anti-CDK5 Regulatory Subunit Associated Protein 1-Like 1 (CDKAL1) Antibodies

Human CDK5 Regulatory Subunit Associated Protein 1-Like 1 (CDKAL1) interaction partners

1. Forced MT1E (show MT1E Antibodies) expression rescues both hypersensitivity of CDKAL1 mutant cells to glycolipotoxicity and pancreatic beta-cell dysfunction in vitro and in vivo.

2. CDKAL1 gene is associated with development of type 2 diabetes. For the HHEX (show HHEX Antibodies)/IDE (show IDE Antibodies) locus, such an association is absent.

3. family-based GWAS of imputed SNPs revealed novel genomic variants in (or near) PTPRG (show PTPRG Antibodies), OSBPL6 (show OSBPL6 Antibodies), and PDCL3 (show PDCL3 Antibodies) that influence risk for Alzheimer's Disease. rs7609954 in the gene PTPRG (show PTPRG Antibodies), rs1347297 in the gene OSBPL6 (show OSBPL6 Antibodies), and rs1513625 near PDCL3 (show PDCL3 Antibodies). In addition, rs72953347 in OSBPL6 (show OSBPL6 Antibodies) and two SNPs in the gene CDKAL1 showed marginally significant association with LOAD (rs10456232, P-value=4.76 x 10-7; rs62400067, P-value=3.54 x 10-7).

4. The multivariate logistic regression analysis with reference to both alleles and genotypes of CDKAL1 SNPs showed significant association, suggesting an important role for this gene in the T2DM pathophysiology. INTERPRETATION & CONCLUSIONS: A significant association was seen of all the three SNPs of CDKAL1 and CDKN2A/B genes with T2DM but none of the two SNPs of HHEX (show HHEX Antibodies).

5. Study provides evidence that SNPs of JMJD1C (show JMJD1C Antibodies) and KCNQ1 (show KCNQ1 Antibodies) are prospectively associated with the risk of type 2 diabetes (T2D) in Korean population. Additionally, CDKAL1 may not be associated with T2D onset over the age of 40.

6. Our results suggest that rs6908425 in CDKAL1 is associated with the risk of developing SAPHO in Han Chinese populations. People who carry the risk allele T of rs6908425 might be more prone to developing SAPHO syndrome.

7. We investigated the association between 8 single-nucleotide polymorphisms (SNPs) at 3 genetic loci (CDKAL1, CDKN2A/2B and FTO (show FTO Antibodies)) with type 2 diabetes (T2D) in a Uyghur population

8. our data suggested that CDKAL1 gene variants have a significant effect on the response to anti-TNF (show TNF Antibodies) therapies among Psoriasis patients

9. Risk alleles for 6 loci increased glucose levels from birth to 5 years of age (ADCY5 (show ADCY5 Antibodies), ADRA2A (show ADRA2A Antibodies), CDKAL1, CDKN2A/B, GRB10 (show GRB10 Antibodies), and TCF7L2 (show TCF7L2 Antibodies)

10. rs10946398 associated with markers of impaired insulin (show INS Antibodies) secretion

Mouse (Murine) CDK5 Regulatory Subunit Associated Protein 1-Like 1 (CDKAL1) interaction partners

1. CDKAL1 may affect such compensatory mechanisms regulating glucose homeostasis through interaction with diet

2. Knockout mice with pancreatic beta-cell-specific lack of cdkal1 show pancreatic islet hypertrophy and impaired blood glucose control.

3. Data show that Cdkal1 is a mammalian methylthiotransferase that biosynthesizes 2-methylthio-N6-threonylcarbamoyladenosine (ms2t6A) in tRNA(Lys (show LYZ Antibodies))(UUU) and that it is required for the accurate translation of AAA (show AAAS Antibodies) and AAG (show C16orf35 Antibodies) codons.

4. CDKAL1 controls first-phase insulin (show INS Antibodies) exocytosis in beta cells by facilitating ATP generation, K(ATP) channel responsiveness and the subsequent activity of Ca(2 (show CA2 Antibodies)+) channels through pathways other than CDK5 (show CDK5 Antibodies)-mediated regulation