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Data found that MYCBP was highly expressed in hepatocellular carcinoma (HCC) tissues. Its overexpression is correlated with poor prognosis which indicates that MYCBP might play a cancer-promoting role in HCC. Further results found that EYA4 suppressed HCC tumor cell growth by repressing MYCBP by dephosphorylating beta-catenin S552.
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Through activating MYCBP and by sponging miR-574-5p.
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c-Myc expression is reduced in pterygium compared with normal conjunctiva.
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Suppression of telomerase activity mediated by PinX1 is involved in the Mad1/c-Myc pathway.
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miR-22 acts as a tumor suppressor through direct repression of MYCBP expression and subsequent reduction of oncogenic c-Myc activities.
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identified a novel AMY-1-binding protein, AAT-1, and determied its expression profiles, genes, and cellular localization; results showed that AAT-1 was specifically expressed in the testis throughout spermatogenesis and was also present in mature sperm
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interacts with S-AKAP84 and AKAP95 in the cytoplasm and the nucleus, respectively, and inhibits enzyme acdtivity by preventing binding of its catalytic subunit to A-kinase-anchoring protein (AKAP) complex
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AMY-1 coordinates ADP-Ribosylation Factors-mediated membrane trafficking and signaling pathways.
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An important role for MBP-1 in the altered cell proliferation and energy utilization that occur in response to an altered glucose concentration.
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AMY-1 was localized in the mitochondria of HeLa and sperm in association with AKAP149 and S-AKAP84, respectively. These results suggest that AMY-1 plays a role in spermatogenesis