C-Type Lectin Domain Family 4, Member M ELISA Kits

CLEC4M encodes a transmembrane receptor and is often referred to as L-SIGN because of its expression in the endothelial cells of the lymph nodes and liver.

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Pre-coated, Samples: Cell Culture Supernatant, Cell Lysate, Plasma, Serum, Tissue Lysate
ReactivityHuman
Detection MethodColorimetric, Sandwich ELISA
Detection RangeQuantitative
Order details Cat. No. ABIN4882575
ISO
$480.70
Plus shipping costs $45.00
Delivery in 31 to 41 Business Days
Pre-coated, Samples: Cell Culture Supernatant, Plasma, Serum
ReactivityHuman
Detection MethodqPCR, Sandwich ELISA
Detection RangeSemi-Quantitative
Order details Cat. No. ABIN6385420
ISO
$591.25
96 tests
Plus shipping costs $45.00
Delivery in 11 to 16 Business Days
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C-Type Lectin Domain Family 4, Member M (CLEC4M) Antigen Profile

Protein Summary

This gene encodes a transmembrane receptor and is often referred to as L-SIGN because of its expression in the endothelial cells of the lymph nodes and liver. The encoded protein is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses, with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations in the number of 23 amino acid repeats in the neck domain of this protein are common and have a significant impact on ligand binding ability. This gene is closely related in terms of both sequence and function to a neighboring gene (GeneID 30835\; often referred to as DC-SIGN or CD209). DC-SIGN and L-SIGN differ in their ligand-binding properties and distribution. Alternative splicing results in multiple variants.

Gene names and symbols associated with CLEC4M

  • C-type lectin domain family 4 member M (CLEC4M) antibody
  • CD209B antibody
  • CD209L antibody
  • CD299 antibody
  • DC-SIGN2 antibody
  • DC-SIGNR antibody
  • DCSIGNR antibody
  • HP10347 antibody
  • L-SIGN antibody
  • LSIGN antibody

Protein level used designations for CLEC4M

C-type lectin domain family 4 member M , CD209 antigen-like protein 1 , CD299 antigen , DC-SIGN-related protein , dendritic cell-specific ICAM-3-grabbing non-integrin 2 , liver/lymph node-specific ICAM-3 grabbing non-integrin , liver/lymph node-specific ICAM-3-grabbing non-integrin , mannose binding C-type lectin DC-SIGNR , CD209b antigen

GENE ID SPECIES
10332 Homo sapiens
455661 Pan troglodytes