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Negative regulator of T-cell proliferation.. Additionally we are shipping BTNL2 Antibodies (19) and BTNL2 Proteins (8) and many more products for this protein.
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Host-genotype analysis revealed an association of the rs2076530 (BTNL2) risk allele with a decrease in bacterial burden in sarcoidosis.
HLA-DPB1*05:01 gene was associated with the geographical region of PV and the BTNL2 gene was significantly associated with family history and age of onset of PV. In conclusion, the HLA-DPB1*05:01 and BTNL2 genes might be responsible for the complicacy of clinical features.
The sarcoidosis risk variant BTNL2 c.1078G.A (rs2076530) was associated with disease in all OFG cases (P (1/4) 0.013; OR (1/4) 1.33; 95% CI, 1.06-1.67) and had a similar OR (1.56) and the same direction of effect as seen in sarcoidosis. However, no association was seen for the subphenotypes of OFG only or OFG+CD.
Despite a significant difference in BTNL2 polymorphism between sarcoid patients and controls, there was no such difference between familial and sporadic sarcoidosis cases and no correlation between BTNL2 polymorphism and disease severity or outcome. Thus, BTNL2 difference cannot be considered as a key marker for disease classification or patient management.
Two new signals were observed at genome-wide significance (P < 5 x 10-8), namely, rs7216064 (17q24.3, BPTF), for overall lung adenocarcinoma risk, and rs3817963 (6p21.3, BTNL2) which is specific to cases with EGFR (show EGFR ELISA Kits) mutations. In further sub-analyses by EGFR (show EGFR ELISA Kits) status, rs9387478 (ROS1 (show ROS1 ELISA Kits)/DCBLD1) and rs2179920 (HLA-DPB1) showed stronger estimated associations in EGFR (show EGFR ELISA Kits)-positive compared to EGFR (show EGFR ELISA Kits)-negative cases
BTNL2 variant is associated with psoriasis.
Butyrophilin-like 2, expressed at various levels by UM cells and macrophages, might interfere with the immune control of the tumor. Butyrophilin-like 2 variants showed highly variable frequencies among ethnically related cohorts. There was no enrichment of BTNL2 variants in patients with UM compared with control patients.
BTNL2 G16071A gene polymorphism may as a likelihood factor contributed to granulomatous disease susceptibility, especially increasing the sarcoidosis susceptibility. In addition, the polymorphism may be greatly associated with likelihood of granulomatous diseases among Caucasians.
BTNL2 may have an inhibitory effect on FOXP3 (show FOXP3 ELISA Kits)(+) T cell proliferation, especially in patients homozygous for the risk alleles.
genetic mutations within or around BTNL2 (rs3763313, rs9268494, rs9268492 and rs9268402) could alter susceptibility to grade IV of dilated cardiomyopathy in a Chinese population
Butyrophilin-like 2 modulates B7 costimulation to induce Foxp3 (show FOXP3 ELISA Kits) expression and regulatory T cell development in mature T cells.
BTNL2 is overexpressed during both the asymptomatic and symptomatic phase of the Mdr1a (show ABCB4 ELISA Kits) knockout model of spontaneous colitis. Soluble BTNL2-Fc protein inhibits proliferation of murine T4 cells from the spleen, mesenteric lymph node, and Peyer's patch.
Negative regulator of T-cell proliferation.
butyrophilin-like protein 2
, butyrophylin-like MHC class II associated
, butyrophilin-like 2 (MHC class II associated)
, butyrophilin-like protein 2-like