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CDH22 is a member of the cadherin superfamily.
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Results describe the expression of Cdh22 in developing mouse brain and compare it to expression of related family members.
spatio-temporal mRNA distribution pattern of Cdh12 and Cdh22 during CNS development; demonstrate presence of Cdh12 and Cdh22 mRNA in both excitatory and inhibitory neurons in adult CNS including cerebellum, neocortex, hippocampus and subcortical nuclei
Results present evidence that CDH22 is hypermethylated and its expression is downregulated in breast cancer.
PRL-3 promoted downregulation of CDH22 expression.
Our results reveal for the first time a new role of CDH22 in progression of colorectal cancer.
This paper deals primarily with the rat ortholog of the human CDH22 gene.
This gene is a member of the cadherin superfamily. The gene product is composed of five cadherin repeat domains and a cytoplasmic tail similar to the highly conserved cytoplasmic region of classical cadherins. Expressed predominantly in the brain, this putative calcium-dependent cell adhesion protein may play an important role in morphogenesis and tissue formation in neural and non-neural cells during development and maintenance of the brain and neuroendocrine organs.
, pituitary and brain cadherin
, cadherin-like 22
, ortholog of rat PB-cadherin