Calbindin 2 Proteins (CALB2)

CALB2 encodes an intracellular calcium-binding protein belonging to the troponin C superfamily. Additionally we are shipping Calretinin Antibodies (201) and Calretinin Kits (24) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CALB2 794 P22676
CALB2 12308 Q08331
CALB2 117059 P47728
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Top Calretinin Proteins at

Showing 10 out of 21 products:

Catalog No. Origin Source Conjugate Images Quantity Delivery Price Details
Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 30 to 35 Days
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 30 to 35 Days
Escherichia coli (E. coli) Human His tag,T7 tag 100 μg 15 to 18 Days
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg 11 Days
Wheat germ Human GST tag 10 μg 11 to 12 Days
Escherichia coli (E. coli) Human His tag 100 μg 15 to 19 Days
Yeast Chicken His tag   1 mg 60 to 71 Days
Yeast Rat His tag   1 mg 60 to 71 Days
Yeast Cow His tag   1 mg 60 to 71 Days
Escherichia coli (E. coli) Mouse Un-conjugated   5 μg 2 to 3 Days

CALB2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, , ,
Mouse (Murine)

Rat (Rattus) ,

More Proteins for Calbindin 2 (CALB2) Interaction Partners

Human Calbindin 2 (CALB2) interaction partners

  1. issue and biofluid enrichment analyses show broad representation of EVs from across the body without bias towards kidney or urine proteins. Among the proteins linked to neurological diseases, SNAP23 and calbindin were the most elevated in Parkinson's disease cases with 86% prediction success for disease diagnosis in the discovery cohort and 76% prediction success in the replication cohort.

  2. the Calreticulin deficiency-mediated increase in cell death was not prevented by calbindin-D28k or Parvalbumin.

  3. we have identified septin 7, an essential cellular component implicated in the final steps of cell division, as a strong Bt-dependent gene regulatory protein binding to the promoter of CALB2.

  4. Calretinin was positive in 20 cases with MM.

  5. Calretinin could be verified as a blood-based marker for Malignant mesothelioma (MM). The assay is robust and shows a performance that is comparable to that of mesothelin. Retrospective analyses would not be limited by storage time. The high specificity supports a combination of calretinin with other markers.

  6. calretinin increases Leydig cell viability and proliferation, possibly via ERK1/2 and AKT pathways, and suppresses apoptosis possibly via the mitochondria-related apoptotic pathway

  7. expression of calretinin in human fetal testis specimens, was examined.

  8. In Malignant mesothelioma , increased calretinin expression is associated with epithelioid histology and better survival.

  9. Calretinin, D2-40 and mesothelin are aberrantly expressed in a proportion of CRC cases.

  10. We studied 38 bone marrow biopsy specimens of non-CML myeloproliferative neoplasms from 31 patients. All eight bone marrow biopsy specimens from patients with mutant CALR showed strong cytoplasmic staining of the megakaryocytes (83.5%; range, 50%-98%; median, 87%) with the CAL2 antibody.

  11. NCX1 and the calcium binding protein calretinin cooperate within the striatum to confer tolerance against cerebral ischemia.

  12. Age-related loss of CB appears to coincide with tangle formation in the BFCN and is associated with the full range of tau pathology, including late appearing epitopes.

  13. Overexpression of human calretinin in mouse primary mesothelial cells inversely affects proliferation and cell migration.

  14. Patients with Down syndrome may have enteric nervous system disorders functionally similar to HD, related to abnormal or imbalanced autonomic innervation, of which distal calretinin hypoinnervation is one manifestation, despite the presence of ganglia.

  15. the unique disposition of CALR at the MII spindle uncovers a physical interaction with endoplasmic reticulum that may mediate cytoskeletal remodelling during oocyte maturation.

  16. In focal cortical dysplasia (FCD), the density of CR positive neurons was increased in cortical layer V compared to non-FCD temporal lobe.

  17. might be used as a marker for the ameloblastomas and could play an important role in the differentiation of aggressiveness of different odontogenic tumors

  18. We concluded that WT1, but not calretinin, is a useful prognostic factor in malignant pleural mesothelioma

  19. This article reviews the information that is currently available on calretinin expression in tumors and on its application as an immunohistochemical marker in diagnostic pathology.

  20. Calretinin positivity was observed in all rectal biopsies of Hirschsprung disease showing the presence of ganglion cells, and the staining was consistently absent in all cases of aganglionosis.

Mouse (Murine) Calbindin 2 (CALB2) interaction partners

  1. calretinin as a Ca(2+)-binding protein participates in the regulation of steroidogenesis via the PLC-Ca(2+)-PKC pathway in Leydig cells

  2. The findings of this study suggest that there are at least three distinct classes of CR+ interneurons in the striatum of the rat and the mouse.

  3. The expression of calretinin was identified in spermatozoa.

  4. Results show that calretinin is differentially expressed, being present in the majority of substance P-, neurokinin B (NKB), gastrin-releasing peptide (GRP) expressing cells, but not in the neurotensin or dynorphin cells; inhibitory Cre-expressing cells in a Tac1(Cre) knock-in mouse are calretinin-immunoreactive.

