BTB and CNC Homology 1, Basic Leucine Zipper Transcription Factor 2 Proteins (BACH2)

Transcriptional regulator that acts as repressor or activator. Additionally we are shipping BACH2 Antibodies (46) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
BACH2 12014  
Rat BACH2 BACH2 313125  
BACH2 60468 Q9BYV9
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Top BACH2 Proteins at antibodies-online.com

Showing 4 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
$13,741.67
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Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
$13,741.67
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Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
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HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 11 Days
$888.80
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BACH2 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , ,
, ,

More Proteins for BTB and CNC Homology 1, Basic Leucine Zipper Transcription Factor 2 (BACH2) Interaction Partners

Mouse (Murine) BTB and CNC Homology 1, Basic Leucine Zipper Transcription Factor 2 (BACH2) interaction partners

  1. Bach2 interacts with Batf family transcription factors and controls Th2 cell development via binding to the regulatory regions in the Th2 cytokine, Batf and Batf3 gene loci.

  2. The study demonstrates that Bach2 is a direct repressor of the interleukin-2 gene in CD4 T cells during the immediate early phase of AP-driven activation, thereby playing an important role in the maintenance of immune quiescence in the steady state

  3. Results suggest that the mTOR-Bach2 cascade regulates proper cell cycle arrest in B cells as well as immunoglobulin gene rearrangement.

  4. The Bach2-C/EBPbeta gene regulatory network pathway tunes multipotent progenitor commitment to myeloid and lymphoid lineages both under normal conditions and after infection.

  5. Data (including data from studies using transgenic/knockout mice) suggest that hyperactivated T-lymphocytes induce specific gene expression patterns in alveolar macrophages and dendritic cells; pulmonary alveolar proteinosis phenotype of Bach2-deficient mice is due to Bach2 deficiency in at least two types of immune cells, alveolar macrophages and dendritic cells.

  6. Data show that B-cell tumour suppressor BTB and CNC homology 2 (Bach2) was significantly downregulated by the loss of NF-kappaB subunit proto-oncogene protein c-rel (c-Rel) .

  7. In this study silencing BACH2 in mantle cell lymphoma cells resulted in increased proliferation and enhanced tumor dispersal in hypoxic microenvironments, suggesting a tumor suppressor-like role of BACH2.

  8. this study shows that the transcription factor BACH2 promotes memory CD8+ T cell generation by blocking access to genomic regulatory sites recognized by AP-1

  9. this study shows that B cells of lower affinity receive weaker T cell help, which results in higher expression of the transcriptional repressor Bach2 and promotes the development of memory B cells

  10. Bach2 controls homeostasis of eosinophils via restricting the production of Il-5 in CD4(+) T cells.

  11. These results suggest that Bach1 and Bach2 work in a complementary manner to maintain the normal function of the AMs and surfactant homeostasis in the lung.

  12. these data also showed that mouse Bach2 mRNA was a novel target of miR-30b.

  13. PI3K-Akt-mTOR pathway inhibits Bach2 by both repressing its expression and inducing its phosphorylation in B cells.

  14. Bach2 is suggested to cooperate with HDAC3-containing co-repressor complexes in B cells to regulate the stage-specific expression of Prdm1 by writing epigenetic modifications at the Prdm1 locus.

  15. These findings demonstrate that BACH2 is a key component of the molecular program of tumor immunosuppression and identify therapeutic targets for the reversal of immunosuppression in cancer.

  16. Our results suggest that Bach2 functions with Bach1 and EBF1 to promote B cell development by repressing myeloid genes in common lymphoid progenitor cells

  17. Menin binding at the Bach2 locus and the Bach2 expression are decreased in the senescent CD4 T cells.

  18. The dynamics of Bach2 expression in response to DNA damage shows that it is a highly sensitive responder to transcription-blocking DNA lesions.

  19. BCL6 and BACH2 cooperate to orchestrate gene expression patterning in Germinal center B cells through both transcriptional and biochemical mechanisms, which collectively determine the proper initiation and timing of terminal differentiation.

  20. Bach2 enforces T cell quiescence, promotes the development and survival of Treg lineage, restrains aberrant differentiation of Treg cells, and protects against immune-mediated diseases.

Human BTB and CNC Homology 1, Basic Leucine Zipper Transcription Factor 2 (BACH2) interaction partners

  1. LY294002 treatment had no effect on decreased expression of Bach2 induced by BCR-ABL.

  2. The authors show that the timed repression of BACH2 through IL-2-mediated ERK/ELK1 signalling pathway directs plasma cell lineage commitment.

  3. The epithelial-mesenchymal transition (EMT) pathway was also influenced by miR-130a-3p down-regulation. In conclusion, miR-130a-3p could bind to BACH2, inhibit nasopharyngeal carcinoma cell abilities, and promote cell apoptosis.

  4. Ikaros regulates expression of the BCL6/BACH2 axis in acute lymphoblastic leukemia cells.

  5. Data show that BACH2 and STAT5B are activated by viral insertions, generating chimeric mRNAs specifically enriched in T regulatory cells favoring their persistence.

