anti-CD68 Molecule (CD68) Antibodies

CD68 encodes a 110-kD transmembrane glycoprotein that is highly expressed by human monocytes and tissue macrophages. Additionally we are shipping CD68 Kits (34) and CD68 Proteins (29) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
CD68 12514 P31996
CD68 287435  
CD68 968 P34810
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Top anti-CD68 Antibodies at

Showing 10 out of 713 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Mouse Rabbit Un-conjugated IHC (fro), IHC (p), WB Anti-CD68 antibody,  IHC(P) IHC(P): Rat Spleen Tissue Anti-CD68 antibody,  IHC(P) IHC(P): Mouse Liver Tissue 100 μg Log in to see 4 to 6 Days
Human Rabbit Un-conjugated IHC (p), WB Lane 3: Recombinant Human CD68 Protein 2.5ng Anti-CD68 antibody, IHC(P) IHC(P): Human Tonsil Tissue 100 μg Log in to see 4 to 6 Days
Human Rabbit Un-conjugated WB Western blot analysis of CD68 using anti-CD68 antibody .  Electrophoresis was performed on a 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours. The sample well of each  Lane was loaded with 50ug of sample under reducing conditions.   Lane 1: human Jurkat whole cell lysates, Lane 2: human blood lysates.  After Electrophoresis, proteins were transferred to a Nitrocellulose membrane at 150mA for 50-90 minutes. Blocked the membrane with 5% Non-fat Milk/ TBS for 1.5 hour at RT. The membrane was incubated with rabbit anti-CD68 antigen affinity purified polyclonal antibody (Catalog # ) at 0.5 µg/mL overnight at 4°C, then washed with TBS-0.1%Tween 3 times with 5 minutes each and probed with a goat anti-rabbit IgG-HRP secondary antibody at a dilution of 1:10000 for 1.5 hour at RT. The signal is developed using an Enhanced Chemiluminescent detection (ECL) kit (Catalog # EK1002) with Tanon 5200 system. A specific band was detected for CD68 at approximately 70KD. The expected band size for CD68 is at 36KD. 100 μg Log in to see 4 to 6 Days
Human Mouse Un-conjugated ICC, FACS, IHC (fro), IF, IHC (p), IP, IHC, WB Immunohistochemistry-Paraffin: CD68/SR-D1 Antibody (KP1) - Unpurified [ABIN152106] - IHC analysis of a formalin fixed paraffin embedded human spleen tissue section using CD68/SR-D1 antibody (clone KP1) with HRP-DAB based detection method and hematoxylin counterstaining. The antibody specifically labelled the macrophage cells in the tested section. 0.5 mL Log in to see 7 to 9 Days
Mouse Rat Un-conjugated FACS, ICC, IF, IHC, IHC (fro), IHC (p), IP, WB Immunocytochemistry/Immunofluorescence: CD68/SR-D1 Antibody (FA-11) [NBP2-33337] - Wehi-3 cells were fixed for 10 minutes using 10% formalin and then permeabilized for 5 minutes using 1X TBS + 0.5% Triton-X100. The cells were incubated with anti CD68 (FA-11) [NBP2-33337] at a 1:100 dilution overnight at 4C and detected with an anti-rat Dylight 488 (Green) at a 1:500 dilution. Actin was detected with Phalloidin 568 (Red) at a 1:200 dilution. Nuclei were counterstained with DAPI (Blue). Cells were imaged using a 40X objective. Immunohistochemistry-Paraffin: CD68/SR-D1 Antibody (FA-11) [NBP2-33337] - Mouse spleen cryosection. 0.1 mg Log in to see 7 to 9 Days
Human Rabbit Un-conjugated IF (cc), IF (p), IHC (p), WB Formalin-fixed and paraffin embedded rat myocardium tissue labeled Anti-CD68 Polyclonal Antibody, unconjugated  (ABIN671406)  at 1: 200, followed by incubation with conjugated secondary antibody and DAB staining Formalin-fixed and rat colitis tissue labeled with Anti-CD68 Polyclonal Antibody, Unconjugated (ABIN671406) at 1:200 followed by conjugation to the secondary antibody, Goat Anti-Rabbit IgG, Cy5 conjugated, 100 μL Log in to see 3 to 7 Days
Mouse Rat Un-conjugated FACS, IHC (fro), IF, IHC (p), IP, WB Staining of permeabilised mouse peritoneal macrophages with RAT ANTI MOUSE CD68 (ABIN181837). 0.1 mg Log in to see 6 to 8 Days
Human Mouse FITC FACS 2 mL Log in to see 5 to 7 Days
Cow Mouse Un-conjugated ICC, FACS, IHC (fro), IF, IHC (p), IP, IHC, RIA, WB 0.125 mg Log in to see 7 to 9 Days
Guinea Pig Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days

