anti-CD200 Receptor 1 (CD200R1) Antibodies

Human CD200 Receptor 1 (CD200R1) interaction partners

1. Reduced expression of monocyte CD200R is associated with enhanced proinflammatory cytokine production in sarcoidosis

2. we demonstrated for the first time that CD200R is highly expressed on cells involved in type 2 immune responses, namely on Th2, Tc2, ILC2, and basophils. All these cell types play a role in type 2 inflammation.

3. Residual CD200 activity may prevent completion of abortions via induction of Treg cells. In chronic histiocytic intervillositis, infiltrating maternal effector T cells may block Treg induction. An autocrine role for CD200-CD200R interaction versus inhibition of soluble CD200 by soluble CD200R is discussed.

4. MMP12-producing monocyte-derived cells in gingival tissue of periodontitis patients also had reduced CD200R surface levels. Treatment with a CD200R ligand reduced CSF2-induced MMP12 production in these cells. This novel association of the CD200/CD200R pathway with MMP12 production by monocyte-derived cells may play a key role in PD progression.

5. Coexpression of CD200R-CD28 enhances function in WT1-specific T-cell receptor - transduced human primary T cells.

6. Our findings suggest a promising role of CD200R as a prognostic marker in predicting elevated recurrence and reduced survival, and a potential therapeutic target in treating hepatocellular carcinoma.

7. we revealed a critical role for CD200R signaling in limiting the growth and metastasis of CD200(+) tumors.

8. Constitutively expressed Siglec-9 inhibits LPS-induced CCR7, but enhances IL-4-induced CD200R expression in human macrophages.

9. Inflammatory Bowel Disease patients showed a significant decrease in the percentage of plasmacytoid dendritic cells and myeloid dendritic cells expressing CD200R1 compared to that of the control group.

10. CD200-CD200R1 signaling may be required for human pregnancy success.

11. This is the first report of CD200R1 expression by human epithelial tumor cells, and specifically, early-stage human breast cancer cells. It is also the first report of CD200R1 expression by term placental villous trophoblasts.

12. data show that the expression of CD200R, CD95 and CD95L was influenced by cardiac surgery and imply the role of these membrane molecules in cell regulation-inhibition and apoptosis following cardiac surgery.

13. The authors showed that the viral orthologues e127 from rat cytomegalovirus and K14 from human herpesvirus 8 do not bind the activating CD200R-like proteins from their respective species, although they do bind the inhibitory receptors.

14. The proportion of CD200R1+ cells in PBMCs, peripheral CD14+ cells and CD4+ T cells was significantly lower in rheumatoid arthritis patients compared to controls.

15. We demonstrate a significant correlation between CD200R1 positive cells and disease severity in rheumatoid arthritis (RA) patients, thus indicating the relevance of the CD200/CD200R1 signaling pathway potential involvement in the pathogenesis of RA.

16. The mechanism underlying ESA might be associated with enhanced expression of CD200 and CD200R in the trophoblast, leading to an upregulation of the immune response during the first trimester of pregnancy.

17. The expression of CD200R as well as B7-H4 co-stimulatory molecules on CD14(+) cells were significantly higher in cord blood when compared with peripheral blood.

18. Measurement of sCD200 and/or sCD200R1 may prove a useful and rapid means of monitoring subjects at risk of bone loss.

19. [review] CD200R1 is comparable to other pathogen-targeted inhibitory receptors; its signaling pathway is utilized by a diverse number of pathogens and represents a novel targeting strategy for infectiouis diseases.

20. Mesenchymal stem cells, through the expression of CD200, play a major role in the regulation of bone resorption and bone physiology and the CD200-CD200R couple could be a new target to control bone diseases.

Mouse (Murine) CD200 Receptor 1 (CD200R1) interaction partners

1. Study in CD200R-/- mice revealed that CD200R deficiency leads to enhanced bacterial burden in neutrophils. CD200R-deficient neutrophils display significantly reduced reactive oxygen species production (ROS), suggesting that CD200R-mediated ROS production in neutrophils is necessary for limiting F.tularensis colonization and proliferation. Overall, data show that CD200R promotes the antimicrobial properties of neutrophils.

2. This study demonstrated that loss of CD200R1 led to high mortality, increased rates of post-stroke infection, and enhanced entry of peripheral leukocytes into the brain after ischemia, with no increase in infarct size.

3. Foxp3 is essential for beneficial outcome of the microglial response and depends upon signalling by the immunoglobulin CD200 through its receptor (CD200R)

4. In adoptive therapy of disseminated leukemia, CD200R-CD28-transduced leukemia-specific CD8 T cells eradicated otherwise lethal disease more efficiently than wild-type cells and bypassed the requirement for interleukin-2 administration to sustain in vivo activity.

5. we revealed a critical role for CD200R signaling in limiting the growth and metastasis of CD200(+) tumors.

6. CD200R signaling inhibits pro-angiogenic gene expression by macrophages and suppresses choroidal neovascularization.

7. Data show that neutrophil infiltration of tissues was markedly decreased in CD200 antigen (tg) transgenic animals and increased in CD200 receptor 1 CD200R1(-/-) knockout mice.

8. we show a causal role for the CD200-CD200R inhibitory axis in arteriogenesis in a murine hindlimb ischemia model.

9. CD200-CD200R1 interaction in glial cells is involved in the neuroprotective action of PPAR-gamma agonists.

10. [review] Influenza-infected CD200R1-deficient mice show less bacterial load and exhibit decreased pathogenesis and mortality than wild-type animals following streptococcal pneumonia superinfection.

11. Anti-CD200R2, anti-IL-9, anti-IL-35, or anti-TGF-beta abolishes increased graft survival and Treg induction induced in cromolyn-treated CD200R1KO.CD200tg mice, and suggest combined role of mast cells and Tregs.

12. AML1-ETO upregulated CD200R1 in lineage(-) cells, which was characteristic of AML1-ETO-positive leukemia in mice.

13. a role for both graft and host CD200/CD200R expression in increased allograft survival.

14. The main sites of CD200/CD200 receptor (CD200R) interaction in neonates and blood vessels, until adulthood, highlight the possible role of the CD200/CD200R system in microglial development and renewal.

15. These data demonstrate an unanticipated and novel requirement for CD200R1 in "licensing" pro-inflammatory functions of TLR2 and in limiting viral replication that are supported by ex vivo and in vivo evidence.

16. CD200R1 does not play an essential role in macrophage homeostasis in the colon.

17. study reports lack of CD200R signaling has a more profound effect on the beneficial but also on the pathological immune responses to viruses in female mice compared to male mice, which can be attributed to the capacity of CD200R to inhibit TLR7 responses

18. It was demonstrated for the first time that the absence of CD200R signaling inhibits outgrowth of an endogenous skin tumor irrespective of CD200 expression by the tumor cells.

19. these results indicate a role of CD200R:CD200 in T cell responses to helminths which has diagnostic and prognostic relevance as a marker of infection for chronic schistosomiasis in mouse and man.

20. Data show thatthat the CD200R1/CD200 pathway is up-regulated in arthritis and plays a significant physiological role in regulating the severity of disease.