anti-C-Type Lectin Domain Family 4, Member M (CLEC4M) Antibodies

CLEC4M encodes a transmembrane receptor and is often referred to as L-SIGN because of its expression in the endothelial cells of the lymph nodes and liver. Additionally we are shipping C-Type Lectin Domain Family 4, Member M Proteins (10) and C-Type Lectin Domain Family 4, Member M Kits (3) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
CLEC4M 10332 Q9H2X3
CLEC4M    
CLEC4M    
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Top anti-C-Type Lectin Domain Family 4, Member M Antibodies at antibodies-online.com

Showing 10 out of 100 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated WB WB Suggested Anti-CLEC4M Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:312500  Positive Control:  Human Muscle 100 μL Log in to see 2 to 3 Days
$289.00
Details
Horse Rabbit Un-conjugated WB WB Suggested Anti-CLEC4M Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:62500  Positive Control:  MCF7 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB WB Suggested Anti-CLEC4M Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:1562500Positive Control: Human kidney WB Suggested Anti-CLEC4M Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:1562500  Positive Control:  Human kidney 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Mouse Un-conjugated BR, CyTOF, FACS Detection of DC-SIGNR/CD299 in Human DC-SIGNR/CD299 Transfected 3T3 Mouse Cell Line by Flow Cytometry. 500 μg Log in to see 8 to 9 Days
$397.76
Details
Human Rabbit Un-conjugated IHC, WB WB Suggested Anti-CLEC4M Antibody Titration:  1.25ug/ml  Positive Control:  HepG2 cell lysate Human kidney 100 μL Log in to see 2 to 3 Days
$229.00
Details
Human Rabbit Un-conjugated WB Western blot analysis of CD299 expression in HEK293T (A), Hela (B), NIH3T3 (C), mouse lung (D), mouse heart (E) whole cell lysates. 200 μL Log in to see 13 to 14 Days
$487.50
Details
Human Mouse PE FACS Detection of DC-SIGNR/CD299 in 3T3 Mouse Cell Line Transfected with Human DC-SIGNR/CD299 by Flow Cytometry. 3T3 mouse embryonic fibroblast cell line transfected with human DC-SIGNR/CD299 was stained with Mouse Anti-Human DC-SIGNR/CD299 PE-conjugated Monoclonal Antibody. 100 Tests Log in to see 8 to 9 Days
$319.79
Details
Human Rabbit Un-conjugated ICC, IHC, WB Figure. Western Blot; Sample: Human Serum. 100 μg Log in to see 13 to 16 Days
$332.00
Details
Human Rabbit Un-conjugated IHC, IHC (p), WB 100 μL Log in to see 11 to 14 Days
$493.17
Details
Human Rabbit Un-conjugated ELISA, IHC (p), WB   100 μL Log in to see Available
$363.46
Details

Top referenced anti-C-Type Lectin Domain Family 4, Member M Antibodies

  1. Human Monoclonal CLEC4M Primary Antibody for BR, CyTOF - ABIN5012885 : Ludwig, Lekkerkerker, Depla, Bosman, Musters, Depraetere, van Kooyk, Geijtenbeek: Hepatitis C virus targets DC-SIGN and L-SIGN to escape lysosomal degradation. in Journal of virology 2004 (PubMed)
    Show all 9 Pubmed References

  2. Human Monoclonal CLEC4M Primary Antibody for FACS - ABIN4898522 : Mukherjee, Dowd, Manhart, Ledgerwood, Durbin, Whitehead, Pierson: Mechanism and significance of cell type-dependent neutralization of flaviviruses. in Journal of virology 2014 (PubMed)
    Show all 3 Pubmed References

  3. Human Polyclonal CLEC4M Primary Antibody for IHC, IHC (p) - ABIN4267479 : Rydz, Swystun, Notley, Paterson, Riches, Sponagle, Boonyawat, Montgomery, James, Lillicrap: The C-type lectin receptor CLEC4M binds, internalizes, and clears von Willebrand factor and contributes to the variation in plasma von Willebrand factor levels. in Blood 2013 (PubMed)

More Antibodies against C-Type Lectin Domain Family 4, Member M Interaction Partners

Human C-Type Lectin Domain Family 4, Member M (CLEC4M) interaction partners

  1. heterozygous VNTR genotypes 57 and 67 of CLEC4M were highly enriched and are the most likely mechanism through which CLEC4M contributes to disease in the Swedish type 1 VWD population

  2. DC-SIGNR promoted gastric cancer liver metastasis mediated with HNRNPKP2 which expression was regulated by STAT5A. And HNRNPKP2 decreased the expression of downstream target gene CXCR4. These findings indicated potential therapeutic candidates for gastric cancer liver metastasis.