Top referenced anti-CD68 Antibodies

  1. Human Monoclonal CD68 Primary Antibody for ICC, FACS - ABIN152106 : Horny, Schaumburg-Lever, Bolz, Geerts, Kaiserling: Use of monoclonal antibody KP1 for identifying normal and neoplastic human mast cells. in Journal of clinical pathology 1990 (PubMed)
    Show all 33 Pubmed References

  2. Mouse (Murine) Polyclonal CD68 Primary Antibody for IHC (fro), IHC (p) - ABIN3044428 : Guo, Liao, Huang, Wang, Huang, Liu: Reversal of adipose tissue loss by probucol in mice with deficiency of both scavenger receptor class B type 1 and LDL receptor on high fat diet. in Biochemical and biophysical research communications 2017 (PubMed)
    Show all 33 Pubmed References

  3. Human Polyclonal CD68 Primary Antibody for IHC (p), WB - ABIN3044053 : Gu, Wu, Yao, Zeng, Shi, Lv, Luo, Song: Intratracheal administration of mitochondrial DNA directly provokes lung inflammation through the TLR9-p38 MAPK pathway. in Free radical biology & medicine 2015 (PubMed)
    Show all 27 Pubmed References

  4. Mouse (Murine) Monoclonal CD68 Primary Antibody for FACS, ICC - ABIN4295377 : Robertson, OConnell, Hudson, Seamark: Granulocyte-macrophage colony-stimulating factor (GM-CSF) targets myeloid leukocytes in the uterus during the post-mating inflammatory response in mice. in Journal of reproductive immunology 2000 (PubMed)
    Show all 24 Pubmed References

  5. Human Polyclonal CD68 Primary Antibody for WB - ABIN5693259 : Ding, Huang, Tong, Yu, Yu: Influence of Kupffer cells on hepatic signal transduction as demonstrated by second messengers and nuclear transcription factors. in World journal of gastroenterology 2003 (PubMed)
    Show all 21 Pubmed References

  6. Human Polyclonal CD68 Primary Antibody for IF (cc), IF (p) - ABIN671406 : Zeng, Zhang, Li, Yang, Chen, Liu: A new method to isolate and culture rat kupffer cells. in PLoS ONE 2013 (PubMed)
    Show all 15 Pubmed References

  7. Human Monoclonal CD68 Primary Antibody for ICC, IHC (fro) - ABIN256057 : da Costa, Annels, Faaij, Forsyth, Hogendoorn, Egeler: Presence of osteoclast-like multinucleated giant cells in the bone and nonostotic lesions of Langerhans cell histiocytosis. in The Journal of experimental medicine 2005 (PubMed)
    Show all 15 Pubmed References

  8. Human Monoclonal CD68 Primary Antibody for FACS - ABIN1741593 : Feuillard, Jacob, Valensi, Maynadié, Gressin, Chaperot, Arnoulet, Brignole-Baudouin, Drénou, Duchayne, Falkenrodt, Garand, Homolle, Husson, Kuhlein, Le Calvez, Sainty, Sotto, Trimoreau, Béné: Clinical and biologic features of CD4(+)CD56(+) malignancies. in Blood 2002 (PubMed)
    Show all 12 Pubmed References

  9. Human Monoclonal CD68 Primary Antibody for CyTOF, FACS - ABIN4899672 : Lumeng, Deyoung, Bodzin, Saltiel: Increased inflammatory properties of adipose tissue macrophages recruited during diet-induced obesity. in Diabetes 2006 (PubMed)
    Show all 6 Pubmed References

  10. Human Monoclonal CD68 Primary Antibody for IHC (f), FACS - ABIN2749213 : Yamagami, Yokoo, Amano, Ebihara: Characterization of bone marrow derived cells in the substantia propria of the human conjunctiva. in Investigative ophthalmology & visual science 2007 (PubMed)
    Show all 5 Pubmed References

More Antibodies against CD68 Interaction Partners

Mouse (Murine) CD68 Molecule (CD68) interaction partners

  1. Findings indicate that human CD68 and its mouse ortholog macrosialin located in the lysosomal membrane and share many structural similarities.

  2. Myeloid osteoclast precursors do not express CD68.

  3. CD68, a putative receptor for sporozoite invasion of Kupffer cells that acts as a gateway for malaria infection of the liver.

  4. Results showed that activated microglia in Alzheimer's disease-like mice showed two-step transition: a CD68-negative activated form at 6-9 months and a CD68-positive form from 12 months of age

  5. Statins promote the beneficial remodeling of plaques in diseased mouse arteries through the stimulation of the CCR7 / CD68 emigration pathway in macrophages

  6. These findings demonstrate a role for CD68 in the function of osteoclasts.

  7. CD68-null mononuclear phagocytes exhibited a trend toward enhanced antigen presentation to CD4+ T cells, indicating that CD68 may function to negatively regulate antigen uptake, loading, or major histocompatibility complex class II trafficking.

  8. Atherogenic diet-induced reduction in lipid levels of Reversa model mouse leads to decreased monocyte-derived CD68-positive cells in advanced atherosclerotic plaques and is associated with emigration of these cells from the atherosclerotic plaques.

