Bone gamma-Carboxyglutamate (Gla) Protein Proteins (BGLAP)

Constitutes 1-2% of the total bone protein. Additionally we are shipping Osteocalcin Antibodies (361) and Osteocalcin Kits (127) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
BGLAP 632 P02818
BGLAP 12096 P86546
Rat BGLAP BGLAP 25295 P04640
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Top Osteocalcin Proteins at

Showing 10 out of 52 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
Escherichia coli (E. coli) Mouse His tag,GST tag 100 μg Log in to see 15 to 18 Days
Escherichia coli (E. coli) Human His tag,GST tag 100 μg Log in to see 15 to 18 Days
Escherichia coli (E. coli) Rat His tag,GST tag 100 μg Log in to see 15 to 18 Days
Yeast Rat His tag Bone gamma-Carboxyglutamate (Gla) Protein (BGLAP) (AA 50-99) protein (His tag) expressed in E. coli 1 mg Log in to see 60 to 71 Days
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 11 Days
Escherichia coli (E. coli) Mouse Un-conjugated SDS-PAGE analysis of Mouse Osteocalcin Protein. 100 μg Log in to see 11 to 18 Days
Wheat germ Human GST tag 2 μg Log in to see 11 to 12 Days
Yeast Camelops hesternus His tag   1 mg Log in to see 60 to 71 Days

BGLAP Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , , ,
, , , ,
Mouse (Murine) ,
Rat (Rattus) ,

Top referenced Osteocalcin Proteins

  1. Mouse (Murine) Osteocalcin Protein expressed in Escherichia coli (E. coli) - ABIN2123429 : Hase, Ozeki, Hiyama, Yamaguchi, Kawai, Kondo, Nakata, Mogi: Products of dentin matrix protein-1 degradation by interleukin-1β-induced matrix metalloproteinase-3 promote proliferation of odontoblastic cells. in Bioscience trends 2015 (PubMed)

More Proteins for Bone gamma-Carboxyglutamate (Gla) Protein (BGLAP) Interaction Partners

Human Bone gamma-Carboxyglutamate (Gla) Protein (BGLAP) interaction partners

  1. OCN levels were inversely correlated with body fat parameters and obesity.

  2. Serum osteocalcin level was not independently associated with blood pressure in a Chinese population

  3. The results of this study suggest that serum osteocalcin is associated with the onset of puberty in girls.

  4. The correlation between Mycobacterium avium subsp. paratuberculosis (MAP) infection and elevation of sera ucOC, reduction of active osteocalcin and increased calcium supports MAP infection role in Crohn's disease and complications with osteoporosis.

  5. The results showed no significant correlation between osteocalcin HindIII gene polymorphism and bone mineral density (BMD) and therefore osteocalcin HindIII gene polymorphism may not have major effects on BMD variation in postmenopausal North Indian women.

  6. Decreased circulating carboxylated osteocalcin is associated with low-energy bone fractures in children.

  7. a decrease in serum osteocalcin levels is associated with future development of type 2 diabetes mellitus.

  8. Findings from the available data indicated an overall significant inverse association between serum osteocalcin and body mass index--{REVIEW}

  9. relatively lower serum osteocalcin levels were associated with a higher risk of MACE in Chinese men with CAD

  10. undercarboxylated form of osteocalcin in serum not related significantly to semen parameters or measured hormones in male infertility

  11. serum level not correlated with gender, race/ethnicity, age, diabetes type, BMI percentile, random C-peptide, glucose, or HbA1c at pediatric diabetes diagnosis; serum level inversely correlated with HbA1c at first office visit following diagnosis

  12. Serum osteocalcin was directly and independently correlated with circulating uric acid in a population of healthy obese subjects.

  13. gamma-carboxylation of OCN on Glu17 residue correlates with insulin resistance and subclinical inflammation, suggesting that gamma-carboxylation of OCN negatively regulates its endocrine action

  14. There were differences in the associations between total osteocalcin and glucose metabolism in Han and Uygur T2DM patients, indicating genetic factors may play a role in modulating OC and glucose metabolism in different ethnic population.

