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Probable pathogen-recognition receptor. Additionally we are shipping CD209b Antigen Antibodies (25) and many more products for this protein.
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Data suggest that SIGNR1(CD209b) expressed in Lewis lung cancer cell-educated macrophages appears to mediate IL-4 (show IL4 Proteins)-induced RAW264.7 macrophage polarization and thus facilitate lung cancer evasion.
SIGNR1-mediated phagocytosis but not SIGNR1-mediated endocytosis and cell adhesion, suppresses the TLR4 (show TLR4 Proteins)-mediated production of specific proinflammatory cytokines via PI3 kinase (show PIK3CA Proteins) signaling.
The subtle carbohydrate preference of SIGNR1 as a phagocytic receptor or as an adhesion molecule (show NCAM1 Proteins) is altered depending on the function.
SIGNR1 is involved in the inhibition of DC maturation
These results indicate that murine SIGNR1 recognizes C. albicans/yeast through a specificity partly distinct from that of its homologue human DC-SIGN (show CD209 Proteins).
enhances TNF-alpha production by macrophages in cooperation with TLR2 upon microbial recognition
Toll-like receptor 2-mediated signalling is negatively regulated by SIGNR1-mediated signalling in dendritic cells, possibly through suppressor of cytokine signalling (show SOCS1 Proteins)-1-mediated degradation of the MyD88-adaptor (show MYD88 Proteins)-like protein.
SIGNR1 was shown to enhance the intracellular oxidative burst of macrophages in response to heat killed C. albicans in cooperation with Dectin-1 (show CLEC7A Proteins).
sugar-modified antigens might be used to induce oral tolerance by targeting SIGNR1 and dendritic cells in the gastrointestinal lamina propria (LPDCs).
isolation of a murine homologue of DC-SIGN (show CD209 Proteins) that is identical to the previously reported murine homologue mSIGNR1; expressed in marginal zone macrophages
Probable pathogen-recognition receptor. May mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. May recognize in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens. Is a receptor for ICAM3, probably by binding to mannose-like carbohydrates.
CD209 antigen-like protein B
, DC-SIGN-related protein 1