  6. BACH2 downregulation contributes to constitutive activation of the nuclear factor-kappaB.

  7. BACH2 haploinsufficiency causing a syndrome of immune deficiency and autoimmunity is described in two families. Affected subjects had lymphocyte-maturation defects that caused immunoglobulin deficiency and intestinal inflammation.

  8. In this study silencing BACH2 in mantle cell lymphoma cells resulted in increased proliferation and enhanced tumor dispersal in hypoxic microenvironments, suggesting a tumor suppressor-like role of BACH2.

  9. we developed a CRISPR-Cas9-based tool for specific DNA methylation consisting of deactivated Cas9 (dCas9) nuclease and catalytic domain of the DNA methyltransferase DNMT3A targeted by co-expression of a guide RNA to any 20 bp DNA sequence followed by the NGG trinucleotide.we demonstrated that directed DNA methylation of a wider promoter region of the target loci IL6ST and BACH2 decreased their expression

  10. genetic association studies in population in the United Kingdom: Data suggest that an SNP in BACH2 (rs3757247) is associated with autoimmune Addison's disease and with polyglandular autoimmune syndrome type 2. These findings were replicated in a Norwegian validation cohort.

  11. The shift in the CSDs by heme binding suggested that heme binding causes Bach2(331-520) to adopt a more compact conformation. In addition, heme binding to the CP-motif could reduce the flexibility of Bach2(331-520) Consequently, the five-coordinated heme binding destabilizes Bach2(331-520), by reducing the flexibility of the polypeptide chain.

  12. The study identifies a strong association of Coeliac Disease with a network of BACH2 regulated genes, supporting emerging evidence of an important role of BACH2 in the regulation of T cell differentiation and prevention of autoimmune disease.

  13. The investigated Bach2 gene polymorphisms (rs11755527, rs3757247, rs12212193 and rs2474619) are not related to the susceptibility to either Vogt-Koyanagi-Harada syndrome and Behcet's disease in our investigated Chinese Han population.

  14. Gene expression analysis revealed that three gene BACH2, PTGER4 and ZFP36L1, are down-regulated in MS patients' blood cells compared to healthy subjects.

  15. These observations suggested that the unstructured region of Bach2 is important for heme binding, and consequently for its functional regulation

  16. A restored BACH2 expression in BACH2-silenced gastric cancer cell lines, and knockdown of BACH2 using short hairpin RNA (i.e. RNA interference) increased cell proliferation in gastric cancer cells.

  17. The type 1 diabetes candidate gene BACH2 regulates proinflammatory cytokine-induced apoptotic pathways in pancreatic beta-cells by crosstalk with another candidate gene, PTPN2, and activation of JNK1 and BIM.

  18. There were multiple independent HIV integrations in several genes, including MKL2 and BACH2; many of these integrations were in clonally expanded cells.

  19. The dynamics of Bach2 expression in response to DNA damage shows that it is a highly sensitive responder to transcription-blocking DNA lesions.

  20. BACH2 expression level is a promising predictor of prognosis for diffuse large B cell lymphoma.

BACH2 Protein Profile

Protein Summary

Transcriptional regulator that acts as repressor or activator. Binds to Maf recognition elements (MARE). Play important roles in coordinating transcription activation and repression by MAFK (By similarity).

Gene names and symbols associated with BACH2

  • BTB and CNC homology, basic leucine zipper transcription factor 2 (Bach2)
  • BTB domain and CNC homolog 2 (Bach2)
  • BTB domain and CNC homolog 2 (BACH2)
  • BTB and CNC homology 1, basic leucine zipper transcription factor 2b (bach2b)
  • BTB domain and CNC homolog 2 (bach2)
  • bach2 protein
  • BTBD25 protein
  • E030004N02Rik protein
  • si:dkeyp-4f12.1 protein
  • si:dkeyp-4f12.2 protein

Protein level used designations for BACH2

BTB and CNC homolog 2 , Transcription regulator protein BACH2 (BTB and CNC homolog 2) , transcription regulator protein BACH2 , BTB and CNC homology 2 , BTB and CNC homology 1, basic leucine zipper transcription factor 2 , transcription regulator protein BACH2-like

GENE ID SPECIES
12014 Mus musculus
313125 Rattus norvegicus
60468 Homo sapiens
421809 Gallus gallus
481923 Canis lupus familiaris
538296 Bos taurus
555350 Danio rerio
702740 Macaca mulatta
100065814 Equus caballus
100218595 Taeniopygia guttata
100351257 Oryctolagus cuniculus
100402816 Callithrix jacchus
100447938 Pongo abelii
100467178 Ailuropoda melanoleuca
100485849 Xenopus (Silurana) tropicalis
100025933 Monodelphis domestica
100554926 Anolis carolinensis
100595920 Nomascus leucogenys
100717541 Cavia porcellus
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