anti-Bone gamma-Carboxyglutamate (Gla) Protein (BGLAP) Antibodies

Constitutes 1-2% of the total bone protein. Additionally we are shipping Osteocalcin Kits (126) and Osteocalcin Proteins (52) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
BGLAP 632 P02818
BGLAP 12096 P86546
BGLAP 25295 P04640
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Top anti-Osteocalcin Antibodies at antibodies-online.com

Showing 10 out of 357 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated IHC (p), WB Anti-Osteocalcin Picoband antibody,  All lanes: Anti-Osteocalcin at 0.5ug/ml WB: Recombinant Human Osteocalcin Protein 0.5ng Predicted bind size: 38KD Observed bind size: 38KD Anti-Osteocalcin Picoband antibody,  IHC(P): Human Osteosarcoma Tissue 100 μg Log in to see 4 to 6 Days
$280.00
Details
Rat Rabbit Un-conjugated IHC (p) IHC analysis of Osteocalcin using anti- Osteocalcin antibody . Osteocalcin was detected in paraffin-embedded section of rat tibia tissues. Heat mediated antigen retrieval was performed in citrate buffer (pH6, epitope retrieval solution) for 20 mins. The tissue section was blocked with 10% goat serum. The tissue section was then incubated with 1µg/ml rabbit anti- Osteocalcin Antibody  overnight at 4°C. Biotinylated goat anti-rabbit IgG was used as secondary antibody and incubated for 30 minutes at 37°C. The tissue section was developed using Strepavidin-Biotin-Complex (SABC)(Catalog # SA1022) with DAB as the chromogen. Flow Cytometry analysis of L6 cells using anti-Osteocalcin antibody . Overlay histogram showing L6 cells stained with  (Blue line).The cells were blocked with 10% normal goat serum. And then incubated with rabbit anti-Osteocalcin Antibody (,1µg/1x106 cells) for 30 min at 20°C. DyLight®488 conjugated goat anti-rabbit IgG (BA1127, 5-10µg/1x106 cells) was used as secondary antibody for 30 minutes at 20°C. Isotype control antibody (Green line) was rabbit IgG (1µg/1x106) used under the same conditions. Unlabelled sample (Red line) was also used as a control. 100 μg Log in to see 4 to 6 Days
$280.00
Details
Mouse Rabbit Un-conjugated IHC (p) IHC analysis of Osteocalcin using anti- Osteocalcin antibody . Osteocalcin was detected in paraffin-embedded section of mouse tibia tissues. Heat mediated antigen retrieval was performed in citrate buffer (pH6, epitope retrieval solution) for 20 mins. The tissue section was blocked with 10% goat serum. The tissue section was then incubated with 1µg/ml rabbit anti- Osteocalcin Antibody  overnight at 4°C. Biotinylated goat anti-rabbit IgG was used as secondary antibody and incubated for 30 minutes at 37°C. The tissue section was developed using Strepavidin-Biotin-Complex (SABC)(Catalog # SA1022) with DAB as the chromogen. Flow Cytometry analysis of L6 cells using anti-Osteocalcin antibody . Overlay histogram showing L6 cells stained with  (Blue line).The cells were blocked with 10% normal goat serum. And then incubated with rabbit anti-Osteocalcin Antibody (,1µg/1x106 cells) for 30 min at 20°C. DyLight®488 conjugated goat anti-rabbit IgG (BA1127, 5-10µg/1x106 cells) was used as secondary antibody for 30 minutes at 20°C. Isotype control antibody (Green line) was rabbit IgG (1µg/1x106) used under the same conditions. Unlabelled sample (Red line) was also used as a control. 100 μg Log in to see 4 to 6 Days
$280.00
Details
Human Rabbit Un-conjugated IHC (p) Osteocalcin was detected in paraffin-embedded sections of human osteosarcoma tissues using rabbit anti-Osteocalcin Antigen Affinity purified polyclonal antibody(Catalog # ) at 1 ??g/mL. The immunohistochemical section was developed using SABC method (Catalog # SA1022). 100 μg Log in to see 4 to 6 Days
$280.00
Details
Human Mouse Un-conjugated CyTOF, FACS, ICC, IHC 100 μg Log in to see 8 to 9 Days
$311.88
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB 0.4 mL Log in to see 6 to 8 Days
$484.00
Details
Human Rabbit Un-conjugated IHC (p), WB Western blot analysis of Osteocalcin (arrow) using rabbit polyclonal Osteocalcin Antibody (N-term) (ABIN388727). 293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected with the BGLAP gene (Lane 2) (Origene Technologies). Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma 400 μL Log in to see 10 to 11 Days
$385.00
Details
Human Rabbit Un-conjugated WB Western blot analysis of Osteocalcin expression in HEK293T (A), Raw264.7 (B), H9C2 (C) whole cell lysates. 200 μL Log in to see 13 to 14 Days
$487.50
Details
Human Goat Un-conjugated ELISA   100 μg Log in to see 6 to 7 Days
$291.53
Details
Human Rabbit Un-conjugated EIA, WB BGLAP Antibody (C80) western blot analysis in HepG2 cell line lysates (35µg/lane).This demonstrates the BGLAP antibody detected the BGLAP protein (arrow). 0.4 mL Log in to see 6 to 8 Days
$484.00
Details

