anti-Branched Chain Amino-Acid Transaminase 1, Cytosolic (BCAT1) Antibodies

BCAT1 encodes the cytosolic form of the enzyme branched-chain amino acid transaminase. Additionally we are shipping BCAT1 Proteins (15) and and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
BCAT1 29592 P54690
BCAT1 586 P54687
BCAT1 12035 P24288
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Top anti-BCAT1 Antibodies at antibodies-online.com

Showing 10 out of 108 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Dog Rabbit Un-conjugated WB WB Suggested Anti-BCAT1 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:1562500  Positive Control:  Human Small Intestine 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-Bcat1 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:62500  Positive Control:  Mouse Heart 100 μL Log in to see 2 to 3 Days
$319.00
Details
Dog Mouse Un-conjugated IHC, IHC (p), WB Immunohistochemistry-Paraffin: BCAT1 Antibody (3F5) [NBP2-01826] - Staining of paraffin-embedded Human prostate tissue using anti-BCAT1 mouse monoclonal antibody. Immunohistochemistry-Paraffin: BCAT1 Antibody (3F5) [NBP2-01826] - Staining of paraffin-embedded Carcinoma of Human liver tissue using anti-BCAT1 mouse monoclonal antibody. 0.1 mL Log in to see 8 to 11 Days
$559.35
Details
Cow Rabbit Un-conjugated WB Western blot analysis of ECA39 expression in Jurkat (A), Ramos (B), NIH3T3 (C), PC12 (D) whole cell lysates. 200 μL Log in to see 13 to 14 Days
$487.50
Details
Cow Rabbit Un-conjugated WB Western blot analysis of ECA39 expression in Jurkat (A), K562 (B), Jurkat (C) whole cell lysates. 200 μL Log in to see 13 to 14 Days
$487.50
Details
Guinea Pig Rabbit Un-conjugated WB 50 μg Log in to see 11 to 14 Days
$551.83
Details
Human Rabbit Un-conjugated IHC (p), WB BCAT1 Antibody (Center) (ABIN654106) immunohistochemistry analysis in formalin fixed and paraffin embedded human kidney carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining All lanes : Anti-BCAT1 Antibody (Center) at 1:1000 dilution Lane 1: MOLT-4 whole cell lysate Lane 2: Ramos whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 43 kDa Blocking/Dilution buffer: 5% NFDM/TBST. Dilution: 1:1000 400 μL Log in to see 10 to 11 Days
$385.00
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB BCAT1 Antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human kidney carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the BCAT1 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated. BCAT1 Antibody (Center) western blot analysis in Ramos cell line lysates (35µg/lane).This demonstrates the BCAT1 antibody detected the BCAT1 protein (arrow). 0.4 mL Log in to see 6 to 8 Days
$484.00
Details
Human Rabbit Un-conjugated ELISA, IHC (p), WB Immunohistochemistry (IHC) analysis of paraffin-embedded Human Lung, antibody was diluted at 1:100. 100 μL Log in to see Available
$181.73
Details
Bat Rabbit Un-conjugated WB 50 μg Log in to see 11 to 14 Days
$551.83
Details

Top referenced anti-BCAT1 Antibodies

  1. Guinea Pig Polyclonal BCAT1 Primary Antibody for WB - ABIN610836 : Cross, Alessi, Cohen, Andjelkovich, Hemmings: Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. in Nature 1996 (PubMed)
    Show all 4 Pubmed References

  2. Freshwater Flatworm (Schmidtea mediterranea) Polyclonal BCAT1 Primary Antibody for IHC - ABIN965644 : Petersen, Reddien: Smed-betacatenin-1 is required for anteroposterior blastema polarity in planarian regeneration. in Science (New York, N.Y.) 2008 (PubMed)

  3. Dog (Canine) Monoclonal BCAT1 Primary Antibody for IHC, IHC (p) - ABIN4283273 : Li, Ye, Xie, Hua, Yang, Wu, Gu, Ren, Mao: Defect of branched-chain amino acid metabolism promotes the development of Alzheimer's disease by targeting the mTOR signaling. in Bioscience reports 2018 (PubMed)

