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C1GALT1C1 encodes a type II transmembrane protein that is similar to the core 1 beta1,3-galactosyltransferase 1, which catalyzes the synthesis of the core-1 structure, also known as Thomsen-Friedenreich antigen, on O-linked glycans. Additionally we are shipping C1GALT1-Specific Chaperone 1 Antibodies (19) and C1GALT1-Specific Chaperone 1 Proteins (7) and many more products for this protein.
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In addition, we found that Tn-expressing colorectal cancers (CRC (show CALR ELISA Kits)) cell lines had either loss-of-function mutations in Cosmc or reversible Tn antigen expression, which was not caused by the deficiency of T-synthase (show C1GALT1 ELISA Kits) activity
elevated Tn levels in cancer and inflammation may be commonly regulated by the cytokine (TNFa (show TNF ELISA Kits) and IL6 (show IL6 ELISA Kits))-Cosmc signaling axis
The data suggest that hypermethylation of the Cosmc promoter may induce the expression of Tn antigen in activated T cells.
results provide new structure-function insight to Cosmc, indicate that Cosmc behaves as a modular protein and suggests points of modulation or regulation of in vivo chaperone function
Data indicate that mRNA levels of both core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1 (C1GALT1 (show C1GALT1 ELISA Kits)) and C1GALT1-specific chaperone 1 protein (C1GALT1C1) determine the rate of secretion of galactose-deficient IgA1 (Gd-IgA1) in IgA1-producing cells.
The terminal glycosylation of secreted IgA1 was altered in response to TGFbeta1 (show TGFB1 ELISA Kits). TGFbeta1 (show TGFB1 ELISA Kits) stimulation significantly decreased the mRNA levels of C1GalT1 (show C1GALT1 ELISA Kits) and Cosmc. TGFbeta1 (show TGFB1 ELISA Kits) may be key in controlling the glycosylation of IgA1, in part via the downregulation of C1GalT1 (show C1GALT1 ELISA Kits) and Cosmc.
mutations c.393T>A and c.72A>G in the exon region of Cosmc gene in children with Henoch-Schonlein purpura (HSP) are not associated with the onset of Henoch-Schonlein purpura
Data suggest that patients with IgA (show IgA ELISA Kits) nephropathy exhibit higher microRNA-374b in B cells compared to controls; microRNA-374b appears to target PTEN (phosphatase and tensin homolog) and Cosmc (C1GALT1 specific chaperone 1) proteins.
These results indicate that Tn antigens expression and T-synthase (show C1GALT1 ELISA Kits) inactivity in HT-29-Tn+ cells can be related to the absence of the Cosmc gene coding sequence in Cosmc active alleles
the impact of COSMC mediated Tn antigen expression in two human pancreatic ductal adenocarcinoma cell lines on cellular oncogenic properties, were investigated.
Cosmc is an inflammatory bowel disease risk factor and is implicated in regulating the spatial pattern of dysbiosis and sex bias in IBD.
These results demonstrated that core 1-derived O-glycan is required for Tim4 (show TIMD4 ELISA Kits)-dependent normal efferocytosis and may contribute to the stable expression of the Tim4 (show TIMD4 ELISA Kits) glycoprotein.
Cosmc is an essential chaperone for correct protein O-glycosylation.
a somatic mutation in the chaperone gene Cosmc abolished function of a glycosyltransferase, disrupting O-glycan Core 1 synthesis & creating a tumor-specific glycopeptidic neo-epitope consisting of a monosaccharide and a specific wild-type protein sequence
This gene encodes a type II transmembrane protein that is similar to the core 1 beta1,3-galactosyltransferase 1, which catalyzes the synthesis of the core-1 structure, also known as Thomsen-Friedenreich antigen, on O-linked glycans. This gene product lacks the galactosyltransferase activity itself, but instead acts as a molecular chaperone required for the folding, stability and full activity of the core 1 beta1,3-galactosyltransferase 1. Mutations in this gene have been associated with Tn syndrome. Alternatively spliced transcript variants encoding the same protein have been identified.
, core 1 UDP-galactose:N-acetylgalactosamine-alpha-R beta 1,3-galactosyltransferase 2
, C1GALT1-specific chaperone 1
, Core 1 beta3-galactosyltransferase-specific molecular chaperone
, C1GALT1-specific chaperone 1-like
, c1GALT1-specific chaperone 1-like
, C38H2-like protein 1
, beta 1,3-galactosyltransferase 2
, core 1 beta1,3-galactosyltransferase 2
, core 1 beta3-Gal-T2
, core 1 beta3-galactosyltransferase-specific molecular chaperone
, beta1,3-galactosyltransferase 2