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CMTM8 belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and the transmembrane 4 superfamilies.
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This is the first extensive study of CMTM8 expression in both normal and tumorous human tissues. Our findings strongly supported the potential role of CMTM8 as a novel tumor suppressor and may shape further functional studies on this gene
our data suggested that CMTM8 is an important tumor suppressor gene in human bladder cancer and qualified as a useful prognostic indicator for patients with bladder cancer.
overexpression of CMTM8 in bladder cancer results in reduced malignant cell growth, migration and invasion, which could make it a potential therapeutic target in the treatment of bladder cancer.
This study identified CMTM8 as a new candidate tumor suppressor gene and GPR177 (show WLS Proteins) as a new candidate oncogene (show RAB1A Proteins) in osteosarcoma.
Down-regulation of CMTM8 also promoted an epithelial mesenchymal transition-like change in MCF-10A cells, indicating a broader role for CMTM8 in regulating cellular transformation.
Bioinformatics based on CKLF2 (show CKLF Proteins) cDNA and protein sequences in combination with experimental validation identified CKLFSF1 (show CMTM1 Proteins)-8 gene clusters, between the SCY and the TM4SF (show TSPAN1 Proteins) gene families. The 8 family members were cloned and characterized.
These results identify CKLFSF8 as a novel regulator of EGF (show EGF Proteins)-induced signaling and indicate that the association of EGFR (show EGFR Proteins) with four transmembrane proteins is critical for EGFR (show EGFR Proteins) desensitization.
Cell proliferation and expression of EGFR (show EGFR Proteins) of tumor cells can be inhibited by transfection of CKLFSF8.
These data implicate CMTM8 as a negative regulator of epidermal growth factor (EGF (show EGF Proteins))-induced signaling.
The cloning and sequencing of an alternative splice form of CMTM8, obtained from a human blood cDNA library, that utilizes apoptotic pathways distinct from CMTM8, is reported.
This gene belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and the transmembrane 4 superfamilies. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 3. This gene is widely expressed in many tissues, but the exact function of the encoded protein is unknown.
MARVEL domain-containing protein 1
, CKLF-like MARVEL transmembrane domain containing 8
, CKLF-like MARVEL transmembrane domain-containing protein 8
, chemokine-like factor super family 8
, chemokine-like factor superfamily 8
, chemokine-like factor superfamily member 8
, chemokine-like related protein 8