anti-Bone Morphogenetic Protein 15 (BMP15) Antibodies

may regulate granulosa cell growth and ovarian follicle formation [RGD, Feb 2006].. Additionally we are shipping BMP15 Kits (35) and BMP15 Proteins (10) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
BMP15 9210 O95972
BMP15 12155 Q9Z0L4
BMP15 59302  
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Top anti-BMP15 Antibodies at antibodies-online.com

Showing 10 out of 106 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Human Rabbit Un-conjugated IHC, ELISA 0.1 mg 2 to 3 Days
$360.00
Details
Human Rabbit Un-conjugated WB Western blot analysis of BMP15 expression in HELA whole cell lysates ( Lane 1) and MCF-7 whole cell lysates ( Lane 2). BMP15 at 56KD was detected using rabbit anti- BMP15 Antigen Affinity purified polyclonal antibody (Catalog # ) at 0.5 ??g/mL. The blot was developed using chemiluminescence (ECL) method (Catalog # EK1002). 100 μg 4 to 6 Days
$240.00
Details
Human Rabbit Un-conjugated EIA, WB 0.4 mL 6 to 8 Days
$484.00
Details
Human Rabbit Un-conjugated EIA, IHC (p) 0.4 mL 6 to 8 Days
$484.00
Details
Human Rabbit Un-conjugated ICC, IHC, WB Figure. Western Blot; Sample: Human SKOV3 Cells. 100 μg 13 to 16 Days
$350.00
Details
Mouse Rabbit Un-conjugated ICC, IHC, WB Figure. Western Blot; Sample: Mouse Testis Tissue. 100 μg 13 to 16 Days
$360.00
Details
Human Rabbit Un-conjugated IHC, IHC (p) Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE) Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg 11 to 14 Days
$616.00
Details
Human Rabbit Un-conjugated IHC (p), WB   100 μg 4 to 6 Days
$280.00
Details
Human Rabbit Un-conjugated ELISA, WB 100 μL Available
$363.46
Details
Human Rabbit Un-conjugated IF, IHC, WB Western blot analysis of extracts of various cells, using BMP15 antibody. Immunohistochemistry of paraffin-embedded rat kidney using BMP15 antibody at dilution of 1:100 (x40 lens). 100 μL 11 to 13 Days
$366.77
Details

Top referenced anti-BMP15 Antibodies

  1. Human Polyclonal BMP15 Primary Antibody for ELISA, WB - ABIN544626 : Galloway, McNatty, Cambridge, Laitinen, Juengel, Jokiranta, McLaren, Luiro, Dodds, Montgomery, Beattie, Davis, Ritvos: Mutations in an oocyte-derived growth factor gene (BMP15) cause increased ovulation rate and infertility in a dosage-sensitive manner. in Nature genetics 2000 (PubMed)
    Show all 3 Pubmed References

  2. Human Polyclonal BMP15 Primary Antibody for IHC (p), ELISA - ABIN544627 : Moore, Otsuka, Shimasaki: Molecular basis of bone morphogenetic protein-15 signaling in granulosa cells. in The Journal of biological chemistry 2002 (PubMed)
    Show all 3 Pubmed References

More Antibodies against BMP15 Interaction Partners

Human Bone Morphogenetic Protein 15 (BMP15) interaction partners

  1. We observed no significant difference associated with POI in the patients when compared with a healthy control group (p > 0.05). Also, no exonic variants were found for the genes BMP15 and FOXL2 in the individuals tested

  2. GDF9 + BMP15, but not separately, significantly induce AMH expression in vitro and in vivo. GDF9 + BMP15, through the PI3K/Akt and Smad2/3 pathways synergistically recruit the coactivator p300 on the AMH promoter region that promotes acetylation of H3K27ac, facilitating AMH expression.

  3. The present mini-review provides an overview of recent findings relating GDF-9 and BMP-15 as fundamental factors implicated in the regulation of ovarian function and discusses their potential role as markers of oocyte quality in women.