  3. the neck domains of DC-SIGN and DC-SIGNR can contribute to the different functions of these receptors by presenting the sugar-binding sites in different contexts.

  4. Together, these studies confirm a role for C-type lectin receptors DC-SIGN and L-SIGN as attachment factors and entry receptors for human metapneumovirus infection.

  5. DC-SIGNR VNTR and DC-SIGN VNTR were not associated with the risk of pulmonary tuberculosis in a sample of Iranian population

  6. CD209L variation may influence susceptibility to HIV-1, response to treatment, and disease progression.

  7. DC-SIGNR expression in peripheral blood mononuclear cells was higher in HIV-1-infected patients, and its positive correlation with viral load and negative with CD4+ T cells counts suggest a potential role of DC-SIGNR in HIV-1 infection.

  8. Study demonstrated that serum levels of DC-SIGNR in lung cancer patients were significantly lower than those in healthy individuals, and correlated significantly with brain metastasis and serum NK cells percentage.

  9. Genetic variations in STXBP5 and CLEC4M are associated with VWF level variation in type 1, but not in type 2 von Willebrand disease.

  10. of an association between CD209 and CD209L polymorphisms and tuberculosis development in a Brazilian population

  11. DC-SIGN and DC-SIGNR are blood-based molecular markers that can potentially be used for the diagnosis of early stage patients

  12. Japanese encephalitis virus infected cells through three virus receptors: DC-SIGN, DC-SIGNR and LSECtin.

  13. The results indicate that neck region polymorphism of L-SIGN can influence the outcome of HCV infection and the four-tandem repeat is associated with clearance of HCV infection.

  14. CLEC4M and CD81 both are still crucial for hepatitis C virus entry into hepatocytes.

  15. The CLEC4M carbohydrate recognition domain rapidly and reversibly releases glycan ligands and Ca(2+) at reduced pH.

  16. these results provide evidence that hDC- and hL-SIGN can mediate the entry of Junin virus into cells, and may play an important role in virus infection and dissemination in the host.

  17. Up-regulation of Raf-MEK-ERK pathway by HCV E2 via L-SIGN provides new insights into signaling cascade of L-SIGN

  18. Our findings suggested that DC-SIGNR neck region VNTR polymorphism was not directly associated with hosts' predisposition for HIV-1 infection and not associated with the HIV-1 routes of infection.

  19. DC-SIGNR has a role in expression of lactic acid dehydrogenase and beta2-microglobulin in non-Hodgkin lymphoma

  20. genetic polymorphism is associated with HIV-1 infection

C-Type Lectin Domain Family 4, Member M (CLEC4M) Antigen Profile

Protein Summary

This gene encodes a transmembrane receptor and is often referred to as L-SIGN because of its expression in the endothelial cells of the lymph nodes and liver. The encoded protein is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses, with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations in the number of 23 amino acid repeats in the neck domain of this protein are common and have a significant impact on ligand binding ability. This gene is closely related in terms of both sequence and function to a neighboring gene (GeneID 30835\; often referred to as DC-SIGN or CD209). DC-SIGN and L-SIGN differ in their ligand-binding properties and distribution. Alternative splicing results in multiple variants.

Gene names and symbols associated with CLEC4M

  • C-type lectin domain family 4 member M (CLEC4M) antibody
  • CD209B antibody
  • CD209L antibody
  • CD299 antibody
  • DC-SIGN2 antibody
  • DC-SIGNR antibody
  • DCSIGNR antibody
  • HP10347 antibody
  • L-SIGN antibody
  • LSIGN antibody

Protein level used designations for CLEC4M

C-type lectin domain family 4 member M , CD209 antigen-like protein 1 , CD299 antigen , DC-SIGN-related protein , dendritic cell-specific ICAM-3-grabbing non-integrin 2 , liver/lymph node-specific ICAM-3 grabbing non-integrin , liver/lymph node-specific ICAM-3-grabbing non-integrin , mannose binding C-type lectin DC-SIGNR , CD209b antigen

GENE ID SPECIES
10332 Homo sapiens
455661 Pan troglodytes
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