anti-CD244 Molecule, Natural Killer Cell Receptor 2B4 (CD244) Antibodies

CD244 encodes a cell surface receptor expressed on natural killer (NK) cells (and some T cells) that mediate non-major histocompatibility complex (MHC) restricted killing. Additionally we are shipping CD244 Proteins (32) and CD244 Kits (8) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
CD244 51744 Q9BZW8
CD244 64025 Q9JLM2
CD244 18106 Q07763
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Top anti-CD244 Antibodies at antibodies-online.com

Showing 10 out of 125 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Human Rabbit Un-conjugated WB 100 μL 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated ELISA, IHC, WB Western blot analysis of Jurkat cell extracts, using CD244 Antibody. The lane on the left is treated with the antigen-specific peptide. Western blot analysis of extracts from mouse brain, using CD244 Antibody. 100 μL 11 to 12 Days
$390.77
Details
Human Goat Un-conjugated IP, ELISA, WB 0.1 mg 2 to 3 Days
$515.63
Details
Rat Rabbit Un-conjugated ICC, IHC, WB Figure. Western Blot; Sample: Lane1: Rat Serum; Lane2: Rat Kidney Tissue. 100 μg 13 to 16 Days
$360.00
Details
Human Goat Un-conjugated IP, ELISA 100 μg 11 to 14 Days
$610.50
Details
Human Rabbit Un-conjugated ELISA, IHC (p), WB Western Blot (WB) analysis of KB cells using CD244 Polyclonal Antibody. 100 μL Available
$363.46
Details
Human Rabbit Un-conjugated WB 100 μL 11 to 14 Days
$551.83
Details
Human Rabbit Un-conjugated IHC (p) A549 cells probed with Rabbit Anti-CD244 Polyclonal Antibody (ABIN740730) at 1:50 for 60 minutes followed by incubation with Goat Anti-Rabbit IgG FITC conjugated secondary at 1:100 (green) for 40 minutes compared to control cells (blue). Paraformaldehyde-fixed, paraffin embedded human kidney, Antigen retrieval by boiling in sodium citrate buffer (pH6) for 15min, Block endogenous peroxidase by 3% hydrogen peroxide for 30 minutes, Blocking buffer (normal goat serum) at 37°C for 20min, Antibody incubation with Rabbit Anti-CD244 Polyclonal Antibody, Unconjugated  at 1:200 overnight at 4°C, followed by a conjugated secondary for 90 minutes and DAB staining. 100 μL 3 to 7 Days
$329.45
Details
Human Rabbit Un-conjugated IHC, WB 100 μL 11 to 13 Days
$366.77
Details
Human Rabbit Un-conjugated IHC (p), WB Anti- CD244 antibody, IHC(P) IHC(P): Human Tonsil Tissue Anti- CD244 antibody, Western blotting All lanes: Anti CD244  at 0.5ug/ml Lane 1: MCF-7 Whole Cell Lysate at 40ug Lane 2: HELA Whole Cell Lysate at 40ug Predicted bind size: 42KD Observed bind size: 42KD 100 μg 4 to 6 Days
$280.00
Details

Top referenced anti-CD244 Antibodies

  1. Human Monoclonal CD244 Primary Antibody for FACS - ABIN2689111 : Mathew, Garni-Wagner, Land, Takashima, Stoneman, Bennett, Kumar: Cloning and characterization of the 2B4 gene encoding a molecule associated with non-MHC-restricted killing mediated by activated natural killer cells and T cells. in Journal of immunology (Baltimore, Md. : 1950) 1993 (PubMed)
    Show all 4 Pubmed References

  2. Human Monoclonal CD244 Primary Antibody for FACS - ABIN2479428 : Gluckman, Jolivet, Scrobohaci, Devergie, Traineau, Bourdeau-Esperou, Lehn, Faure, Drouet: Use of prostaglandin E1 for prevention of liver veno-occlusive disease in leukaemic patients treated by allogeneic bone marrow transplantation. in British journal of haematology 1990 (PubMed)
    Show all 4 Pubmed References

  3. Human Monoclonal CD244 Primary Antibody for FACS, IP - ABIN2479430 : Romero, Zapater, Calvo, Kalko, de la Fuente, Tovar, Ockeloen, Pizcueta, Engel: CD229 (Ly9) lymphocyte cell surface receptor interacts homophilically through its N-terminal domain and relocalizes to the immunological synapse. in Journal of immunology (Baltimore, Md. : 1950) 2005 (PubMed)
    Show all 4 Pubmed References

  4. Human Monoclonal CD244 Primary Antibody for FACS - ABIN2479431 : Raziorrouh, Schraut, Gerlach, Nowack, Grüner, Ulsenheimer, Zachoval, Wächtler, Spannagl, Haas, Diepolder, Jung: The immunoregulatory role of CD244 in chronic hepatitis B infection and its inhibitory potential on virus-specific CD8+ T-cell function. in Hepatology (Baltimore, Md.) 2010 (PubMed)
    Show all 4 Pubmed References

