C1GALT1-Specific Chaperone 1 (C1GALT1C1) ELISA Kits

C1GALT1C1 encodes a type II transmembrane protein that is similar to the core 1 beta1,3-galactosyltransferase 1, which catalyzes the synthesis of the core-1 structure, also known as Thomsen-Friedenreich antigen, on O-linked glycans. Additionally we are shipping C1GALT1-Specific Chaperone 1 Antibodies (21) and C1GALT1-Specific Chaperone 1 Proteins (7) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
C1GALT1C1 29071 Q96EU7
C1GALT1C1 59048 Q9JMG2
C1GALT1C1 302499 Q499P3
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Top C1GALT1-Specific Chaperone 1 ELISA Kits at antibodies-online.com

Showing 4 out of 7 products:

Catalog No. Reactivity Sensitivity Range Images Quantity Supplier Delivery Price Details
Rat < 46.9 pg/mL 78 pg/mL - 5000 pg/mL   96 Tests Log in to see 11 to 18 Days
Mouse < 46.9 pg/mL 78 pg/mL - 5000 pg/mL   96 Tests Log in to see 11 to 18 Days
Human < 0.188 ng/mL 0.313 ng/mL - 20 ng/mL   96 Tests Log in to see 11 to 18 Days
  96 Tests Log in to see 15 to 18 Days

More ELISA Kits for C1GALT1-Specific Chaperone 1 Interaction Partners

Human C1GALT1-Specific Chaperone 1 (C1GALT1C1) interaction partners

  1. In addition, we found that Tn-expressing colorectal cancers (CRC) cell lines had either loss-of-function mutations in Cosmc or reversible Tn antigen expression, which was not caused by the deficiency of T-synthase activity

  2. elevated Tn levels in cancer and inflammation may be commonly regulated by the cytokine (TNFa and IL6)-Cosmc signaling axis

  3. The data suggest that hypermethylation of the Cosmc promoter may induce the expression of Tn antigen in activated T cells.

  4. results provide new structure-function insight to Cosmc, indicate that Cosmc behaves as a modular protein and suggests points of modulation or regulation of in vivo chaperone function

  5. Data indicate that mRNA levels of both core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1 (C1GALT1) and C1GALT1-specific chaperone 1 protein (C1GALT1C1) determine the rate of secretion of galactose-deficient IgA1 (Gd-IgA1) in IgA1-producing cells.

  6. The terminal glycosylation of secreted IgA1 was altered in response to TGFbeta1. TGFbeta1 stimulation significantly decreased the mRNA levels of C1GalT1 and Cosmc. TGFbeta1 may be key in controlling the glycosylation of IgA1, in part via the downregulation of C1GalT1 and Cosmc.

  7. mutations c.393T>A and c.72A>G in the exon region of Cosmc gene in children with Henoch-Schonlein purpura (HSP) are not associated with the onset of Henoch-Schonlein purpura

  8. Data suggest that patients with IgA nephropathy exhibit higher microRNA-374b in B cells compared to controls; microRNA-374b appears to target PTEN (phosphatase and tensin homolog) and Cosmc (C1GALT1 specific chaperone 1) proteins.

  9. These results indicate that Tn antigens expression and T-synthase inactivity in HT-29-Tn+ cells can be related to the absence of the Cosmc gene coding sequence in Cosmc active alleles

  10. the impact of COSMC mediated Tn antigen expression in two human pancreatic ductal adenocarcinoma cell lines on cellular oncogenic properties, were investigated.

  11. hypermethylation of Cosmc promoter region could be a key mechanism for the reduction of Cosmc mRNA expression in IgAN lymphocytes with associated increase in aberrantly glycosylated IgA1

  12. Cosmc and T-synthase are transcriptionally regulated at a basal level by the specificity protein/Kruppel-like transcription factor family of members.

  13. CBRT is a unique recognition motif for Cosmc to promote its regulation and formation of active T-synthase and represents the first sequence-specific chaperone recognition system in the ER/Golgi required for normal protein O-glycosylation

  14. Data indicate that cytotoxin associated gene A protein (CagA) promoted the underglycosylation of IgA1, which at least partly attributed to the downregulation of beta1,3-galactosyltransferase (C1GALT1) and its chaperone Cosmc.

