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BCAT1 encodes the cytosolic form of the enzyme branched-chain amino acid transaminase. Additionally we are shipping BCAT1 Proteins (15) and and many more products for this protein.
Showing 10 out of 106 products:
Guinea Pig Polyclonal BCAT1 Primary Antibody for WB - ABIN610836
Cross, Alessi, Cohen, Andjelkovich, Hemmings: Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. in Nature 1996
Show all 4 Pubmed References
Freshwater Flatworm (Schmidtea mediterranea) Polyclonal BCAT1 Primary Antibody for IHC - ABIN965644
Petersen, Reddien: Smed-betacatenin-1 is required for anteroposterior blastema polarity in planarian regeneration. in Science (New York, N.Y.) 2008
Data suggest that both oncogenic mutations and cancer tissue-of-origin influence BCAA (show ARID4B Antibodies) (branched-chain amino acid) metabolism in neoplastic tissue and neoplastic expression of cytosolic BCAT1 and mitochondrial BCAT2 (show BCAT2 Antibodies). (BCAT = branched-chain-amino-acid transaminase) [REVIEW]
by limiting intracellular alphaKG, BCAT1 links branched-chain amino acid catabolism to HIF1alpha (show HIF1A Antibodies) stability and regulation of the epigenomic landscape, mimicking the effects of IDH (show IDH1 Antibodies) mutations; results suggest the BCAA (show ARID4B Antibodies)-BCAT1-alphaKG pathway as a therapeutic target to compromise leukaemia stem-cell function in patients with IDH (show IDH1 Antibodies)(WT)TET2 (show TET2 Antibodies)(WT) AML (show RUNX1 Antibodies)
BCAT1 plays a pathogenic role in hepatocellular carcinoma (HCC (show FAM126A Antibodies)) by causing cell proliferation and chemoresistance. The MYC (show MYC Antibodies) transcription factor is involved in regulating the transcriptional activity of BCAT1. BCAT1 expression has prognostic significance for the survival of patients with HCC (show FAM126A Antibodies).
Phenotypic analyses using a lentiviral-mediated BCAT1 short hairpin RNA knockdown revealed that BCAT1 sustains proliferation in addition to migration and invasion and that its overexpression enhanced the capacity of antiestrogen-sensitive cells to grow in the presence of antiestrogens.
The tumor suppressive role of miR-218 was mediated by negatively regulating branched-chain amino acid transaminase 1 (BCAT1) protein expression. Importantly, overexpression of BCAT1 decreased the chemosensitivity to cis-diaminedichloroplatinum treatment of PC3 and DU145 cells.
It has been demonstrated that branched-chain amino acid (BCAA (show ARID4B Antibodies)) catabolism is activated in human breast cancer, and abolishment of BCAA (show ARID4B Antibodies) catabolism by knocking down BCAT1 inhibits breast cancer cell growth by repressing mTOR (show FRAP1 Antibodies)-mediated mitochondrial biogenesis and function.
BCAT1 expression is significantly upregulated in human masticatory mucosa during wound healing
Mechanistic investigation revealed that BCAT1 might be an important regulator responsible for DOT1L (show DOT1L Antibodies)-mediated sphere formation and cell migration in breast cancer cells
BCAT1 overexpression is associated with advanced tumour status, and implies adverse clinical outcomes of urothelial carcinoma
BCAT1 is strongly overexpressed in ovarian cancer.
results suggest transcriptional adaptations occur in BCATm (show BCAT2 Antibodies) KO mice that along with altered nutrient signaling may contribute to their previously reported protein turnover, metabolic and exercise phenotypes
BCATc as a novel regulator of T cell activation and metabolism
leucine supplementation increased the expression of enzymes (BCAT1, BCAT2 (show BCAT2 Antibodies) and BCKDK (show BCKDK Antibodies)) that metabolize branched-chain amino acids.
analysis of the biochemical mechanism of BCATm (show BCAT2 Antibodies) (branched-chain aminotransferase) catalysis of reversible transamination of leucine and alpha-ketoglutarate to KIC and glutamate (show GRIN1 Antibodies)
Bcat1 is a candidate for the type I diabetes susceptibility locus Idd6
Bcat1 is part of the complex multigenic Pas1 locus, with a functional role for its intragenic polymorphisms in lung tumor susceptibility.
These results demonstrate that the expression of the BCATc gene in the brain is specifically regulated by BDNF (show BDNF Antibodies) in a time- and region-dependent fashion.
BCATc mRNA gradually appears in different brain regions starting from early stages of neural development, and is maintained until adulthood.
BCATm (show BCAT2 Antibodies)(-/-) mice had elevated plasma branched-chain amino acids & decreased adiposity & body weight, despite eating more food, along with increased energy expenditure, improvements in glucose & insulin (show INS Antibodies) tolerance & protection from diet-induced obesity
This gene encodes the cytosolic form of the enzyme branched-chain amino acid transaminase. This enzyme catalyzes the reversible transamination of branched-chain alpha-keto acids to branched-chain L-amino acids essential for cell growth. Two different clinical disorders have been attributed to a defect of branched-chain amino acid transamination: hypervalinemia and hyperleucine-isoleucinemia. As there is also a gene encoding a mitochondrial form of this enzyme, mutations in either gene may contribute to these disorders. Alternatively spliced transcript variants have been described.
branched-chain-amino-acid aminotransferase, cytosolic
, branched chain aminotransferase 1, cytosolic
, branched chain amino-acid transaminase 1, cytosolic
, branched-chain-amino-acid aminotransferase, cytosolic-like
, placental protein 18
, cytosolic branched-chain amino acid aminotransferase