anti-CD6 (CD6) Antibodies

CD6 encodes a protein found on the outer membrane of T-lymphocytes as well as some other immune cells. Additionally we are shipping CD6 Kits (21) and CD6 Proteins (17) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
CD6 12511 Q61003
CD6 923 P30203
CD6 25752  
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Top anti-CD6 Antibodies at antibodies-online.com

Showing 10 out of 321 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Cow Rabbit Un-conjugated WB 100 μL 2 to 3 Days
$289.00
Details
Human Mouse Un-conjugated ELISA, FACS, ICC, IHC, WB Black line: Control Antigen (100 ng);Purple line: Antigen(10ng);Blue line: Antigen (50 ng);Red line: Antigen (100 ng); Dilution: 1/10000 Figure 1: Western blot analysis using CD6 mAb against human CD6(AA: 18-199) recombinant protein. (Expected MW is 44.8 kDa) Dilution: 1/500 - 1/2000 100 μL 8 to 11 Days
$577.50
Details
Human Mouse Un-conjugated ELISA, IHC, WB Black line: Control Antigen (100 ng);Purple line: Antigen(10ng);Blue line: Antigen (50 ng);Red line: Antigen (100 ng); Dilution: 1/10000 Figure 1: Western blot analysis using CD6 mAb against human CD6 recombinant protein. (Expected MW is 46.9 kDa) Dilution: 1/500 - 1/2000 100 μL 8 to 11 Days
$577.50
Details
Human Mouse Un-conjugated ELISA, FACS, IHC, WB Black line: Control Antigen (100 ng);Purple line: Antigen(10ng);Blue line: Antigen (50 ng);Red line: Antigen (100 ng); Dilution: 1/10000 Figure 1: Western blot analysis using CD6 mAb against human CD6 (AA: Extra(18-199)) recombinant protein. (Expected MW is 44.8 kDa) Dilution: 1/500 - 1/2000 100 μL 8 to 11 Days
$577.50
Details
Human Mouse Un-conjugated ELISA, IHC, WB 100 μg 11 to 14 Days
$551.83
Details
Human Mouse Un-conjugated FACS, IHC (p), IP, WB   0.1 mg 6 to 8 Days
$258.50
Details
Human Mouse PE FACS, IHC (p), IP, WB Surface staining of human peripheral blood cells with anti-human CD6 (MEM-98) FITC. 100 Tests 5 to 7 Days
$497.45
Details
Human Mouse PE FACS, IF, IHC (f) 250 μL 3 to 4 Days
$441.85
Details
Human Mouse APC FACS, IF, IHC (f) 250 μL 3 to 4 Days
$441.85
Details
Human Mouse PerCP FACS, IF, IHC (f) 250 μL 3 to 4 Days
$441.85
Details

Top referenced anti-CD6 Antibodies

  1. Human Monoclonal CD6 Primary Antibody for FACS, IHC (p) - ABIN94206 : Castro, Oliveira, Nunes, Fabre, Barbosa, Peixoto, Brown, Parnes, Bismuth, Moreira, Rocha, Carmo: Extracellular isoforms of CD6 generated by alternative splicing regulate targeting of CD6 to the immunological synapse. in Journal of immunology (Baltimore, Md. : 1950) 2007 (PubMed)
    Show all 5 Pubmed References

  2. Rat (Rattus) Monoclonal CD6 Primary Antibody for IHC (fro), FACS - ABIN2689349 : Lawetzky, Tiefenthaler, Kubo, Hünig: Identification and characterization of rat T cell subpopulations expressing T cell receptors alpha/beta and gamma/delta. in European journal of immunology 1990 (PubMed)
    Show all 3 Pubmed References

  3. Pig (Porcine) Monoclonal CD6 Primary Antibody for IHC (fro), FACS - ABIN2472176 : Pescovitz, Book, Aasted, Dominguez, Bullido, Trebichavsky, Novikov, Valpotic, Nielsen, Arn, Sachs, Lunney, Boyd, Walker, Lee, Petrinec, Saalmüller: Analyses of monoclonal antibodies reacting with porcine wCD6: results from the Second International Swine CD Workshop. in Veterinary immunology and immunopathology 1998 (PubMed)
    Show all 4 Pubmed References

