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The cannabinoid delta-9-tetrahydrocannabinol is the principal psychoactive ingredient of marijuana.
Showing 7 out of 17 products:
Rat (Rattus) CNR2 ELISA Kit for Sandwich ELISA - ABIN434138
Wang, Zheng, Kulkarni, Wang, Garg, Prather, Hauer-Jensen: Palmitoylethanolamide Regulates Development of Intestinal Radiation Injury in a Mast Cell-Dependent Manner. in Digestive diseases and sciences 2014
Histological analyses revealed numerous endocrinal cell clusters or islets which were distributed among exocrine adenomeri in connectival tissue. Immunohistochemistry showed that endocrine-islets contained some CB2-positive cells with a very peculiar localization that is a few primarily localized at the edges of islets and some of them also scattered in the center of the cluster.
genetic or chemical inhibition of cannabinoid receptor (Cnr (show PCDHA1 ELISA Kits)) activity disrupts liver development and metabolic function in zebrafish.
Cannabinoid Receptor-2 Regulates Embryonic Hematopoietic Stem Cell Development via Prostaglandin E2 and P-Selectin (show SELP ELISA Kits) Activity.
Activation of the Cnr2 receptor inhibits leukocyte migration in response to acute injury.
Carriers of the minor allele of rs3123554 variant of CB2R gene loose less body weight during two different hypocaloric diets. The improvement of metabolic parameters was better in no A allele carriers than A allele carriers.
All of the epithelial layers in 94, 78, 96, 73 and 80% of pterygia cases, exhibited CB1 (show CNR1 ELISA Kits), CB2, TRPV1 (show TRPV1 ELISA Kits), TRPV2 (show TRPV2 ELISA Kits) and TRPV3 (show TRPV3 ELISA Kits) cytoplasmic immunoreactivity, respectively.
CB2 activation with sub-micromolar doses of agonists, which could be more similar to endogenous levels of cannabinoids, promote colon cancer progression in a process that involves AKT and GSK3beta.
stimulation of MAPK (show MAPK1 ELISA Kits) contributes to the peripheral analgesic effect of CB2 receptor agonists.
Describe PM226, a chromenoisoxazole, as a selective CB2 receptor agonist with neuroprotective properties.
Our data indicate that CB2 may directly contribute to the pathogenesis of eosinophil-driven diseases. Moreover, we provide new insights into the molecular mechanisms underlying the CB2 -mediated priming of eosinophils.
hepatic expression of CB1 (show CNR1 ELISA Kits) and CB2 plays an important role during the progression of fibrosis induced by chronic hepatitis B
analysis of the interplay between the CB2-RR variant and liver necroinflammation in chronic hepatitis patients with HIV/HCV coinfection
Patients with schizophrenia showed increased CB2R expression in cells of the innate immune system and simpler correlation network between cytokines and CBRs expression when compared with controls.
Data suggest that signaling via endocannabinoids and CNR1/CNR2 plays central role in food intake; the endocannabinoid system regulates bidirectional communication (in the context of energy intake and storage) between the brain and peripheral tissues (adipose tissue, liver, gastrointestinal tract, endocrine pancreas, and skeletal muscle). [REVIEW]
Activation of cannabinoid receptor subtype 2 (CB2R) eliminates acetylcholine (ACh (show FGFR3 ELISA Kits))-induced Ca(2 (show CA2 ELISA Kits)+) oscillations and L-arginine (show GATM ELISA Kits)-induced enhancement of Ca(2 (show CA2 ELISA Kits)+) signaling in mouse pancreatic acinar cells.
Altogether our findings highlight a pro-meiotic role of CB2R in male and female germ cells and suggest that the use of cannabis in pregnant female might represent a risk for fertility and reproductive lifespan in female offspring.
Evidence has been obtained for CB2 receptor involvement in LPS-induced reduction of cAMP intracellular levels in uterine explants from pregnant mice.
CB2 receptor activation in macrophages protects from alcohol-induced steatosis by inhibiting hepatic inflammation through an autophagy-dependent pathway
Combined deficiency of the Cnr1 and Cnr2 receptors protects against age-related bone loss by osteoclast inhibition.
The results of this study suggested that the Cb2 receptor system is rapidly induced during anxiogenic social interactions plus fear conditioning or exercise; with responses potentially adaptive for coping mechanisms.
CB2 activation is crucial in regulating pulmonary NK cell function, and suggest that NK cells serve to limit ILC2 group 2 innate lymphoid cell activation (show ENTPD1 ELISA Kits) and subsequent allergic airway inflammation.
Results provide direct pharmacological evidence in vitro and in vivo of a role of CB2R in central glucoregulation. Additionally, it found that glucoregulation by endogenous CB2R signalling is negatively affected by beta-amyloidosis, thought to be the first pathological step in Alzheimer's disease.
Deletion of the CB2R has been shown to worsen outcome, while selective CB2R agonists have been demonstrated to be neuroprotective following stroke
The cannabinoid delta-9-tetrahydrocannabinol is the principal psychoactive ingredient of marijuana. The proteins encoded by this gene and the cannabinoid receptor 1 (brain) (CNR1) gene have the characteristics of a guanine nucleotide-binding protein (G-protein)-coupled receptor for cannabinoids. They inhibit adenylate cyclase activity in a dose-dependent, stereoselective, and pertussis toxin-sensitive manner. These proteins have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. The cannabinoid receptors are members of family 1 of the G-protein-coupled receptors.
cannabinoid receptor 2 (macrophage)
, cannabinoid receptor 2
, cannabinoid receptor 2 type A
, cannabinoid receptor-like cb2-zf
, testis-dominant CNR2 isoform CB2
, CB2 receptor
, peripheral cannabinoid receptor
, cannabinoid receptor 2 (spleen)