Bone gamma-Carboxyglutamate (Gla) Protein Proteins (BGLAP)

Constitutes 1-2% of the total bone protein. Additionally we are shipping Osteocalcin Antibodies (351) and Osteocalcin Kits (119) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
BGLAP 632 P02818
BGLAP 12096 P86546
Rat BGLAP BGLAP 25295 P04640
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Top Osteocalcin Proteins at

Showing 10 out of 49 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
Escherichia coli (E. coli) Mouse His tag,GST tag 100 μg Log in to see 15 to 18 Days
Yeast Rabbit His tag   1 mg Log in to see 60 to 71 Days
Yeast Horse His tag   1 mg Log in to see 60 to 71 Days
Yeast Cynomolgus His tag   1 mg Log in to see 60 to 71 Days
Yeast Chimpanzee His tag   1 mg Log in to see 60 to 71 Days
Yeast Rat His tag Bone gamma-Carboxyglutamate (Gla) Protein (BGLAP) (AA 50-99) protein (His tag) expressed in E. coli 1 mg Log in to see 60 to 71 Days
Escherichia coli (E. coli) Human His tag,GST tag 100 μg Log in to see 15 to 18 Days
Escherichia coli (E. coli) Rat His tag,GST tag 100 μg Log in to see 15 to 18 Days

BGLAP Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , , ,
, , , ,
Mouse (Murine) ,
Rat (Rattus) ,

Top referenced Osteocalcin Proteins

  1. Mouse (Murine) Osteocalcin Protein expressed in Escherichia coli (E. coli) - ABIN2123429 : Hase, Ozeki, Hiyama, Yamaguchi, Kawai, Kondo, Nakata, Mogi: Products of dentin matrix protein-1 degradation by interleukin-1β-induced matrix metalloproteinase-3 promote proliferation of odontoblastic cells. in Bioscience trends 2015 (PubMed)

More Proteins for Bone gamma-Carboxyglutamate (Gla) Protein (BGLAP) Interaction Partners

Human Bone gamma-Carboxyglutamate (Gla) Protein (BGLAP) interaction partners

  1. XPS showed that similar amounts of hOC and dhOC were absorbed onto hydroxyapaptite and octacalcium phosphate surfaces, but ToF (show FEZF2 Proteins)-SIMS detected some small differences in the amino acid fragment intensities on these surfaces for adsorbed hOC and dhOC.

  2. Common polymorphism rs1800247 in osteocalcin gene was associated with hypertension and diastolic blood pressure levels. The association of rs1800247 with hypertension was affected by its interaction with HOMA-IR.

  3. Demonstrate a positive association between osteocalcin, a factor known to regulate bone remodelling, with cognitive performance in older non-demented women.

  4. Common genetic variants of the osteocalcin gene may not be a major contributor to variations in serum osteocalcin or BMD (show BEST1 Proteins) in postmenopausal and elderly Chinese women.

  5. Low serum osteocalcin concentrations are associated with type 2 diabetes.

  6. Decreased blood concentration of Carboxylated osteocalcin is associated with metabolic complications and inflammation.

  7. Total and undercarboxylated osteocalcin levels were significantly correlated with insulin secretion and insulin resistance indices, but not adiponectin levels, in pregnant women.

  8. Osteocalcin and Sex Hormone Binding Globulin Compete on a Specific Binding Site of GPRC6A.

  9. Osteocalcin plays an essential role for the maturation of mineral species and modulates osteogenic differentiation of mesenchymal stromal cells (MSCs).

  10. Serum osteocalcin levels in pediatric obstructive sleep apnea hypopnea syndrome patients were significantly lower than normal controls before adenotonsillectomy.

Mouse (Murine) Bone gamma-Carboxyglutamate (Gla) Protein (BGLAP) interaction partners

  1. the uncarboxylated form of osteocalcin does not trigger Akt (show AKT1 Proteins) phosphorylation and glucose uptake by itself but promotes insulin (show INS Proteins)-induced glucose uptake in myotubes, probably by up-regulating Akt (show AKT1 Proteins) signaling through ERK (show EPHB2 Proteins) activation

  2. The Twist2 (show TWIST2 Proteins)-Cre, Osterix (show SP7 Proteins)-Cre and osteocalcin-Cre lines to generate conditional beta1 integrin deletions, were used to investigate the role of beta1 integrins on skeletal phenotype.

  3. OCN is gamma-carboxylated by the gamma-carboxylase (GGCX (show GGCX Proteins)) on three glutamic acid residues, a cellular process requiring reduction of vitamin K by a second enzyme, VKORC1 (show VKORC1 Proteins).

  4. results showed an increase in the expression of Cbfa1 (show RUNX2 Proteins) and OCN in fibroblasts and osteoblasts exposed to fluoride.

