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The CD3 complex mediates signal transduction (By similarity).
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expressed and refolded porcine CD3 ectodomain molecules include CD3epsilon (show CD3E ELISA Kits), CD3gamma, CD3delta (show CD3D ELISA Kits), CD3epsilongamma heterodimer, CD3epsilondelta heterodimer, CD3epsilongamma single-chain fusion protein and CD3epsilondelta single-chain fusion protein
The data show that CD3epsilon chain couples to Cbl via simultaneous binding of both proteins to Numb, thus mediating TCR degradation
IL-17 (show IL17A ELISA Kits)-producing CD3 (show CD3E ELISA Kits)(bright) gammadelta T cells responded promptly and strongly to pneumococcal infection and during skin inflammation.
these results suggest that CD3zeta can be degraded by two pathways: SLAP/c-Cbl, which targets internalized cell surface CD3zeta dependent on TCR signaling, and LAPTM5, which targets intracellular CD3zeta independent of TCR signaling.
these results indicate that membrane association of the CD3epsilon (show CD3E ELISA Kits) signaling domain is required for optimal thymocyte development and peripheral T cell function.
These results suggest that proteasome-mediated degradation is involved in hypophosphorylated LAT (show LAT ELISA Kits) and PLCgamma1 (show PLCG1 ELISA Kits) in Dow2-induced anergic T cells. The novel CD3 (show CD3E ELISA Kits)-specific Ab, Dow2, may provide us with a unique tool for inducing immunosuppression
that Nck (show NCK1 ELISA Kits) recruitment to the TCR is fundamental to mount an efficient T cell response in vivo, and that the Nck (show NCK1 ELISA Kits)-CD3epsilon (show CD3E ELISA Kits) interaction may represent a target for pharmacological modulation of the immune response.
Structure of murine CD3epsilon (show CD3E ELISA Kits) complexed with the mitogenic anti-CD3epsilon (show CD3E ELISA Kits) antibody 2C11 enabled structural comparisons of antibody-liganded and unliganded forms of CD3epsilon (show CD3E ELISA Kits) revealing that antibody binding does not induce any substantial rearrangements within CD3epsilon (show CD3E ELISA Kits).
CFTR (show CFTR ELISA Kits) dysfunction in T cells can lead directly to aberrant immune responses in CD3 (show CD3E ELISA Kits)+ lymphocytes
analysis of the transgenic integration site in immunodeficient tgepsilon26 human CD3epsilon (show CD3E ELISA Kits) transgenic mice
Polymorphisms of the CD3varepsilon ectodomain exist in mice,some of which lead to amino acid substitutions which cause structural changes and affect anti-CD3 (show CD3E ELISA Kits) antibody binding.
The CD3 complex mediates signal transduction.
CD3 epsilon subunit
, T-cell surface glycoprotein CD3 epsilon chain
, CD3 glycoprotein
, CD3 type I transmembrane glycoprotein
, CD3D antigen delta
, CD3D antigen, delta polypeptide (TiT3 complex)
, T-cell surface glycoprotein CD3 delta chain
, T-cell surface protein
, T-cell surface antigen T3/Leu-4 epsilon chain
, CD3 molecule, gamma/delta (CD3-TCR complex)
, CD3g molecule S homeolog
, CD3g molecule, gamma (CD3-TCR complex)
, T-cell surface glycoprotein CD3 gamma/delta chain homolog