C-Type Lectin Domain Family 4, Member E Proteins (CLEC4E)

CLEC4E encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Additionally we are shipping CLEC4E Antibodies (49) and CLEC4E Kits (12) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CLEC4E 26253 Q9ULY5
CLEC4E 56619 Q9R0Q8
Rat CLEC4E CLEC4E 450223 Q67EQ1
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Top CLEC4E Proteins at antibodies-online.com

Showing 8 out of 12 products:

Catalog No. Origin Source Conjugate Images Quantity Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 50 Days
$6,749.58
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg 50 to 55 Days
$5,262.31
Details
Human Cells Human His tag   50 μg 4 Days
$385.00
Details
Escherichia coli (E. coli) Human His tag 100 μg 13 to 16 Days
$553.85
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg 11 Days
$888.80
Details
Human Cells Rhesus Monkey Fc Tag,ECD 50 μg 14 to 16 Days
$634.76
Details
Wheat germ Human GST tag 10 μg 11 to 12 Days
$414.29
Details
Human Cells Human His tag   10 μg 15 to 16 Days
$225.00
Details

CLEC4E Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , ,
, , ,
Mouse (Murine)
,

Top referenced CLEC4E Proteins

  1. Human CLEC4E Protein expressed in HEK-293 Cells - ABIN2712869 : Wevers, Kaptein, Zijlstra-Willems, Theelen, Boekhout, Geijtenbeek, Gringhuis: Fungal engagement of the C-type lectin mincle suppresses dectin-1-induced antifungal immunity. in Cell host & microbe 2014 (PubMed)

More Proteins for C-Type Lectin Domain Family 4, Member E (CLEC4E) Interaction Partners

Human C-Type Lectin Domain Family 4, Member E (CLEC4E) interaction partners

  1. variations at rs10841845 and rs10841847 of CLEC4E gene are associated with increased individual protection against Pulmonary tuberculosis

  2. Mincle has the ability to survey mycolate-derived glycolipids from actinomycetes, distinguishing non-pathogenic (e.g. Rhodococcus spp.) and pathogenic (e.g. Mycobacterium tuberculosis) species on the basis of alpha-chain length.

  3. No association was detected with any of the SNPs analysed and susceptibility to tuberculosis.

  4. combination adjuvant systems demonstrate markedly different immune activation with age, with combined DC activation via Macrophage-inducible C-type lectin and TLR7/8 representing a novel approach to enhance the efficacy of early-life vaccines.

  5. We here show that Mincle gene expression was induced in alveolar macrophages and neutrophils in bronchoalveolar lavage fluids of mice and patients with pneumococcal pneumonia

  6. a nonredundant role for Clec4e in coordinating major biological pathways involved in atherosclerosis

  7. CLEC4E expression is significantly upregulated in human masticatory mucosa during wound healing

  8. The expression of Mincle increases significantly during the early period of Aspergillus fumigatus infection, while expression of eight corresponding cytokines changes. Mincle, as a pattern recognition receptor, may play a role in the early innate immune response of the corneal resistance against fungus.

  9. Induction of Mincle by Helicobacter pylori and consequent anti-inflammatory signaling denote a bacterial survival strategy.

  10. our findings identify mincle as a contributor to the inflammatory response after traumatic brain injury

  11. results suggest that cholesterol crystals are an endogenous ligand for hMincle and that they activate innate immune responses

  12. Data indicate that MINCLE receptor is able to mediate the response to trehalose-6,6-dimycolate (TDM) dependent on SYK kinase and CARD9 protein.

  13. mincle is a fungal receptor that can suppress antifungal immunity and, as such, is a potential therapeutic target.

  14. These results demonstrated that GroMM is a unique ligand for human Mincle that is not recognized by mouse Mincle.

  15. Results show the molecular mechanism of glycolipid recognition through C-type lectin receptors, which may provide clues to rational design for effective adjuvants.

  16. Macrophage-inducible C-type lectin is associated with anti-cyclic citrullinated peptide antibodies-positive rheumatoid arthritis in men.

  17. Mincle is a potentially critical player in human B cell responses.

  18. Data indicate an unusual pattern of reciprocal expression of Mincle on peripheral blood monocytes or neutrophils.

  19. silencing of renal DNaseI gene expression initiates a cascade of inflammatory signals including activation of Toll like receptors and Clec4e, leading to progression of both murine and human lupus nephritis

  20. Our data suggest that Mincle is induced in adipose tissue macrophages in obesity at least partly through the saturated fatty acid/TLR4/NF-kappaB pathway, thereby suggesting its pathophysiologic role in obesity-induced adipose tissue inflammation.

Mouse (Murine) C-Type Lectin Domain Family 4, Member E (CLEC4E) interaction partners

  1. Mice deficient in macrophage C-type lectin protein (Mincle) or with selective depletion of tyrosine-protein kinase SYK (Syk) had increased systemic translocation of gut microbiota.

  2. our results indicate that Mincle plays an important role in neutrophil infiltration and suggest that Mincle signaling may provide a therapeutic target for treating sepsis

  3. Mincle activation by cholesterol sulfate causes the secretion of a range of proinflammatory mediators in response to skin damage.

