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Positive regulator of neurite outgrowth by stabilizing myosin regulatory light chain (MRLC). Additionally we are shipping CNPY2 Kits (9) and CNPY2 Proteins (9) and many more products for this protein.
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Free CNPY2 then engages protein kinase (show CDK7 Antibodies) R-like endoplasmic reticulum kinase (PERK (show EIF2AK3 Antibodies)) to induce expression of the transcription factor C/EBP homologous protein (CHOP (show DDIT3 Antibodies)), thereby initiating the unfolded protein response.
CNPY2 may play a critical role in colorectal cancer development by enhancing cell proliferation, migration, and angiogenesis and by inhibiting apoptosis through negative regulation of the p53 (show TP53 Antibodies) pathway
The data demonstrate CNPY2 is widely distributed in tissues and suggest the protein has biological functions that have yet to be identified.
CNPY2 is a HIF-1alpha (show HIF1A Antibodies)-regulated, secreted angiogenic growth factor that promotes smooth muscle cell migration, proliferation, and tissue revascularization.
Overexpression of CNPY2 can activate the AKT (show AKT1 Antibodies)/GSK3beta pathway, which leads to the inactivation of GSK-3beta. The inactivation of GSK-3beta increases the level of Snail (show SNAI1 Antibodies), and then decreases the expression of E-cadherin (show CDH1 Antibodies) to promote EMT (show ITK Antibodies).
CNPY2 can serve as a therapeutic target to promote the effect of chemotherapy in non-small cell lung cancer.
CNPY2 isoform2 represents as a novel and valuable prognostic indicator for colorectal cancer patients.
These findings suggested that CNPY2 promoted cancer cell growth in renal cell carcinoma (show MOK Antibodies) cells through regulating TP53 (show TP53 Antibodies) gene expression.
Our results are consistent with an important role of FGF21 (show FGF21 Antibodies) and Cnpy2/Msap in the regulation of LDLRs in cultured cells.
MSAP is a novel MIR-interacting protein that enhances neurite outgrowth and increases myosin regulatory light chain in fetal and adult brain.
Positive regulator of neurite outgrowth by stabilizing myosin regulatory light chain (MRLC). It prevents MIR-mediated MRLC ubiquitination and its subsequent proteasomal degradation (By similarity).
MIR-interacting saposin-like protein
, protein canopy homolog 2
, putative secreted protein ZSIG9
, transmembrane protein 4
, canopy 2 homolog
, putative secreted protein Zsig9