anti-CD244 Molecule, Natural Killer Cell Receptor 2B4 (CD244) Antibodies

CD244 encodes a cell surface receptor expressed on natural killer (NK) cells (and some T cells) that mediate non-major histocompatibility complex (MHC) restricted killing.

list all antibodies Gene Name GeneID UniProt
Anti-Human CD244 CD244 51744 Q9BZW8
Anti-Rat CD244 CD244 64025 Q9JLM2
Anti-Mouse CD244 CD244 18106 Q07763
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Top anti-CD244 Antibodies at antibodies-online.com

Showing 10 out of 137 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Mouse Un-conjugated FACS   0.1 mg Log in to see 15 to 18 Days
$122.36
Details
Human Goat PE FACS Detection of 2B4/CD244/SLAMF4 in Human PBMCs by Flow Cytometry. Human peripheral blood mononuclear cells (PBMCs) were stained with Mouse Anti-Human NCAM-1/CD56 APC-conjugated Monoclonal Antibody. 100 Tests Log in to see 8 to 9 Days
$293.25
Details
Human Goat Un-conjugated IP, ELISA, WB 0.1 mg Log in to see 2 to 3 Days
$481.25
Details
Rat Rabbit Un-conjugated ICC, IHC, WB Figure. Western Blot; Sample: Lane1: Rat Serum; Lane2: Rat Kidney Tissue. 100 μg Log in to see 13 to 16 Days
$360.00
Details
Human Goat Un-conjugated IP, ELISA 100 μg Log in to see 7 to 9 Days
$610.50
Details
Mouse Goat Biotin FACS, IHC, WB   50 μg Log in to see 8 to 9 Days
$446.20
Details
Mouse Goat Un-conjugated CyTOF, FACS, IHC, WB   100 μg Log in to see 8 to 9 Days
$416.30
Details
Human Goat Un-conjugated Agon, CyTOF, ELISA (Capture), FACS, IHC, WB 2B4/CD244/SLAMF4 in Human Spleen. 2B4/CD244/SLAMF4 was detected in immersion fixed paraffin-embedded sections of human spleen using Goat Anti-Human 2B4/CD244/SLAMF4 Antigen Affinity-purified Polyclonal Antibody. Specific staining was localized to splenocytes. Detection of 2B4/CD244/SLAMF4 in Human PBMCs by Flow Cytometry. Human peripheral blood mononuclear cells (PBMCs) were stained with Mouse Anti-Human NCAM-1/CD56 APC-conjugated Monoclonal Antibody. 100 μg Log in to see 8 to 9 Days
$416.30
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 7 to 9 Days
$551.83
Details

Top referenced anti-CD244 Antibodies

  1. Human Monoclonal CD244 Primary Antibody for FACS - ABIN2689111 : Mathew, Garni-Wagner, Land, Takashima, Stoneman, Bennett, Kumar: Cloning and characterization of the 2B4 gene encoding a molecule associated with non-MHC-restricted killing mediated by activated natural killer cells and T cells. in Journal of immunology (Baltimore, Md. : 1950) 1993 (PubMed)
    Show all 4 Pubmed References

  2. Human Monoclonal CD244 Primary Antibody for FACS - ABIN2479431 : Gluckman, Jolivet, Scrobohaci, Devergie, Traineau, Bourdeau-Esperou, Lehn, Faure, Drouet: Use of prostaglandin E1 for prevention of liver veno-occlusive disease in leukaemic patients treated by allogeneic bone marrow transplantation. in British journal of haematology 1990 (PubMed)
    Show all 4 Pubmed References

  3. Human Monoclonal CD244 Primary Antibody for FACS, IP - ABIN2479426 : Romero, Zapater, Calvo, Kalko, de la Fuente, Tovar, Ockeloen, Pizcueta, Engel: CD229 (Ly9) lymphocyte cell surface receptor interacts homophilically through its N-terminal domain and relocalizes to the immunological synapse. in Journal of immunology (Baltimore, Md. : 1950) 2005 (PubMed)
    Show all 4 Pubmed References

