anti-Basigin (Ok Blood Group) (BSG) Antibodies

Cow (Bovine) Basigin (Ok Blood Group) (BSG) interaction partners

1. Data suggest that EMMPRIN derived from endometrial epithelial cells regulates expression of matrix metalloproteinases (MMP-2; MMP-14) in endometrial stromal cells; progesterone-rich conditions stimulate expression of EMMPRIN in endometrium.

2. The selective S-nitrosylation of EMMPRIN and GOLPH3 at the Golgi apparatus in endothelial cells results from the physical proximity to eNOS-derived nitric oxide.

Human Basigin (Ok Blood Group) (BSG) interaction partners

1. Silencing of CD147 in endothelial cells inhibited Human cytomegalovirus entry but not entry into fibroblasts.

2. ectopic CD147-polarized distribution on basolateral membrane promotes hepatocyte depolarization by activation of the CD147-integrin alpha5beta1-E-cadherin ubiquitination-partitioning defective 3 decrease and beta-catenin translocation signaling cascade, replenishing a molecular pathway in hepatic carcinogenesis

3. CD147 and the beta2-adrenergic receptor form hetero-oligomeric complexes.Actinin-4 directly binds to the cytosolic tail of CD147 and governs the assembly of CD147-beta2-adrenergic receptor complexes in highly ordered clusters at bacterial adhesion sites.

4. Plasma sCD147 levels are elevated in breast cancer patients. Soluble CD147 is also associated with tumour size, lymph node metastasis, high recurrent risk, and chemoresistance.

5. overexpression of CD147 may promote OSF progression.

6. these findings show that CD147 is a novel and key mediator of IL-22-induced psoriatic alterations in the epidermis and might be a therapeutic target in patients with psoriasis.

7. Data indicate that CD147 promotes breast cancer cell proliferation, metastasis, and invasion by modulating matrix metalloproteinase 9 (MMP-9) and vascular endothelial growth factor (VEGF) expression.

8. BSG expression is indicative of a poor prognosis in pulmonary adenocarcinoma

9. CD147 expression was associated with clinicopathological features and biomarkers related to triple-negative breast cancer, particularly basal-like breast cancer.

10. Characterization of the role of CD147 in the development of tumors should lead to a better understanding of the changes occurring at the molecular level during the development and progression of primary human bone cancer.

11. Results find CD147 expression level increased in colorectal cancer (CRC) tumors and cell lines and inversely correlated with mir-485 expression. Also, CD147 is a target gene of miR485 which negatively regulates its gene expression.

12. Our results indicate that concomitant stimulation and colocalization of galectin-3 with CD147 are associated with increased gelatinolytic activity in the actively ulcerating human cornea

13. These findings reveal an important cytomegalovirus mechanism for evading antiviral innate immunity through its encoded microRNA US25-1-5p by targeting transmembrane glycoprotein CD147.

14. on a major part of fibroblastic cells in encapsulating peritoneal sclerosis

15. Review: Bsg is an extracellular receptor for CyPA that promotes cell proliferation and inflammation. Thus, the CyPA/Bsg system is potentially a novel therapeutic target for cardiovascular diseases.

16. protein-protein interaction studies on TRAF6 and BSG to get molecular level insights of the reactions.

17. results showed that the rs4919862 SNP of CD147 was closely associated with carotid atherosclerotic plaques formation; thus, polymorphisms of the CD147 gene may be related to the tendency for carotid atherosclerotic plaques

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19. Results indicated that higher expression of CD147/EMMPRIN potentially may be a prognostic marker for most cancers. CD147/EMMPRIN overexpression predicted a high risk for chemotherapy drugs resistance. CD147/EMMPRIN is a central player in tumor progression and predicts a poor prognosis. [review]

20. BSG mutation is associated with early-onset high myopia.

Mouse (Murine) Basigin (Ok Blood Group) (BSG) interaction partners

1. ectopic CD147-polarized distribution on basolateral membrane promotes hepatocyte depolarization by activation of the CD147-integrin alpha5beta1-E-cadherin ubiquitination-partitioning defective 3 decrease and beta-catenin translocation signaling cascade, replenishing a molecular pathway in hepatic carcinogenesis

2. CD147 deletion in hepatic stellate cells alleviated CCl4-induced liver fibrosis and inhibited HSCs activation. Overexpression of CD147 upregulated the secretion of CXCL1.

3. A new molecular mechanism for high angiogenic capacity, whereby microglia cells release basigin via up-regulation of PI3K-AKT and IGF-1 pathway to induce angiogenesis is unveiled.

4. EMMPRIN inhibited bFGF-induced IL-6 secretion by reducing the p65 subunit phosphorylation, it might be concluded that bFGF and EMMPRIN crosstalk in their respective signaling pathways.

5. protein-protein interaction studies on TRAF6 and BSG to get molecular level insights of the reactions.

6. This study has highlighted basigin as a common essential molecule for various stimuli-induced impairment of retinal vascular barrier, which can be a target for strategies to establish a curative treatment of diabetic retinopathy

7. Deletion of N-linked glycosylation at Asn152 on CD147 significantly suppressed in situ tumor metastasis in hepatocellular carcinoma.

8. MCT1 and Basigin variant-2, but not Basigin variant-1, are expressed within the mouse pineal gland.

9. this study provided a new mechanistic concept that CD147 can be a target for lymphocyte lineage reprogramming.

10. these results suggested that CD147 plays a key role in reducing extrinsic apoptosis in spermatocytes, but not spermatogonia, through modulating NFkappaB signaling pathway.

11. results establish neuroplastin and basigin as obligatory auxiliary subunits of native Plasma Membrane Calcium Atpases and key regulators of intracellular Ca2+ concentration.

12. Data show that caveolin-3 binds to low glycosylated extracellular matrix metalloproteinase inducer (LG-EMMPRIN) in cardiac cells and in the hearts of healthy mice.

13. These results suggest that basigin has a functional role as a binding partner with MCT2 in testicular and epididymal spermatozoa.

14. both caveolin-1 and EMMPRIN mRNA levels increased gradually with progression of developmental stages, and peaked at day two postnatal. The current finding suggests that both caveolin-1 and EMMPRIN take part in mouse tooth development, especially in the differentiation and organization of odontogenic tissues.

15. knockdown of CD147 on Hepa1-6 cells resulted in significantly increased T cells chemotaxis induced by CypA both in vivo and in vitro.

16. These findings indicate that TGF-beta1-CD147 loop plays a key role in regulating the HSC activation and combination of TGF-beta receptor inhibitor and anti-CD147 antibody might be promised to reverse fibrogenesis.

17. Decreased CD147 expression inhibited osteoclast formation and bone resorption, inhibited RANKL-induced nuclear translocation of the nuclear factor of activated T cells NFATc1.

18. EMMPRIN promotes tumor growth and metastasis by recruitment of bone marrow-derived cells through controlling secretion and paracrine signaling of SDF-1 and VEGF.

19. Results indicate the crucial roles of intracellular and extracellular Bsg in the pathogenesis of cardiac hypertrophy, fibrosis, and failure.

20. Disruption of BASIGIN in tumour cells and in MEFs has no action on the production of MMPs.

Rabbit Basigin (Ok Blood Group) (BSG) interaction partners

1. CD147 is required for the expression of MCT1 and MCT4 in the corneal endothelium. Silencing CD147 slows lactate efflux, resulting in stromal lactate accumulation and corneal edema.