Calcium Channel, Voltage Dependent, T Type, alpha 1I Subunit Proteins (CACNA1I)

CACNA1I encodes the pore-forming alpha subunit of a voltage gated calcium channel. Additionally we are shipping CACNA1I Antibodies (21) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Mouse CACNA1I CACNA1I 239556  
CACNA1I 8911 Q9P0X4
Rat CACNA1I CACNA1I 56827 Q9Z0Y8
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Top CACNA1I Proteins at antibodies-online.com

Showing 2 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$6,749.58
Details
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
Details

CACNA1I Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,

More Proteins for Calcium Channel, Voltage Dependent, T Type, alpha 1I Subunit (CACNA1I) Interaction Partners

Human Calcium Channel, Voltage Dependent, T Type, alpha 1I Subunit (CACNA1I) interaction partners

  1. analyses suggest that a single copy of Chr22: 39665939G > A CACNA1I has the capacity to disrupt CaV3.3 channel-dependent functions, including rebound bursting in TRN neurons, with potential implications for schizophrenia pathophysiology.

  2. low-voltage activation characteristics of CaV3.3 channels

  3. CACNA1I is a risk gene for schizophrenia in the Han Chinese population

  4. human Cav3.1, Cav3.2, and Cav3.3 T-type channels specifically associate with CaM at helix 2 of the gating brake in the I-II linker of the channels.

  5. In gastric cancer, expression of all the CACNA (1G, 1H, 1I) genes was associated with overall survival (OS) among stage I-IV patients. By combining the three potential biomarkers, a TTCC signature was developed, which retained a significant association with OS both in stage IV and stage I-III patients. Alterations in CACNA gene expression are linked to tumour prognosis.

  6. significant association exists between the CACNA1I gene and schizophrenia in the Uighur Chinese population

  7. CACNA1I variant is associated with differential antiepileptic drug response in childhood absence epilepsy.

  8. CaV3.1, CaV3.2 and CaV3.3 channels, are best recognized for their negative voltage of activation and inactivation thresholds that allow them to operate near the resting membrane potential of neurons.

  9. Extracellular pressure increases [Ca(2+)]i via Cav3.3, driving a PKC-beta- IKK- IkB-NF-kB pathway that stimulates cancer cell proliferation

  10. Ethanol primarily affects the CaV3.2 isoform of T-type Ca(2)+ channels, acting through protein kinase C.

  11. Specific contribution of human T-type calcium channel isotypes (alpha(1G), alpha(1H) and alpha(1I)) to neuronal excitability.

  12. intracellular regions after repeats I and IV play a role in gating interdependently, suggesting a direct interaction, and splice variation of Cav3.3 channels provides a mechanism for fine-tuning latency and duration of low-threshold spikes.

  13. CatSper1 and CatSper2 can associate with and modulate the function of the Ca(v)3.3 channel, which might be important in the regulation of sperm function.

  14. two distinct regions of the Cav3.3 channel are necessary and sufficient for complete M1 receptor-mediated channel inhibition

  15. The sodium channel toxins tetrodotoxin and saxitoxin interact with the alpha-subunit of T-type Ca 2+ channels.

CACNA1I Protein Profile

Protein Summary

This gene encodes the pore-forming alpha subunit of a voltage gated calcium channel. The encoded protein is a member of a subfamily of calcium channels referred to as is a low voltage-activated, T-type, calcium channel. The channel encoded by this protein is characterized by a slower activation and inactivation compared to other T-type calcium channels. This protein may be involved in calcium signaling in neurons. Alternate splicing results in multiple transcript variants.

Gene names and symbols associated with CACNA1I

  • calcium voltage-gated channel subunit alpha1 I (CACNA1I)
  • voltage-dependent T-type calcium channel subunit alpha-1I (LOC100555412)
  • calcium channel, voltage-dependent, alpha 1I subunit (Cacna1i)
  • calcium voltage-gated channel subunit alpha1 I (Cacna1i)
  • calcium channel, voltage-dependent, T type, alpha 1I subunit (cacna1i)
  • Ca(v)3.3 protein
  • CACNA1L protein
  • Cav3.3 protein
  • si:ch211-51h13.1 protein

Protein level used designations for CACNA1I

alpha1I T-type calcium channel subunit , calcium channel, voltage-dependent, T type, alpha 1I subunit , voltage-dependent T-type calcium channel alpha-1I subunit , voltage-dependent T-type calcium channel subunit alpha-1I-like , low voltage-activated T-type calcium channel alpha-1 subunit (CACNA1I) , low-voltage-activated calcium channel alpha13.3 , calcium channel, voltage-dependent, alpha 1I subunit , voltage-dependent T-type calcium channel subunit alpha-1I , voltage-gated calcium channel subunit alpha Cav3.3 , caVT.3 , hypothetical gene supported by NM_020084 , voltage-dependent calcium channel

GENE ID SPECIES
282413 Bos taurus
427900 Gallus gallus
458848 Pan troglodytes
708146 Macaca mulatta
100432497 Pongo abelii
100555412 Anolis carolinensis
100587399 Nomascus leucogenys
239556 Mus musculus
8911 Homo sapiens
56827 Rattus norvegicus
566351 Danio rerio
481243 Canis lupus familiaris
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