Calcium Channel, Voltage Dependent, T Type, alpha 1I Subunit Proteins (CACNA1I)

CACNA1I encodes the pore-forming alpha subunit of a voltage gated calcium channel.

list all proteins Gene Name GeneID UniProt
Mouse CACNA1I CACNA1I 239556  
Human CACNA1I CACNA1I 8911 Q9P0X4
Rat CACNA1I CACNA1I 56827 Q9Z0Y8
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Top CACNA1I Proteins at antibodies-online.com

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Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,960.83
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Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
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More Proteins for Calcium Channel, Voltage Dependent, T Type, alpha 1I Subunit (CACNA1I) Interaction Partners

Mouse (Murine) Calcium Channel, Voltage Dependent, T Type, alpha 1I Subunit (CACNA1I) interaction partners

  1. Membrane-protein extraction and use of an intracellular protein (show CKAP2 Proteins)-transport inhibitor showed that GDF-15 (show GDF15 Proteins) promoted CaV3.1 (show CACNA1G Proteins) and CaV3.3 alpha-subunit (show POLG Proteins) expression by trafficking to the membrane.

  2. Extracellular pressure increases [Ca(2 (show CA2 Proteins)+)]i via Cav3.3, driving a PKC-beta (show PRKCB Proteins)- IKK (show CHUK Proteins)- IkB (show NFKBIB Proteins)-NF-kB pathway that stimulates cancer cell proliferation

  3. using Ca(V)3.3(-/-) mice we found that Ca(V)3.3 channels trigger synaptic plasticity in reticular thalamic neurons

  4. data identify a central role for Ca(V)3.3 channels in the rhythmogenic properties of the sleep-spindle generator and provide a molecular target to elucidate the roles of sleep spindles for brain function and development.

Human Calcium Channel, Voltage Dependent, T Type, alpha 1I Subunit (CACNA1I) interaction partners

  1. analyses suggest that a single copy of Chr22: 39665939G > A CACNA1I has the capacity to disrupt CaV3.3 channel-dependent functions, including rebound bursting in TRN (show TNPO1 Proteins) neurons, with potential implications for schizophrenia pathophysiology.

  2. low-voltage activation characteristics of CaV3.3 channels

  3. CACNA1I is a risk gene for schizophrenia in the Han Chinese population

  4. human Cav3.1, Cav3.2, and Cav3.3 T-type channels specifically associate with CaM at helix 2 of the gating brake in the I-II linker of the channels.

  5. significant association exists between the CACNA1I gene and schizophrenia in the Uighur Chinese population

  6. CACNA1I variant is associated with differential antiepileptic drug response in childhood absence epilepsy.

  7. CaV3.1 (show CACNA1G Proteins), CaV3.2 (show CACNA1H Proteins) and CaV3.3 channels, are best recognized for their negative voltage of activation and inactivation thresholds that allow them to operate near the resting membrane potential of neurons.

  8. Extracellular pressure increases [Ca(2 (show CA2 Proteins)+)]i via Cav3.3, driving a PKC-beta (show PRKCB Proteins)- IKK (show CHUK Proteins)- IkB (show NFKBIB Proteins)-NF-kB pathway that stimulates cancer cell proliferation

  9. Ethanol primarily affects the CaV3.2 isoform of T-type Ca(2)+ channels, acting through protein kinase C.

  10. Specific contribution of human T-type calcium channel isotypes (alpha(1G (show CACNA1G Proteins)), alpha(1H) and alpha(1I)) to neuronal excitability.

CACNA1I Protein Profile

Protein Summary

This gene encodes the pore-forming alpha subunit of a voltage gated calcium channel. The encoded protein is a member of a subfamily of calcium channels referred to as is a low voltage-activated, T-type, calcium channel. The channel encoded by this protein is characterized by a slower activation and inactivation compared to other T-type calcium channels. This protein may be involved in calcium signaling in neurons. Alternate splicing results in multiple transcript variants.

Gene names and symbols associated with CACNA1I

  • calcium voltage-gated channel subunit alpha1 I (CACNA1I)
  • voltage-dependent T-type calcium channel subunit alpha-1I (LOC100555412)
  • calcium channel, voltage-dependent, alpha 1I subunit (Cacna1i)
  • calcium voltage-gated channel subunit alpha1 I (Cacna1i)
  • calcium channel, voltage-dependent, T type, alpha 1I subunit (cacna1i)
  • Ca(v)3.3 protein
  • CACNA1L protein
  • Cav3.3 protein
  • si:ch211-51h13.1 protein

Protein level used designations for CACNA1I

alpha1I T-type calcium channel subunit , calcium channel, voltage-dependent, T type, alpha 1I subunit , voltage-dependent T-type calcium channel alpha-1I subunit , voltage-dependent T-type calcium channel subunit alpha-1I-like , low voltage-activated T-type calcium channel alpha-1 subunit (CACNA1I) , low-voltage-activated calcium channel alpha13.3 , calcium channel, voltage-dependent, alpha 1I subunit , voltage-dependent T-type calcium channel subunit alpha-1I , voltage-gated calcium channel subunit alpha Cav3.3 , caVT.3 , hypothetical gene supported by NM_020084 , voltage-dependent calcium channel

GENE ID SPECIES
282413 Bos taurus
427900 Gallus gallus
458848 Pan troglodytes
708146 Macaca mulatta
100432497 Pongo abelii
100555412 Anolis carolinensis
100587399 Nomascus leucogenys
239556 Mus musculus
8911 Homo sapiens
56827 Rattus norvegicus
566351 Danio rerio
481243 Canis lupus familiaris
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