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BCAM encodes Lutheran blood group glycoprotein, a member of the immunoglobulin superfamily and a receptor for the extracellular matrix protein, laminin.
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Lu/BCAM may have a critical role in facilitating the accumulation of monocytes and macrophages, thereby exacerbating renal injury in crescentic glomerulonephritis.
Lutheran (Lu), also known as basal cell adhesion molecule (B-CAM), competes with integrins for binding to laminin alpha5, a subunit of LM-511, a major component of basement membranes.
Lu/BCAM, as a laminin receptor, is involved in vivo in the maintenance of normal basement membrane organization in the kidney and intestine.
This is the first report showing that Lu/BCAM, in the presence of its ligand laminin, is oncogenic in human urothelial cancers and may have potential as a novel therapeutic target.
data show that the BCAM/LAMA5 system plays a functional role in the metastatic spreading of KRAS-mutant colorectal cancer
The serum levels of IL-8 (show IL8 ELISA Kits), MIP-1 alpha (show CCL3 ELISA Kits), MIP-1 beta (show CCL4 ELISA Kits), MMP-8 (show MMP8 ELISA Kits), Resistin (show RETN ELISA Kits), FLRG (show FSTL3 ELISA Kits), and BCAM (show BCAT2 ELISA Kits) were significantly higher in breast cancer patients, but LAP and TSH-beta (show TSHB ELISA Kits) levels were lower.
Cytometry analysis evidenced a specific expression profile on reticulocytes of SCA infants, with notably an increased expression of the adhesion molecules Lu/BCAM, ICAM-4 (show ICAM4 ELISA Kits) and LFA-3, both in percentage of positive cells and in surface density.
Through molecular genotyping we also identified polymorphisms in RhCE, Kell, Duffy, Colton, Lutheran and Scianna loci in donors and patients.
The variable levels of expression of mutated JAK2 (show JAK2 ELISA Kits) and BCAM (show BCAT2 ELISA Kits) proteins determine different adhesion patterns of erythrocytes from polycythemia vera (show IGF2BP3 ELISA Kits) patients.
These studies revealed amino acids 720 to 1014 of CNF1 as the binding site for Lu/BCAM.
High BCAM (show BCAT2 ELISA Kits) expression is associated with hepatocellular carcinoma.
Adhesion of sickle reticulocytes to HC-treated endothelial cells was decreased despite the HC-derived increase of Lu/BCAM expression.
tumor cell migration on LM-511 requires that Lu/B-CAM competitively modulates cell attachment through integrins.
This gene encodes Lutheran blood group glycoprotein, a member of the immunoglobulin superfamily and a receptor for the extracellular matrix protein, laminin. The protein contains five extracellular immunoglobulin domains, a single transmembrane domain, and a short C-terminal cytoplasmic tail. This protein may play a role in epithelial cell cancer and in vaso-occlusion of red blood cells in sickle cell disease. Polymorphisms in this gene define some of the antigens in the Lutheran system and also the Auberger system. Inactivating variants of this gene result in the recessive Lutheran null phenotype, Lu(a-b-), of the Lutheran blood group. Two transcript variants encoding different isoforms have been found for this gene.
basal cell adhesion molecule (Lutheran blood group)
, Auberger b antigen
, Lutheran blood group
, basal cell adhesion molecule (Lu and Au blood groups)
, basal cell adhesion molecule
, basal cell adhesion molecule-like
, B-CAM cell surface glycoprotein
, lutheran antigen
, lutheran glycoprotein
, B-cell adhesion molecule
, F8/G253 antigen
, antigen identified by monoclonal antibody F8
, glycoprotein 95kDa
, Lutheran blood group (Auberger b antigen included)