  5. Data indicate that Ca2 (show CA2 Proteins)+ binding triggered a similar conformational transition in both gamma-carboxyglutamic acid-containing protein osteocalcin (Gla (show GLA Proteins)-OCN) and Glu (show GCG Proteins)-OCN from a disordered structure to a more compact/stable form.

  6. In primary adipocytes, both carboxylated and uncarboxylated osteocalcin increased basal and insulin (show INS Proteins)-stimulated glucose transport.

  7. Taken together, these findings demonstrate that SMILE (show CREBZF Proteins) negatively regulates osteocalcin via a direct interaction with RUNX2 (show RUNX2 Proteins)

  8. Osteoblast-specific expression of Fra-2 (show FOSL2 Proteins)/AP-1 (show JUN Proteins) controls adiponectin and osteocalcin expression and affects metabolism.

  9. contribution of OC-OPN (show SPP1 Proteins) to fracture toughness is related to their presence at the extrafibrillar organic-mineral interfaces

  10. Insulin (show INS Proteins) resistance in osteoblasts led to a decrease in circulating levels of the active form of osteocalcin, thereby decreasing insulin (show INS Proteins) sensitivity in skeletal muscle.

Cow (Bovine) Bone gamma-Carboxyglutamate (Gla) Protein (BGLAP) interaction partners

  1. Osteopontin, osteocalcin and OB-cadherin expression in Synthetic nanohydroxyapatite vs bovine hydroxyapatite cultured Osteoblastic-like cells.

  2. Data suggest that helical content of 3 Glu (show DCTN1 Proteins)-OCN is 57% and is independent of calcium binding; 3 Glu (show DCTN1 Proteins)-OCN contains 3 alpha-helices around a hydrophobic core; study includes first high-resolution structure of bovine 3 Glu (show DCTN1 Proteins)-OCN using X-ray crystallography.

  3. Serum osteocalcin levels in non-periparturient Holstein dairy cows were highest in the youngest cows, decreasing with age until time of first calving. In periparturient cows, serum osteocalcin levels were higher in primiparous than in multiparous cows.

  4. Osteocalcin is released from the bone matrix during bone resorption as intact molecules and fragments; serum osteocalcin should be considered as a marker of bone turnover rather than bone formation

Zebrafish Bone gamma-Carboxyglutamate (Gla) Protein (BGLAP) interaction partners

  1. In zebrafish, bgp and mgp (show MGP Proteins) mRNAs were localized in all mineralized tissues during and after calcification including bone and calcified cartilage of branchial arches.

Osteocalcin (BGLAP) Protein Profile

Protein Summary

Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium.

Gene names and symbols associated with BGLAP

  • bone gamma-carboxyglutamate protein (BGLAP)
  • bone gamma carboxyglutamate protein (Bglap)
  • bone gamma-carboxyglutamate protein (Bglap)
  • bone gamma-carboxyglutamate protein S homeolog (bglap.S)
  • bone gamma-carboxyglutamate (gla) protein (bglap)
  • osteocalcin (ocn)
  • bone gamma-carboxyglutamate (gla) protein (BGLAP)
  • bone gamma-carboxyglutamate protein (bglap)
  • osteocalcin (LOC100286409)
  • osteocalcin (LOC100529177)
  • polyamine-modulated factor 1 (LOC100146589)
  • BGLAP protein
  • Bglap1 protein
  • Bglap2 protein
  • bgp protein
  • Bgpr protein
  • Bgpra protein
  • GLA protein
  • LOC792433 protein
  • LOC100286409 protein
  • mOC-A protein
  • OC protein
  • ocn protein
  • OG1 protein
  • PMF1 protein

Protein level used designations for BGLAP

bone Gla protein , bone gamma-carboxyglutamate (gla) protein (osteocalcin) , gamma-carboxyglutamic acid-containing protein , osteocalcin , BGP , bone gamma carboxyglutamate protein 1 , bone Gla-protein , bone gamma-carboxyglutamate protein 2 , bone gamma-carboxyglutamic acid (Gla) protein (osteocalcin) , xBGP , osteocalcin preproprotein , hypothetical protein LOC792433 , bone gamma-carboxyglutamate protein osteocalcin , Bone Gla protein , Gamma-carboxyglutamic acid-containing protein , Osteocalcin , bone gamma-carboxyglutamate (gla) protein , polyamine-modulated factor 1

632 Homo sapiens
12096 Mus musculus
25295 Rattus norvegicus
281646 Bos taurus
396348 Gallus gallus
397530 Sus scrofa
399370 Xenopus laevis
677670 Ovis aries
718296 Macaca mulatta
792433 Danio rerio
100136174 Oncorhynchus mykiss
100190891 Pan troglodytes
100192339 Salmo salar
100286409 Salmo salar
100529177 Oryzias latipes
100534506 Oreochromis niloticus
100735766 Cavia porcellus
403762 Canis lupus familiaris
101085947 Felis catus
100861188 Capra hircus
100340503 Oryctolagus cuniculus
100146589 Equus caballus
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