More Antibodies against BCAT1 Interaction Partners

Human Branched Chain Amino-Acid Transaminase 1, Cytosolic (BCAT1) interaction partners

  1. up-regulation of BCAT1 indicated a poor survival rate of gastric cancer and may serve as a useful marker for predicting the outcome of patients with gastric cancer

  2. Branched chain amino acid transaminase 1 (BCAT1) is overexpressed and hypomethylated in patients with non-alcoholic fatty liver disease who experience adverse clinical events

  3. regulatory role in macrophage function

  4. Data suggest that both oncogenic mutations and cancer tissue-of-origin influence BCAA (branched-chain amino acid) metabolism in neoplastic tissue and neoplastic expression of cytosolic BCAT1 and mitochondrial BCAT2. (BCAT = branched-chain-amino-acid transaminase) [REVIEW]

  5. by limiting intracellular alphaKG, BCAT1 links branched-chain amino acid catabolism to HIF1alpha stability and regulation of the epigenomic landscape, mimicking the effects of IDH mutations; results suggest the BCAA-BCAT1-alphaKG pathway as a therapeutic target to compromise leukaemia stem-cell function in patients with IDH(WT)TET2(WT) AML

  6. BCAT1 plays a pathogenic role in hepatocellular carcinoma (HCC) by causing cell proliferation and chemoresistance. The MYC transcription factor is involved in regulating the transcriptional activity of BCAT1. BCAT1 expression has prognostic significance for the survival of patients with HCC.

  7. Phenotypic analyses using a lentiviral-mediated BCAT1 short hairpin RNA knockdown revealed that BCAT1 sustains proliferation in addition to migration and invasion and that its overexpression enhanced the capacity of antiestrogen-sensitive cells to grow in the presence of antiestrogens.

  8. The tumor suppressive role of miR-218 was mediated by negatively regulating branched-chain amino acid transaminase 1 (BCAT1) protein expression. Importantly, overexpression of BCAT1 decreased the chemosensitivity to cis-diaminedichloroplatinum treatment of PC3 and DU145 cells.

  9. It has been demonstrated that branched-chain amino acid (BCAA) catabolism is activated in human breast cancer, and abolishment of BCAA catabolism by knocking down BCAT1 inhibits breast cancer cell growth by repressing mTOR-mediated mitochondrial biogenesis and function.

  10. BCAT1 expression is significantly upregulated in human masticatory mucosa during wound healing

  11. Mechanistic investigation revealed that BCAT1 might be an important regulator responsible for DOT1L-mediated sphere formation and cell migration in breast cancer cells

  12. BCAT1 overexpression is associated with advanced tumour status, and implies adverse clinical outcomes of urothelial carcinoma

  13. BCAT1 is strongly overexpressed in ovarian cancer.

  14. Focal deletions of the BCAT1 were associated with B-cell precursor acute lymphoblastic leukemia.

  15. levels of branched-chain aminotransferase-1 (BCAT1) transcripts are significantly decreased on the polysomes of both RPS19 and RPL11 cells and that translation of BCAT1 protein is especially impaired in cells with small RP gene mutations

  16. Over-expression of BCAT1, a c-Myc target gene, induces cell proliferation, migration and invasion in nasopharyngeal carcinoma.

  17. A central role for BCAT1 in glioma pathogenesis, making BCAT1 and branched-chain amino acids metabolism attractive targets for the development of targeted therapeutic approaches to treat patients with glioblastoma.

  18. The mitochondrial isoform human brain BCAT 2 is largely confined to vascular endothelial cells, whereas the cytosolic human brain BCAT 1 is restricted to neurons.

  19. BCATc (cytosolic) has an overall redox potential that is 30 mV lower than BCATm (mitochondrial). Furthermore, the CXXC motif of BCATc was estimated to be 80 mV lower, suggesting that BCATm is more oxidizing in nature.