  4. Data suggest that GDF9 and BMP15 are oocyte-secreted factors with leading roles in control of ovarian function in female reproduction, modulating both fate of somatic granulosa cells and quality/developmental competence of the egg. (GDF9 = growth and differentiation factor-9; BMP15 = bone morphogenetic protein-15) [REVIEW]

  5. the expression of BMP15 in follicular fluid and Smad1 in granulosa cells was significantly decreased in the PCOS group compared with the control (P<0.05). The data suggested that the BMP15/Smad1 signalling pathway may be involved in granulosa cell apoptosis

  6. BMP15 did not seem critical for follicles to enter the growth phase. Genetic counselling should be performed and fertility preservation discussed before progressive loss of follicular reserve

  7. Mutations in BMP15 associated with primary ovarian insufficiency reduce mature protein production, activity, or synergy with GDF9.

  8. Human GDF9 and BMP15 act synergistically to stimulate granulosa cell proliferation, a response that also involves species-specific non-SMAD signalling pathways.

  9. GDF9 c.169G>T (D57Y), c.546G>A (rs1049127), and BMP15 rs79377927 (788_789insTCT) were associated with premature ovarian failure in the Chinese Hui population.

  10. BMP15 supplementation differentially modulates reductive metabolism and mitochondrial localization within the oocyte.

  11. results support a model of activation for human GDF9 dependent on cumulin formation through heterodimerization with BMP15. Oocyte-secreted cumulin is likely to be a central regulator of fertility in mono-ovular mammals.

  12. GDF9 and BMP15 expression is reduced in primordial, primary, and secondary follicles in ovarian tissues of PCOS patients.

  13. The results showed no direct association between BMP15-9G or 852T and the development of premature ovarian failure (POF). Women with the 538A mutation are up to five times more likely to develop POF. The 788insTCT polymorphism had low biological impact.

  14. the BMP15 c.-9G allele is related to BMP15 increased transcription, supporting c.-9C>G as a causal agent of premature ovarian failure

  15. BMP15 polymorphism is not associated with ovarian reserve.

  16. BMP15 is a critical regulator of folliculogenesis and granulosa cell activities. Variations in BMP15 gene dosage have a relevant influence on ovarian function and can account for several defects of female fertility.

  17. Data suggest upregulation of mRNA for BMP15 and GDF9 (growth differentiation factor 9) in cumulus granulosa cells serves as biomarker for oocyte maturation, fertilization, embryo quality, and pregnancy in couples undergoing ICSI for male infertility.

  18. Oocyte-derived BMP15 decreases gap junction intercellular communication activity between human granulosa cells by down-regulating Cx43 expression, most likely via a Smad-dependent signaling pathway.

  19. BMP15 down-regulates StAR expression and decreases progesterone production in human granulosa cells, likely via ALK3-mediated SMAD1/5/8 signaling.

  20. Data from cultured mouse preantral follicles suggest that [human recombinant] BMP15 promotes follicle growth in short term (24 hours) incubation; subsequently BMP15 (48-72 hours) causes follicular atresia with increased granulosa cell apoptosis.

Mouse (Murine) Bone Morphogenetic Protein 15 (BMP15) interaction partners

  1. GDF9 + BMP15, but not separately, significantly induce AMH expression in vitro and in vivo. GDF9 + BMP15, through the PI3K/Akt and Smad2/3 pathways synergistically recruit the coactivator p300 on the AMH promoter region that promotes acetylation of H3K27ac, facilitating AMH expression.

  2. these data provide evidence that the preovulatory LH surge leads to upregulation of several forms of BMP15 protein secreted by the oocyte for putative sequestration and/or interaction with ovarian follicular somatic cells.

  3. Data show that Rac1 induced nuclear import of STAT3 by physical binding, and nuclear STAT3 directly activated the transcription of essential oocyte-specific genes, including Jagged1, GDF9 and BMP15.

