anti-Calcium Independent Phospholipase A2 (PNPLA2) Antibodies

PNPLA2 encodes an enzyme which catalyzes the first step in the hydrolysis of triglycerides in adipose tissue. Additionally we are shipping Calcium Independent Phospholipase A2 Kits (7) and and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
PNPLA2 57104 Q96AD5
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Top anti-Calcium Independent Phospholipase A2 Antibodies at

Showing 5 out of 5 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Human Rabbit Un-conjugated IF/ICC, IHC, IP, WB Western blot analysis of (1) Human U87-MG Cells and (2) Mouse Testis Tissue. Western blot analysis of recombinant Human iPLA2. 100 μg 11 to 18 Days
Mouse Rabbit Un-conjugated IF/ICC, IHC, IP, WB Western blot analysis of Rat Testis lysate, using Mouse iPLA2 Antibody (1 µg/ml) and HRP-conjugated Goat Anti-Rabbit antibody ( Western blot analysis of the recombinant protein. 100 μg 11 to 18 Days
Rat Rabbit Un-conjugated IF/ICC, IHC, IP, WB Western blot analysis of the recombinant protein. IHC-P analysis of Liver tissue, with DAB staining. 100 μg 11 to 18 Days
Human Mouse Un-conjugated IF/ICC, IHC, IP, WB   200 μg 11 to 18 Days
Rat Mouse Un-conjugated IF/ICC, IHC, IP, WB   200 μg 11 to 18 Days

More Antibodies against Calcium Independent Phospholipase A2 Interaction Partners

Human Calcium Independent Phospholipase A2 (PNPLA2) interaction partners

  1. Gene analysis for PNPLA2 revealed an identical homozygous mutation c.757+1G>T in all patients

  2. ATGL is highly expressed in hepatocellular carcinoma (HCC) tissues and predicts a poor prognosis. ATGL promotes HCC cell growth by maintaining elevated levels of diacylglycerol and free fatty acids in vitro and in vivo.

  3. Obese patients had a decrease in ATGL expression in subcutaneous adipose tissue.

  4. loss of ATGL may thus increase cancer aggressiveness by activation of pro-oncogenic signaling via SRC kinase and increased levels of bioactive lipids.

  5. Evidence for a previously uncovered tumor-suppressor function of ATGL in hepatocellular carcinoma, with the outlined molecular mechanisms shedding light on new potential targets for anticancer therapy.

  6. No difference in the genotype frequency of rs7925131 or rs7942159 in PNPLA2 between the normal free fatty acids (FFA) group and the high FFA group in a Chinese Han population.

  7. Non-cardiac ATGL-mediated modulation of the cardiac lipidome may play an important role in the pathogenesis of chronic heart failure.

  8. Although we found evidence for moderate association between PNPLA2 tagSNPs and anthropometric and metabolic parameters in our cohort, no evidence for association between polymorphisms in the PNPLA2 gene and the presence and severity of non-alcoholic fatty liver disease was identified.

  9. Study reports the derivation of iPSCs from fibroblasts of two Neutral Lipid Storage Disease with Myopathy (NLSDM)patients carrying different ATGL mutations. These iPSCs exhibited defects in neutral lipid metabolism similar to those of NLSDM fibroblasts. NLSDM-iPSCs were able to undergo directed differentiation into cardiomyocytes.

  10. Thus, ATGL in leucocytes may be an important biomarker for the diagnosis of TGCV and our assay may provide insights into pathophysiology and elucidate the underlying mechanism of TGCV and related disorders.

  11. The ATGL gene was frequently deleted in various forms of human cancers and was associated with poor prognosis.

  12. a Snail1-ATGL axis that regulates adipose lipolysis and fatty acid release, is reported.

  13. ABHD5 possesses a PNPLA2-independent function in regulating autophagy and tumorigenesis.

  14. Oxidative stress decreased the levels of PNPLA2 transcripts with no effect on ALOX5 expression. Exogenous additions of P1 peptide or overexpression of the PNPLA2 gene decreased both LTB4 levels and death of RPE cells undergoing oxidative stress.

  15. Results suggest that increased adipose triglyceride lipase (ATGL) expression is associated with increased adiposity and stromal proliferation in patients with pancreatic ductal adenocarcinoma (PDAC).

  16. A missense mutation in PNPLA2 is the rare cause of severe dilated cardiomyopathy secondary to neutral lipid storage disease.

  17. A novel deletion was identified in PNPLA2 protein from a patient with complete deficiency of adipose triglyceride lipase.

  18. Rab32 controls intracellular lipid accumulation through inducing lipolysis via enhancing ATGL expression indirectly.

  19. Data indicate that a tumor suppressor mechanism by which G0/G1 switch gene 2 product (G0S2) directly inhibits activity of a key intracellular adipose triglyceride lipase (ATGL).

  20. Authors show that rat ATGL, coactivated by rat CGI-58, efficiently hydrolyzes triglycerides and retinyl ester.

Calcium Independent Phospholipase A2 (PNPLA2) Antigen Profile

Protein Summary

This gene encodes an enzyme which catalyzes the first step in the hydrolysis of triglycerides in adipose tissue. Mutations in this gene are associated with neutral lipid storage disease with myopathy.

Gene names and symbols associated with PNPLA2

  • patatin like phospholipase domain containing 2 (PNPLA2) antibody
  • 1110001C14Rik antibody
  • ATGL antibody
  • iPLA2zeta antibody
  • PEDF-R antibody
  • TTS-2.2 antibody
  • TTS2 antibody

Protein level used designations for PNPLA2

IPLA2-zeta , TTS2.2 , adipose triglyceride lipase , calcium-independent phospholipase A2 , desnutrin , patatin-like phospholipase domain containing protein 2 , patatin-like phospholipase domain-containing protein 2 , pigment epithelium-derived factor , transport-secretion protein 2.2 , triglyceride hydrolase

57104 Homo sapiens
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