anti-Brain Protein 44-Like (BRP44L) Antibodies

may be involved in apoptosis of neuronal cells. Additionally we are shipping Brain Protein 44-Like Kits (6) and Brain Protein 44-Like Proteins (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
BRP44L 51660 Q9Y5U8
BRP44L 55951 P63030
BRP44L 171087 P63031
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Top anti-Brain Protein 44-Like Antibodies at antibodies-online.com

Showing 10 out of 39 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB Host: Rabbit Target Name: Mpc1 Sample Tissue: Rat Spleen lysates Antibody Dilution: 1.0 µg/mL 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated IC, IF, IHC, WB Immunofluorescent analysis of BRP44L staining in A549 cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 °C in a hidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue). Immunohistochemical analysis of BRP44L staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugad compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. 200 μL Log in to see 13 to 14 Days
$487.50
Details
Human Rabbit Un-conjugated IF, IHC, ELISA, WB Western blot analysis of extracts from COLO/HeLa cells, using BRP44L Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human heart tissue, using BRP44L Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated ELISA, IF, IHC, WB 100 μL Log in to see Available
$363.46
Details
Human Rabbit Un-conjugated ELISA, ICC, IF, IHC, WB ABIN6274923 staining COLO205 by IF/ICC. The sample were fixed with PFA and permeabilized in 0.1% Triton X-100,then blocked in 10% serum for 45 minutes at 25°C. The primary antibody was diluted at 1/200 and incubated with the sample for 1 hour at 37°C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) Ab, diluted at 1/600, was used as the secondary antibody. Western blot analysis of extracts from COLO cells using BRP44L antibody. 100 μL Log in to see 11 to 12 Days
$390.77
Details
Human Rabbit Un-conjugated ICC, IHC, WB Figure. Western Blot; Sample: Recombinant protein. Figure.DAB staining on IHC-P. Samples: Human Tissue 100 μg Log in to see 13 to 16 Days
$386.00
Details
Cow Rabbit Un-conjugated WB 100 μL Log in to see 11 to 14 Days
$551.83
Details
Human Rabbit Un-conjugated ELISA, IF, IHC (p), WB 200 μL Log in to see 12 to 14 Days
$438.90
Details
Human Rabbit Un-conjugated ELISA, IF, IHC (p), WB Immunohistochemistry analysis of paraffin-embedded human heart tissue using BRP44L polyclonal antibody . Peptide Immunofluorescence analysis of A-549 cells, using BRP44L polyclonal antibody . Peptide 100 μg Log in to see 11 to 12 Days
$413.58
Details
Human Rabbit Un-conjugated WB 100 μL Log in to see 10 to 11 Days
$385.00
Details

Top referenced anti-Brain Protein 44-Like Antibodies

  1. Human Polyclonal BRP44L Primary Antibody for ICC, IF - ABIN4285411 : Konstantakou, Voutsinas, Velentzas, Basogianni, Paronis, Balafas, Kostomitsopoulos, Syrigos, Anastasiadou, Stravopodis: 3-BrPA eliminates human bladder cancer cells with highly oncogenic signatures via engagement of specific death programs and perturbation of multiple signaling and metabolic determinants. in Molecular cancer 2015 (PubMed)
    Show all 3 Pubmed References

  2. Human Polyclonal BRP44L Primary Antibody for WB - ABIN2801962 : Zhang, Ye, Wu, Ren, Zhao, Zhao, Fu, Shen, Fan, Lu, Zhong, Xu, Han, Zhang, Tao, Huang, Zhou, Hu, Gu, Chen, Chen: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. in Genome research 2000 (PubMed)
    Show all 4 Pubmed References

More Antibodies against Brain Protein 44-Like Interaction Partners

Human Brain Protein 44-Like (BRP44L) interaction partners

  1. The mitochondrial pyruvate carrier (MPC) links glycolysis and mitochondrial metabolism. Retina-specific deletion of MPC1 results in progressive retinal degeneration and decline of visual function in both rod and cone photoreceptors.

  2. The present study has shown that reduced MPC1 expression is involved in EMT in pancreatic cancer and CRC cell lines. Such changes have not been observed in MPC2. The tendency for MPC1 expression in carcinomas to be lower in comparison to normal cells promotes EMT through glutamine metabolism.

  3. The data demonstrated that CtBP1 directly bound to the promoters of MPC1 and MPC2 and transcriptionally repressed them, leading to increased levels of free NADH in the cytosol and nucleus, thus positively feeding back CtBP1's functions.