  4. results support a model of activation for human GDF9 dependent on cumulin formation through heterodimerization with BMP15. Oocyte-secreted cumulin is likely to be a central regulator of fertility in mono-ovular mammals.

  5. modified oocyte glycoproteins alter GDF9:BMP15 expression modifying follicle development resulting in the generation of more follicles

  6. findings that GDF9:BMP15 heterodimers are the most bioactive ligands in mice and humans compared with homodimers explain many puzzling genetic and physiological data and have important implications for improving female fertility in mammals

  7. show that purified mature regions of GDF9 and BMP15 synergistically interact in a specific manner which is not dependent on the presence of a pro-region.

  8. Integral role of GDF-9 and BMP-15 in ovarian function.

  9. oocyte-derived GDF9 and Bmp15 coordinate to promote the development of cumulus cells E2 and oocyte-derived paracrine factors GDF9 and bone morphogenetic protein 15 coordinate to promote the development of cumulus cells

  10. The results showed that both GDF-9 and BMP-15 were detectable in oocytes from primary follicles onward, besides, BMP-15 also presented in granulosa cells (GCs) and follicular follicle of mature follicles in mouse

  11. bone morphogenetic protein-15 could play a physiological role in the monotropic rise of FSH secretion by the pituitary during the estrous and menstrual cycle

  12. GCNF-dependent repression of Bmp15 mediates gamete regulation of female fertility.

  13. Bmp15 has a role in the development and function of the oocyte-cumulus cell complex in mice.

  14. Based on the biological role of BMP-15, defects in the production of mouse BMP-15 mature protein could correlate with the high ovulation quota and litter size observed in mice

  15. The functional mature form of BMP-15 is barely detectable in mouse oocytes until just before ovulation, when it is markedly increased.

  16. BMP15 levels increase during gonadotropin-induced follicular development, in parallel with oocyte maturation

  17. oocyte-derived BMP15 and FGFs cooperate to promote glycolysis in cumulus cells.

  18. oocyte-derived paracrine factors, particularly, BMP15 and GDF9, promote cholesterol biosynthesis in cumulus cells, probably as compensation for oocyte deficiencies in cholesterol production

  19. RT-PCR data shows an increase in oogenesis specific gene transcripts (Nobox, Oct4, Bmp15, Gdf9, Oogenesin1 and Oogenesin2) between the primordial until the preantral stages, with the exception of the Oogenesin1 transcripts under gonadotropin-induction.

  20. The highest Bmp15 mRNA levels were detected in oocytes in the pre-antral follicle stage.

Zebrafish Bone Morphogenetic Protein 15 (BMP15) interaction partners

  1. Females deficient in Bmp15 begin development normally but switch sex during the mid- to late- juvenile stage, and become fertile males.

  2. Incubation with antiserum increased oocyte maturaation whereas incubation with recombinant human BMP-15 suppressed human chorionic gonadotropin-induced oocyte maturation.

  3. BMP-15 modulates follicular growth and prevents premature oocyte maturation in zebrafish.

  4. These findings suggest that activin-A, TGF-beta1, and BMP-15 may target common gene(s) to regulate oocyte maturation.

Cow (Bovine) Bone Morphogenetic Protein 15 (BMP15) interaction partners

  1. oocytes maintain complex integrity by preventing granulosa cell differentiation and participate in follicular antrum formation via GDF9 and BMP15

  2. This study concluded that the improved pregnancy rate after porcine LH-induced ovulation reported previously occurred through greater activation of intrafollicular transforming growth factor-beta1 superfamily members, as these proteins promote cumulus expansion and oocyte competence.

  3. Amphiregulin co-operates with bone morphogenetic protein 15 to increase bovine oocyte developmental competence.

  4. In conclusion, BMP-15 should be considered as a potential genetic marker for sperm quality, based on its association with fresh sperm motility.