Top referenced anti-Osteocalcin Antibodies

  1. Human Monoclonal Osteocalcin Primary Antibody for CyTOF, FACS - ABIN4900835 : Curran, Chen, Hunt: The guidance of human mesenchymal stem cell differentiation in vitro by controlled modifications to the cell substrate. in Biomaterials 2006 (PubMed)
    Show all 20 Pubmed References

  2. Human Polyclonal Osteocalcin Primary Antibody for IHC (p), WB - ABIN3042320 : Qiu, Jin, Shao, Zhao: 17β-estradiol induces the proliferation of hematopoietic stem cells by promoting the osteogenic differentiation of mesenchymal stem cells. in The Tohoku journal of experimental medicine 2014 (PubMed)
    Show all 11 Pubmed References

  3. Rat (Rattus) Polyclonal Osteocalcin Primary Antibody for IHC (p) - ABIN4886487 : Chen, Bai, Liao, Peng, Wu, Wang, Zeng, Xie: Electrospun poly(L-lactide)/poly(?-caprolactone) blend nanofibrous scaffold: characterization and biocompatibility with human adipose-derived stem cells. in PLoS ONE 2013 (PubMed)
    Show all 7 Pubmed References

  4. Mouse (Murine) Polyclonal Osteocalcin Primary Antibody for IHC (p) - ABIN4886486 : Cheng, Wang, Zhang, Shi: The osteogenic potential of mesoporous bioglasses/silk and non-mesoporous bioglasses/silk scaffolds in ovariectomized rats: in vitro and in vivo evaluation. in PLoS ONE 2014 (PubMed)
    Show all 6 Pubmed References

  5. Human Polyclonal Osteocalcin Primary Antibody for IHC (p) - ABIN4886485 : Yin, Cheng, Qin, Yu, Yu, Zhong, Sun, Zhang: Effects of Naringin on Proliferation and Osteogenic Differentiation of Human Periodontal Ligament Stem Cells In Vitro and In Vivo. in Stem cells international 2015 (PubMed)
    Show all 6 Pubmed References

  6. Human Monoclonal Osteocalcin Primary Antibody for FACS - ABIN4898812 : Spina, Montella, Liccardo, De Rosa, Laino, Mitsiadis, La Noce: NZ-GMP Approved Serum Improve hDPSC Osteogenic Commitment and Increase Angiogenic Factor Expression. in Frontiers in physiology 2016 (PubMed)
    Show all 5 Pubmed References