  15. overexpression of Cosmc is associated with colorectal cancer.

  16. COSMC is a novel regulator for VEGFR2 signaling in endothelial cells and dysregulation of COSMC expression may contribute to the pathogenesis of hemangioma

  17. The mRNA expression level of Cosmc gene in IgA nephropathy patients was significantly lower than that of controls. De-methylation modification up regulated the Cosmc gene expression significantly.

  18. Results show that soluble Cosmc directly interacts in a specific manner with denatured, but not native, T-synthase to form a noncovalent and reversible complex that results in the acquisition of T-synthase catalytic activity.

  19. Results indicate that Cosmc mediates the co-translational activation of C1GalT and that it may prevent the unfavorable aggregation of C1GalT.

  20. The transmembrane domain of the molecular chaperone Cosmc directs its localization to the endoplasmic reticulum

Mouse (Murine) C1GALT1-Specific Chaperone 1 (C1GALT1C1) interaction partners

  1. Cosmc is an inflammatory bowel disease risk factor and is implicated in regulating the spatial pattern of dysbiosis and sex bias in IBD.

  2. These results demonstrated that core 1-derived O-glycan is required for Tim4-dependent normal efferocytosis and may contribute to the stable expression of the Tim4 glycoprotein.

  3. Cosmc is an essential chaperone for correct protein O-glycosylation.

  4. a somatic mutation in the chaperone gene Cosmc abolished function of a glycosyltransferase, disrupting O-glycan Core 1 synthesis & creating a tumor-specific glycopeptidic neo-epitope consisting of a monosaccharide and a specific wild-type protein sequence

C1GALT1-Specific Chaperone 1 (C1GALT1C1) Antigen Profile

Antigen Summary

This gene encodes a type II transmembrane protein that is similar to the core 1 beta1,3-galactosyltransferase 1, which catalyzes the synthesis of the core-1 structure, also known as Thomsen-Friedenreich antigen, on O-linked glycans. This gene product lacks the galactosyltransferase activity itself, but instead acts as a molecular chaperone required for the folding, stability and full activity of the core 1 beta1,3-galactosyltransferase 1. Mutations in this gene have been associated with Tn syndrome. Alternatively spliced transcript variants encoding the same protein have been identified.

Gene names and symbols associated with C1GALT1C1

  • C1GALT1-specific chaperone 1 (c1galt1c1) antibody
  • C1GALT1 specific chaperone 1 (C1GALT1C1) antibody
  • C1GALT1 specific chaperone 1 (c1galt1c1) antibody
  • C1GALT1 specific chaperone 1 L homeolog (c1galt1c1.L) antibody
  • C1GALT1-specific chaperone 1 (C1galt1c1) antibody
  • 1500002I11Rik antibody
  • AB030184 antibody
  • C1GalT2 antibody
  • C38H2-L1 antibody
  • C81205 antibody
  • Cosmc antibody
  • MGC88924 antibody
  • MST143 antibody
  • RGD1311230 antibody
  • TNPS antibody
  • wu:fc17f08 antibody
  • wu:fc59b02 antibody
  • zgc:66375 antibody

Protein level used designations for C1GALT1C1

fc59b02 , core 1 UDP-galactose:N-acetylgalactosamine-alpha-R beta 1,3-galactosyltransferase 2 , C1GALT1-specific chaperone 1 , Core 1 beta3-galactosyltransferase-specific molecular chaperone , C1GALT1-specific chaperone 1-like , c1GALT1-specific chaperone 1-like , C1Gal-T2 , C38H2-like protein 1 , beta 1,3-galactosyltransferase 2 , core 1 beta1,3-galactosyltransferase 2 , core 1 beta3-Gal-T2 , core 1 beta3-galactosyltransferase-specific molecular chaperone , beta1,3-galactosyltransferase 2 , mC1Gal-T2

324052 Danio rerio
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448225 Xenopus (Silurana) tropicalis
465837 Pan troglodytes
495031 Xenopus laevis
696662 Macaca mulatta
100397132 Callithrix jacchus
100441547 Pongo abelii
100594094 Nomascus leucogenys
29071 Homo sapiens
59048 Mus musculus
302499 Rattus norvegicus
531644 Bos taurus
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