Baculoviral IAP Repeat-Containing 6 (BIRC6) ELISA Kits

Human Baculoviral IAP Repeat-Containing 6 (BIRC6) interaction partners

1. Data indicate BRUCE/Apollon/Birc6, an inhibitor of apoptosis protein (IAP (show BIRC2 ELISA Kits)), as a new autophagy regulator.

2. Since specific expression of BRUCE protein was revealed in majority of gastric carcinoma tissues, BRUCE protein may be a useful therapeutic target for cancer therapy.

3. BIRC6 targeting inhibited the growth of enzalutamide-resistant castration-resistant prostate cancer models and may represent a new option for clinical treatment of advanced, enzalutamide-resistant prostate cancer

4. AVEN and BIRC6 are inhibited by combination therapy of miR (show MLXIP ELISA Kits)-30e and proanthocyanidin in glioblastoma stem cells

5. Apollon expression is associated with the biological characteristics of esophageal squamous cell carcinoma (ESCC), and may be a valuable prognostic factor and a novel chemotherapeutic target for ESCC treatment.

6. Apollon role in the multidrug resistance of human chronic myelogenous leukemia cells

7. Apollon gene silencing can induce apoptosis and growth impairment in HeLa cells. In this regard, apollon can be considered a candidate therapeutic target in HeLa cells as a positive human papillomavirus cancer cell line.

8. BRUCE protein was detected in 82% of tumors and tumor progression stage and invasion depth correlated significantly with BRUCE protein expression

9. Results show that in addition to the scaffolding function in complex formation, BRUCE has an E3 ligase function to promote BRIT1 (show MCPH1 ELISA Kits) deubiquitination by USP8 (show USP8 ELISA Kits) leading to accumulation of BRIT1 (show MCPH1 ELISA Kits) at DNA double-strand break.

10. BIRC6 overexpression is a predictor of poor prognosis in colorectal cancer and could be a potential target for colorectal cancer therapy.

Cow (Bovine) Baculoviral IAP Repeat-Containing 6 (BIRC6) interaction partners

1. The results of this study reveal the importance of BIRC6 expression for embryo survival during bovine preimplantation embryo development.

Mouse (Murine) Baculoviral IAP Repeat-Containing 6 (BIRC6) interaction partners

1. Data indicate BRUCE/Apollon/Birc6, an inhibitor of apoptosis protein (IAP (show BIRC2 ELISA Kits)), as a new autophagy regulator.

2. Humanin signaling pathway via htHNR/JAKs/STAT3 (show STAT3 ELISA Kits) increased the expression levels of mRNA and protein of Apollon/Bruce, an unusual member of the inhibitors of apoptosis proteins

3. BRUCE acts as a scaffold, bridging the ubiquitin-specific peptidase 8 (USP8 (show USP8 ELISA Kits)) and BRIT1 (show MCPH1 ELISA Kits) in a complex to coordinate USP8 (show USP8 ELISA Kits)-catalyzed deubiquitination of BRIT1 (show MCPH1 ELISA Kits).

4. BRUCE protects cells against apoptosis and functions as an inhibitor of apoptosis.

5. BRUCE is broadly expressed in embryonic, extraembryonic, and adult mouse tissues, this bifunctional protein might play a unique role in normal trophoblast differentiation and embryonic survival

6. p53 (show TP53 ELISA Kits) is a downstream effector of Bruce, and, in response to loss of Bruce function, p53 (show TP53 ELISA Kits) activates Pidd/caspase-2 (show CASP2 ELISA Kits) and Bax (show BAX ELISA Kits)/Bak (show BAK1 ELISA Kits), leading to mitochondrial apoptosis

7. Birc6 plays a role in cell division

8. These results establish a previously unrecognized link between NFAT (show NFATC1 ELISA Kits) signaling and regulation of IAP (show ALPI ELISA Kits) expression and are the first to identify a signaling pathway that increases BRUCE expression.