anti-BTB and CNC Homology 1, Basic Leucine Zipper Transcription Factor 1 (BACH1) Antibodies

Zebrafish BTB and CNC Homology 1, Basic Leucine Zipper Transcription Factor 1 (BACH1) interaction partners

1. Bach1 regulates the liver specificity and transience of the Nrf2a-dependent induction of hmox1a and that heme mediates this regulation through Bach1 inhibition based on its level in each tissue.

2. The Bach1b-MafK heterodimer represses the zymogen promoters, whereas the Nrf2a-MafK heterodimer activates them.

Mouse (Murine) BTB and CNC Homology 1, Basic Leucine Zipper Transcription Factor 1 (BACH1) interaction partners

1. heme binding to the intrinsically disordered region of Bach1

2. disordered-ordered transition such as "coupled folding and binding" is not involved in the Bach1-heme system.

3. Decreasing malondialdehyde levels via nuclear factor (erythroidderived 2)like 2 protein/BTB and CNC homology 1 mediated antioxidant effect.

4. overexpression of miR-98-5p inhibited Bach1 expression while suppression of miR-98-5p promoted Bach1 expression in neurons.

5. Anemia of inflammation and myelodysplastic syndrome might involve reduced activity of Bach 1 and Bach2.

6. Theraputic effects of Pirfenidone for induced pulmonary fibrosis were involved in Nrf2/Bach1 equilibrium which regulated the capacity of oxidative stress.

7. Data suggest that Abcb10 silencing results in alteration in heme biosynthesis transcriptional profile due to repression by transcriptional regulator Bach1. (Abcb10 = ATP-binding cassette, sub-family B [MDR-TAP], member 10; Bach1 = BTB and CNC homology 1, basic leucine zipper transcription factor 1)

8. This study showed that RANKL favors osteoclastogenesis via attenuation of Nrf2-mediated antioxidant enzyme expression by competing with Bach1 nuclear accumulation.

9. this study provides new insight into the function of iron and Bach1 in erythroblast maturation by using efficacious regimens that can induce severe ID.

10. miR-196a, which binds to the 3'-untranslated region of the transcriptional repressor BTB and CNC homology 1 (Bach1) and regulates its expression, and subsequently leads to higher levels of lung HO-1 mRNA.

11. Bach1 siRNA exerts protective effects against bleomycin-induced pulmonary fibrosis in mice.

12. These results suggest that Bach1 and Bach2 work in a complementary manner to maintain the normal function of the AMs and surfactant homeostasis in the lung.

13. By integrating the chromatin immunoprecipitation and next-generation sequencing data with a comparative analysis of gene expression in Bach1-deficient and wild type immortalized mouse embryonic fibroblasts (iMEFs), study found 35 new genes whose expression was repressed by BACH1. Known functions of some of these genes suggested a role of BACH1 in adipocyte differentiation, which was verified using iMEFs.

14. Bach1 deficiency reduces the severity of osteoarthritis-like changes. This may be due to maintenance of cartilage homeostasis and joint health by antioxidant effects

15. Bach1 suppresses angiogenesis after ischemic injury and impairs Wnt/beta-catenin signaling by disrupting the interaction between beta-catenin and TCF4 and by recruiting histone deacetylase 1 to the promoter of TCF4-targeted genes.

16. Bach1 deficiency and accompanying overexpression of HO-1 did not influence aging or p53 deficiency-driven tumorigenesis.

17. Our results suggest that Bach2 functions with Bach1 and EBF1 to promote B cell development by repressing myeloid genes in common lymphoid progenitor cells

18. HO-1 induction after ischemia was associated to down-regulation of transcriptional repressor Bach-1, and induction of HO-1 when HO enzymatic activity was inhibited was related to worst outcome after brain ischemia.

19. Bach1 deficiency ameliorates TNBS colitis.

20. Our data provide evidence for a critical role of Bach1 in cell transformation and tumor growth induced by activated H-Ras(V12).

Human BTB and CNC Homology 1, Basic Leucine Zipper Transcription Factor 1 (BACH1) interaction partners

1. Nfr2 and Bach1 expression are altered in colorectal carcinoma but in different ways

2. Anemia of inflammation and myelodysplastic syndrome might involve reduced activity of Bach 1 and Bach2

3. In conclusion, these findings highlight the central role of Bach1 in HO-1-dependent neuronal response to oxidative stress.

4. BACH1 performs stabilization of mitotic spindle orientation together with HMMR and CRM1 in mitosis, and that the cell cycle-specific phosphorylation switches the transcriptional and mitotic functions of BACH1.

5. BACH1 is overexpressed in prostate cancer

6. BACH1 may inhibit the progression of colorectal cancer through BACH1/CXCR4 pathway.

7. BACH1 overexpression impaired the association between p53 and SP1 via competitive binding p53, and antagonized the impact of p53 on MGMT expression.

8. In light of a pivotal role of NRF2 and BACH1 in response to oxidative stress and regulation of HO-1, we examined if smoke-induced HO-1 expression is modulated through the NRF2/BACH1 axis. We demonstrated that smoke causes significant nuclear translocation of NRF2, but only a slight decrease in nuclear BACH1.

9. these findings suggested that increased miR-155 expression in activated monocytes leads to enhanced phagocytic activity via BACH-1 regulation in beta-thalassemia/HbE.

10. The electrophilic character of quinones ensure their conjugation with Bach1, which is important for the downregulation of Bach1 and the upregulation of Nrf2 signaling.

11. Our results suggest that the bach1-specific small interfering RNA effectively decrease CXCR4 receptor, matrix metalloproteinase-9 expression and breast adenocarcinoma cells invasive, also increased the expression of tumor-suppressive microRNA-203 and miR-145

12. BACH1 down-regulation in HT29 colon cancer cells had no effect on cell growth but did inhibit cell migration by decreasing metastasis-related genes expression.

13. This study indicates that the expression of BACH1 could be elevated as a compensatory mechanism to decrease the globin chain imbalance as well as to reduce the oxidative stress found in hemoglobin E/beta-thalassemia.

14. A short while ago some studies suggested that BACH1 is involved in cancers, especially breast cancer. This factor is mentioned as a novel master regulator which adjusts several genes involved in bone metastasis of breast cancer, especially CXCR4 and MMP1, two main genes in the enhancement of cancer cell migration and invasion to distant organs. [Review]

15. Bach1 suppresses cell proliferation and induces cell-cycle arrest and apoptosis.

16. Induction of GSH-related genes xCT and GCLM were oxygen and Bach1-insensitive during long-term culture under 5% O2, providing the first evidence that genes related to GSH synthesis mediate protection afforded by Nrf2-Keap1 defense pathway

17. heme oxygenase-1 expression is induced by gold nanoparticles through Nrf2 activation and Bach1 export in human vascular endothelial cells

18. Cyanidin-3-O-glucoside protects HUVECs from palmitic acid-induced injuryby modulating the balance of Nrf2 versus Bach1 inside the nucleus so influencing upregulation of electrophile responsive element mediated gene expression.

19. sensitizer-induced up-regulation of both the endogenous HMOX1 and the luciferase constructs under the control of the HMOX1-ARE or the full HMOX1 promoter appear to be under the control of both Nrf2 and Bach1.

20. This study demonstrated that Bach1 overexpression in Down syndrome correlates with the alteration of the HO-1/BVR-a system.