  4. Human Monoclonal CD6 Primary Antibody for FACS, IHC (p) - ABIN192058 : Hassan, Simmonds, Clarkson, Hanrahan, Puklavec, Bomb, Barclay, Brown: CD6 regulates T-cell responses through activation-dependent recruitment of the positive regulator SLP-76. in Molecular and cellular biology 2006 (PubMed)
    Show all 5 Pubmed References

  5. Human Monoclonal CD6 Primary Antibody for IHC, ELISA - ABIN1098118 : Alonso, Buors, Le Dantec, Hillion, Pers, Saraux, Montero, Marianowski, Loisel, Devauchelle, Youinou, Renaudineau: Aberrant expression of CD6 on B-cell subsets from patients with Sjögren's syndrome. in Journal of autoimmunity 2010 (PubMed)
    Show all 4 Pubmed References

  6. Human Monoclonal CD6 Primary Antibody for IHC (fro), FACS - ABIN2689348 : Bott, Doshi, Li, McMurtry, Sanders, Fox: Transcriptional regulation of CD6 expression on human T lymphocytes by phorbol ester. in Journal of immunology (Baltimore, Md. : 1950) 1994 (PubMed)
    Show all 2 Pubmed References

  7. Human Monoclonal CD6 Primary Antibody for FACS, IP - ABIN2472169 : Pauleikhoff, Harper, Marshall, Bird: Aging changes in Bruch's membrane. A histochemical and morphologic study. in Ophthalmology 1990 (PubMed)
    Show all 4 Pubmed References

  8. Human Monoclonal CD6 Primary Antibody for FACS - ABIN2472171 : Bazil, Stefanová, Hilgert, Kristofová, Van?k, Bukovský, Horejsí: Monoclonal antibodies against human leucocyte antigens. III. Antibodies against CD45R, CD6, CD44 and two newly described broadly expressed glycoproteins MEM-53 and MEM-102. in Folia biologica 1990 (PubMed)
    Show all 4 Pubmed References

  9. Human Monoclonal CD6 Primary Antibody for FACS - ABIN536115 : Zimmerman, Joosten, Torensma, Parnes, van Leeuwen, Figdor: Long-term engagement of CD6 and ALCAM is essential for T-cell proliferation induced by dendritic cells. in Blood 2006 (PubMed)
    Show all 2 Pubmed References

  10. Human Monoclonal CD6 Primary Antibody for FACS, IHC (p) - ABIN535464 : Osorio, De Santiago, Aguilar-Santelises, Mellstedt, Jondal: CD6 ligation modulates the Bcl-2/Bax ratio and protects chronic lymphocytic leukemia B cells from apoptosis induced by anti-IgM. in Blood 1997 (PubMed)
    Show all 3 Pubmed References

More Antibodies against CD6 Interaction Partners

Mouse (Murine) CD6 interaction partners

  1. Binding studies show that both soluble and membrane-bound forms of CD5 and CD6 bind to intact viable protoscoleces from E. granulosus s.l. through recognition of metaperiodate-resistant tegumental components.

  2. Results indicate Cdcp1 (CD318) as a ligand of T-cell differentiation antigen CD6 (CD6) and a potential target for the diagnosis and treatment of autoimmune diseases.

  3. These results suggest that (i) CD6 is a negative regulator of T-cell activation, (ii) at the same time, CD6 is a positive regulator of activated T-cell survival/proliferation and infiltration; and (iii) CD6 is a potential new target for treating multiple sclerosis (MS)and potentially other T-cell-driven autoimmune conditions.

  4. these data indicate that CD6 modulates the threshold for thymocyte selection and the generation and/or function of several peripheral T cell subpopulations, including T reg cells

  5. results reveal an unexpected role of CD6 in the pathogenesis of intestinal IR-induced injury by regulating the self-renewal of B1a cells.