  20. Our results suggest that ECA39 is a dominant predictive factor for distant metastasis in patients with advanced colorectal cancer (CRC).

Mouse (Murine) Branched Chain Amino-Acid Transaminase 1, Cytosolic (BCAT1) interaction partners

  1. regulatory role in macrophage function

  2. results suggest transcriptional adaptations occur in BCATm KO mice that along with altered nutrient signaling may contribute to their previously reported protein turnover, metabolic and exercise phenotypes

  3. BCATc as a novel regulator of T cell activation and metabolism

  4. leucine supplementation increased the expression of enzymes (BCAT1, BCAT2 and BCKDK) that metabolize branched-chain amino acids.

  5. analysis of the biochemical mechanism of BCATm (branched-chain aminotransferase) catalysis of reversible transamination of leucine and alpha-ketoglutarate to KIC and glutamate

  6. Bcat1 is a candidate for the type I diabetes susceptibility locus Idd6

  7. Bcat1 is part of the complex multigenic Pas1 locus, with a functional role for its intragenic polymorphisms in lung tumor susceptibility.

  8. These results demonstrate that the expression of the BCATc gene in the brain is specifically regulated by BDNF in a time- and region-dependent fashion.

  9. BCATc mRNA gradually appears in different brain regions starting from early stages of neural development, and is maintained until adulthood.

  10. BCATm(-/-) mice had elevated plasma branched-chain amino acids & decreased adiposity & body weight, despite eating more food, along with increased energy expenditure, improvements in glucose & insulin tolerance & protection from diet-induced obesity

BCAT1 Antigen Profile

Protein Summary

This gene encodes the cytosolic form of the enzyme branched-chain amino acid transaminase. This enzyme catalyzes the reversible transamination of branched-chain alpha-keto acids to branched-chain L-amino acids essential for cell growth. Two different clinical disorders have been attributed to a defect of branched-chain amino acid transamination: hypervalinemia and hyperleucine-isoleucinemia. As there is also a gene encoding a mitochondrial form of this enzyme, mutations in either gene may contribute to these disorders. Alternatively spliced transcript variants have been described.

Gene names and symbols associated with BCAT1

  • branched chain amino-acid transaminase 1, cytosolic (bcat1) antibody
  • branched chain amino acid transaminase 1 (BCAT1) antibody
  • branched chain amino-acid transaminase 1, cytosolic L homeolog (bcat1.L) antibody
  • branched chain aminotransferase 1, cytosolic (bcat1) antibody
  • branched chain amino acid transaminase 1 (bcat1) antibody
  • branched chain amino acid transaminase 1 (Bcat1) antibody
  • branched chain aminotransferase 1, cytosolic (Bcat1) antibody
  • BCATc antibody
  • BCT1 antibody
  • Eca39 antibody
  • fj66g02 antibody
  • MECA39 antibody
  • PNAS121 antibody
  • PP18 antibody
  • wu:fj66g02 antibody
  • zgc:73157 antibody

Protein level used designations for BCAT1

branched-chain-amino-acid aminotransferase, cytosolic , branched chain aminotransferase 1, cytosolic , branched chain amino-acid transaminase 1, cytosolic , branched-chain-amino-acid aminotransferase, cytosolic-like , BCAT(c) , placental protein 18 , cytosolic branched-chain amino acid aminotransferase

GENE ID SPECIES
337412 Danio rerio
465345 Pan troglodytes
494683 Xenopus laevis
707321 Macaca mulatta
100068713 Equus caballus
100124778 Xenopus (Silurana) tropicalis
100195810 Salmo salar
100460550 Pongo abelii
100539235 Meleagris gallopavo
100553843 Anolis carolinensis
100591100 Nomascus leucogenys
29592 Rattus norvegicus
586 Homo sapiens
418193 Gallus gallus
486633 Canis lupus familiaris
505926 Bos taurus
443485 Ovis aries
12035 Mus musculus
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