normal sputum, containing SPLUNC1 and SPLUNC1-derived peptides, inhibited epithelial Na(+) channel in both normal and CF human bronchial epithelial cells.

  2. data indicate that SPLUNC1 is an allosteric regulator of ENaC that dissociates alphabetagamma-ENaC to generate a new SPLUNC1-beta-ENaC complex.

  3. Study proposes that BPIFA1 (SPLUNC1) is the epithelium-derived smooth muscle relaxing factor and it functions by internalizing Orai1. BPIFA1 deficiency in asthmatic airways promotes Orai1 hyperactivity, increased airway smooth muscle contraction and airway hyperresponsiveness.

  4. BPIFA1 and BPIFB1 expressions are correlated with goblet cell metaplasia and inversely correlated with lung function parameters of airway obstruction (FEV1 and FEV1/FVC) in COPD patients.

  5. SPLUNC1 has antimicrobial and antibiofilm activities against the Burkholderia cepacia complex.

  6. Data show that the palate, lung, and nasal epithelium clone (PLUNC) protein level was highly expressed in nontumor nasopharyngeal epithelium than that in nasopharyngeal carcinoma (NPC) tissues.

  7. These studies identify the role of SPLUNC1 in sinonasal innate immunity and the pathogenesis of CRS. Defective expression of SPLUNC1 in CRSwNP patients may lead to insufficient maintenance of the epithelial barrier function

  8. High serum SPLUNC1 levels are associated with Pleural Effusion from Lung Cancer Compared to Tuberculosis.

  9. PLUNC is a protein of the tear film and suggest that it plays a role in fluid balance and surface tension regulation at the ocular surface.

  10. SPLUNC1 can weaken the inflammatory response induced by EBV infection in NPC cells through the regulation of the TLR9/NF-kappaB signaling pathway and control of the tumor inflammatory microenvironment

  11. The G allele of rs1078761 may be detrimental to lung function in cystic fibrosis owing to decreased levels of BPIFA1 and BPIFB1.

  12. LUNX silencing disrupted primary tumor growth, local invasion, and metastatic colonization

  13. pleural fluid LUNX mRNA provided a valuable adjunct in distinguishing malignant pleural effusion caused by lung cancer from benign pleural effusion

  14. The observations suggest that, in response to agents or chemical factors, nasal mucosal epithelium will react and produce PLUNC proteins

  15. discoveries provide insight into the specific determinants governing the interaction between SPLUNC1 and lipids and also shed light on novel functions that SPLUNC1 and other PLUNC family members perform in host defense

  16. 12 retinoid X receptors heterodimer binding sites exist in the SPLUNC1 promoter region, which is up-regulated by all-trans-retinoic acid. SPLUNC1 plays a role in ATRA-induced growth inhibition and differentiation in nasopharyngeal carcinoma cells.

  17. Our results indicate that BPIFA1 is a novel target for autoantibodies in cystic fibrosis.

  18. The correlation between SPLUNC1 levels and Vol2(increase) in non-smokers may indicate involvement of SPLUNC1in the regulation of the normal function of the nasal mucosa.

  19. In patients with chronic rhinosinusitis with nasal polyps, decreased PLUNC expression is associated with multibacterial colonization, specifically those mediated by Staphyloccocus aureus and Pseudomonas aeruginosa.

  20. BPIFA1 protein displays bacteriocidal activity against Gram-negative bacteria.

Pig (Porcine) BPI Fold Containing Family A, Member 1 (BPIFA1) interaction partners

  1. High expression level in trachea and lung tissue only

Mouse (Murine) BPI Fold Containing Family A, Member 1 (BPIFA1) interaction partners

  1. Bpifa1-deficient (Bpifa1-/-) mice exhibited spontaneous airway hyperresponsiveness and that excised tracheas from Bpifa1+/+ but not Bpifa1-/- mice were capable of reducing airway smooth muscle contraction.

  2. this study shows that BPIFA1/SPLUNC1 restricts influenza A virus infection

  3. SPLUNC1-knockout mice was established in a LPS-induced acute lung injury (ALI) mouse model to study the anti-inflammatory effect of SPLUNC1. Results found that SPLUNC1 deficiency upregulated levels of ALI-related cytokines leading to more severe lung injury after LPS injection. Moreover, further data discovered that the presence of SPLUNC1 can suppress the recruitment of CD11b+Gr-1+ MDSCs to the spleen in LPS-induced ALI.

  4. Loss of Splunc1 predisposes mice to the development of otitis media.

  5. SPLUNC1 is a crucial component of mucosal innate immune defense against pulmonary infection.

  6. Knowledge of the complex expression patterns of BPIF proteins in these regions will allow the use of tractable mouse models of disease to dissect their function.

  7. SPLUNC1 is present at high concentrations in murine airways under basal conditions, whereas it is suppressed by low-level environmental pathogen-associated molecular patterns and inflammatory signals.

  8. SPLUNC1 KO mice demonstrated significantly higher numbers of eosinophils in the lung after OVA challenges than did wild-type mice.

  9. Our findings demonstrate a critical in vivo role of SPLUNC1 in host defense against bacterial infection

  10. Our data for the first time suggest that airway epithelial TLR2 signaling is pivotal in mycoplasma-induced SPLUNC1 production.

  11. splunc5, splunc1, and lplunc1 are expressed in unique domains along a continuous corridor of oral, lingual, pharyngeal, and respiratory epithelia

  12. SPLUNC1 protein decreases Mycoplasma pneumoniae (Mp) levels and inhibits epithelial IL-8 production induced by Mp-derived lipoproteins.

BPIFA1 Protein Profile

Protein Summary

This gene is the human homolog of murine plunc, and like the mouse gene, is specifically expressed in the upper airways and nasopharyngeal regions. The exact biological function of this gene is not known, however, it has been suggested to be involved in inflammatory responses to irritants in the upper airways. It may also serve as a potential molecular marker for detection of micrometastasis in non-small-cell lung cancer. Multiple transcript variants resulting from alternative splicing in the 3' UTR have been detected, but the full-length nature of only three are known.

Gene names and symbols associated with BPIFA1

  • BPI fold containing family A member 1 (BPIFA1)
  • BPI fold containing family A, member 1 (Bpifa1)
  • bA49G10.5 protein
  • LUNX protein
  • NASG protein
  • Plunc protein
  • SPLUNC1 protein
  • SPURT protein

Protein level used designations for BPIFA1

BPI fold-containing family A member 1 , ligand-binding protein RYA3 , lung-specific protein X , nasopharyngeal carcinoma-related protein , palate lung and nasal epithelium clone protein , palate, lung and nasal epithelium associated , protein Plunc , secretory protein in upper respiratory tracts , tracheal epithelium enriched protein , tracheal epithelium-enriched protein , von Ebner protein Hl , palate, lung and nasal epithelium carcinoma associated , lung and nasal epithelium carcinoma-associated protein , palate, lung and nasal epithelium carcinoma associated protein , palate, lung, and nasal epithelium associated , palate, lung, and nasal epithelium clone , palate, lung, and nasal epithelium expressed transcript , ES cell-related protein , palate, lung, and nasal epithelium carcinoma associated protein

51297 Homo sapiens
609982 Canis lupus familiaris
449524 Sus scrofa
281989 Bos taurus
18843 Mus musculus
246238 Rattus norvegicus
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