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Constitutes 1-2% of the total bone protein. Additionally we are shipping Osteocalcin Antibodies (352) and Osteocalcin Kits (118) and many more products for this protein.
Showing 10 out of 49 products:
Mouse (Murine) Osteocalcin Protein expressed in Escherichia coli (E. coli) - ABIN2123429
Hase, Ozeki, Hiyama, Yamaguchi, Kawai, Kondo, Nakata, Mogi: Products of dentin matrix protein-1 degradation by interleukin-1β-induced matrix metalloproteinase-3 promote proliferation of odontoblastic cells. in Bioscience trends 2015
gamma-carboxylation of OCN on Glu17 residue correlates with insulin (show INS Proteins) resistance and subclinical inflammation, suggesting that gamma-carboxylation of OCN negatively regulates its endocrine action
There were differences in the associations between total osteocalcin and glucose metabolism in Han and Uygur T2DM patients, indicating genetic factors may play a role in modulating OC and glucose metabolism in different ethnic population.
The study demonstrated that undercarboxylated osteocalcin (ucOC) is related to 25(OH)D and adiponectin concentrations. Both ucOC and 25(OH)D were lower in overweight and obese adolescents.
Increased advanced glycation end products and protein oxidative damage markers in the course of obesity may contribute to decreased carboxylated osteocalcin serum level.
Progressive calcification of atherosclerotic plaques is accompanied by insignificant accumulation of calcitonin (show CALCA Proteins) and osteoprotegerin (show TNFRSF11B Proteins), whereas the osteocalcin expression significantly increased during calcification.
Undercarboxylated osteocalcin reflects the reserve capacity of beta-cell function, such as the bolus insulin (show INS Proteins) secretion ability in patients with type 2 diabetes.
XPS showed that similar amounts of hOC and dhOC were absorbed onto hydroxyapaptite and octacalcium phosphate surfaces, but ToF (show FEZF2 Proteins)-SIMS detected some small differences in the amino acid fragment intensities on these surfaces for adsorbed hOC and dhOC.
Common polymorphism rs1800247 in osteocalcin gene was associated with hypertension and diastolic blood pressure levels. The association of rs1800247 with hypertension was affected by its interaction with HOMA-IR.
Demonstrate a positive association between osteocalcin, a factor known to regulate bone remodelling, with cognitive performance in older non-demented women.
Common genetic variants of the osteocalcin gene may not be a major contributor to variations in serum osteocalcin or BMD (show BEST1 Proteins) in postmenopausal and elderly Chinese women.
the uncarboxylated form of osteocalcin does not trigger Akt (show AKT1 Proteins) phosphorylation and glucose uptake by itself but promotes insulin (show INS Proteins)-induced glucose uptake in myotubes, probably by up-regulating Akt (show AKT1 Proteins) signaling through ERK (show EPHB2 Proteins) activation
The Twist2 (show TWIST2 Proteins)-Cre, Osterix (show SP7 Proteins)-Cre and osteocalcin-Cre lines to generate conditional beta1 integrin deletions, were used to investigate the role of beta1 integrins on skeletal phenotype.
OCN is gamma-carboxylated by the gamma-carboxylase (GGCX (show GGCX Proteins)) on three glutamic acid residues, a cellular process requiring reduction of vitamin K by a second enzyme, VKORC1 (show VKORC1 Proteins).
results showed an increase in the expression of Cbfa1 (show RUNX2 Proteins) and OCN in fibroblasts and osteoblasts exposed to fluoride.
Data indicate that Ca2 (show CA2 Proteins)+ binding triggered a similar conformational transition in both gamma-carboxyglutamic acid-containing protein osteocalcin (Gla (show GLA Proteins)-OCN) and Glu (show GCG Proteins)-OCN from a disordered structure to a more compact/stable form.
In primary adipocytes, both carboxylated and uncarboxylated osteocalcin increased basal and insulin (show INS Proteins)-stimulated glucose transport.
Taken together, these findings demonstrate that SMILE (show CREBZF Proteins) negatively regulates osteocalcin via a direct interaction with RUNX2 (show RUNX2 Proteins)
Osteoblast-specific expression of Fra-2 (show FOSL2 Proteins)/AP-1 (show JUN Proteins) controls adiponectin and osteocalcin expression and affects metabolism.
contribution of OC-OPN (show SPP1 Proteins) to fracture toughness is related to their presence at the extrafibrillar organic-mineral interfaces
Insulin (show INS Proteins) resistance in osteoblasts led to a decrease in circulating levels of the active form of osteocalcin, thereby decreasing insulin (show INS Proteins) sensitivity in skeletal muscle.
Osteopontin, osteocalcin and OB-cadherin expression in Synthetic nanohydroxyapatite vs bovine hydroxyapatite cultured Osteoblastic-like cells.
Data suggest that helical content of 3 Glu (show DCTN1 Proteins)-OCN is 57% and is independent of calcium binding; 3 Glu (show DCTN1 Proteins)-OCN contains 3 alpha-helices around a hydrophobic core; study includes first high-resolution structure of bovine 3 Glu (show DCTN1 Proteins)-OCN using X-ray crystallography.
Serum osteocalcin levels in non-periparturient Holstein dairy cows were highest in the youngest cows, decreasing with age until time of first calving. In periparturient cows, serum osteocalcin levels were higher in primiparous than in multiparous cows.
Osteocalcin is released from the bone matrix during bone resorption as intact molecules and fragments; serum osteocalcin should be considered as a marker of bone turnover rather than bone formation
In zebrafish, bgp and mgp (show MGP Proteins) mRNAs were localized in all mineralized tissues during and after calcification including bone and calcified cartilage of branchial arches.
Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium.
bone Gla protein
, bone gamma-carboxyglutamate (gla) protein (osteocalcin)
, gamma-carboxyglutamic acid-containing protein
, bone gamma carboxyglutamate protein 1
, bone Gla-protein
, bone gamma-carboxyglutamate protein 2
, bone gamma-carboxyglutamic acid (Gla) protein (osteocalcin)
, osteocalcin preproprotein
, hypothetical protein LOC792433
, bone gamma-carboxyglutamate protein osteocalcin
, Bone Gla protein
, Gamma-carboxyglutamic acid-containing protein
, bone gamma-carboxyglutamate (gla) protein
, polyamine-modulated factor 1