  4. this study shows that mincle inhibits neutrophils and macrophages apoptosis in Aspergillus fumigatus keratitis

  5. Mincle is induced specifically on M1 macrophages, where Mincle-Syk signaling promotes and maintains inflammatory phenotypes of M1 macrophages in acute renal inflammation.

  6. work implicates a novel innate immune driver of Con A hepatitis and, more broadly, suggests a potential role for Mincle in diseases governed by sterile inflammation.

  7. Mincle deletion results in TLR4-mediated inflammation.

  8. Priming by Mincle-deficient dendritic cells (DCs).

  9. Thus, macrophage activation by the corynebacterial cell wall relies on TLR2-driven robust Mincle expression and the cooperative action of both receptors.

  10. this study shows that immune activation in vitro and in vivo by trehalose esters of simple fatty acids requires two acyl chains of length and involves Mincle

  11. Attenuated neutrophil extracellular trap formation in Mincle-/- neutrophils correlates with impaired autophagy activation in vitro and in vivo, whereas reactive oxygen species formation in these neutrophils remained intact.

  12. We here show that Mincle gene expression was induced in alveolar macrophages and neutrophils in bronchoalveolar lavage fluids of mice and patients with pneumococcal pneumonia

  13. this study shows a significant role for Mincle in Pneumocystis modulating host defense during infection

  14. The authors report that microbial stimulation triggers Mincle (Clec4e) expression through the myeloid differentiation primary response gene 88 (MyD88) pathway; a process that does not require MCL (Clecsf8, Clec4d). Conversely, they show that MCL is constitutively expressed but retained intracellularly until Mincle is induced, whereupon the receptors form heterodimers which are translocated to the cell surface.

  15. a nonredundant role for Clec4e in coordinating major biological pathways involved in atherosclerosis

  16. this paper shows that mycobacterial cell envelope glycolipid TDM modulates TLR2-mediated IL-10 and IL-12p40 responses in macrophages through Mincle, which is, in turn, up-regulated by Mycobacterium bovis BCG

  17. Data show that Mincle, the inducible receptor for mycobacterial cord factor, is the key switch for the transition of macrophages from cytokine expression to high nitric oxide production.

  18. Mincle Activation and the Syk/Card9 Signaling Axis Are Central to the Development of Autoimmune Disease of the Eye

  19. work shows parallel networks of necroptosis-induced CXCL1 and Mincle signalling that promote macrophage-induced adaptive immune suppression and thereby enable pancreatic ductal adenocarcinoma progression

  20. The results indicate differential roles for Dectin-2 and Mincle in the generation of adaptive immune responses to F. pedrosoi fungal infection in mice.

Cow (Bovine) C-Type Lectin Domain Family 4, Member E (CLEC4E) interaction partners

  1. Targeting the Mincle and TLR3 receptor using the dual agonist cationic adjuvant formulation 9 (CAF09) induces humoral and polyfunctional memory T cell responses in calves

  2. The structure of an extended portion of the extracellular domain of mincle, beyond the minimal C-type carbohydrate recognition domain, also constrains the way the binding domains may interact on the surface of macrophages.

  3. The data demonstrate how mincle bridges between the surfaces of the macrophage and the mycobacterium.

Guinea Pig C-Type Lectin Domain Family 4, Member E (CLEC4E) interaction partners

  1. the function of the guinea pig homologue of Mincle (gpMincle) and MCL (gpMCL). gpMincle directly bound to trehalose-6,6'-dimycolate

CLEC4E Protein Profile

Protein Summary

This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type II transmembrane protein is a downstream target of CCAAT/enhancer binding protein (C/EBP), beta (CEBPB) and may play a role in inflammation. Alternative splice variants have been described but their full-length sequence has not been determined. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region.

Gene names and symbols associated with CLEC4E

  • C-type lectin domain family 4 member E (CLEC4E)
  • C-type lectin domain family 4, member e (Clec4e)
  • C-type lectin domain family 4, member E (Clec4e)
  • C-type lectin domain family 4 member E (LOC611538)
  • C-type lectin domain family 4 member E (Clec4e)
  • C86253 protein
  • CLEC4E protein
  • Clecsf9 protein
  • Mincle protein

Protein level used designations for CLEC4E

C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 9 , C-type lectin domain family 4 member E , C-type lectin superfamily member 9 , macrophage-inducible C-type lectin , C-type (calcium dependent, carbohydrate recognition domain) lectin, superfamily member 9 , C-type lectin, superfamily member 9 , immunoreceptor , C-type lectin domain family 4, member E

GENE ID SPECIES
26253 Homo sapiens
56619 Mus musculus
450223 Rattus norvegicus
514797 Bos taurus
611538 Canis lupus familiaris
722250 Macaca mulatta
735637 Pan troglodytes
100135686 Ovis aries
100350649 Oryctolagus cuniculus
100726838 Cavia porcellus
102121864 Macaca fascicularis
110260748 Sus scrofa
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