anti-BRCA2 and CDKN1A Interacting Protein (BCCIP) Antibodies

BCCIP product was isolated on the basis of its interaction with BRCA2 and p21 proteins. Additionally we are shipping BCCIP Proteins (10) and BCCIP Kits (6) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
BCCIP 56647 Q9P287
BCCIP 66165 Q9CWI3
BCCIP 361666  
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Top anti-BCCIP Antibodies at antibodies-online.com

Showing 10 out of 57 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Human Rabbit Un-conjugated IHC, WB Western blot analysis of extracts of various cells, using BCCIP antibody. Immunohistochemistry of paraffin-embedded human gastric cancer using BCCIP antibody at dilution of 1:100 (x40 lens). 100 μL 11 to 13 Days
$366.77
Details
Human Rabbit Un-conjugated ELISA, ICC, IF, WB Western blot analysis of BCCIP using Jurkat whole cell lysates ABIN6279204 staining Hela cells by IF/ICC. The sample were fixed with PFA and permeabilized in 0.1% Triton X-100,then blocked in 10% serum for 45 minutes at 25¡ãC. The primary antibody was diluted at 1/200 and incubated with the sample for 1 hour at 37¡ãC. An  Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) antibody(Cat.# S0006), diluted at 1/600, was used as secondary antibod 100 μL 11 to 12 Days
$390.77
Details
Human Rabbit Un-conjugated ICC, IF, IHC (p), WB IHC-P Image BCCIP antibody detects BCCIP protein at nucleus on BT483 xenograft by immunohistochemical analysis. Sample: Paraffin-embedded BT483 xenograft. BCCIP antibody , dilution: 1:500. IHC-P Image BCCIP antibody detects BCCIP protein at nucleus on U373 xenograft by immunohistochemical analysis. Sample: Paraffin-embedded U373 xenograft. BCCIP antibody , dilution: 1:500. 100 μL 3 to 4 Days
$466.18
Details
Human Rabbit Un-conjugated ELISA, WB   100 μL Available
$363.46
Details
Human Mouse Un-conjugated WB   100 μg 11 to 14 Days
$815.83
Details
Human Mouse Un-conjugated IF, WB Western Blot analysis of BCCIP expression in transfected 293T cell line by BCCIP MaxPab polyclonal antibody.Lane 1: BCCIP transfected lysate(34.54 KDa).Lane 2: Non-transfected lysate. Immunofluorescence of purified MaxPab antibody to BCCIP on HeLa cell. [antibody concentration 10 ug/ml] 50 μL 11 to 12 Days
$440.00
Details
Human Mouse Un-conjugated DB   50 μg 11 to 14 Days
$493.17
Details
Human Rabbit Un-conjugated ICC, IHC, IHC (p), WB   100 μL 11 to 14 Days
$537.17
Details
Human Rabbit Un-conjugated IHC, WB Western blot analysis of extracts of various cell lines, using BCCIP antibody. Immunohistochemistry of paraffin-embedded human gastric cancer using BCCIP antibody. 100 μL 13 to 14 Days
$393.25
Details
Human Mouse Un-conjugated IF, WB Western Blot analysis of BCCIP expression in transfected 293T cell line by BCCIP MaxPab polyclonal antibody.Lane 1: BCCIP transfected lysate(35.42 KDa).Lane 2: Non-transfected lysate. Immunofluorescence of purified MaxPab antibody to BCCIP on HeLa cell. [antibody concentration 10 ug/ml] 50 μg 11 to 12 Days
$440.00
Details

More Antibodies against BCCIP Interaction Partners

Human BRCA2 and CDKN1A Interacting Protein (BCCIP) interaction partners

  1. BCCIP stabilized YY1 protein in colorectal cancer cells.Transcriptional regulation of BCCIP was associated with its ability to stabilize YY1.BCCIP promoter region contains YY1 binding site (CCGCCATC).BCCIP binds to and activates its promoter in a YY1-dependent fashion.

  2. We analyzed the BCCIP protein level in 470 cases of human breast cancer to determine the associations between BCCIP and 53BP1, p53, and subtypes of breast cancer. We further constructed a unique BCCIP knockdown mouse model to determine whether a partial BCCIP deficiency leads to spontaneous breast cancer formation

  3. BCCIPbeta, as a S7 modulator, contributes to the regulation of ribosomal and extraribosomal functions of S7 and has implications in cell growth and tumor development.

  4. this study identifies BCCIP as a novel factor critical for microtubule regulation and explicates a mechanism utilized by BCCIP in tumor suppression.

  5. Expression of BCCIP beta was notably higher in tumor tissues of esophageal squamous cell carcinoma (ESCC) and Eca 109 cells. In vitro studies such as starvation and refeeding assay along with BCCIP beta-shRNA transfection assay demonstrated that BCCIP beta expression promoted proliferation of ESCC cells.

  6. we demonstrate that BCCIPbeta induces a conformational change within the RAD51 filament that promotes release of ADP to help maintain an active presynaptic filament. Our findings reveal a functional role for BCCIPbeta as a RAD51 accessory factor in HR.

