anti-Bone gamma-Carboxyglutamate (Gla) Protein (BGLAP) Antibodies

Constitutes 1-2% of the total bone protein. Additionally we are shipping Osteocalcin Kits (128) and Osteocalcin Proteins (54) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
BGLAP 632 P02818
BGLAP 12096 P86546
BGLAP 25295 P04640
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Top anti-Osteocalcin Antibodies at antibodies-online.com

Showing 10 out of 359 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Mouse Un-conjugated CyTOF, FACS, ICC, IHC 100 μg Log in to see 8 to 9 Days
$308.20
Details
Human Rabbit Un-conjugated IHC (p), WB Anti-Osteocalcin Picoband antibody,  All lanes: Anti-Osteocalcin at 0.5ug/ml WB: Recombinant Human Osteocalcin Protein 0.5ng Predicted bind size: 38KD Observed bind size: 38KD Anti-Osteocalcin Picoband antibody,  IHC(P): Human Osteosarcoma Tissue 100 μg Log in to see 4 to 6 Days
$280.00
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated IHC (p), WB Western blot analysis of Osteocalcin (arrow) using rabbit polyclonal Osteocalcin Antibody (N-term) (ABIN388727). 293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected with the BGLAP gene (Lane 2) (Origene Technologies). Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma 400 μL Log in to see 10 to 11 Days
$335.50
Details
Human Rabbit Un-conjugated WB Western blot analysis of Osteocalcin expression in HEK293T (A), Raw264.7 (B), H9C2 (C) whole cell lysates. 200 μL Log in to see 13 to 14 Days
$487.50
Details
Human Rabbit Un-conjugated IHC (p) Osteocalcin was detected in paraffin-embedded sections of human osteosarcoma tissues using rabbit anti-Osteocalcin Antigen Affinity purified polyclonal antibody(Catalog # ) at 1 ??g/mL. The immunohistochemical section was developed using SABC method (Catalog # SA1022). 100 μg Log in to see 4 to 6 Days
$280.00
Details
Mouse Rabbit Un-conjugated IHC (p) IHC analysis of Osteocalcin using anti- Osteocalcin antibody . Osteocalcin was detected in paraffin-embedded section of mouse tibia tissues. Heat mediated antigen retrieval was performed in citrate buffer (pH6, epitope retrieval solution) for 20 mins. The tissue section was blocked with 10% goat serum. The tissue section was then incubated with 1µg/ml rabbit anti- Osteocalcin Antibody  overnight at 4°C. Biotinylated goat anti-rabbit IgG was used as secondary antibody and incubated for 30 minutes at 37°C. The tissue section was developed using Strepavidin-Biotin-Complex (SABC)(Catalog # SA1022) with DAB as the chromogen. Flow Cytometry analysis of L6 cells using anti-Osteocalcin antibody . Overlay histogram showing L6 cells stained with  (Blue line).The cells were blocked with 10% normal goat serum. And then incubated with rabbit anti-Osteocalcin Antibody (,1µg/1x106 cells) for 30 min at 20°C. DyLight®488 conjugated goat anti-rabbit IgG (BA1127, 5-10µg/1x106 cells) was used as secondary antibody for 30 minutes at 20°C. Isotype control antibody (Green line) was rabbit IgG (1µg/1x106) used under the same conditions. Unlabelled sample (Red line) was also used as a control. 100 μg Log in to see 4 to 6 Days
$280.00
Details
Rat Rabbit Un-conjugated IHC (p) IHC analysis of Osteocalcin using anti- Osteocalcin antibody . Osteocalcin was detected in paraffin-embedded section of rat tibia tissues. Heat mediated antigen retrieval was performed in citrate buffer (pH6, epitope retrieval solution) for 20 mins. The tissue section was blocked with 10% goat serum. The tissue section was then incubated with 1µg/ml rabbit anti- Osteocalcin Antibody  overnight at 4°C. Biotinylated goat anti-rabbit IgG was used as secondary antibody and incubated for 30 minutes at 37°C. The tissue section was developed using Strepavidin-Biotin-Complex (SABC)(Catalog # SA1022) with DAB as the chromogen. Flow Cytometry analysis of L6 cells using anti-Osteocalcin antibody . Overlay histogram showing L6 cells stained with  (Blue line).The cells were blocked with 10% normal goat serum. And then incubated with rabbit anti-Osteocalcin Antibody (,1µg/1x106 cells) for 30 min at 20°C. DyLight®488 conjugated goat anti-rabbit IgG (BA1127, 5-10µg/1x106 cells) was used as secondary antibody for 30 minutes at 20°C. Isotype control antibody (Green line) was rabbit IgG (1µg/1x106) used under the same conditions. Unlabelled sample (Red line) was also used as a control. 100 μg Log in to see 4 to 6 Days
$280.00
Details
Human Mouse APC FACS Detection of Osteocalcin in Human Osteoblasts by Flow Cytometry. Human osteoblasts were stained with Mouse Anti-Human Osteocalcin APC-conjugated Monoclonal Antibody. Detection of Osteocalcin in Saos-2 Human Cell Line by Flow Cytometry. Saos-2 human osteosarcoma cell line was stained with Mouse Anti-Human Osteocalcin APC-conjugated Monoclonal Antibody. 100 Tests Log in to see 8 to 9 Days
$346.15
Details
Human Rabbit Un-conjugated EIA, WB BGLAP Antibody (C80) western blot analysis in HepG2 cell line lysates (35µg/lane).This demonstrates the BGLAP antibody detected the BGLAP protein (arrow). 0.4 mL Log in to see 6 to 8 Days
$390.50
Details

