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Genome-wide significant (P < 5 x 10(-8) ) interaction with MTNR1B and joint effects were detected for CMIP intronic rs17197883.
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each copy of CMIP rs2925979_T allele was associated with a 29% higher risk of T2DM in females (p = 9.30 x 10(-4)), while it was not significantly associated with T2DM in males (p = 0.705).
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CMIP knockdown was observed to result in the downregulation of MDM2 and mitogen activated protein kinase (MAPK) expression at the mRNA level and CMIP was a direct target of miR1013p.
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CMIP is oncogenic and could be a potential target for human glioma diagnosis and therapy.
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These findings suggest that CMIP haploinsufficiency is the likely cause of syndromic Autism spectrum disorder in our patients.
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Wilm's tumor protein (WT1) bound to 2 WT1 response elements, located at positions -290/-274 and -57/-41 relative to transcription start site.
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Results suggest that c-mip and RelA define two distinct types of renal damage associated with VEGF-targeted therapies.
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c-mip has an active role in the podocyte disorders of membranous nephropathy.
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These results suggest that alterations in NF-kappaB activity might result from the up-regulation of c-mip and are likely to contribute to podocyte disorders in cases of idiopathic nephrotic syndrome.
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we provide novel evidence that the language-disorder candidate gene CMIP is implicated in reading processes.
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Eight suggestive significant loci were detected with a series of genes expressed within the inner ear that underlie the auditory function, such as: DCLK1, PTPRD, GRM8, CMIP.
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results identify c-mip as a key component in the molecular pathogenesis of acquired podocyte diseases
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Induction of c-mip in Hodgkin-Reed Sternberg cells and podocytes is associated with minimal change nephrotic syndrome in classical Hodgkin lymphoma.
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Data demonstrate that c-mip interacts with Dip1 and upregulates DAPK, which blocks the nuclear translocation of ERK1/2.
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results suggest that Tc-mip plays a critical role in Th2 signaling pathway and represents the first proximal signaling protein which links TCR-mediated signal to the activation of c-maf Th2 specific factor
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Filamin-A interacts with c-mip/Tc-mip in a new T-cell signaling pathway.
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c-mip inhibits the degradation of I-kappaBalpha and impedes the dissociation of the NF-kappaB/I-kappaBalpha complexes.
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CMIP modulates phonological short-term memory in language impairment.