  4. Hypoxia induces lactate secretion and glycolytic efflux by downregulating MPC1/MPC2 levels in HUVEC cells.

  5. Low MPC1 expression is associated with epithelial-mesenchymal transition in cholangiocarcinoma.

  6. Levels of lactate and mitochondrial pyruvate carrier (MPC1) mRNA were determined to scrutinize the prevalence of aerobic glycolysis..MT-RNR2 plays its anti-apoptotic role partly by avoiding deploying energy from complete oxidation of organic compounds to inorganic wastes. Thus MT-RNR2 can potentially serve as a new biomarker in the diagnosis of bladder carcinoma especially that it is present in blood circulation

  7. Low MPC1 expression is associated with prostate cancer.

  8. Utilizing zebrafish to examine the genetic relationship between MPC1 and Adenomatous polyposis coli (APC), a key tumor suppressor in colorectal cancer, the authors found that apc controls the levels of mpc1 and that knock down of mpc1 recapitulates phenotypes of impaired apc function including failed intestinal differentiation.

  9. Results indicate mitochondrial pyruvate transporter (MPC) to be the key regulatory junction perturbed by virulent strains of Mycobacterium tuberculosis leading to alteration of mitochondrial metabolic flux and regulation of acetyl-CoA formation.

  10. GTPBP3 plays a role in the regulation of MCP1 protein through AMPK signaling.

  11. Tumor cells expressing MPC1 and MPC2 display increased mitochondrial pyruvate oxidation, with no changes in cell growth in adherent culture.

  12. genetic studies of 3 families with children suffering from lactic acidosis and hyperpyruvatemia revealed a causal locus that mapped to MPC1 (BRP44L) changing single amino acids that are conserved throughout eukaryotes; data demonstrate that Mpc1 and Mpc2 form an essential part of the mitochondrial pyruvate carrier

  13. the apparent occurrence of an unusual TG 3' splice site in intron 1 is discussed

Mouse (Murine) Brain Protein 44-Like (BRP44L) interaction partners

  1. Retina-specific deletion of MPC1 results in progressive retinal degeneration and decline of visual function in both rod and cone photoreceptors.

  2. the MPC1 knockout blocks mitochondrial pyruvate uptake and OXPHOS, which results in metabolic reprogramming towards aerobic Warburg glycolysis with reduced ATP production capability.

  3. Heterozygous MPC1 KO weakens fertility and influences the metabolism of glucose and fatty acid and bodyweight in mice.

  4. This study suggests that inhibition of MPC1 activity can boost fatty acid oxidation to provide sufficient energy to the body.

  5. Our study indicates that MPC1 and MPC2 expressions are of prognostic values in PCAs and that positive expression of MPC1 or MPC2 is a predictor of favorable outcome.

  6. Results show that Mpc1 is required for mammalian embryonic development and efficient pyruvate metabolism.

  7. This resulted in embryonic lethality at around E13.5. Mouse embryonic fibroblasts (MEFs) derived from mutant mice displayed defective pyruvate-driven respiration as well as perturbed metabolic profiles, and both defects could be restored by reexpression of MPC1.

  8. Oxidative glutaminolysis supports the TCA cycle in mouse cells lacking MPC1/2.

Brain Protein 44-Like (BRP44L) Antigen Profile

Protein Summary

The protein encoded by this gene is part of an MPC1/MPC2 heterodimer that is responsible for transporting pyruvate into mitochondria. The encoded protein is found in the inner mitochondrial membrane. Defects in this gene are a cause of mitochondrial pyruvate carrier deficiency. Several transcript variants, some protein coding and one non-protein coding, have been found for this gene.

Gene names and symbols associated with BRP44L

  • mitochondrial pyruvate carrier 1 (mpc1) antibody
  • mitochondrial pyruvate carrier 1 S homeolog (mpc1.S) antibody
  • uncharacterized protein (LOC542696) antibody
  • mitochondrial pyruvate carrier 1 (MPC1) antibody
  • mitochondrial pyruvate carrier 1 L homeolog (mpc1.L) antibody
  • brain protein 44-like (LOC100164048) antibody
  • brain protein 44-like (LOC100167201) antibody
  • mitochondrial pyruvate carrier 1 (Mpc1) antibody
  • 0610006G08Rik antibody
  • 3830411I18Rik antibody
  • Brp44l antibody
  • brp44la antibody
  • brp44lb antibody
  • CGI-129 antibody
  • dJ68L15.3 antibody
  • MGC64469 antibody
  • MGC90013 antibody
  • MPC1 antibody
  • MPYCD antibody

Protein level used designations for BRP44L

brain protein 44-like , brain protein 44-like protein a , brain protein 44-like protein b , brain protein 44-like protein , putative brain protein 44-like variant 2 , mitochondrial pyruvate carrier 1 , HSPC040 protein , apoptosis-regulating basic protein

GENE ID SPECIES
448739 Xenopus (Silurana) tropicalis
496160 Xenopus laevis
542696 Zea mays
737234 Pan troglodytes
780760 Xenopus laevis
100164048 Acyrthosiphon pisum
100167201 Acyrthosiphon pisum
100190286 Taeniopygia guttata
767977 Bos taurus
428592 Gallus gallus
609356 Canis lupus familiaris
51660 Homo sapiens
55951 Mus musculus
171087 Rattus norvegicus
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