  5. BMP15 and FGF10 stimulate expansion of in cumulus-oocyte complexes by driving glucose metabolism toward hyaluronic acid production and controlling gene expression in the ovulatory cascade.

  6. Immunization against GDF9 and BMP15, alone or together, altered follicular development and ovulation rate in cattle.

  7. BMP15 expression in the oocytes of calf and adult ovaries was not significantly different. BMP15 transcripts were detected in ovarian tissues, but were not detected in any other tissues examined by RT-PCR.

  8. Maternal BMP15 transcripts persisted during oocyte in vitro maturation and fertilization and in preimplantation embryo until the five- to eight-cell or morula stage, but transcription was not reactivated at the time of embryonic genome activation.

  9. polymorphism in the bovine bone morphogenetic protein 15 (BMP15) gene

Pig (Porcine) Bone Morphogenetic Protein 15 (BMP15) interaction partners

  1. These results show that GDF9 and BMP15 participate in cumulus expansion and that they stimulate MPF and MAPK activities in porcine oocytes during in vitro maturation.

  2. Report temporal regulation of BMP15 mRNA expression in the oocyte, granulosa and theca cells of developing preovulatory follicles in the pig.

  3. BMP15mRNA and its encoded protein were expressed at low levels in immature oocytes and increased to the highest level at 18 h of IVM, which coincides with the time of cumulus cell expansion

Goat Bone Morphogenetic Protein 15 (BMP15) interaction partners

  1. bone morphogenetic protein 15 up-regulates the expression of Anti-Mullerian hormone via the p38 mitogen activated protein kinase signaling pathway, and this process involves the SRY-related HMG box 9 transcription factor in goats

  2. Studied six SNPs in goat BMPR1B, BMP15, and GDF9 for their association with litter size in seven breeds of Indian goats. Found no association between these SNPs and prolificacy in the breeds investigated.

  3. Expression of BMP15 (p < 0.01) and GDF9 (p < 0.05) mRNAs was more abundant in the small than the large antral follicles of Black Bengal goat.

  4. Mutations in BMP15 gene has been associated with prolificacy.

  5. The expression level of BMP15 mRNA in follicle of Lezhi black goat was 5.72-fold greater than that in Tibetan goat.

BMP15 Antigen Profile

Protein Summary

may regulate granulosa cell growth and ovarian follicle formation

Gene names and symbols associated with BMP15

  • bone morphogenetic protein 15 (BMP15) antibody
  • bone morphogenetic protein 15 (Bmp15) antibody
  • bone morphogenetic protein 15 (bmp15) antibody
  • AU015375 antibody
  • AU018861 antibody
  • AU021453 antibody
  • BMP-15 antibody
  • BMP15 antibody
  • C86824 antibody
  • C87336 antibody
  • fi35a05 antibody
  • Gdf-9b antibody
  • GDF9B antibody
  • ODG2 antibody
  • POF4 antibody
  • wu:fi35a05 antibody

Protein level used designations for BMP15

BMP-15 , GDF-9B , growth/differentiation factor 9B , growth differentiation factor-9B , BMP-15/GDF-9B , bone morphogenetic protein 15 proprotein , growth differentiation factor 9B , bone morphogenetic protein 15 , bone morphogenetic protein 15-like

GENE ID SPECIES
9210 Homo sapiens
12155 Mus musculus
59302 Rattus norvegicus
334183 Danio rerio
353351 Bos taurus
428697 Gallus gallus
448811 Sus scrofa
473873 Pan troglodytes
695457 Macaca mulatta
100052461 Equus caballus
100141303 Ovis aries
100301545 Oryctolagus cuniculus
100306941 Felis catus
100441790 Pongo abelii
100583339 Nomascus leucogenys
100856301 Canis lupus familiaris
100355411 Oryctolagus cuniculus
100732890 Cavia porcellus
100861233 Capra hircus
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