Top referenced anti-Osteocalcin Antibodies

  1. Human Monoclonal Osteocalcin Primary Antibody for CyTOF, FACS - ABIN4900835 : Curran, Chen, Hunt: The guidance of human mesenchymal stem cell differentiation in vitro by controlled modifications to the cell substrate. in Biomaterials 2006 (PubMed)
    Show all 15 Pubmed References

  2. Human Polyclonal Osteocalcin Primary Antibody for IHC (p), WB - ABIN3042320 : Qiu, Jin, Shao, Zhao: 17β-estradiol induces the proliferation of hematopoietic stem cells by promoting the osteogenic differentiation of mesenchymal stem cells. in The Tohoku journal of experimental medicine 2014 (PubMed)
    Show all 5 Pubmed References

  3. Human Monoclonal Osteocalcin Primary Antibody for FACS - ABIN4898812 : Spina, Montella, Liccardo, De Rosa, Laino, Mitsiadis, La Noce: NZ-GMP Approved Serum Improve hDPSC Osteogenic Commitment and Increase Angiogenic Factor Expression. in Frontiers in physiology 2016 (PubMed)
    Show all 3 Pubmed References

  4. Cow (Bovine) Polyclonal Osteocalcin Primary Antibody for IHC (fro) - ABIN2475977 : Lopes, Knowles, Kuru, Santos, Monteiro, Olsen: Flow cytometry for assessing biocompatibility. in Journal of biomedical materials research 1998 (PubMed)
    Show all 3 Pubmed References

  5. Human Polyclonal Osteocalcin Primary Antibody for IF (p), IHC (p) - ABIN1385851 : Li, Zhou, Wang, Yang, Ding, Zhou: Controlled dual delivery of BMP-2 and dexamethasone by nanoparticle-embedded electrospun nanofibers for the efficient repair of critical-sized rat calvarial defect. in Biomaterials 2015 (PubMed)
    Show all 2 Pubmed References

  6. Mouse (Murine) Polyclonal Osteocalcin Primary Antibody for IHC (fro), IF - ABIN2475969 : Gundberg, Clough, Carpenter: Development and validation of a radioimmunoassay for mouse osteocalcin: paradoxical response in the Hyp mouse. in Endocrinology 1992 (PubMed)
    Show all 4 Pubmed References

  7. Human Monoclonal Osteocalcin Primary Antibody for ELISA - ABIN2475972 : Gindraux, Obert, Laganier, Barnouin: Industrial approach in developing an advanced therapy product for bone repair. in Journal of tissue engineering and regenerative medicine 2010 (PubMed)

  8. Human Monoclonal Osteocalcin Primary Antibody for IF - ABIN2475975 : Kover, Tong, Pacicca, Clements, Bodker, Eidson, Sheldon, Southard, Zaidi, Moore: Bone marrow cavity: a supportive environment for islet engraftment. in Islets 2011 (PubMed)