  5. Human Monoclonal CD244 Primary Antibody for FACS, IP - ABIN2479426 : Bengsch, Martin, Thimme: Restoration of HBV-specific CD8+ T cell function by PD-1 blockade in inactive carrier patients is linked to T cell differentiation. in Journal of hepatology 2014 (PubMed)
    Show all 4 Pubmed References

  6. Human Polyclonal CD244 Primary Antibody for Agon, CyTOF - ABIN5012830 : Roda-Navarro, Vales-Gomez, Chisholm, Reyburn: Transfer of NKG2D and MICB at the cytotoxic NK cell immune synapse correlates with a reduction in NK cell cytotoxic function. in Proceedings of the National Academy of Sciences of the United States of America 2006 (PubMed)
    Show all 2 Pubmed References

  7. Human Polyclonal CD244 Primary Antibody for IHC (p) - ABIN740730 : Peiffer, Wang, Zimmerman, Ransom, Carmella, Kuo, Chen, Oshima, Huang, Hecht, Stoner: Dietary Consumption of Black Raspberries or Their Anthocyanin Constituents Alters Innate Immune Cell Trafficking in Esophageal Cancer. in Cancer immunology research 2016 (PubMed)

  8. Mouse (Murine) Polyclonal CD244 Primary Antibody for FACS, IHC - ABIN4898999 : Cao, Wagers, Karsunky, Zhao, Reeves, Wong, Stevenson, Weissman, Contag: Heme oxygenase-1 deficiency leads to disrupted response to acute stress in stem cells and progenitors. in Blood 2008 (PubMed)

  9. Mouse (Murine) Polyclonal CD244 Primary Antibody for CyTOF, FACS - ABIN4899297 : Wahle, Paraiso, Kendig, Lawrence, Chen, Wu, Kerr: Inappropriate recruitment and activity by the Src homology region 2 domain-containing phosphatase 1 (SHP1) is responsible for receptor dominance in the SHIP-deficient NK cell. in Journal of immunology (Baltimore, Md. : 1950) 2007 (PubMed)

More Antibodies against CD244 Interaction Partners

Human CD244 Molecule, Natural Killer Cell Receptor 2B4 (CD244) interaction partners

  1. The Emerging Role of CD244 Signaling in Immune Cells of the Tumor Microenvironment.

  2. Sole engagement of NKG2D, 2B4 or DNAM-1 is insufficient for NF-kappaB activation.

  3. We determined a significantly lower expression of CD244 on monocytes in systemic lupus erythematosus patients compared to healthy controls. Furthermore, monocyte CD244 expression was negatively associated with several serum autoantibody titres.

  4. SLAMF4 is a marker of intestinal immune cells which contributes to the protection against enteric pathogens and whose expression is dependent on the presence of the gut microbiota

  5. The present study provides further insights into the role of the 2B4-CD48 interaction in the fine regulation of CD8(+) T-cell effector function upon antigenic stimulation.

  6. Data show that 2B4 not only can bind to CD48 in trans but also interacts with CD48 in cis by using the same binding interface. Also, the results demonstrated that constitutive phosphorylation of 2B4 occurs only in the presence of CD48, and that cis binding is sufficient to induce substantial levels of baseline phosphorylation.

  7. 2B4 expression is increased on CD4+ T cells in septic patients

  8. Self-iNKR(-) NK cells in X-linked lymphoproliferative disease 1 patients are functional even in resting conditions, suggesting a role of the inhibitory 2B4/CD48 pathway in the education process during NK-cell maturation.

  9. our results provide strong evidence that CD244 co-operates with c-Kit to regulate leukemogenesis through SHP-2/p27 signaling.

  10. SLAMF4 gene and surface protein expression was down-regulated in CD8+ T cells from SLE patients compared with that in cells obtained from healthy donors. SLAMF4+ effector memory cells produced more granzyme B and perforin than SLAMF4- cells.

  11. GSK-3 undergoes inhibitory phosphorylation at regulatory serine residues by the engagement of NKG2D and 2B4, either individually or in combination.

  12. Cytomegalovirus-Induced Expression of CD244 after Liver Transplantation Is Associated with CD8+ T Cell Hyporesponsiveness to Alloantigen

  13. CD8(+) T cells require 2B4 for Epstein-Barr virus-specific immune control, because 2B4 blockade after CD8(+) T-cell depletion did not further aggravate symptoms of the infection.

  14. CD244 expression/signaling in tuberculosis correlates with high levels of a long noncoding RNA (lncRNA)-BC050410 [named as lncRNA-AS-GSTT1(1-72) or lncRNA-CD244] in the CD244(+)CD8(+) T-cell subpopulation.

  15. show that in addition to NKG2D, human CEACAM1 can inhibit NK-cell activation via NKp30 or 2B4

  16. this study investigates the structural requirements for the recruitment of the human-activating NK-cell receptors NKG2D and 2B4 to detergent-resistant membrane fractions in the murine BA/F3 cell line and in the human NK-cell line NKL.

