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May play a role in the regulation of the immune system. Additionally we are shipping CD5L Kits (44) and CD5L Proteins (21) and many more products for this protein.
Showing 10 out of 131 products:
Human Polyclonal CD5L Primary Antibody for WB - ABIN1881187
Qu, Du, Li, Yan: Myeloid-specific expression of Api6/AIM/Sp alpha induces systemic inflammation and adenocarcinoma in the lung. in Journal of immunology (Baltimore, Md. : 1950) 2009
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Human Polyclonal CD5L Primary Antibody for WB - ABIN550285
Miyazaki, Hirokami, Matsuhashi, Takatsuka, Naito: Increased susceptibility of thymocytes to apoptosis in mice lacking AIM, a novel murine macrophage-derived soluble factor belonging to the scavenger receptor cysteine-rich domain superfamily. in The Journal of experimental medicine 1999
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Human Polyclonal CD5L Primary Antibody for WB - ABIN550286
Haruta, Kato, Hashimoto, Minjares, Kennedy, Uto, Yamauchi, Kobayashi, Yusa, Müller, Hayashi, Miyazaki: Association of AIM, a novel apoptosis inhibitory factor, with hepatitis via supporting macrophage survival and enhancing phagocytotic function of macrophages. in The Journal of biological chemistry 2001
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Human Polyclonal CD5L Primary Antibody for IHC (p), WB - ABIN2472166
Ruibal Francisco, Seara Aguilar, Fernández Méndez, Noya Beiroa, Reverte Blanc, Valor García, Cabranes Díaz, Casado de Frías: [Nocturnal use of pirenzepine by a group of insulin dependent juvenile diabetics]. in Anales españoles de pediatría 1992
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Human Polyclonal CD5L Primary Antibody for IHC (p), WB - ABIN2472165
Sarrias, Roselló, Sánchez-Barbero, Sierra, Vila, Yélamos, Vives, Casals, Lozano: A role for human Sp alpha as a pattern recognition receptor. in The Journal of biological chemistry 2005
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Taken together with our results on the aberrant ex vivo production of CD5L, this study has provided new evidence for the potential immunopathological role of CD5L in the exacerbation of SLE disease, and circulating concentration of CD5L may act as a potential disease marker for the monitoring of disease severity and therapeutic effects in SLE patients.
AIM enhances intratubular debris clearance and ameliorates acute kidney injury via interaction with KIM-1.
The present study provides the first evidence that apoptosis inhibitor of macrophages binds to IGFBP2, 3 and 4.
CD36 is involved in autophagy; the CD5L-CD36 axis has a role in the induction of macrophage autophagy
CD5L is a key protein in the control of immune homeostasis and inflammatory disease. (Review)
Apoptosis inhibitor of macrophage levels were markedly higher in patients with advanced liver damage, regardless of disease type, and correlated significantly with multiple parameters representing liver function.
AIM contributes to key macrophage responses to M. tuberculosis
Our data represent the first evidence that human AIM is involved in macrophage survival, adhesion, and foam cell formation
N-glycosylation plays important roles in the secretion and lipolytic function of AIM
AIM is involved in the progression of MetS in both an advancing and inhibitory fashion. Regulation of AIM could therefore be therapeutically applicable for MetS.
Spalpha is an active constituent of the innate immune response of the host
CD5L and ApoE were significantly up-regulated or down-regulated, respectively, in the plasma from AD patients compared with that from healthy donors.
Dysregulation of myeloid cell populations by extracellular transgene Api6 signaling leads to abnormal myelopoiesis and lung cancer in bitransgenic mice.
AIM/CD5L-deficient mice demonstrated a smaller infarct size and less of an inflammatory response via inflammatory pathways after myocardial infarction; these data provide the first evidence that AIM/CD5L plays an important role in the inflammatory responses after myocardial injury
CD5L as a critical regulator that distinguishes Th17 functional states and identified T cell lipid metabolism as an integral component of the pathways regulating Th17 cell pathogenicity.
plays a general homeostatic role by supporting innate immunity during pathogen aggression
the assembled p40-CD5L heterodimer does not recapitulate the biological activity of IL-12.
AIM-IgM association plays a critical role in the obesity-associated autoimmune process.
SREBP-1a specifically activates the Api6 gene through a binding site in its proximal promoter, thus establishing the Api6 gene as a newly identified SREBP-1a target gene
AIM induces lipolysis in a manner distinct from that of hormone-dependent lipolysis, without activation or augmentation of lipases.
Apoptosis inhibitor of macrophage (AIM) is required for obesity-associated recruitment of inflammatory macrophages into adipose tissue.
AIM binds to cytosolic FAS protein at various regions responsible for elongation of fatty acids, release of synthesized palmitate, and stabilization of FAS dimerization.
The protein inhibits apoptosis of T cells and NKT cells in Corynebacterium-induced granuloma formation in mice.
Api6 production facilitates macrophage survival within atherosclerotic lesions and that loss of Api6 decreases early lesion development by increasing macrophage apoptosis
Bacterial lipoteichoic acid might affect the pathogenesis of epithelial inflammation followed by fibrosis in systemic multifocal epithelial inflammations in chronic colitis-harboring TCR alpha(-/-) x AIM(-/-) mice
May play a role in the regulation of the immune system. Seems to play a role as an inhibitor of apoptosis.
, CD5 antigen-like (scavenger receptor cysteine rich family)
, apoptosis inhibitor 6
, igM-associated peptide
, Pdp 1/6
, apoptosis inhibitor expressed by macrophages
, CD5 molecule-like