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Potent inhibitor of the complement membrane attack complex (MAC) action. Additionally we are shipping CD59a Antigen Kits (5) and CD59a Antigen Proteins (3) and many more products for this protein.
Showing 9 out of 11 products:
Mouse (Murine) Monoclonal CD59A Primary Antibody for Func, IA - ABIN2191855
Harris, Hanna, Mizuno, Holt, Marchbank, Morgan: Characterization of the mouse analogues of CD59 using novel monoclonal antibodies: tissue distribution and functional comparison. in Immunology 2003
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Mouse (Murine) Monoclonal CD59A Primary Antibody for Func, IA - ABIN2191856
Williams, Mizuno, Richards, Holt, Morgan: Deletion of the gene encoding CD59a in mice increases disease severity in a murine model of rheumatoid arthritis. in Arthritis and rheumatism 2004
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Data (including data from studies using knockout mice) suggest that CD59a (show CD59 Antibodies), CD59b (show CD59 Antibodies), and ApoE (show APOE Antibodies) are involved in development of diabetes-induced atherosclerosis; here, deficiency of CD59a/CD59b (show CD59 Antibodies) (in ApoE (show APOE Antibodies) deficient mice) accelerates development of atherosclerosis in mice with type 1 diabetes. (CD59a (show CD59 Antibodies) = CD59a antigen; CD59b (show CD59 Antibodies) = CD59b antigen; ApoE (show APOE Antibodies) = apolipoprotein E (show APOE Antibodies))
Varicella-zoster virus infection upregulates host CD59 (show CD59 Antibodies) expression in a tissue-specific manner.
This study support a role of Cd59a (show CD59 Antibodies) in controlling the innate immune status of the RPE (show RPE Antibodies)-choroidal complex and emphasizes the particular vulnerability of this ocular compartment to the dysregulation of alternative complement pathway during aging
results implicate CD59 (show CD59 Antibodies) as an important modulator of the immune response in NMO, and provide a novel animal model of NMO that closely recapitulates human NMO pathology.
Soluble forms of CD59 (show CD59 Antibodies) (sCD59) have been investigated in mouse laser-induced choroidal neovascularization, a model for "wet" age related macular degeneration.
both CD59 (show CD59 Antibodies) and C-PC could inhibit the progress of atherosclerosis, and the anti-atherosclerotic effects of C-PC might be fulfilled by promoting CD59 (show CD59 Antibodies) expression, preventing smooth muscle cell proliferation and the apoptosis of endothelial cells
CD59a (show CD59 Antibodies) inhibits systemic autoimmunity in MRL/lpr (show FAS Antibodies) mice through a complement-independent mechanism.
While the connection between CFH (show CFH Antibodies) deficiency and failure to upregulate CD59a (show CD59 Antibodies) remains unknown, these results suggest that expression of CD59 (show CD59 Antibodies) is tissue-specific and that neuroretinal regulation depends on CFH (show CFH Antibodies).
Actively immunized experimental autoimmune myasthenia gravis mice deficient in either CD55 (show CD55 Antibodies) or CD59 (show CD59 Antibodies) showed significant differences in adaptive immune responses and worsened disease outcome associated with increased levels of serum cytokines, modified production of acetylcholine receptor (show CHRNB1 Antibodies) antibodies, and more complement deposition at the neuromuscular junction.
HBx can up-regulate CD59 (show CD59 Antibodies) and Crry (show CR1L Antibodies) expression in podocytes through activating the P38 (show CRK Antibodies) pathway.
Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore (By similarity).
, CD59A glycoprotein
, MAC-inhibitory protein
, membrane attack complex inhibition factor