  9. Human Monoclonal Osteocalcin Primary Antibody for FACS - ABIN4898810 : Takahashi, Satoh, Takahashi, Osaki, Nasu, Tamada, Okabayashi, Nakamura, Morino: Dysregulation of ossification-related miRNAs in circulating osteogenic progenitor cells obtained from patients with aortic stenosis. in Clinical science (London, England : 1979) 2016 (PubMed)

  10. Human Monoclonal Osteocalcin Primary Antibody for FACS - ABIN4898811 : Maddaloni, Xia, Park, DEon, Tinsley, St-Louis, Khamaisi, Li, King, Keenan: High density lipoprotein modulates osteocalcin expression in circulating monocytes: a potential protective mechanism for cardiovascular disease in type 1 diabetes. in Cardiovascular diabetology 2017 (PubMed)

More Antibodies against Osteocalcin Interaction Partners

Human Bone gamma-Carboxyglutamate (Gla) Protein (BGLAP) interaction partners

  1. a decrease in serum osteocalcin levels is associated with future development of type 2 diabetes mellitus.

  2. Findings from the available data indicated an overall significant inverse association between serum osteocalcin and body mass index--{REVIEW}

  3. relatively lower serum osteocalcin levels were associated with a higher risk of MACE in Chinese men with CAD (show CAD Antibodies)

  4. undercarboxylated form of osteocalcin in serum not related significantly to semen parameters or measured hormones in male infertility

  5. Serum osteocalcin was directly and independently correlated with circulating uric acid in a population of healthy obese subjects.

  6. gamma-carboxylation of OCN on Glu17 residue correlates with insulin (show INS Antibodies) resistance and subclinical inflammation, suggesting that gamma-carboxylation of OCN negatively regulates its endocrine action

  7. There were differences in the associations between total osteocalcin and glucose metabolism in Han and Uygur T2DM patients, indicating genetic factors may play a role in modulating OC and glucose metabolism in different ethnic population.

  8. The study demonstrated that undercarboxylated osteocalcin (ucOC) is related to 25(OH)D and adiponectin concentrations. Both ucOC and 25(OH)D were lower in overweight and obese adolescents.

  9. Increased advanced glycation end products and protein oxidative damage markers in the course of obesity may contribute to decreased carboxylated osteocalcin serum level.

  10. Progressive calcification of atherosclerotic plaques is accompanied by insignificant accumulation of calcitonin (show CALCA Antibodies) and osteoprotegerin (show TNFRSF11B Antibodies), whereas the osteocalcin expression significantly increased during calcification.

Mouse (Murine) Bone gamma-Carboxyglutamate (Gla) Protein (BGLAP) interaction partners

  1. the uncarboxylated form of osteocalcin does not trigger Akt (show AKT1 Antibodies) phosphorylation and glucose uptake by itself but promotes insulin (show INS Antibodies)-induced glucose uptake in myotubes, probably by up-regulating Akt (show AKT1 Antibodies) signaling through ERK (show EPHB2 Antibodies) activation

  2. The Twist2 (show TWIST2 Antibodies)-Cre, Osterix (show SP7 Antibodies)-Cre and osteocalcin-Cre lines to generate conditional beta1 integrin deletions, were used to investigate the role of beta1 integrins on skeletal phenotype.

  3. OCN is gamma-carboxylated by the gamma-carboxylase (GGCX (show GGCX Antibodies)) on three glutamic acid residues, a cellular process requiring reduction of vitamin K by a second enzyme, VKORC1 (show VKORC1 Antibodies).

  4. results showed an increase in the expression of Cbfa1 (show RUNX2 Antibodies) and OCN in fibroblasts and osteoblasts exposed to fluoride.

  5. Data indicate that Ca2 (show CA2 Antibodies)+ binding triggered a similar conformational transition in both gamma-carboxyglutamic acid-containing protein osteocalcin (Gla (show GLA Antibodies)-OCN) and Glu (show GCG Antibodies)-OCN from a disordered structure to a more compact/stable form.

  6. In primary adipocytes, both carboxylated and uncarboxylated osteocalcin increased basal and insulin (show INS Antibodies)-stimulated glucose transport.

  7. Taken together, these findings demonstrate that SMILE (show CREBZF Antibodies) negatively regulates osteocalcin via a direct interaction with RUNX2 (show RUNX2 Antibodies)

  8. Osteoblast-specific expression of Fra-2 (show FOSL2 Antibodies)/AP-1 (show JUN Antibodies) controls adiponectin and osteocalcin expression and affects metabolism.

