Biotin-Protein Ligase (HLCS) ELISA Kits

HLCS encodes an enzyme that catalyzes the binding of biotin to carboxylases and histones. Additionally we are shipping Biotin-Protein Ligase Antibodies (30) and Biotin-Protein Ligase Proteins (5) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
HLCS 110948 Q920N2
HLCS 3141 P50747
Anti-Rat HLCS HLCS 288240  
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Top Biotin-Protein Ligase ELISA Kits at antibodies-online.com

Showing 2 out of 4 products:

Catalog No. Reactivity Sensitivity Range Images Quantity Supplier Delivery Price Details
Mouse < 0.094 ng/mL 0.156 ng/mL - 10 ng/mL   96 Tests Log in to see 11 to 18 Days
$810.17
Details
Human < 0.094 ng/mL 0.156 ng/mL - 10 ng/mL   96 Tests Log in to see 11 to 18 Days
$810.17
Details

More ELISA Kits for Biotin-Protein Ligase Interaction Partners

Human Biotin-Protein Ligase (HLCS) interaction partners

  1. The function of HCS and biotin in metabolism and human disease, a putative role for the enzyme in histone biotinylation, and its participation as a nuclear factor in chromatin dynamics is discussed.

  2. The transcriptional function of HCS was shown by in vitro pull down and in vivo co-immunoprecipitation assays to depend on its interaction with the histone deacetylases HDAC1, HDAC2 and HDAC7

  3. Data suggest that direct interactions of HLCS (holocarboxylase synthetase) with NCOR1 (nuclear receptor corepressor 1) and HDAC1 (histone deacetylase 1) contribute toward transcriptional repression of repeats, presumably increasing genome stability.

  4. study characterizes three functional promoters in the human HLCS gene

  5. HLCS interacts physically with the DNA methyltransferase DNMT1 and the methyl CpG binding protein MeCP2 to facilitate the binding of HLCS to chromatin.

  6. This study showed that modification of HSP72 and demonstrated that binding of biotin to extracellular HSP72 prepares cells for a strong immune response.

  7. individuals with HLCS SNPs may benefit from supplemental biotin, yet to different extents depending on the genotype

  8. HLCS methionine-58 is a functional translation start site in human cells.

  9. Holocarboxylase synthetase interacts directly with histone H3, causing biotinylation of lysine K9 and K18.

  10. Mutation analysis by polymerase chain reaction-sequencing of the entire coding region of the HLCS gene revealed the c.1522C>T (p.R508W) mutation in six of the eight mutant alleles. suggests it as the most common mutation in the Thai population

  11. The results of this study suggest that miR-539 is among the factors sensing biotin and regulating holocarboxylase synthetase expression.

  12. Data suggest that the N-terminal domain of hHCS recognizes the charged region of biotin acceptor protein, distinctly from the recognition by the catalytic domain.

  13. the localisation of HCS and its isoforms

  14. The mutations R508W and V363D of holocarboxylase synthetase might be hot-spots in Chinese children with holocarboxylase synthetas deficiency.

  15. The study shows that not all the proteins and polypeptides that interact with holocarboxylase synthetase are targets for biotinylation, but that carboxylase- and histone-like structures are preferred HCS targets.

  16. These results provide insights into substrate recognition by hHCS, which can be distinguished from BirA in this respect.

  17. 12 patients with multiple carboxylase deficiency, six mutations were found in the BT gene and 4 in the HLCS gene, including 5 novel mutations.

  18. 6 HLCS mutations were identified, including 2 new (N511K and G582R) and 4 known missense mutations (L216R, R508W, V550M, and G581S). 5 are in the biotin-binding domain. Tthe L216R change is in the N-terminal region outside the biotin-binding domain.

  19. Detection of mutations by tandem mass spectrometry in Carnitine transporter deficiency.

  20. findings from this study are consistent with the theory that HCS senses biotin, and that biotin regulates its own cellular uptake by participating in HCS-dependent chromatin remodeling events at the SMVT promoter 1 locus in Jurkat cells.

Biotin-Protein Ligase (HLCS) Antigen Profile

Antigen Summary

This gene encodes an enzyme that catalyzes the binding of biotin to carboxylases and histones. The protein plays an important role in gluconeogenesis, fatty acid synthesis and branched chain amino acid catabolism. Defects in this gene are the cause of holocarboxylase synthetase deficiency. Multiple alternatively spliced variants, encoding the same protein, have been identified.

Gene names and symbols associated with Biotin-Protein Ligase (HLCS) ELISA Kits

  • holocarboxylase synthetase (biotin- [propriony-Coenzyme A-carboxylase (ATP-hydrolysing)] ligase) (Hlcs) antibody
  • holocarboxylase synthetase (HLCS) antibody
  • holocarboxylase synthetase (Hlcs) antibody
  • 410I21.SP6 antibody
  • D16Jhu34 antibody
  • HCS antibody
  • RGD1565360 antibody

Protein level used designations for Biotin-Protein Ligase (HLCS) ELISA Kits

biotin apo-protein ligase , biotin- [propriony-Coenzyme A-carboxylase (ATP-hydrolysing)] ligase , biotin--protein ligase , biotin--[acetyl-CoA-carboxylase] ligase , biotin--[methylcrotonoyl-CoA-carboxylase] ligase , biotin--[methylmalonyl-CoA-carboxytransferase] ligase , holocarboxylase synthetase (biotin-(proprionyl-Coenzyme A-carboxylase (ATP-hydrolysing)) ligase) , holocarboxylase synthetase (biotin- [propriony-Coenzyme A-carboxylase (ATP-hydrolysing)] ligase)

GENE ID SPECIES
110948 Mus musculus
3141 Homo sapiens
288240 Rattus norvegicus
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