CD209b Antigen Proteins (CD209B)

Probable pathogen-recognition receptor. Additionally we are shipping CD209b Antigen Antibodies (27) and and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CD209B 69165 Q8CJ91
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Top CD209b Antigen Proteins at

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Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 50 to 55 Days
Human Cells Mouse His tag 100 μg Log in to see 14 to 16 Days

CD209B Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) ,

More Proteins for CD209b Antigen (CD209B) Interaction Partners

Mouse (Murine) CD209b Antigen (CD209B) interaction partners

  1. Data suggest that SIGNR1(CD209b) expressed in Lewis lung cancer cell-educated macrophages appears to mediate IL-4-induced RAW264.7 macrophage polarization and thus facilitate lung cancer evasion.

  2. SIGNR1-mediated phagocytosis but not SIGNR1-mediated endocytosis and cell adhesion, suppresses the TLR4-mediated production of specific proinflammatory cytokines via PI3 kinase signaling.

  3. The subtle carbohydrate preference of SIGNR1 as a phagocytic receptor or as an adhesion molecule is altered depending on the function.

  4. mediates uptake of mannose-decorated particles leading to cell maturation of peritoneal DC-like cells

  5. SIGNR1 is involved in the inhibition of DC maturation

  6. SIGN-R1 in the MZ rapidly accelerates C3 deposition on circulating apoptotic cells by interacting with C1q, thus promoting the systemic clearance of apoptotic cells and maintaining immune tolerance in vivo.

  7. These results indicate that murine SIGNR1 recognizes C. albicans/yeast through a specificity partly distinct from that of its homologue human DC-SIGN.

  8. enhances TNF-alpha production by macrophages in cooperation with TLR2 upon microbial recognition

  9. Toll-like receptor 2-mediated signalling is negatively regulated by SIGNR1-mediated signalling in dendritic cells, possibly through suppressor of cytokine signalling-1-mediated degradation of the MyD88-adaptor-like protein.

  10. SIGNR1 was shown to enhance the intracellular oxidative burst of macrophages in response to heat killed C. albicans in cooperation with Dectin-1.

  11. sugar-modified antigens might be used to induce oral tolerance by targeting SIGNR1 and dendritic cells in the gastrointestinal lamina propria (LPDCs).

  12. isolation of a murine homologue of DC-SIGN that is identical to the previously reported murine homologue mSIGNR1; expressed in marginal zone macrophages

  13. Dendritic cell-specific ICAM-3-grabbing nonintegrin homolog SIGNR1 has been identified as a major mannose receptor for fungal and other pathogens present on murine resident peritoneal macrophages.

  14. Recognizes pathogens and contributes to innate immunity.

  15. data suggest that although SIGNR1 has a similar binding specificity as DC-SIGN, its role is limited during murine M. tuberculosis infection

  16. Antigens are presented by SIGNR1 expressed by marginal zone macrophages to the developing marginal zone B cell population thereby influencing the repertoire of this B cell population, which is pivotal for the early immune response.

  17. This study highlights the finding that although there was binding of SIGNR1 to immunogenic factors produced in the S. mansoni life cycle, this recognition does not translate to a functional in vivo role for the PRR during infection.

  18. These results show that cross-linking of SIGNR1 triggers phosphorylation of SFKs, which leads to activation of the JNK pathway and induction of TNF-alpha production in macrophage-like RAW264.7 cells.

CD209b Antigen (CD209B) Protein Profile

Protein Summary

Probable pathogen-recognition receptor. May mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. May recognize in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens. Is a receptor for ICAM3, probably by binding to mannose-like carbohydrates.

Gene names and symbols associated with CD209b Antigen Proteins (CD209B)

  • CD209b antigen (Cd209b)
  • 1810030I22Rik protein
  • mSIGNR1 protein
  • OtB7 protein
  • SIGNR1 protein

Protein level used designations for CD209b Antigen Proteins (CD209B)

CD209 antigen-like protein B , DC-SIGN-related protein 1 , DC-SIGNR1

69165 Mus musculus
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