  9. Macrosialin does not function as an oxLDL receptor on the cell surface.

  10. Data show that macrosialin (CD68), a macrophage-specific protein, is increased by aging in selected brain regions of male C57BL/6NNia mice.

Human CD68 Molecule (CD68) interaction partners

  1. Combined detection of tumor-associated macrophages markers, CD68 and Sema4D, in gastric carcinoma tissue shows potential to predict the trend of gastric carcinoma progression.

  2. The study revealed that CD16-CD68-expressing macrophages appear to participate in ureteral neoplastic transformation.

  3. A combination of CD68/CD206 density and HBV-positivity improves further predictive value for post-operative recurrence of hepatocellular carcinoma (HCC) . Quantification of CD68/CD206 macrophages and their distribution can be exploited for better postsurgical management of HCC patients.

  4. Report CD68 over-expression in multinucleated giant cells and mononuclear cells in central and peripheral giant cell granuloma of jaw.

  5. This study shown the CD68 expression in Microglia and Astrocytes in stroke, Alzheimer's disease, and Lewy body dementia.

  6. The results of this study found that the expression levels of Cd68 and Atp5b were significantly correlated with the neurofibrillary tangle burden in the Alzheimer's Disease brain and with their cognition.

  7. Taken together, these results suggested that the changes, including ox-LDL/LDL ratio, CD68(+)/RANK(+) cells number, and the levels of RANKL and HMGB1 in AS patients, favored osteoclastogenesis.

  8. High expression of CD68 is associated with nonalcoholic steatohepatitis.

  9. increased amount of CD68+TAM in gaps of ductal tumor structures is protective against metastatic spread in regional lymph nodes.

  10. Most cases of histiocytic sarcoma expressed histiocytic markers CD68 (6 of 7 cases), CD163 (5 of 5 cases), and PU.1 (3 of 4 cases).

  11. Renal expression of CD68 and the chronicity index are associated with progression to chronic kidney disease in patients with proliferative lupus nephritis.

  12. Results indicate that the expression of FoxP3 was not significantly associated with survival, and suggest prognostic significance of high CD68 expression in primary central nervous system lymphoma (PCNSL).

  13. Her-2 overexpression results in ICA were similar to previous reports, the finding of 28% in HGD was unexpected and may have clinical implications. Positive Her-2 DISH in 6% of LGD is novel, suggesting a role of Her-2 during BE progression

  14. CD68 may play key roles in the pathogenesis of Alzheimer's disease (AD) and its complications may be via induction of inflammation; CD68 may be considered as a risk factor for development of AD and also psychotic symptoms in the patients

  15. hCD68GFP/ApoE(-/-) mice provide a new approach to study macrophage accumulation in atherosclerotic plaque progression and to identify cells recruited from adoptively transferred monocytes.

  16. Findings indicate that human CD68 and its mouse ortholog macrosialin located in the lysosomal membrane and share many structural similarities.

  17. The strong CD68 and S100 co-expression in our case did not allow a clear-cut discrimination between the immunophenotype of histiocytic neoplasms and amelanotic melanoma, because of CD68 immunoreactivity occurring in 75% of metastatic malignant melanomas

  18. Using double labeling with Iba-1 and cd68 could determine the physiological state of microglia in brain contusion based on their morphology and immunoreactivity.

  19. we confirmed the similarities between epithelial ovarian cancer and fallopian tube, normal and adenocarcinoma using FOLR1, FOLR2, CD68 and CD11b markers

  20. Inhibitory Profile of Liver CD68+ Cells during HCV Infection as Observed by an Increased CD80 and PD-L1 but Not CD86 Expression

CD68 Antigen Profile

Protein Summary

This gene encodes a 110-kD transmembrane glycoprotein that is highly expressed by human monocytes and tissue macrophages. It is a member of the lysosomal/endosomal-associated membrane glycoprotein (LAMP) family. The protein primarily localizes to lysosomes and endosomes with a smaller fraction circulating to the cell surface. It is a type I integral membrane protein with a heavily glycosylated extracellular domain and binds to tissue- and organ-specific lectins or selectins. The protein is also a member of the scavenger receptor family. Scavenger receptors typically function to clear cellular debris, promote phagocytosis, and mediate the recruitment and activation of macrophages. Alternative splicing results in multiple transcripts encoding different isoforms.

Gene names and symbols associated with anti-CD68 Molecule (CD68) Antibodies

  • CD68 molecule (CD68) antibody
  • CD68 antigen (Cd68) antibody
  • Cd68 molecule (Cd68) antibody
  • GP110 antibody
  • LAMP4 antibody
  • SCARD1 antibody

Protein level used designations for anti-CD68 Molecule (CD68) Antibodies

macrosialin , CD68 antigen , macrophage antigen CD68 , scavenger receptor class D, member 1

100344094 Oryctolagus cuniculus
12514 Mus musculus
287435 Rattus norvegicus
968 Homo sapiens
504960 Bos taurus
101099002 Felis catus
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