  5. In this study we demonstrate dynamic changes in the number of calretinin- (CR) and neuropeptide Y-expressing (NPY) interneurons in the motor cortex of the familial hSOD1(G93A) ALS mouse model, suggesting their potential involvement in motor neuron circuitry defects.

  6. This study investigated the distribution of Ca2+-binding proteins (CaBPs), such as calbindin D28k, parvalbumin, and calretinin, in the Superior Olivary Complex of the circling mouse on postnatal day 16.

  7. Absence of calretinin in mouse primary mesothelial cells inversely affects proliferation and cell migration.

  8. CR may play an important role in the development of the paralemniscal pathway.

  9. Melatonin favors calretinin-positive neurons in the dentate gyrus of young mice but hippocampal neurogenesis and plasma levels of melatonin decrease during aging.

  10. EF-hand Ca(2+) buffers regulate presynaptic IHC function for metabolically efficient sound coding.

  11. distribution of the cell-specific markers, calretinin and calbindin, in reelin-immunoreactive cells during postnatal rat and mouse neocortical development

  12. calretinin can serve as a marker of the intermediate olfactory receptor neurons.

  13. Expression of calretinin in various hippocampal subfields is significantly lower in the circling mouse compared to wild-type.

  14. an unexpected role for CR in directly modulating effectors such as Ca(v)2.1, which may have major consequences for Ca(2+) signaling and neuronal excitability.

  15. Calretinin, a member of the EF-hand family of calcium-binding proteins, is preferentially associated with mutated huntingtin (Htt), although it also interacts with wild-type Htt.

  16. The decrease or absence of calretinin in granule cells of circling mice may perturb Purkinje cell function in vivo, which may affect normal behavior.

  17. calbindin D28-k and calretinin differences due to electromagnetic field exposure could cause changes in cellular Ca(2+)levels, which could have deleterious effect on normal hippocampal functions concerned with neuronal connectivity and integration.

  18. The present study showed that 86.59% (38,842/44,857) of mouse retinal ganglion cells contained calretinin.

  19. The expression of CR and its colocalization with neuronal nitric oxide synthase have been determined in different populations of hippocampal GABAergic neurons.

  20. calretinin protects neurons from Ca(2+)-dependent L-glutamate-induced delayed cytotoxicity

Zebrafish Calbindin 2 (CALB2) interaction partners

  1. Calb2a and Calb2b are highly conserved across vertebrate species and originated from the same ancestral gene long back in the evolution. Homology modeling and docking with the similar structure and Ca(2+) binding sites for both proteins provide the evidence that both the proteins may have similar function and one can compensate for the loss of other.

  2. Downregulation of CRT gene may cause omphalocele in the Cd chick model by disrupting CRT-mediated Ca(2+) signaling and AJs.

  3. pattern of expression in the retina at different developmental stages, as well as during optic nerve regeneration

  4. CR immunocytochemistry revealed patterns of fibers and neuropil in several telencephalic and diencephalic regions, indicating that it is a useful marker for characterizing neural centers, pathways, and neuronal subpopulations in the zebrafish forebrain.

  5. Calretinin (CD) is a marker of various neuronal populations distributed throughout the brainstem, as well as of characteristic tracts of fibers and neuropil. CR may prove useful for characterizing a number of neuronal subpopulations in zebrafish.

  6. The distribution of calretinin in mechanosensory (neuromasts of the lateral line system; maculae and cristae ampullaris of the inner ear) and chemosensory (superficial and oral taste buds; olfactory epithelium) cells in adult zebrafish (Danio rerio).

  7. the presence of calretinin in amacrine and ganglion cells is a conserved feature along vertebrate phylogeny and bipoly cell.

  8. The present study shows that CR-ir changes during lamprey spinal cord development in different types of neurons, sometimes in opposite ways.

Calretinin (CALB2) Protein Profile

Protein Summary

This gene encodes an intracellular calcium-binding protein belonging to the troponin C superfamily. Members of this protein family have six EF-hand domains which bind calcium. This protein plays a role in diverse cellular functions, including message targeting and intracellular calcium buffering. It also functions as a modulator of neuronal excitability, and is a diagnostic marker for some human diseases, including Hirschsprung disease and some cancers. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with Calbindin 2 Proteins (CALB2)

  • calbindin 2 (CALB2)
  • calbindin 2 (Calb2)
  • calbindin 2a (calb2a)
  • calbindin 2b (calb2b)
  • CAB29 protein
  • CAL2 protein
  • calb2 protein
  • calb2l protein
  • CR protein
  • wu:fq17g09 protein
  • wu:fq18e08 protein
  • zgc:73099 protein
  • zgc:73115 protein

Protein level used designations for Calbindin 2 Proteins (CALB2)

29 kDa calbindin , calbindin 2, (29kD, calretinin) , calbindin D29K , calretinin , CR , calbindin 2, 29kDa , calbindin 2, 29kDa (calretinin) , calbindin 2, like , calbindin 2 , calbindin 2, (calretinin) , calbindin 2b, (calretinin)

100068401 Equus caballus
794 Homo sapiens
12308 Mus musculus
117059 Rattus norvegicus
100127479 Sus scrofa
513947 Bos taurus
100731028 Cavia porcellus
610586 Canis lupus familiaris
101105843 Ovis aries
396255 Gallus gallus
393691 Danio rerio
393684 Danio rerio
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