Bone gamma-Carboxyglutamate (Gla) Protein Proteins (BGLAP)

Constitutes 1-2% of the total bone protein. Additionally we are shipping Osteocalcin Antibodies (359) and Osteocalcin Kits (129) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
BGLAP 632 P02818
BGLAP 12096 P86546
Rat BGLAP BGLAP 25295 P04640
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Top Osteocalcin Proteins at antibodies-online.com

Showing 10 out of 54 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$6,869.04
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$6,869.04
Details
Escherichia coli (E. coli) Mouse His tag,GST tag 100 μg Log in to see 15 to 18 Days
$688.00
Details
Escherichia coli (E. coli) Human His tag,GST tag 100 μg Log in to see 15 to 18 Days
$608.00
Details
Escherichia coli (E. coli) Rat His tag,GST tag 100 μg Log in to see 15 to 18 Days
$733.00
Details
Yeast Rat His tag Bone gamma-Carboxyglutamate (Gla) Protein (BGLAP) (AA 50-99) protein (His tag) expressed in E. coli 1 mg Log in to see 60 to 71 Days
$2,020.33
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see Available
$814.00
Details
Wheat germ Human GST tag 2 μg Log in to see 11 to 12 Days
$338.33
Details
Escherichia coli (E. coli) Mouse Un-conjugated SDS-PAGE analysis of Mouse Osteocalcin Protein. 100 μg Log in to see 11 to 18 Days
$639.61
Details
Yeast Camelops hesternus His tag   1 mg Log in to see 60 to 71 Days
$1,994.67
Details

BGLAP Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , , ,
, , , ,
Mouse (Murine) ,
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Rat (Rattus) ,
,

Top referenced Osteocalcin Proteins

  1. Mouse (Murine) Osteocalcin Protein expressed in Escherichia coli (E. coli) - ABIN2123429 : Hase, Ozeki, Hiyama, Yamaguchi, Kawai, Kondo, Nakata, Mogi: Products of dentin matrix protein-1 degradation by interleukin-1β-induced matrix metalloproteinase-3 promote proliferation of odontoblastic cells. in Bioscience trends 2015 (PubMed)

More Proteins for Bone gamma-Carboxyglutamate (Gla) Protein (BGLAP) Interaction Partners

Human Bone gamma-Carboxyglutamate (Gla) Protein (BGLAP) interaction partners

  1. a decrease in serum osteocalcin levels is associated with future development of type 2 diabetes mellitus.

  2. Findings from the available data indicated an overall significant inverse association between serum osteocalcin and body mass index--{REVIEW}

  3. relatively lower serum osteocalcin levels were associated with a higher risk of MACE in Chinese men with CAD

  4. undercarboxylated form of osteocalcin in serum not related significantly to semen parameters or measured hormones in male infertility

  5. Serum osteocalcin was directly and independently correlated with circulating uric acid in a population of healthy obese subjects.

  6. gamma-carboxylation of OCN on Glu17 residue correlates with insulin (show INS Proteins) resistance and subclinical inflammation, suggesting that gamma-carboxylation of OCN negatively regulates its endocrine action

  7. There were differences in the associations between total osteocalcin and glucose metabolism in Han and Uygur T2DM patients, indicating genetic factors may play a role in modulating OC and glucose metabolism in different ethnic population.

  8. The study demonstrated that undercarboxylated osteocalcin (ucOC) is related to 25(OH)D and adiponectin concentrations. Both ucOC and 25(OH)D were lower in overweight and obese adolescents.

  9. Increased advanced glycation end products and protein oxidative damage markers in the course of obesity may contribute to decreased carboxylated osteocalcin serum level.

  10. Progressive calcification of atherosclerotic plaques is accompanied by insignificant accumulation of calcitonin (show CALCA Proteins) and osteoprotegerin (show TNFRSF11B Proteins), whereas the osteocalcin expression significantly increased during calcification.

Mouse (Murine) Bone gamma-Carboxyglutamate (Gla) Protein (BGLAP) interaction partners

  1. the uncarboxylated form of osteocalcin does not trigger Akt (show AKT1 Proteins) phosphorylation and glucose uptake by itself but promotes insulin (show INS Proteins)-induced glucose uptake in myotubes, probably by up-regulating Akt (show AKT1 Proteins) signaling through ERK (show EPHB2 Proteins) activation

  2. The Twist2 (show TWIST2 Proteins)-Cre, Osterix (show SP7 Proteins)-Cre and osteocalcin-Cre lines to generate conditional beta1 integrin deletions, were used to investigate the role of beta1 integrins on skeletal phenotype.

  3. OCN is gamma-carboxylated by the gamma-carboxylase (GGCX (show GGCX Proteins)) on three glutamic acid residues, a cellular process requiring reduction of vitamin K by a second enzyme, VKORC1 (show VKORC1 Proteins).

  4. results showed an increase in the expression of Cbfa1 (show RUNX2 Proteins) and OCN in fibroblasts and osteoblasts exposed to fluoride.