  15. The study demonstrated that undercarboxylated osteocalcin (ucOC) is related to 25(OH)D and adiponectin concentrations. Both ucOC and 25(OH)D were lower in overweight and obese adolescents.

  16. Increased advanced glycation end products and protein oxidative damage markers in the course of obesity may contribute to decreased carboxylated osteocalcin serum level.

  17. Progressive calcification of atherosclerotic plaques is accompanied by insignificant accumulation of calcitonin and osteoprotegerin, whereas the osteocalcin expression significantly increased during calcification.

  18. Undercarboxylated osteocalcin reflects the reserve capacity of beta-cell function, such as the bolus insulin secretion ability in patients with type 2 diabetes.

  19. XPS showed that similar amounts of hOC and dhOC were absorbed onto hydroxyapaptite and octacalcium phosphate surfaces, but ToF-SIMS detected some small differences in the amino acid fragment intensities on these surfaces for adsorbed hOC and dhOC.

  20. Common polymorphism rs1800247 in osteocalcin gene was associated with hypertension and diastolic blood pressure levels. The association of rs1800247 with hypertension was affected by its interaction with HOMA-IR.

Mouse (Murine) Bone gamma-Carboxyglutamate (Gla) Protein (BGLAP) interaction partners

  1. expression in offspring bone not changed by maternal high fat diet

  2. the uncarboxylated form of osteocalcin does not trigger Akt phosphorylation and glucose uptake by itself but promotes insulin-induced glucose uptake in myotubes, probably by up-regulating Akt signaling through ERK activation

  3. The Twist2-Cre, Osterix-Cre and osteocalcin-Cre lines to generate conditional beta1 integrin deletions, were used to investigate the role of beta1 integrins on skeletal phenotype.

  4. OCN is gamma-carboxylated by the gamma-carboxylase (GGCX) on three glutamic acid residues, a cellular process requiring reduction of vitamin K by a second enzyme, VKORC1.

  5. results showed an increase in the expression of Cbfa1 and OCN in fibroblasts and osteoblasts exposed to fluoride.

  6. Data indicate that Ca2+ binding triggered a similar conformational transition in both gamma-carboxyglutamic acid-containing protein osteocalcin (Gla-OCN) and Glu-OCN from a disordered structure to a more compact/stable form.

  7. In primary adipocytes, both carboxylated and uncarboxylated osteocalcin increased basal and insulin-stimulated glucose transport.

  8. Taken together, these findings demonstrate that SMILE negatively regulates osteocalcin via a direct interaction with RUNX2

  9. Osteoblast-specific expression of Fra-2/AP-1 controls adiponectin and osteocalcin expression and affects metabolism.

  10. contribution of OC-OPN to fracture toughness is related to their presence at the extrafibrillar organic-mineral interfaces

  11. Insulin resistance in osteoblasts led to a decrease in circulating levels of the active form of osteocalcin, thereby decreasing insulin sensitivity in skeletal muscle.

  12. loss of osteocalcin/Gprc6a signaling has a profound effect on beta-cell mass accrual during late pancreas morphogenesis

  13. This study reveals that the skeleton via osteocalcin influences cognition and contributes to the maternal influence on fetal brain development.

  14. T3 stimulates the activation of Rho-kinase in osteoblasts, which functions as a negative regulator of T3-stimulated osteocalcin synthesis

  15. Uncarboxylated osteocalcin acts via Gprc6a to induce GLP-1 release from the gut; the stimulatory effect of uncarboxylated osteocalcin on insulin secretion is largely mediated by GLP-1.

  16. These results indicate that PP2A Calpha and its activity play a negative role in osteoblast differentiation and Osterix is a key factor responsible for regulating the expressions of Bsp and OCN during PP2A Calpha-mediated osteoblast differentiation.

  17. alphaNAC interacts with histone deacetylase corepressors to control Myogenin and Osteocalcin gene expression.

  18. Data from TR4 (steroid/thyroid hormone receptor 4) knockout mice suggest that TR4 binds to promoter region of osteocalcin gene and induces osteocalcin expression; this interaction maintains osteoblast activity during bone development/remodeling.

