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BUB1B encodes a kinase involved in spindle checkpoint function. Additionally we are shipping BUB1B Proteins (8) and BUB1B Kits (1) and many more products for this protein.
Showing 10 out of 191 products:
Human Monoclonal BUB1B Primary Antibody for CyTOF, FACS - ABIN151818
Chan, Jablonski, Sudakin, Hittle, Yen: Human BUBR1 is a mitotic checkpoint kinase that monitors CENP-E functions at kinetochores and binds the cyclosome/APC. in The Journal of cell biology 1999
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Human Polyclonal BUB1B Primary Antibody for WB - ABIN2801914
Donadelli, Benatti, Remuzzi, Morigi, Gullans, Benigni, Remuzzi, Noris: Identification of a novel gene--SSK1--in human endothelial cells exposed to shear stress. in Biochemical and biophysical research communications 1998
Show all 5 Pubmed References
Human Polyclonal BUB1B Primary Antibody for IP, WB - ABIN152011
Tang, Erikson, Liu: Checkpoint kinase 1 (Chk1) is required for mitotic progression through negative regulation of polo-like kinase 1 (Plk1). in Proceedings of the National Academy of Sciences of the United States of America 2006
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Human Monoclonal BUB1B Primary Antibody for IHC (p), PLA - ABIN560109
Chambers: The molecular basis of pluripotency in mouse embryonic stem cells. in Cloning and stem cells 2005
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Human Polyclonal BUB1B Primary Antibody for IF (p), IHC (p) - ABIN713831
Qu, Zou, Zhang, Sheng, Wang, Wang, Wang, Ji: Chelidonine induces mitotic slippage and apoptotic-like death in SGC-7901 human gastric carcinoma cells. in Molecular medicine reports 2016
Human Polyclonal BUB1B Primary Antibody for ICC, IF - ABIN251710
On, Chen, Ma, Chow, Poon: Determinants of mitotic catastrophe on abrogation of the G2 DNA damage checkpoint by UCN-01. in Molecular cancer therapeutics 2011
Human Monoclonal BUB1B Primary Antibody for ICC, IF - ABIN2668286
Liu, Rattner, Jablonski, Yen: Mapping the assembly pathways that specify formation of the trilaminar kinetochore plates in human cells. in The Journal of cell biology 2006
Finally, the authors show that the kinetochore localization of BUB1 (show BUB1 Antibodies) and BUBR1 decreases with the age of the oocyte donors. This could contribute to oocyte aneuploidy.
Authors show that two distinct pools of BubR1/Bub3 (show BUB3 Antibodies) exist at kinetochores and we uncouple these with defined BubR1/Bub3 (show BUB3 Antibodies) mutants to address their function.
Small sequence differences in Bub1 (show BUB1 Antibodies) and BubR1 direct Bub3 (show BUB3 Antibodies) to different phosphorylated targets in the spindle assembly checkpoint signaling cascade.
we found that FOXM1 (show FOXM1 Antibodies) inhibitor attenuated tumorigenesis and radioresistance of glioblastoma (GBM) both in vitro and in vivo. Altogether, BUB1B promotes tumor proliferation and induces radioresistance in GBM, indicating that BUB1B could be a potential therapeutic target for GBM.
Data show that BRCA2 was required for HDAC2/3 association with acetylated BubR1 in nocodazole (Noc)-arrested cells.
Results from phylogenomic study identified of a novel conserved cassette of short linear motifs in BubR1 essential for the spindle checkpoint
BubR1 N-terminal domain was necessary, but not sufficient to protect against aneuploidy and cancer. In contrast, BubR1 lacking the internal Cdc20 (show CDC20 Antibodies)-binding domain provided protection against both, which coincided with improved microtubule-kinetochore attachment error correction and spindle assembly checkpoint activity.
Low BUB1B expression is associated with Chromophobe Renal Cell Carcinomas.
Whether carriers of pathogenic BUB1B mutations, such as the parents of MVA (show MYO5A Antibodies) syndrome patients, have an increased risk for cancer remains of interest, as studies in mice have suggested that haploinsufficiency of BUB1B may cause an increase in carcinogen-induced tumors
structure of the PP2A (show PPP2R4 Antibodies) B56-BubR1 complex provides important insights into how the B56 subunit directs the recruitment of PP2A (show PPP2R4 Antibodies) to specific targets.
BubR1 insufficiency impairs angiogenesis and results in limb loss in ischemic hind limbs.
Up-regulation of desmocollin-1 (DSC1 (show DSC1 Antibodies)) was observed in wild-type, but not Low-budding uninhibited by benzimidazole-related 1(BubR1)-expressing mutant (BubR1(L/L)) mice after partial hepatectomy (PHx).
The combination of budding uninhibited by benzimidazole-related 1 (BUBR1) insufficiency and administration of KBrO3 worsens the proliferative capacity compared with the impaired proliferation induced by BUBR1 insufficiency alone.
Age-related decline in BubR1 impairs adult hippocampal neurogenesis.
Consistent with defective myelination, BubR1(H/H) mice exhibited various motor deficits, including impaired motor strength, coordination, and balance, irregular gait patterns and reduced locomotor activity.
EZH2 (show EZH2 Antibodies) directly interacted with and stabilized BubR1, an effect driving EZH2 (show EZH2 Antibodies) into the concert of meiosis regulation.
we quantified the frequency of aneuploidy of three autosomes in the cerebral cortex and cerebellum of adult and developing brain of Bub1b(H/H) mice, which have a faulty mitotic checkpoint (show BUB3 Antibodies), and Ercc1 (show ERCC1 Antibodies)(-/Delta7) mice, defective in nucleotide excision repair and inter-strand cross-link repair.we found that Bub1b(H/H), but not Ercc1 (show ERCC1 Antibodies)(-/Delta7) mice, have a significantly higher frequency of aneuploid nuclei relative to wild-t...
Data show that compound mutant spindle assembly checkpoint components BubR1 and Sgo1 (show SGOL1 Antibodies) embryonic fibroblasts (MEFs) grew at a much slower rate, and a small fraction of cells exhibited morphologies of senescent cells at early passages.
These data reveal that BubR1 plays a multifaceted role in chromosome segregation during the first meiotic division and suggest that age-related decline of BubR1 is a key determinant of the formation of aneuploid oocytes during aging.
BubR1 (-/-) embryos were aneuploid and had an increased level of premature sister chromatid separation.
Together, our findings demonstrate that Bub1 (show BUB1 Antibodies) acts at multiple points to assure the correct kinetochore formation.
Our data implicate a previously unknown function of Bub1 that can be hijacked by pathogens to facilitate their entry, and Bub1 may serve as a potential antiviral therapy target for limiting viral entry.
This gene encodes a kinase involved in spindle checkpoint function. The protein has been localized to the kinetochore and plays a role in the inhibition of the anaphase-promoting complex/cyclosome (APC/C), delaying the onset of anaphase and ensuring proper chromosome segregation. Impaired spindle checkpoint function has been found in many forms of cancer.
MAD3/BUB1-related protein kinase
, budding uninhibited by benzimidazoles 1 homolog beta
, mitotic checkpoint kinase MAD3L
, mitotic checkpoint serine/threonine-protein kinase BUB1 beta
, budding uninhibited by benzimidazoles 1 beta
, budding uninhibited by benzimidazoles 1 homolog, beta
, BUB1 budding uninhibited by benzimidazoles 1 homolog beta
, budding uninhibited by benzimidazoles 1 homolog beta (yeast)
, mitotic checkpoint serine/threonine-protein kinase BUB1 beta-like