  7. the existence of both INO80 and YY1 is required for recruiting the INO80/YY1 complex to BCCIP promoter region. Our findings strongly indicate that BCCIP is a potential target gene of the INO80/YY1 complex.

  8. The BCCIPbeta, but not BCCIPalpha, interacts with EIF6 and RPL23/UL14 and stabilizes the latter.

  9. Results indicate that BCCIP germ line mutations are unlikely to be a major contributor to familial breast/ovarian cancer risk in our population.

  10. In BRCA2, two novel frame shift mutations were identified as 5073-5074delCT and 6866delC.

  11. BRCA2 germline mutations appear to have a milder clinical phenotype when compared to non-BRCA2 mutations, since survival is higher among breast cancer patients carrying a BRCA2 mutation compared to sporadic breast cancers.

  12. Unique de novo mutation of BRCA2 has been identified in a woman with early onset breast cancer.

  13. Overexpression of BCCIP beta delays the G1 to S progression and results in an elevated p21 expression

  14. BCCIP is critical for BRCA2- and RAD51-dependent responses to DNA damage and homologous recombinational repair.

  15. BCCIP in maintaining the transactivation activity of wild type p53; down-regulation of BCCIP as a novel mechanism to impair the p53 function in cells harboring wild type p53

  16. suggest an essential role of BCCIP in the maintenance of genomic integrity

  17. BCCIP-dependent repair of double strand breaks by homologous recombination is an early RAD51 response to ionizing radiation-induced DNA damage.

  18. LYRIC/AEG-1 is a negative regulator of BCCIPalpha, promoting proteasomal degradation either through direct interaction, or potentially through an indirect mechanism involving downstream effects of the NF-kappaB signaling pathway.

  19. BCCIP is phosphorylated by the Src tyrosine kinase and dephosphorylated by the PTPmu tyrosine phosphatase; neurite outgrowth assays suggest that BCCIP and PTPmu are in a common signal transduction pathway.

  20. BCCIP protein expression was not detectable in approximately 45% of all astrocytic tumors.

Mouse (Murine) BRCA2 and CDKN1A Interacting Protein (BCCIP) interaction partners

  1. We analyzed the BCCIP protein level in 470 cases of human breast cancer to determine the associations between BCCIP and 53BP1, p53, and subtypes of breast cancer. We further constructed a unique BCCIP knockdown mouse model to determine whether a partial BCCIP deficiency leads to spontaneous breast cancer formation

  2. BCCIP represents a paradoxical class of modulators for tumorigenesis as a suppressor for initiation but a requisite for progression.

  3. BCCIP and its anti-replication stress functions are essential for normal neural development by maintaining an orderly proliferation of neural progenitors.

  4. these data suggest a unique function of BCCIP, not only in repair of DNA damage, but also in resolving stalled replication forks and prevention of replication stress

BCCIP Antigen Profile

Protein Summary

This gene product was isolated on the basis of its interaction with BRCA2 and p21 proteins. It is an evolutionarily conserved nuclear protein with multiple interacting domains. The N-terminal half shares moderate homology with regions of calmodulin and M-calpain, suggesting that it may also bind calcium. Functional studies indicate that this protein may be an important cofactor for BRCA2 in tumor suppression, and a modulator of CDK2 kinase activity via p21. This protein has also been implicated in the regulation of BRCA2 and RAD51 nuclear focus formation, double-strand break-induced homologous recombination, and cell cycle progression. Multiple transcript variants encoding different isoforms have been described for this gene.

Gene names and symbols associated with BCCIP

  • BRCA2 and CDKN1A interacting protein (BCCIP) antibody
  • BRCA2 and CDKN1A interacting protein (bccip) antibody
  • BRCA2 and CDKN1A interacting protein L homeolog (bccip.L) antibody
  • BRCA2 and CDKN1A interacting protein (Bccip) antibody
  • 1110013J05Rik antibody
  • BCCIP antibody
  • DKFZp459K2416 antibody
  • MGC82792 antibody
  • MGC89311 antibody
  • mp:zf637-1-000774 antibody
  • TOK-1 antibody
  • TOK1 antibody
  • zgc:110272 antibody

Protein level used designations for BCCIP

BRCA2 and CDKN1A interacting protein , protein BCCIP homolog , BRCA2 and CDKN1A-interacting protein , bccip-like , BCCIPalpha , BCCIPbeta , BRCA2 and Cip1/p21 interacting protein , TOK-1alpha , TOK-1beta , cdk inhibitor p21 binding protein , p21- and CDK-associated protein 1 , protein TOK-1

GENE ID SPECIES
426225 Gallus gallus
541348 Danio rerio
738638 Pan troglodytes
100173923 Pongo abelii
100528563 Ictalurus punctatus
444344 Xenopus laevis
448392 Xenopus (Silurana) tropicalis
56647 Homo sapiens
66165 Mus musculus
512466 Bos taurus
477864 Canis lupus familiaris
100157478 Sus scrofa
361666 Rattus norvegicus
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