  6. this analysis identified 65 proteins not associated before with the Zap70-Lat-SLP-76 network and thus should provide cues for future functional experiments.

Human CD6 interaction partners

  1. This study provides evidence that CD6 is involved in the susceptibility to Behcet's disease in a Chinese Han population.

  2. These results suggest that (i) CD6 is a negative regulator of T-cell activation, (ii) at the same time, CD6 is a positive regulator of activated T-cell survival/proliferation and infiltration; and (iii) CD6 is a potential new target for treating multiple sclerosis (MS)and potentially other T-cell-driven autoimmune conditions.

  3. These data are consistent with a model in which bivalent recruitment of a GADS/SLP-76 complex is required for costimulation by CD6.

  4. Data indicate that the T cell-specific adaptor protein (TSAd) SH2 domain interacts with CD6 antigen and linker for activation of T cells protein (LAT) phosphotyrosine (pTyr) peptides.

  5. Results from recent genetic association studies provide evidence for a role of CD6 in multiple sclerosis and in rheumatoid arthritis pathogenesis. [review]

  6. Study provides evidence on the role of CD6, a lymphocyte-specific surface receptor from to the ancient and highly conserved Scavenger Receptor Cysteine-Rich (SRCR) superfamily, as a pattern recognition receptor, and the functional consequences this may have on T cell activation and differentiation. [review]

  7. Data show the multiple aspects that determine the nature of the signals transmitted via CD6 and the context that may define a dual role for this important T cell surface molecule. [review]

  8. Data show a role for extracellular and intracellular interactions of CD6 in lateral movement in response to T cell activation. [review]

  9. The binding sites on CD6 and CD166 have been characterized to show that a SNP in CD6 causes glycosylation that hinders the CD6/CD166 interaction.

  10. CD6 regulatory T cells are characterized by CD6 expression and FOXP3 expression.

  11. interaction of Galectin-1 and -3 with CD6

  12. upon T cell activation, SRSF1 becomes limiting, and its function in CD6 exon 5 splicing is countered by an increase in CD6 transcription, dependent on chromatin acetylation.

  13. The CD6 polymorphism conferred reduced odds of optic neuritis as an attack location

  14. In a Korean population, one SNP in CD6 was associated with neuromyelitis optica.

  15. Our findings reveal that this new MS-associated CD6 risk haplotype significantly modifies expression of CD6 on CD4(+) and CD8(+) T cells.

  16. A novel level of regulation of CD6 function by intracytoplasmic serine phosphorylation.

  17. Data suggest that genetic variations within CD6 and syntaxin binding protein 6 (STXBP6) may influence response to TNFalpha inhibitors in patients with rheumatoid arthritis (RA).

  18. Cd6 is a signaling attenuator whose expression alone, i.e. in the absence of ligand engagement, is sufficient to restrain signaling in T cells.

  19. These findings indicate that the multiple sclerosis risk allele in the CD6 locus is associated with altered proliferation of CD4(+) T cells

  20. CD6 expression on peripheral NK cells marks a novel CD56(dim) subpopulation associated with distinct patterns of cytokine and chemokine secretion.

CD6 Antigen Profile

Protein Summary

This gene encodes a protein found on the outer membrane of T-lymphocytes as well as some other immune cells. The encoded protein contains three scavenger receptor cysteine-rich (SRCR) domains and a binding site for an activated leukocyte cell adhesion molecule. The gene product is important for continuation of T cell activation. This gene may be associated with susceptibility to multiple sclerosis (PMID: 19525953, 21849685). Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with anti-CD6 (CD6) Antibodies

  • CD6 antigen (Cd6) antibody
  • CD6 molecule (CD6) antibody
  • Cd6 molecule (Cd6) antibody
  • OX52 antibody
  • TP120 antibody

Protein level used designations for anti-CD6 (CD6) Antibodies

T-cell differentiation antigen CD6 , CD6 antigen , T12 , CD6 antigen, Tp120

GENE ID SPECIES
12511 Mus musculus
923 Homo sapiens
25752 Rattus norvegicus
100513519 Sus scrofa
282881 Bos taurus
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