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CMTM4 belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and the transmembrane 4 superfamilies of signaling molecules. Additionally we are shipping CMTM4 Antibodies (34) and CMTM4 Proteins (5) and many more products for this protein.
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CMTM6 (show CMTM6 ELISA Kits) is present at the cell surface, associates with the PD-L1 (show CD274 ELISA Kits) protein, reduces its ubiquitination and increases PD-L1 (show CD274 ELISA Kits) protein half-life; CMTM6 (show CMTM6 ELISA Kits) enhances the ability of PD-L1 (show CD274 ELISA Kits)-expressing tumour cells to inhibit T cells; collectively, our data reveal that PD-L1 (show CD274 ELISA Kits) relies on CMTM6 (show CMTM6 ELISA Kits)/4 to efficiently carry out its inhibitory function, and suggest potential new avenues to block this pathway
CMTM4 is downregulated and exhibits tumour-suppressor activities in clear cell renal cell carcinoma, and could be exploited as a target for clear cell renal cell carcinoma treatment.
Data show that CMTM4 might be an important gene involved in cell growth and cell cycle regulation.
Bioinformatics based on CKLF2 (show CKLF ELISA Kits) cDNA and protein sequences in combination with experimental validation identified CKLFSF1 (show CMTM1 ELISA Kits)-8 gene clusters, between the SCY (show CELSR1 ELISA Kits) and the TM4SF (show TSPAN1 ELISA Kits) gene families. The 8 family members were cloned and characterized.
This gene belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and the transmembrane 4 superfamilies of signaling molecules. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 16. Alternatively spliced transcript variants encoding different isoforms have been identified.
CKLF-like MARVEL transmembrane domain-containing protein 4
, chemokine-like factor super family 4
, chemokine-like factor superfamily member 4
, chemokine-like factor superfamily 4