Brain and Acute Leukemia, Cytoplasmic Proteins (BAALC)

BAALC was identified by gene expression studies in patients with acute myeloid leukemia (AML). Additionally we are shipping BAALC Antibodies (50) and BAALC Kits (7) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
BAALC 79870 Q8WXS3
BAALC 118452 Q8VHV1
BAALC 140720 Q920K5
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Top BAALC Proteins at antibodies-online.com

Showing 6 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$5,370.21
Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$6,749.58
Details
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
Details
Escherichia coli (E. coli) Human His tag 100 μg Log in to see 15 to 19 Days
$676.92
Details
Yeast Wild boar His tag   1 mg Log in to see 60 to 71 Days
$2,311.83
Details
Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
$2,311.83
Details

BAALC Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

Rat (Rattus)

More Proteins for Brain and Acute Leukemia, Cytoplasmic (BAALC) Interaction Partners

Human Brain and Acute Leukemia, Cytoplasmic (BAALC) interaction partners

  1. despite of their well-known adverse role in prognosis of AML, neither BAALC nor ERG expression levels at diagnosis had effect on survival of AML patients who underwent allo-HSCT.

  2. BAALC expression-based minimal residual disease detection during therapy may be considered a strategy to identify patients at high risk of relapse.

  3. Study provide evidence for an association of rs62527607 [GT] SNP of BAALC gene with multidrug resistance in childhood ALL.

  4. BAALC and ERG genes are specific significant molecular markers in acute myeloid leukemia disease progression, response to treatment and survival.

  5. demonstrated that BAALC blocks ERK-mediated monocytic differentiation of acute myeloid leukemia cells by trapping Kruppel-like factor 4 (KLF4) in the cytoplasm and inhibiting its function in the nucleus

  6. combined determination of both miR-3151 and BAALC improved this prognostic stratification, with patients with low levels of both parameters showing a better outcome compared with those patients harboring increased levels of one or both markers

  7. study indicates that overexpression of BAALC serves as an independent prognostic biomarker in acute myeloid leukemia

  8. Evaluating WT1 and BAALC gene expression at diagnosis may improve standard risk stratification and possibly refine the therapeutic approach for Myelodysplastic Syndromes patients.

  9. Thus low MDR1/low BAALC expression identifies a subgroup of intermediate cytogenetic risk AML patients with a remarkably good long-term outcome achieved by chemotherapy alone.

  10. miR-3151 introns within BAALC have roles in driving leukemogenesis by deregulating the TP53 pathway

  11. Higher BAALC expression and FLT3-ITD mutation, both individually and in combination, were associated with worse survival outcomes in CN-AML, and this was also applicable in NPM1-mutated CN-AML, known as a favorable-risk group.

  12. BAALC overexpression retains its negative prognostic role across all cytogenetic risk groups in acute myeloid leukemia patients.

  13. higher post-HSCT BAALC and WT1 expressions in patients with CBF-AML may be good markers of minimal residual disease for the prediction of survival and relapse after HSCT.

  14. Investigated the prognostic impact of brain and acute leukemia, cytoplasmic (BAALC) expression in acute myeloid leukemia with normal karyotype.

  15. data show that higher levels of VEGF-A(CSF) are closely related to CNS leukemia (CNSL), and VEGF-A(CSF) may be a better predictor than the other risk factors elucidating the pathogenesis and development of CNSL

  16. high expression of miR-3151 is an independent prognosticator for poor outcome in cytogenetically normal-AML and affects different outcome end points than its host gene, BAALC

  17. A high MEBE (MN1,ERG, BAALC, EVI1) expression score is an unfavorable prognostic marker in Myelodysplastic syndrome and is associated with an increased risk for progression to Acute myeloid leukemia.

  18. identify a heritable genomic feature predisposing to overexpression of an oncogene (BAALC), thereby possibly leading to enhanced AML leukemogenesis

  19. These findings indicate that BAALC gene is "paused" and that in leukemia cells its transcription can be activated or repressed by mechanisms acting on epigenetic marks.

  20. Presence of FLT3-ITD and high BAALC expression are independent prognostic markers in childhood acute myeloid leukemia.

Mouse (Murine) Brain and Acute Leukemia, Cytoplasmic (BAALC) interaction partners

  1. BAALC/Baalc is a marker of the mesodermal lineage, especially muscle.

BAALC Protein Profile

Protein Summary

This gene was identified by gene expression studies in patients with acute myeloid leukemia (AML). The gene is conserved among mammals and is not found in lower organisms. Tissues that express this gene develop from the neuroectoderm. Multiple alternatively spliced transcript variants that encode different proteins have been described for this gene\; however, some of the transcript variants are found only in AML cell lines.

Gene names and symbols associated with BAALC

  • BAALC, MAP3K1 and KLF4 binding (BAALC)
  • brain and acute leukemia, cytoplasmic (baalc)
  • brain and acute leukemia, cytoplasmic (BAALC)
  • brain and acute leukemia, cytoplasmic (Baalc)
  • BAALC, MAP3K1 and KLF4 binding (Baalc)
  • 2810457D07Rik protein
  • BAALC protein
  • si:ch211-215i13.3 protein
  • si:zc215i13.3 protein

Protein level used designations for BAALC

brain and acute leukemia cytoplasmic protein , brain and acute leukemia, cytoplasmic

GENE ID SPECIES
612780 Canis lupus familiaris
614130 Bos taurus
368908 Danio rerio
420261 Gallus gallus
694238 Macaca mulatta
742690 Pan troglodytes
79870 Homo sapiens
118452 Mus musculus
100170128 Sus scrofa
140720 Rattus norvegicus
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