  19. Alterations of responses in knockout mice that suggest participation of osteocalcin in transmission of information about those sensory stimuli.

  20. BMP2 induces osteoblast differentiation through Runx2-dependent ATF6 expression, which directly regulates Oc transcription.

Cow (Bovine) Bone gamma-Carboxyglutamate (Gla) Protein (BGLAP) interaction partners

  1. Osteopontin, osteocalcin and OB-cadherin expression in Synthetic nanohydroxyapatite vs bovine hydroxyapatite cultured Osteoblastic-like cells.

  2. Data suggest that helical content of 3 Glu-OCN is 57% and is independent of calcium binding; 3 Glu-OCN contains 3 alpha-helices around a hydrophobic core; study includes first high-resolution structure of bovine 3 Glu-OCN using X-ray crystallography.

  3. Serum osteocalcin levels in non-periparturient Holstein dairy cows were highest in the youngest cows, decreasing with age until time of first calving. In periparturient cows, serum osteocalcin levels were higher in primiparous than in multiparous cows.

  4. Osteocalcin is released from the bone matrix during bone resorption as intact molecules and fragments; serum osteocalcin should be considered as a marker of bone turnover rather than bone formation

  5. A molecular mechanism of lead toxicity for calcium binding proteins.

Zebrafish Bone gamma-Carboxyglutamate (Gla) Protein (BGLAP) interaction partners

  1. In zebrafish, bgp and mgp mRNAs were localized in all mineralized tissues during and after calcification including bone and calcified cartilage of branchial arches.

Osteocalcin (BGLAP) Protein Profile

Protein Summary

Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium.

Gene names and symbols associated with BGLAP

  • bone gamma-carboxyglutamate protein (BGLAP)
  • bone gamma carboxyglutamate protein (Bglap)
  • bone gamma-carboxyglutamate protein (Bglap)
  • bone gamma-carboxyglutamate protein S homeolog (bglap.S)
  • bone gamma-carboxyglutamate (gla) protein (bglap)
  • osteocalcin (ocn)
  • bone gamma-carboxyglutamate (gla) protein (BGLAP)
  • bone gamma-carboxyglutamate protein (bglap)
  • osteocalcin (LOC100529177)
  • polyamine-modulated factor 1 (LOC100146589)
  • BGLAP protein
  • Bglap1 protein
  • Bglap2 protein
  • bgp protein
  • Bgpr protein
  • Bgpra protein
  • GLA protein
  • LOC792433 protein
  • mOC-A protein
  • OC protein
  • ocn protein
  • OG1 protein
  • PMF1 protein

Protein level used designations for BGLAP

bone Gla protein , bone gamma-carboxyglutamate (gla) protein (osteocalcin) , gamma-carboxyglutamic acid-containing protein , osteocalcin , BGP , bone gamma carboxyglutamate protein 1 , bone Gla-protein , bone gamma-carboxyglutamate protein 2 , bone gamma-carboxyglutamic acid (Gla) protein (osteocalcin) , xBGP , osteocalcin preproprotein , hypothetical protein LOC792433 , bone gamma-carboxyglutamate protein osteocalcin , Bone Gla protein , Gamma-carboxyglutamic acid-containing protein , Osteocalcin , bone gamma-carboxyglutamate (gla) protein , polyamine-modulated factor 1

632 Homo sapiens
12096 Mus musculus
25295 Rattus norvegicus
281646 Bos taurus
396348 Gallus gallus
397530 Sus scrofa
399370 Xenopus laevis
677670 Ovis aries
718296 Macaca mulatta
792433 Danio rerio
100136174 Oncorhynchus mykiss
100190891 Pan troglodytes
100192339 Salmo salar
100529177 Oryzias latipes
100534506 Oreochromis niloticus
100735766 Cavia porcellus
403762 Canis lupus familiaris
101085947 Felis catus
100861188 Capra hircus
100340503 Oryctolagus cuniculus
100146589 Equus caballus
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