  5. Data indicate that Ca2 (show CA2 Proteins)+ binding triggered a similar conformational transition in both gamma-carboxyglutamic acid-containing protein osteocalcin (Gla (show GLA Proteins)-OCN) and Glu (show GCG Proteins)-OCN from a disordered structure to a more compact/stable form.

  6. In primary adipocytes, both carboxylated and uncarboxylated osteocalcin increased basal and insulin (show INS Proteins)-stimulated glucose transport.

  7. Taken together, these findings demonstrate that SMILE (show CREBZF Proteins) negatively regulates osteocalcin via a direct interaction with RUNX2 (show RUNX2 Proteins)

  8. Osteoblast-specific expression of Fra-2 (show FOSL2 Proteins)/AP-1 (show JUN Proteins) controls adiponectin and osteocalcin expression and affects metabolism.

  9. contribution of OC-OPN (show SPP1 Proteins) to fracture toughness is related to their presence at the extrafibrillar organic-mineral interfaces

  10. Insulin (show INS Proteins) resistance in osteoblasts led to a decrease in circulating levels of the active form of osteocalcin, thereby decreasing insulin (show INS Proteins) sensitivity in skeletal muscle.

Cow (Bovine) Bone gamma-Carboxyglutamate (Gla) Protein (BGLAP) interaction partners

  1. Osteopontin, osteocalcin and OB-cadherin expression in Synthetic nanohydroxyapatite vs bovine hydroxyapatite cultured Osteoblastic-like cells.

  2. Data suggest that helical content of 3 Glu (show DCTN1 Proteins)-OCN is 57% and is independent of calcium binding; 3 Glu (show DCTN1 Proteins)-OCN contains 3 alpha-helices around a hydrophobic core; study includes first high-resolution structure of bovine 3 Glu (show DCTN1 Proteins)-OCN using X-ray crystallography.

  3. Serum osteocalcin levels in non-periparturient Holstein dairy cows were highest in the youngest cows, decreasing with age until time of first calving. In periparturient cows, serum osteocalcin levels were higher in primiparous than in multiparous cows.

  4. Osteocalcin is released from the bone matrix during bone resorption as intact molecules and fragments; serum osteocalcin should be considered as a marker of bone turnover rather than bone formation

Zebrafish Bone gamma-Carboxyglutamate (Gla) Protein (BGLAP) interaction partners

  1. In zebrafish, bgp and mgp (show MGP Proteins) mRNAs were localized in all mineralized tissues during and after calcification including bone and calcified cartilage of branchial arches.

Osteocalcin (BGLAP) Protein Profile

Protein Summary

Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium.

Gene names and symbols associated with BGLAP

  • bone gamma-carboxyglutamate protein (BGLAP)
  • bone gamma carboxyglutamate protein (Bglap)
  • bone gamma-carboxyglutamate protein (Bglap)
  • bone gamma-carboxyglutamate protein S homeolog (bglap.S)
  • bone gamma-carboxyglutamate (gla) protein (bglap)
  • osteocalcin (ocn)
  • bone gamma-carboxyglutamate (gla) protein (BGLAP)
  • bone gamma-carboxyglutamate protein (bglap)
  • osteocalcin (LOC100529177)
  • polyamine-modulated factor 1 (LOC100146589)
  • BGLAP protein
  • Bglap1 protein
  • Bglap2 protein
  • bgp protein
  • Bgpr protein
  • Bgpra protein
  • GLA protein
  • LOC792433 protein
  • mOC-A protein
  • OC protein
  • ocn protein
  • OG1 protein
  • PMF1 protein

Protein level used designations for BGLAP

bone Gla protein , bone gamma-carboxyglutamate (gla) protein (osteocalcin) , gamma-carboxyglutamic acid-containing protein , osteocalcin , BGP , bone gamma carboxyglutamate protein 1 , bone Gla-protein , bone gamma-carboxyglutamate protein 2 , bone gamma-carboxyglutamic acid (Gla) protein (osteocalcin) , xBGP , osteocalcin preproprotein , hypothetical protein LOC792433 , bone gamma-carboxyglutamate protein osteocalcin , Bone Gla protein , Gamma-carboxyglutamic acid-containing protein , Osteocalcin , bone gamma-carboxyglutamate (gla) protein , polyamine-modulated factor 1

GENE ID SPECIES
632 Homo sapiens
12096 Mus musculus
25295 Rattus norvegicus
281646 Bos taurus
396348 Gallus gallus
397530 Sus scrofa
399370 Xenopus laevis
677670 Ovis aries
718296 Macaca mulatta
792433 Danio rerio
100136174 Oncorhynchus mykiss
100190891 Pan troglodytes
100192339 Salmo salar
100529177 Oryzias latipes
100534506 Oreochromis niloticus
100735766 Cavia porcellus
403762 Canis lupus familiaris
101085947 Felis catus
100861188 Capra hircus
100340503 Oryctolagus cuniculus
100146589 Equus caballus
Selected quality suppliers for Osteocalcin Proteins (BGLAP)
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