anti-Carbonic Anhydrase IV (CA4) Antibodies

Human Carbonic Anhydrase IV (CA4) interaction partners

1. CA4 is a novel tumour suppressor in Colorectal cancer through the inhibition of the Wnt (show WNT2 Antibodies) signalling pathway by targeting the WTAP (show WTAP Antibodies)-WT1 (show WT1 Antibodies)-TBL1 (show TBL1X Antibodies) axis. CA4 methylation may serve as an independent biomarker for the recurrence of Colorectal cancer .

2. Carbonic anhydrase 4 is lost in papillary thyroid carcinoma but not thyroid nodules

3. Although CA IV has been shown to be active in mediating CO2 and HCO3 (-) transport in many important tissues like kidney and lung, and in isolated cells from brain and muscle, the gene for CA IV appears not to be essential.

4. Coexpression of CAIV with MCT1 (show CMA1 Antibodies) and MCT4 (show SLC16A4 Antibodies) resulted in a significant increase in MCT (show MCAT Antibodies) transport activity.

5. The generation of CA III (show CA3 Antibodies) and IV autoantibodies, antioxidant enzymes, and cytokines might influence each other.

6. membrane-associated CA IV contributes robust catalytic activity intracellularly, and this activity participates in regulating H(+) dynamics in the cytosol

7. Two SNPs of carbonic anhydrase IV, which are responsible for amino acid changes, were found. The frequencies of these SNPs were not significantly different between the caries-free group and the group with caries

8. data suggest that extracellular membrane-bound CAIV, but not cytosolic CAII (show CA2 Antibodies), augments transport activity of MCT2 (show SLC16A7 Antibodies) in a non-catalytic manner, possibly by facilitating a proton pathway other than His-88

9. compared the subcellular localization and post-translational processing of wild-type (WT)- and retinitis pigmentosa 17 mutant-CAIV in three cell types

10. The results suggest that the expression level of carbonic anhydrase IV may be important to maintain retina function in retinitis pigmentosa.

Mouse (Murine) Carbonic Anhydrase IV (CA4) interaction partners

1. Mice with a mutant thyroid hormone receptor alpha1 (show THRA Antibodies) have permanently reduced Car4 in lung and brain. These findings identify a previously unknown marker of thyroid hormone receptor alpha1 (show THRA Antibodies) action in brain and lung.

2. two CA isoforms, CAII (show CA2 Antibodies) and CAIV, are distributed along the epididymal epithelium and appear with the onset of puberty

3. eosinophils express CAR4 following IL-5 (show IL5 Antibodies) or allergen exposure, and that CAR4 is involved in regulating the lung transcriptome associated with allergic airway inflammation

4. membrane-associated CA IV contributes robust catalytic activity intracellularly, and this activity participates in regulating H(+) dynamics in the cytosol in neurons

5. Data show a 32.13% reduction in total CA activity in CA IV(-/-) mice.

6. Car4, Car6, and Car12 showed moderate expression levels in the mouse harderian gland.

7. Data show that spermatozoa pick up membrane-bound carbonic anhydrase IV during their passage through the epididymal duct.

8. Both carbonic anhydrase 4 (CA4) and CA14 (show CA14 Antibodies) contribute to neuronal pH regulation by enabling the acid-loading function of anion exchanger AE3 (show SLC4A3 Antibodies) protein.

9. Decreased expression of colonic Slc26a3 (show SLC26A3 Antibodies) and carbonic anhydrase iv as a cause of fatal infectious diarrhea in mice.

10. study demonstrated that the sour-sensing cells act as the taste sensors for carbonation, and showed that carbonic anhydrase 4, a glycosylphosphatidylinositol-anchored enzyme, functions as the principal CO2 taste sensor