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may regulate granulosa cell growth and ovarian follicle formation [RGD, Feb 2006].. Additionally we are shipping BMP15 Antibodies (114) and BMP15 Kits (43) and many more products for this protein.
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the expression of BMP15 in follicular fluid and Smad1 (show GARS Proteins) in granulosa cells was significantly decreased in the PCOS group compared with the control (P<0.05). The data suggested that the BMP15/Smad1 (show GARS Proteins) signalling pathway may be involved in granulosa cell apoptosis
BMP15 did not seem critical for follicles to enter the growth phase. Genetic counselling should be performed and fertility preservation discussed before progressive loss of follicular reserve
Mutations in BMP15 associated with primary ovarian insufficiency reduce mature protein production, activity, or synergy with GDF9 (show GDF9 Proteins).
Human GDF9 (show GDF9 Proteins) and BMP15 act synergistically to stimulate granulosa cell proliferation, a response that also involves species-specific non-SMAD (show SMAD1 Proteins) signalling pathways.
GDF9 (show GDF9 Proteins) c.169G>T (D57Y), c.546G>A (rs1049127), and BMP15 rs79377927 (788_789insTCT) were associated with premature ovarian failure in the Chinese Hui population.
BMP15 supplementation differentially modulates reductive metabolism and mitochondrial localization within the oocyte.
results support a model of activation for human GDF9 (show GDF9 Proteins) dependent on cumulin formation through heterodimerization with BMP15. Oocyte-secreted cumulin is likely to be a central regulator of fertility in mono-ovular mammals.
GDF9 (show GDF9 Proteins) and BMP15 expression is reduced in primordial, primary, and secondary follicles in ovarian tissues of PCOS patients.
The results showed no direct association between BMP15-9G or 852T and the development of premature ovarian failure (POF (show POF1B Proteins)). Women with the 538A mutation are up to five times more likely to develop POF (show POF1B Proteins). The 788insTCT polymorphism had low biological impact.
the BMP15 c.-9G allele is related to BMP15 increased transcription, supporting c.-9C>G as a causal agent of premature ovarian failure
these data provide evidence that the preovulatory LH surge leads to upregulation of several forms of BMP15 protein secreted by the oocyte for putative sequestration and/or interaction with ovarian follicular somatic cells.
Data show that Rac1 induced nuclear import of STAT3 (show STAT3 Proteins) by physical binding, and nuclear STAT3 (show STAT3 Proteins) directly activated the transcription of essential oocyte-specific genes, including Jagged1 (show JAG1 Proteins), GDF9 (show GDF9 Proteins) and BMP15.
modified oocyte glycoproteins alter GDF9 (show GDF9 Proteins):BMP15 expression modifying follicle development resulting in the generation of more follicles
findings that GDF9 (show GDF9 Proteins):BMP15 heterodimers are the most bioactive ligands in mice and humans compared with homodimers explain many puzzling genetic and physiological data and have important implications for improving female fertility in mammals
show that purified mature regions of GDF9 (show GDF9 Proteins) and BMP15 synergistically interact in a specific manner which is not dependent on the presence of a pro-region.
Integral role of GDF-9 (show GDF9 Proteins) and BMP-15 in ovarian function.
oocyte-derived GDF9 (show GDF9 Proteins) and Bmp15 coordinate to promote the development of cumulus cells E2 and oocyte-derived paracrine factors GDF9 (show GDF9 Proteins) and bone morphogenetic protein 15 coordinate to promote the development of cumulus cells
The results showed that both GDF-9 (show GDF9 Proteins) and BMP-15 were detectable in oocytes from primary follicles onward, besides, BMP-15 also presented in granulosa cells (GCs (show UGCG Proteins)) and follicular follicle of mature follicles in mouse
bone morphogenetic protein-15 could play a physiological role in the monotropic rise of FSH (show BRD2 Proteins) secretion by the pituitary during the estrous and menstrual cycle
Females deficient in Bmp15 begin development normally but switch sex during the mid- to late- juvenile stage, and become fertile males.
Incubation with antiserum increased oocyte maturaation whereas incubation with recombinant human BMP-15 suppressed human chorionic gonadotropin-induced oocyte maturation.
BMP-15 modulates follicular growth and prevents premature oocyte maturation in zebrafish.
These findings suggest that activin-A (show INHBA Proteins), TGF-beta1 (show TGFB1 Proteins), and BMP-15 may target common gene(s) to regulate oocyte maturation.
Amphiregulin (show AREG Proteins) co-operates with bone morphogenetic protein 15 to increase bovine oocyte developmental competence.
In conclusion, BMP-15 should be considered as a potential genetic marker for sperm quality, based on its association with fresh sperm motility.
BMP15 and FGF10 (show FGF10 Proteins) stimulate expansion of in cumulus-oocyte complexes by driving glucose metabolism toward hyaluronic acid production and controlling gene expression in the ovulatory cascade.
Immunization against GDF9 (show GDF9 Proteins) and BMP15, alone or together, altered follicular development and ovulation rate in cattle.
BMP15 expression in the oocytes of calf and adult ovaries was not significantly different. BMP15 transcripts were detected in ovarian tissues, but were not detected in any other tissues examined by RT-PCR.
Maternal BMP15 transcripts persisted during oocyte in vitro maturation and fertilization and in preimplantation embryo until the five- to eight-cell or morula stage, but transcription was not reactivated at the time of embryonic genome activation.
polymorphism in the bovine bone morphogenetic protein 15 (BMP15) gene
These results show that GDF9 (show GDF9 Proteins) and BMP15 participate in cumulus expansion and that they stimulate MPF (show MSLN Proteins) and MAPK (show MAPK1 Proteins) activities in porcine oocytes during in vitro maturation.
Report temporal regulation of BMP15 mRNA expression in the oocyte, granulosa and theca cells of developing preovulatory follicles in the pig.
Studied six SNPs in goat BMPR1B (show BMPR1B Proteins), BMP15, and GDF9 (show GDF9 Proteins) for their association with litter size in seven breeds of Indian goats. Found no association between these SNPs and prolificacy in the breeds investigated.
Expression of BMP15 (p < 0.01) and GDF9 (show GDF9 Proteins) (p < 0.05) mRNAs was more abundant in the small than the large antral follicles of Black Bengal goat.
Mutations in BMP15 gene has been associated with prolificacy.
The expression level of BMP15 mRNA in follicle of Lezhi black goat was 5.72-fold greater than that in Tibetan goat.
may regulate granulosa cell growth and ovarian follicle formation
, growth/differentiation factor 9B
, growth differentiation factor-9B
, bone morphogenetic protein 15 proprotein
, growth differentiation factor 9B
, bone morphogenetic protein 15
, bone morphogenetic protein 15-like