  4. Human Monoclonal CD244 Primary Antibody for FACS, IP - ABIN2479430 : Raziorrouh, Schraut, Gerlach, Nowack, Grüner, Ulsenheimer, Zachoval, Wächtler, Spannagl, Haas, Diepolder, Jung: The immunoregulatory role of CD244 in chronic hepatitis B infection and its inhibitory potential on virus-specific CD8+ T-cell function. in Hepatology (Baltimore, Md.) 2010 (PubMed)
    Show all 4 Pubmed References

  5. Human Monoclonal CD244 Primary Antibody for FACS - ABIN2479428 : Bengsch, Martin, Thimme: Restoration of HBV-specific CD8+ T cell function by PD-1 blockade in inactive carrier patients is linked to T cell differentiation. in Journal of hepatology 2014 (PubMed)
    Show all 4 Pubmed References

  6. Human Polyclonal CD244 Primary Antibody for Agon, CyTOF - ABIN5012830 : Roda-Navarro, Vales-Gomez, Chisholm, Reyburn: Transfer of NKG2D and MICB at the cytotoxic NK cell immune synapse correlates with a reduction in NK cell cytotoxic function. in Proceedings of the National Academy of Sciences of the United States of America 2006 (PubMed)
    Show all 2 Pubmed References

  7. Human Polyclonal CD244 Primary Antibody for IHC (p) - ABIN740730 : Peiffer, Wang, Zimmerman, Ransom, Carmella, Kuo, Chen, Oshima, Huang, Hecht, Stoner: Dietary Consumption of Black Raspberries or Their Anthocyanin Constituents Alters Innate Immune Cell Trafficking in Esophageal Cancer. in Cancer immunology research 2016 (PubMed)

  8. Human Polyclonal CD244 Primary Antibody for FACS - ABIN4895306 : Mattiola, Pesant, Tentorio, Molgora, Marcenaro, Lugli, Locati, Mavilio: Priming of Human Resting NK Cells by Autologous M1 Macrophages via the Engagement of IL-1β, IFN-β, and IL-15 Pathways. in Journal of immunology (Baltimore, Md. : 1950) 2015 (PubMed)

  9. Mouse (Murine) Polyclonal CD244 Primary Antibody for FACS, IHC - ABIN4898999 : Cao, Wagers, Karsunky, Zhao, Reeves, Wong, Stevenson, Weissman, Contag: Heme oxygenase-1 deficiency leads to disrupted response to acute stress in stem cells and progenitors. in Blood 2008 (PubMed)

  10. Mouse (Murine) Polyclonal CD244 Primary Antibody for CyTOF, FACS - ABIN4899297 : Wahle, Paraiso, Kendig, Lawrence, Chen, Wu, Kerr: Inappropriate recruitment and activity by the Src homology region 2 domain-containing phosphatase 1 (SHP1) is responsible for receptor dominance in the SHIP-deficient NK cell. in Journal of immunology (Baltimore, Md. : 1950) 2007 (PubMed)

More Antibodies against CD244 Interaction Partners

Human CD244 Molecule, Natural Killer Cell Receptor 2B4 (CD244) interaction partners

  1. SLAMF4 is a marker of intestinal immune cells which contributes to the protection against enteric pathogens and whose expression is dependent on the presence of the gut (show GUSB Antibodies) microbiota

  2. The present study provides further insights into the role of the 2B4-CD48 (show CD48 Antibodies) interaction in the fine regulation of CD8 (show CD8A Antibodies)(+) T-cell effector function upon antigenic stimulation.

  3. Data show that 2B4 not only can bind to CD48 (show CD48 Antibodies) in trans but also interacts with CD48 (show CD48 Antibodies) in cis (show CISH Antibodies) by using the same binding interface. Also, the results demonstrated that constitutive phosphorylation of 2B4 occurs only in the presence of CD48 (show CD48 Antibodies), and that cis (show CISH Antibodies) binding is sufficient to induce substantial levels of baseline phosphorylation.

  4. 2B4 expression is increased on CD4 (show CD4 Antibodies)+ T cells in septic patients

  5. Self-iNKR(-) NK cells in X-linked lymphoproliferative disease 1 patients are functional even in resting conditions, suggesting a role of the inhibitory 2B4/CD48 (show CD48 Antibodies) pathway in the education process during NK-cell maturation.

  6. our results provide strong evidence that CD244 co-operates with c-Kit (show KIT Antibodies) to regulate leukemogenesis through SHP-2 (show PTPN11 Antibodies)/p27 (show PAK2 Antibodies) signaling.