  7. Human Polyclonal Osteocalcin Primary Antibody for IHC (p), ELISA - ABIN544881 : Yousfi, Lasmoles, Marie: TWIST inactivation reduces CBFA1/RUNX2 expression and DNA binding to the osteocalcin promoter in osteoblasts. in Biochemical and biophysical research communications 2002 (PubMed)
    Show all 3 Pubmed References

  8. Human Polyclonal Osteocalcin Primary Antibody for IF (p), IHC (p) - ABIN1385851 : Li, Zhou, Wang, Yang, Ding, Zhou: Controlled dual delivery of BMP-2 and dexamethasone by nanoparticle-embedded electrospun nanofibers for the efficient repair of critical-sized rat calvarial defect. in Biomaterials 2015 (PubMed)
    Show all 2 Pubmed References

  9. Cow (Bovine) Polyclonal Osteocalcin Primary Antibody for IHC (fro) - ABIN2475977 : Lopes, Knowles, Kuru, Santos, Monteiro, Olsen: Flow cytometry for assessing biocompatibility. in Journal of biomedical materials research 1998 (PubMed)
    Show all 3 Pubmed References

  10. Human Monoclonal Osteocalcin Primary Antibody for FACS - ABIN4898811 : Maddaloni, Xia, Park, DEon, Tinsley, St-Louis, Khamaisi, Li, King, Keenan: High density lipoprotein modulates osteocalcin expression in circulating monocytes: a potential protective mechanism for cardiovascular disease in type 1 diabetes. in Cardiovascular diabetology 2017 (PubMed)
    Show all 2 Pubmed References

More Antibodies against Osteocalcin Interaction Partners

Human Bone gamma-Carboxyglutamate (Gla) Protein (BGLAP) interaction partners

  1. there is no significant difference in circulating OPG and OCN levels between RA patients and OA patients. However, plasma/serum OPN level is significantly higher in RA patients compared with OA patients.

  2. The present study has concluded that obesity is an undesirable factor for bone metabolism by reducing serum osteocalcin and by increasing hs-CRP and PTH which contribute to bone resorption.

  3. Osteocalcin plays an important role in glucose and lipid metabolism for protection against nonalcoholic fatty liver disease occurrence and progression.

  4. OCN levels were inversely correlated with body fat parameters and obesity.

  5. Serum osteocalcin level was not independently associated with blood pressure in a Chinese population

  6. The results of this study suggest that serum osteocalcin is associated with the onset of puberty in girls.

  7. The correlation between Mycobacterium avium subsp. paratuberculosis (MAP) infection and elevation of sera ucOC, reduction of active osteocalcin and increased calcium supports MAP infection role in Crohn's disease and complications with osteoporosis.

  8. The results showed no significant correlation between osteocalcin HindIII gene polymorphism and bone mineral density (BMD) and therefore osteocalcin HindIII gene polymorphism may not have major effects on BMD variation in postmenopausal North Indian women.

  9. Decreased circulating carboxylated osteocalcin is associated with low-energy bone fractures in children.

  10. a decrease in serum osteocalcin levels is associated with future development of type 2 diabetes mellitus.

  11. Findings from the available data indicated an overall significant inverse association between serum osteocalcin and body mass index--{REVIEW}

  12. relatively lower serum osteocalcin levels were associated with a higher risk of MACE in Chinese men with CAD

  13. undercarboxylated form of osteocalcin in serum not related significantly to semen parameters or measured hormones in male infertility

  14. serum level not correlated with gender, race/ethnicity, age, diabetes type, BMI percentile, random C-peptide, glucose, or HbA1c at pediatric diabetes diagnosis; serum level inversely correlated with HbA1c at first office visit following diagnosis

  15. Serum osteocalcin was directly and independently correlated with circulating uric acid in a population of healthy obese subjects.

