anti-Carbonic Anhydrase IV (CA4) Antibodies

Human Carbonic Anhydrase IV (CA4) interaction partners

1. CA4 is a novel tumour suppressor in Colorectal cancer through the inhibition of the Wnt signalling pathway by targeting the WTAP-WT1-TBL1 axis. CA4 methylation may serve as an independent biomarker for the recurrence of Colorectal cancer .

2. Carbonic anhydrase 4 is lost in papillary thyroid carcinoma but not thyroid nodules

3. Although CA IV has been shown to be active in mediating CO2 and HCO3 (-) transport in many important tissues like kidney and lung, and in isolated cells from brain and muscle, the gene for CA IV appears not to be essential.

4. Coexpression of CAIV with MCT1 and MCT4 resulted in a significant increase in MCT transport activity.

5. The generation of CA III and IV autoantibodies, antioxidant enzymes, and cytokines might influence each other.

6. membrane-associated CA IV contributes robust catalytic activity intracellularly, and this activity participates in regulating H(+) dynamics in the cytosol

7. Two SNPs of carbonic anhydrase IV, which are responsible for amino acid changes, were found. The frequencies of these SNPs were not significantly different between the caries-free group and the group with caries

8. data suggest that extracellular membrane-bound CAIV, but not cytosolic CAII, augments transport activity of MCT2 in a non-catalytic manner, possibly by facilitating a proton pathway other than His-88

9. compared the subcellular localization and post-translational processing of wild-type (WT)- and retinitis pigmentosa 17 mutant-CAIV in three cell types

10. The results suggest that the expression level of carbonic anhydrase IV may be important to maintain retina function in retinitis pigmentosa.

11. renal injury inflicted by expression of human carbonic anhydrase IV folding mutants was markedly enhanced by haploinsufficiency of the endoplasmic reticulum cochaperone p58(IPK).

12. binding by extracellular loop 4 of the human AE1 Cl-/HCO3- exchanger

13. carbonic anhydrase IV binds EC4 of NBC1, and this interaction is essential for full NBC1 activity

14. mutation was found to cosegregate with the retinitis pigmentosa RP17 phenotype in two large families

15. CA inhibitors may have long-term adverse effects on vision.

16. characterized the CA IV expressed in Capan-1 cells

17. A novel mutation has been identified in CA4 that provides further evidence that impaired pH regulation may underlie photoreceptor degeneration in retinitis pigmentosa

18. No mutation was found in the coding regions and intron-exon boundaries of the genes for CA II, CA IV, CA XIV, kNCB1, NHE3, NHE8, NHRF1, NHRF2 and SLC26A6 amplified from genomic DNA of family members with pRTA.

19. CAIV p.R14W sequence variant found in one of the patients with Bothnia dystrophy phenotype is benign polymorphism in population of northern Sweden.

20. Apoptosis induced by the CA IV mutants could be prevented, at least partially, by treating the cells with dorzolamide, a CA inhibitor

Mouse (Murine) Carbonic Anhydrase IV (CA4) interaction partners

1. Mice with a mutant thyroid hormone receptor alpha1 have permanently reduced Car4 in lung and brain. These findings identify a previously unknown marker of thyroid hormone receptor alpha1 action in brain and lung.

2. two CA isoforms, CAII and CAIV, are distributed along the epididymal epithelium and appear with the onset of puberty

3. eosinophils express CAR4 following IL-5 or allergen exposure, and that CAR4 is involved in regulating the lung transcriptome associated with allergic airway inflammation

4. membrane-associated CA IV contributes robust catalytic activity intracellularly, and this activity participates in regulating H(+) dynamics in the cytosol in neurons

5. Data show a 32.13% reduction in total CA activity in CA IV(-/-) mice.

6. Car4, Car6, and Car12 showed moderate expression levels in the mouse harderian gland.

7. Both methazolamide and dichlorphenamide increased the tetanic muscle force in the treated M. extensor digitorum longus muscle group.

8. Data show that spermatozoa pick up membrane-bound carbonic anhydrase IV during their passage through the epididymal duct.

9. studies on hippocampal slices on these KO mice showed that either CA can mediate buffering after synaptic transmission in hippocampal slices in the absence of the other, but that eliminating both is as effective in blocking the buffering seen in WT mice

10. Both carbonic anhydrase 4 (CA4) and CA14 contribute to neuronal pH regulation by enabling the acid-loading function of anion exchanger AE3 protein.

11. Decreased expression of colonic Slc26a3 and carbonic anhydrase iv as a cause of fatal infectious diarrhea in mice.

12. study demonstrated that the sour-sensing cells act as the taste sensors for carbonation, and showed that carbonic anhydrase 4, a glycosylphosphatidylinositol-anchored enzyme, functions as the principal CO2 taste sensor