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The BAZ1A gene encodes the accessory subunit of the ATP-dependent chromatin assembly factor (ACF), a member of the ISWI ('imitation switch') family of chromatin remodeling complexes (summarized by Racki et al., 2009 [PubMed 20033039]).[supplied by OMIM, Apr 2010].. Additionally we are shipping BAZ1A Antibodies (34) and many more products for this protein.
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Results from the study suggest that acute cocaine exposure increased Baz1a expression in nucleus accumbens while repeated cocaine exposure produced the opposite effect. Findings implicate BAZ1A in molecular and behavioral plasticity to cocaine and offer new insight into the pathophysiology of cocaine addiction.
promotes recovery after DNA damage, in part by recruiting SMARCA5 (show SMARCA5 Proteins) to damaged chromatin
Study reports de novo mutation in BAZ1A, in a patient with a syndromic form of intellectual disability (ID). This mutation affects the expression of genes involved in several biological pathways such as vitamin D regulation, Wnt (show WNT2 Proteins) signaling, and postsynaptic signaling. Data point to an important role for BAZ1A in neurodevelopment, and highlight a possible link for BAZ1A to ID.
CHD3.1 and ACF1-SNF2H (show SMARCA5 Proteins) display counteractive activities but similar histone affinities.
ISWI (show SMARCA1 Proteins) proteins Snf2H (show SMARCA5 Proteins), Snf2L (show SMARCA1 Proteins) as well as Acf1 accumulate at UV-induced DNA damage sites within tens of seconds and reach a plateau after a few minutes.
hACF1-containing factors are more generally involved in the DNA damage response.
The ACF1 and its complexes play important roles in DNA double-strand breaks (DSBs) repair.
The data support a model in which the human ACF (show A1CF Proteins) anf (show NPPA Proteins) yeast RSC remodeling enzymes move nucleosomes to new locations by a general sequence-independent mechanism.
ACF1 alters the remodeling strategy of SNF2h (show SMARCA5 Proteins)
Has a critical role in the transcriptional repression of specific nuclear hormone receptor (show NR0B1 Proteins)-regulated genes.
Baz1a deficiency causes male-specific sterility in accord with its high expression in male germ cells, where it displays dynamic, stage-specific patterns of chromosomal localization.
The BAZ1A gene encodes the accessory subunit of the ATP-dependent chromatin assembly factor (ACF), a member of the ISWI ('imitation switch') family of chromatin remodeling complexes (summarized by Racki et al., 2009
ATP-dependent chromatin remodeling protein
, ATP-dependent chromatin-remodeling protein
, ATP-utilizing chromatin assembly and remodeling factor 1
, CHRAC subunit ACF1
, bromodomain adjacent to zinc finger domain protein 1A
, williams syndrome transcription factor-related chromatin-remodeling factor 180
, bromodomain adjacent to zinc finger domain, 1A
, ATP-utilizing chromatin assembly factor 1
, bromodomain adjacent to zinc finger domain protein 1A-like
, gene trap locus 5
, LOW QUALITY PROTEIN: bromodomain adjacent to zinc finger domain protein 1A