  16. gamma-carboxylation of OCN on Glu17 residue correlates with insulin resistance and subclinical inflammation, suggesting that gamma-carboxylation of OCN negatively regulates its endocrine action

  17. There were differences in the associations between total osteocalcin and glucose metabolism in Han and Uygur T2DM patients, indicating genetic factors may play a role in modulating OC and glucose metabolism in different ethnic population.

  18. The study demonstrated that undercarboxylated osteocalcin (ucOC) is related to 25(OH)D and adiponectin concentrations. Both ucOC and 25(OH)D were lower in overweight and obese adolescents.

  19. Increased advanced glycation end products and protein oxidative damage markers in the course of obesity may contribute to decreased carboxylated osteocalcin serum level.

  20. Progressive calcification of atherosclerotic plaques is accompanied by insignificant accumulation of calcitonin and osteoprotegerin, whereas the osteocalcin expression significantly increased during calcification.

Mouse (Murine) Bone gamma-Carboxyglutamate (Gla) Protein (BGLAP) interaction partners

  1. expression in offspring bone not changed by maternal high fat diet

  2. the uncarboxylated form of osteocalcin does not trigger Akt phosphorylation and glucose uptake by itself but promotes insulin-induced glucose uptake in myotubes, probably by up-regulating Akt signaling through ERK activation

  3. The Twist2-Cre, Osterix-Cre and osteocalcin-Cre lines to generate conditional beta1 integrin deletions, were used to investigate the role of beta1 integrins on skeletal phenotype.

  4. OCN is gamma-carboxylated by the gamma-carboxylase (GGCX) on three glutamic acid residues, a cellular process requiring reduction of vitamin K by a second enzyme, VKORC1.

  5. results showed an increase in the expression of Cbfa1 and OCN in fibroblasts and osteoblasts exposed to fluoride.

  6. Data indicate that Ca2+ binding triggered a similar conformational transition in both gamma-carboxyglutamic acid-containing protein osteocalcin (Gla-OCN) and Glu-OCN from a disordered structure to a more compact/stable form.

  7. In primary adipocytes, both carboxylated and uncarboxylated osteocalcin increased basal and insulin-stimulated glucose transport.

  8. Taken together, these findings demonstrate that SMILE negatively regulates osteocalcin via a direct interaction with RUNX2

  9. Osteoblast-specific expression of Fra-2/AP-1 controls adiponectin and osteocalcin expression and affects metabolism.

  10. contribution of OC-OPN to fracture toughness is related to their presence at the extrafibrillar organic-mineral interfaces

  11. Insulin resistance in osteoblasts led to a decrease in circulating levels of the active form of osteocalcin, thereby decreasing insulin sensitivity in skeletal muscle.

  12. loss of osteocalcin/Gprc6a signaling has a profound effect on beta-cell mass accrual during late pancreas morphogenesis

  13. This study reveals that the skeleton via osteocalcin influences cognition and contributes to the maternal influence on fetal brain development.

  14. T3 stimulates the activation of Rho-kinase in osteoblasts, which functions as a negative regulator of T3-stimulated osteocalcin synthesis

  15. Uncarboxylated osteocalcin acts via Gprc6a to induce GLP-1 release from the gut; the stimulatory effect of uncarboxylated osteocalcin on insulin secretion is largely mediated by GLP-1.

  16. These results indicate that PP2A Calpha and its activity play a negative role in osteoblast differentiation and Osterix is a key factor responsible for regulating the expressions of Bsp and OCN during PP2A Calpha-mediated osteoblast differentiation.

  17. alphaNAC interacts with histone deacetylase corepressors to control Myogenin and Osteocalcin gene expression.

  18. Data from TR4 (steroid/thyroid hormone receptor 4) knockout mice suggest that TR4 binds to promoter region of osteocalcin gene and induces osteocalcin expression; this interaction maintains osteoblast activity during bone development/remodeling.

  19. Alterations of responses in knockout mice that suggest participation of osteocalcin in transmission of information about those sensory stimuli.