  9. contribution of OC-OPN (show SPP1 Antibodies) to fracture toughness is related to their presence at the extrafibrillar organic-mineral interfaces

  10. Insulin (show INS Antibodies) resistance in osteoblasts led to a decrease in circulating levels of the active form of osteocalcin, thereby decreasing insulin (show INS Antibodies) sensitivity in skeletal muscle.

Cow (Bovine) Bone gamma-Carboxyglutamate (Gla) Protein (BGLAP) interaction partners

  1. Osteopontin, osteocalcin and OB-cadherin expression in Synthetic nanohydroxyapatite vs bovine hydroxyapatite cultured Osteoblastic-like cells.

  2. Data suggest that helical content of 3 Glu (show DCTN1 Antibodies)-OCN is 57% and is independent of calcium binding; 3 Glu (show DCTN1 Antibodies)-OCN contains 3 alpha-helices around a hydrophobic core; study includes first high-resolution structure of bovine 3 Glu (show DCTN1 Antibodies)-OCN using X-ray crystallography.

  3. Serum osteocalcin levels in non-periparturient Holstein dairy cows were highest in the youngest cows, decreasing with age until time of first calving. In periparturient cows, serum osteocalcin levels were higher in primiparous than in multiparous cows.

  4. Osteocalcin is released from the bone matrix during bone resorption as intact molecules and fragments; serum osteocalcin should be considered as a marker of bone turnover rather than bone formation

Zebrafish Bone gamma-Carboxyglutamate (Gla) Protein (BGLAP) interaction partners

  1. In zebrafish, bgp and mgp (show MGP Antibodies) mRNAs were localized in all mineralized tissues during and after calcification including bone and calcified cartilage of branchial arches.

Osteocalcin (BGLAP) Antigen Profile

Protein Summary

Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium.

Gene names and symbols associated with BGLAP

  • bone gamma-carboxyglutamate protein (BGLAP) antibody
  • bone gamma carboxyglutamate protein (Bglap) antibody
  • bone gamma-carboxyglutamate protein (Bglap) antibody
  • bone gamma-carboxyglutamate protein S homeolog (bglap.S) antibody
  • bone gamma-carboxyglutamate (gla) protein (bglap) antibody
  • osteocalcin (ocn) antibody
  • bone gamma-carboxyglutamate (gla) protein (BGLAP) antibody
  • bone gamma-carboxyglutamate protein (bglap) antibody
  • osteocalcin (LOC100529177) antibody
  • polyamine-modulated factor 1 (LOC100146589) antibody
  • BGLAP antibody
  • Bglap1 antibody
  • Bglap2 antibody
  • bgp antibody
  • Bgpr antibody
  • Bgpra antibody
  • GLA antibody
  • LOC792433 antibody
  • mOC-A antibody
  • OC antibody
  • ocn antibody
  • OG1 antibody
  • PMF1 antibody

Protein level used designations for BGLAP

bone Gla protein , bone gamma-carboxyglutamate (gla) protein (osteocalcin) , gamma-carboxyglutamic acid-containing protein , osteocalcin , BGP , bone gamma carboxyglutamate protein 1 , bone Gla-protein , bone gamma-carboxyglutamate protein 2 , bone gamma-carboxyglutamic acid (Gla) protein (osteocalcin) , xBGP , osteocalcin preproprotein , hypothetical protein LOC792433 , bone gamma-carboxyglutamate protein osteocalcin , Bone Gla protein , Gamma-carboxyglutamic acid-containing protein , Osteocalcin , bone gamma-carboxyglutamate (gla) protein , polyamine-modulated factor 1

GENE ID SPECIES
632 Homo sapiens
12096 Mus musculus
25295 Rattus norvegicus
281646 Bos taurus
396348 Gallus gallus
397530 Sus scrofa
399370 Xenopus laevis
677670 Ovis aries
718296 Macaca mulatta
792433 Danio rerio
100136174 Oncorhynchus mykiss
100190891 Pan troglodytes
100192339 Salmo salar
100529177 Oryzias latipes
100534506 Oreochromis niloticus
100735766 Cavia porcellus
403762 Canis lupus familiaris
101085947 Felis catus
100861188 Capra hircus
100340503 Oryctolagus cuniculus
100146589 Equus caballus
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