Breast Cancer Metastasis Suppressor 1 Proteins (BRMS1)

BRMS1 reduces the metastatic potential, but not the tumorogenicity, of human breast cancer and melanoma cell lines. Additionally we are shipping BRMS1 Antibodies (79) and BRMS1 Kits (7) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
BRMS1 25855 Q9HCU9
BRMS1 293668 Q5M7T3
BRMS1 107392 Q99N20
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Top BRMS1 Proteins at antibodies-online.com

Showing 7 out of 9 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$5,370.21
Details
Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$5,370.21
Details
Escherichia coli (E. coli) Human T7 tag 100 μg Log in to see 13 to 16 Days
$953.85
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see Available
$547.80
Details
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
Details
Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
$2,629.00
Details
Yeast Cow His tag   1 mg Log in to see 60 to 71 Days
$2,629.00
Details

BRMS1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, , ,
Rat (Rattus)

Mouse (Murine)

More Proteins for Breast Cancer Metastasis Suppressor 1 (BRMS1) Interaction Partners

Human Breast Cancer Metastasis Suppressor 1 (BRMS1) interaction partners

  1. overexpression of miR-3200-5p significantly decreased BRMS1 levels and promoted OS cell invasion and migration, while depletion of miR-3200-5p significantly increased BRMS1 levels and inhibited OS cell invasion and migration. Study revealed that miR-3200-5p may be a critical regulator of OS cell invasiveness.

  2. Low BRMS1 expression is associated with Hepatocellular carcinoma.

  3. Low BRMS1 expression is associated with high metastatic capacity of breast cancer.

  4. High BRMS1 Expression is associated with Metastases and recurrence in Lung Adenocarcinoma.

  5. The results showed that reduction in the breast cancer metastasis suppressor 1 [BRMS1] expression level was linked directly to clinico-pathological features of breast cancer significantly. The loss of expression or reduced levels of BRMS1 is potentially a strong indicator of the metastatic capacity of breast cancer with poor prognosis.

  6. The RAS-related nuclear protein ((P) ran), breast cancer metastasis suppressor 1 ((P) brms1) and minichromosome maintenance complex component 5 ((P) mcm5) promoters have the specificity and strength needed for cancer-specific expression-targeted gene therapy.

  7. we identify a therapeutically exploitable posttranslational mechanism by which CK2alpha-mediated degradation of BRMS1 promotes metastases in lung cancer

  8. our study characterized DAPK1 as a novel transcriptional target of BRMS1. Transcriptional activation of DAPK1 might be another important mechanism accounting for the metastasis suppressive activity of BRMS1.

  9. BRMS1 promoter methylation and aberrant protein expression seem to be related to high-risk types of human papilloma virus-induced carcinogenesis in uterine cervix.

  10. miR-346 promotes migration and invasion of nasopharyngeal carcinoma cells via targeting BRMS1.

  11. expression of BRMS1 and/or HPA might be closely related to the carcinogenesis, clinical biological behaviors, and prognosis of gallbladder adenocarcinoma

  12. A novel link has been discussed between CDK2 expression and cell migration by characterizing the CDK2-mediated phosphorylation of BRMS1.

  13. Phosphorylation of BRMS1 by CDK2 regulates the migration of tumor cells.

  14. Data show that Cullin3 exerts its function through promoting breast-cancer metastasis suppressor 1 (BRMS1) protein degradation, which was associated with epithelial-mesenchymal transition (EMT), migration and invasion.

  15. The studies reviewed here with respect to BRMS1 structure, cellular effects, intracellular signaling, and clinical value consolidate the importance of BRMS1 in the development of metastasis.

  16. Aberrant methylation of BRMS1 frequently occurs in the down-regulation of BRMS1 in triple negative breast cancer and that it may play a role in the metastasis of breast cancer.

  17. the present study demonstrates a mechanical cascade of BRMS1 suppressing cancer cell invasion through downregulating HIF-1alpha transcript and consequently reducing Snail and TWIST1 expression.

  18. MRTF-A and STAT3 synergistically recruited DNMT1 to hypermethylate the promoter of BRMS1 and affect the expression of BRMS1.MRTF-A and STAT3 promote breast cancer cell migration via hypermethylating BRSM1.

  19. BRMS1 expression in human breast cancer is negatively correlated with JARID1C expression. Our results, for the first time, portray a pivotal role of JARID1C in regulating metastatic behaviors of breast cancer cells

  20. high expression of BRSM1 in rectal cancer plays an essential role in tumor progression

Mouse (Murine) Breast Cancer Metastasis Suppressor 1 (BRMS1) interaction partners

  1. The Brms1 suppressed pulmonary metastasis and promoted apoptosis of tumor cells located in the lungs but not in the mammary glands.

  2. Comparative sequence analysis in eight inbred strains

  3. BRMS1 may participate in transcriptional regulation via interaction with the mSin3.HDAC complex

  4. results show for the first time that BRMS1 contains both nuclear import and export signals enabling its nucleo-cytoplasmic shuttling

BRMS1 Protein Profile

Protein Summary

This gene reduces the metastatic potential, but not the tumorogenicity, of human breast cancer and melanoma cell lines. The protein encoded by this gene localizes primarily to the nucleus and is a component of the mSin3a family of histone deacetylase complexes (HDAC). The protein contains two coiled-coil motifs and several imperfect leucine zipper motifs. Alternative splicing results in two transcript variants encoding different isoforms.

Gene names and symbols associated with BRMS1

  • breast cancer metastasis suppressor 1 (BRMS1)
  • breast cancer metastasis-suppressor 1 (Brms1)
  • breast cancer metastasis suppressor 1 L homeolog (brms1.L)
  • breast cancer metastasis suppressor 1 (Brms1)
  • breast cancer metastasis suppressor 1 (brms1)
  • AV003220 protein
  • AW554636 protein
  • BRMS1 protein
  • BRMS1L protein
  • MGC98869 protein
  • si:zc188c22.3 protein
  • si:zc194c5.2 protein
  • wu:fb57b08 protein
  • zgc:56414 protein

Protein level used designations for BRMS1

breast cancer metastasis-suppressor 1 , breast cancer metastasis suppressor 1 , breast cancer metastasis-suppressor 1 homolog , breast cancer metastasis-suppressor 1-like protein

GENE ID SPECIES
25855 Homo sapiens
293668 Rattus norvegicus
734272 Xenopus laevis
100307034 Ovis aries
611920 Canis lupus familiaris
615952 Bos taurus
107392 Mus musculus
100728792 Cavia porcellus
100058315 Equus caballus
100518234 Sus scrofa
791681 Danio rerio
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