  20. BMP2 induces osteoblast differentiation through Runx2-dependent ATF6 expression, which directly regulates Oc transcription.

Cow (Bovine) Bone gamma-Carboxyglutamate (Gla) Protein (BGLAP) interaction partners

  1. Osteopontin, osteocalcin and OB-cadherin expression in Synthetic nanohydroxyapatite vs bovine hydroxyapatite cultured Osteoblastic-like cells.

  2. Data suggest that helical content of 3 Glu-OCN is 57% and is independent of calcium binding; 3 Glu-OCN contains 3 alpha-helices around a hydrophobic core; study includes first high-resolution structure of bovine 3 Glu-OCN using X-ray crystallography.

  3. Serum osteocalcin levels in non-periparturient Holstein dairy cows were highest in the youngest cows, decreasing with age until time of first calving. In periparturient cows, serum osteocalcin levels were higher in primiparous than in multiparous cows.

  4. Osteocalcin is released from the bone matrix during bone resorption as intact molecules and fragments; serum osteocalcin should be considered as a marker of bone turnover rather than bone formation

  5. A molecular mechanism of lead toxicity for calcium binding proteins.

Zebrafish Bone gamma-Carboxyglutamate (Gla) Protein (BGLAP) interaction partners

  1. In zebrafish, bgp and mgp mRNAs were localized in all mineralized tissues during and after calcification including bone and calcified cartilage of branchial arches.

Osteocalcin (BGLAP) Antigen Profile

Protein Summary

Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium.

Gene names and symbols associated with BGLAP

  • bone gamma-carboxyglutamate protein (BGLAP) antibody
  • bone gamma carboxyglutamate protein (Bglap) antibody
  • bone gamma-carboxyglutamate protein (Bglap) antibody
  • bone gamma-carboxyglutamate protein S homeolog (bglap.S) antibody
  • bone gamma-carboxyglutamate (gla) protein (bglap) antibody
  • osteocalcin (ocn) antibody
  • bone gamma-carboxyglutamate (gla) protein (BGLAP) antibody
  • bone gamma-carboxyglutamate protein (bglap) antibody
  • osteocalcin (LOC100529177) antibody
  • polyamine-modulated factor 1 (LOC100146589) antibody
  • BGLAP antibody
  • Bglap1 antibody
  • Bglap2 antibody
  • bgp antibody
  • Bgpr antibody
  • Bgpra antibody
  • GLA antibody
  • LOC792433 antibody
  • mOC-A antibody
  • OC antibody
  • ocn antibody
  • OG1 antibody
  • PMF1 antibody

Protein level used designations for BGLAP

bone Gla protein , bone gamma-carboxyglutamate (gla) protein (osteocalcin) , gamma-carboxyglutamic acid-containing protein , osteocalcin , BGP , bone gamma carboxyglutamate protein 1 , bone Gla-protein , bone gamma-carboxyglutamate protein 2 , bone gamma-carboxyglutamic acid (Gla) protein (osteocalcin) , xBGP , osteocalcin preproprotein , hypothetical protein LOC792433 , bone gamma-carboxyglutamate protein osteocalcin , Bone Gla protein , Gamma-carboxyglutamic acid-containing protein , Osteocalcin , bone gamma-carboxyglutamate (gla) protein , polyamine-modulated factor 1

GENE ID SPECIES
632 Homo sapiens
12096 Mus musculus
25295 Rattus norvegicus
281646 Bos taurus
396348 Gallus gallus
397530 Sus scrofa
399370 Xenopus laevis
677670 Ovis aries
718296 Macaca mulatta
792433 Danio rerio
100136174 Oncorhynchus mykiss
100190891 Pan troglodytes
100192339 Salmo salar
100529177 Oryzias latipes
100534506 Oreochromis niloticus
100735766 Cavia porcellus
403762 Canis lupus familiaris
101085947 Felis catus
100861188 Capra hircus
100340503 Oryctolagus cuniculus
100146589 Equus caballus
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