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CRCP encodes a membrane protein that functions as part of a receptor complex for a small neuropeptide that increases intracellular cAMP levels.
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CGRP (show CALCA ELISA Kits) can inhibit microglia activation in vivo in EAE. CGRP (show CALCA ELISA Kits) and its receptor may represent novel protective factors in EAE.
CGRP-receptor component protein has been found to interact only with calcitonin (show CALCA ELISA Kits)-like receptor and represents a novel neuroendocrine regulatory step in calcitonin gene-related peptide (show CALCA ELISA Kits) signaling.
The mouse cDNA for calcitonin receptor-like receptor (CRLR (show CALCRL ELISA Kits)) was cloned. The signal transduction mechanism through the CGRP (show CALCA ELISA Kits) receptor was studied. mCRLR is a 462-amino acid G-protein-coupled heptahelical receptor (show AGTR1 ELISA Kits).
data reinforce and clarify our understanding of CGRP (show S100A12 ELISA Kits) receptor localization, and provide evidence that antagonist antibodies bind to target sites in the trigeminovascular system of primates that are involved in the pathology of migraine
CGRP (show S100A12 ELISA Kits) family of receptors displays both ligand- and RAMP-dependent signaling bias among the Galphas (show GNAS ELISA Kits), Galphai, and Galphaq (show GNAQ ELISA Kits)/11 pathways.
In this review, the influence of the CGRP (show S100A12 ELISA Kits) family peptides in reproduction and pregnancy is explored and discussed.
This study demonstrates the detailed expression of CGRP (show S100A12 ELISA Kits) and its receptor components within spinal trigeminal nucleus in the brainstem and in the spinal cord at C1-level
The extracellular protein domains corresponding to residues 23-133 of calcitonin receptor-like receptor (show CALCRL ELISA Kits) and residues 26-117 of receptor activity-modifying protein 1 (RAMP1 (show RAMP1 ELISA Kits)) are shown to be sufficient for formation of a stable, folded monodisperse complex.
Data describe the role of residues 23-60 of the calcitonin receptor-like receptor (show CALCRL ELISA Kits) in binding with interaction sites within the N-terminus of the calcitonin gene-related peptide (show CALCA ELISA Kits) receptor.
Expression of CGRP-RCP was detected in CD34 (show CD34 ELISA Kits)+ cells and also in some mature granulocyte samples, providing evidence that CGRP-RCP may be regulated independently of RAMP1 (show RAMP1 ELISA Kits) and CRLR (show CALCRL ELISA Kits) in hematopoietic cells.
human CGRP-RCP is the genuine orthologue of C17. CGRP-RCP was found to functionally replace C17 in Deltarpc17 yeast cells; CGRP-RCP was identified in a purified human Pol III preparation.
inhibition of ACE (show ACE ELISA Kits) seems to augment CGRP (show S100A12 ELISA Kits) catabolism.
Increased mRNA expression CGRP-RCP in gravid myometrium supports the possibility of involvement of CGRP (show S100A12 ELISA Kits) in the control of myometrial contractility.
This gene encodes a membrane protein that functions as part of a receptor complex for a small neuropeptide that increases intracellular cAMP levels. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
calcitonin gene-related peptide-receptor component protein
, DNA-directed RNA polymerase III subunit RPC9
, CGRP-receptor component protein
, RNA polymerase III subunit C9