  7. SLAMF4 gene and surface protein expression was down-regulated in CD8 (show CD8A Antibodies)+ T cells from SLE patients compared with that in cells obtained from healthy donors. SLAMF4+ effector memory cells produced more granzyme B and perforin (show PRF1 Antibodies) than SLAMF4- cells.

  8. GSK-3 undergoes inhibitory phosphorylation at regulatory serine residues by the engagement of NKG2D (show KLRK1 Antibodies) and 2B4, either individually or in combination.

  9. Cytomegalovirus-Induced Expression of CD244 after Liver Transplantation Is Associated with CD8 (show CD8A Antibodies)+ T Cell Hyporesponsiveness to Alloantigen

  10. CD8 (show CD8A Antibodies)(+) T cells require 2B4 for Epstein-Barr virus-specific immune control, because 2B4 blockade after CD8 (show CD8A Antibodies)(+) T-cell depletion did not further aggravate symptoms of the infection.

Mouse (Murine) CD244 Molecule, Natural Killer Cell Receptor 2B4 (CD244) interaction partners

  1. SLAMF4 is a marker of intestinal immune cells which contributes to the protection against enteric pathogens and whose expression is dependent on the presence of the gut (show GUSB Antibodies) microbiota

  2. 2B4 expression is increased on CD4 (show CD4 Antibodies)+ T cells in septic animals

  3. 2B4 dampens T-independent B cell responses.

  4. DCs from CD244(-/-) mice elicited increased NK cell activation in vitro. These data add CD244 to a growing list of immuno-modulatory receptors found on DCs.

  5. Data show that enforced expression of inhibitor of differentiation protein Id3 (show ID3 Antibodies) specifically increased the persistence of Cd244 protein 2B4(+) virus-specific CD8 (show CD8A Antibodies)(+) T cells.

  6. Molecular dynamic simulation explains unbinding and unfolding of CD48 (show CD48 Antibodies)-2B4 protein complexes.

  7. Signaling via SLAMF4 controls expansion of cytotoxic CD8alphabeta(+) IELs, which regulate the reversible depletion of lamina propria phagocytes and inflammation in the small intestine.

  8. CD244 (2B4) has a regulatory effect on mast cells and eosinophils in murine allergic inflammation.

  9. NKG2D (show KLRK1 Antibodies) ligation relieves 2B4-mediated NK-cell self-tolerance in mice.

  10. blockade of CD28 (show CD28 Antibodies) signals in the presence of preserved CTLA-4 (show CTLA4 Antibodies) signals results in the unique up-regulation of 2B4 on primary CD8 (show CD8A Antibodies)(+) effectors, and that this 2B4 expression plays a critical functional role in controlling antigen-specific T8 cell responses

CD244 Antigen Profile

Protein Summary

This gene encodes a cell surface receptor expressed on natural killer (NK) cells (and some T cells) that mediate non-major histocompatibility complex (MHC) restricted killing. The interaction between NK-cell and target cells via this receptor is thought to modulate NK-cell cytolytic activity. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with CD244

  • CD244 molecule (CD244) antibody
  • CD244 molecule (Cd244) antibody
  • CD244 natural killer cell receptor 2B4 (Cd244) antibody
  • 2B4 antibody
  • C9.1 antibody
  • CD244 antibody
  • F730046O15Rik antibody
  • Ly90 antibody
  • NAIL antibody
  • NKR2B4 antibody
  • Nmrk antibody
  • SLAMF4 antibody

Protein level used designations for CD244

CD244 molecule, natural killer cell receptor 2B4 , natural killer cell receptor 2B4 , NK cell activation inducing ligand NAIL , NK cell activation-inducing ligand , NK cell type I receptor protein 2B4 , SLAM family member 4 , h2B4 , signaling lymphocytic activation molecule 4 , CD244 natural killer cell receptor 2B4 , NKR2B4 , non MHC restricted killing associated , non-MHC restricted killing associated , transmembrane NK cell receptor 2B4 , NK cell receptor 2B4

GENE ID SPECIES
488644 Canis lupus familiaris
513468 Bos taurus
100594419 Nomascus leucogenys
51744 Homo sapiens
64025 Rattus norvegicus
18106 Mus musculus
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