  17. Study of SAP expression is specific but may have insufficient sensitivity for screening XLP1 as a single tool; however, combination with 2B4 functional assay allows identification of all cases

  18. Blockade of 2B4/CD48 interaction resulted in improvement in function via perforin expression and degranulation as measured by CD107a surface mobilization on HTLV-1 specific CD8+ T cells.

  19. In patients suffering from X-linked lymphoproliferative disease (XLP1), SAP is nonfunctional, not only abolishing the activating function of 2B4, but rendering this receptor inhibitory.

  20. XLP1 inhibitory effect by 2B4 does not affect DNAM-1 and NKG2D activating pathways in NK cells.

Mouse (Murine) CD244 Molecule, Natural Killer Cell Receptor 2B4 (CD244) interaction partners

  1. Phenotypic analysis revealed an increased frequency of murine EBV homolog-specific CD8(+) T cells expressing the 2B4 coinhibitory receptor in septic animals compared with sham controls.

  2. these data indicate that 2B4 signals function to alter T cell glucose metabolism, thereby limiting the proliferation and accumulation of CD8(+) T cells.

  3. SLAMF4 is a marker of intestinal immune cells which contributes to the protection against enteric pathogens and whose expression is dependent on the presence of the gut microbiota

  4. 2B4 expression is increased on CD4+ T cells in septic animals

  5. 2B4 dampens T-independent B cell responses.

  6. DCs from CD244(-/-) mice elicited increased NK cell activation in vitro. These data add CD244 to a growing list of immuno-modulatory receptors found on DCs.

  7. Data show that enforced expression of inhibitor of differentiation protein Id3 specifically increased the persistence of Cd244 protein 2B4(+) virus-specific CD8(+) T cells.

  8. Molecular dynamic simulation explains unbinding and unfolding of CD48-2B4 protein complexes.

  9. Signaling via SLAMF4 controls expansion of cytotoxic CD8alphabeta(+) IELs, which regulate the reversible depletion of lamina propria phagocytes and inflammation in the small intestine.

  10. CD244 (2B4) has a regulatory effect on mast cells and eosinophils in murine allergic inflammation.

  11. NKG2D ligation relieves 2B4-mediated NK-cell self-tolerance in mice.

  12. blockade of CD28 signals in the presence of preserved CTLA-4 signals results in the unique up-regulation of 2B4 on primary CD8(+) effectors, and that this 2B4 expression plays a critical functional role in controlling antigen-specific T8 cell responses

  13. In the absence of SAP, signaling through the SLAM family members Ly108 and 2B4 resulted in increased recruitment of the SHP-1 phosphatase, associated with altered SHP-1 localization and decreased activation of Src kinases at the synapse.

  14. Ox-LDL significantly promoted the interaction of natural killer cells and dendritic cells via CD48-2B4 contact-dependent mechanisms.

  15. Slamf4 has a natural killer (NK) cell-independent negative regulatory function in vivo and can contribute to tolerance to chromatin in murine models of systemic lupus erythematosus.

  16. CD48 on surrounding NK or non-NK cells serves primarily as a ligand to stimulate 2B4 on the adjacent NK cells in mice

  17. The interaction of SHIP, 2B4 activating receptor, and the major histocompatibility complex influence the regulation of natural killer (NK) cell receptor repertoire, cytolytic function, and interferon-gamma production.

  18. Regulation of CD8(+) T cell proliferation

  19. Increased blood flow observed in response to topical application of capsaicin involves activation of NK 1 receptors.

  20. Due to a CxC cysteine motif found in the transmembrane region, 2B4 localizes in glycolipid-enriched microdomains of NK and T cell plasma membranes, where it associates with LAT.

CD244 Antigen Profile

Protein Summary

This gene encodes a cell surface receptor expressed on natural killer (NK) cells (and some T cells) that mediate non-major histocompatibility complex (MHC) restricted killing. The interaction between NK-cell and target cells via this receptor is thought to modulate NK-cell cytolytic activity. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with CD244

  • CD244 molecule (CD244) antibody
  • CD244 molecule (Cd244) antibody
  • CD244 natural killer cell receptor 2B4 (Cd244) antibody
  • 2B4 antibody
  • C9.1 antibody
  • CD244 antibody
  • F730046O15Rik antibody
  • Ly90 antibody
  • NAIL antibody
  • NKR2B4 antibody
  • Nmrk antibody
  • SLAMF4 antibody

Protein level used designations for CD244

CD244 molecule, natural killer cell receptor 2B4 , natural killer cell receptor 2B4 , NK cell activation inducing ligand NAIL , NK cell activation-inducing ligand , NK cell type I receptor protein 2B4 , SLAM family member 4 , h2B4 , signaling lymphocytic activation molecule 4 , CD244 natural killer cell receptor 2B4 , NKR2B4 , non MHC restricted killing associated , non-MHC restricted killing associated , transmembrane NK cell receptor 2B4 , NK cell receptor 2B4

GENE ID SPECIES
488644 Canis lupus familiaris
513468 Bos taurus
100594419 Nomascus leucogenys
51744 Homo sapiens
64025 Rattus norvegicus
18106 Mus musculus
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