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Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. Additionally we are shipping Carbonic Anhydrase IX Kits (58) and Carbonic Anhydrase IX Proteins (25) and many more products for this protein.
Showing 10 out of 304 products:
Dog (Canine) Polyclonal CA9 Primary Antibody for ChIP, ELISA - ABIN151877
Kaidi, Moorghen, Williams, Paraskeva: Is the downregulation of EphB2 receptor expression during colorectal tumorigenesis due to hypoxia? in Gut 2007
Show all 144 Pubmed References
Dog (Canine) Polyclonal CA9 Primary Antibody for ELISA, ICC - ABIN251625
Bui, Seligson, Han, Pantuck, Dorey, Huang, Horvath, Leibovich, Chopra, Liao, Stanbridge, Lerman, Palotie, Figlin, Belldegrun: Carbonic anhydrase IX is an independent predictor of survival in advanced renal clear cell carcinoma: implications for prognosis and therapy. in Clinical cancer research : an official journal of the American Association for Cancer Research 2003
Show all 7 Pubmed References
Dog (Canine) Polyclonal CA9 Primary Antibody for ELISA, IHC (fro) - ABIN251626
Sathornsumetee, Cao, Marcello, Herndon, McLendon, Desjardins, Friedman, Dewhirst, Vredenburgh, Rich: Tumor angiogenic and hypoxic profiles predict radiographic response and survival in malignant astrocytoma patients treated with bevacizumab and irinotecan. in Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2008
Show all 5 Pubmed References
Human Monoclonal CA9 Primary Antibody for CyTOF, ELISA - ABIN4287748
Cai, Alshehri, Choksi, Pestronk: Regional ischemic immune myopathy: a paraneoplastic dermatomyopathy. in Journal of neuropathology and experimental neurology 2014
Show all 3 Pubmed References
Human Monoclonal CA9 Primary Antibody for FACS, ELISA - ABIN1724882
Pinheiro, Sousa, Albergaria, Paredes, Dufloth, Vieira, Schmitt, Baltazar: GLUT1 and CAIX expression profiles in breast cancer correlate with adverse prognostic factors and MCT1 overexpression. in Histology and histopathology 2011
Show all 2 Pubmed References
Human Monoclonal CA9 Primary Antibody for IHC, ELISA - ABIN1724883
Neumeister, Sullivan, Lindner, Lezon-Geyda, Li, Zavada, Martel, Glazer, Tuck, Rimm, Harris: Hypoxia-induced protein CAIX is associated with somatic loss of BRCA1 protein and pathway activity in triple negative breast cancer. in Breast cancer research and treatment 2012
Show all 2 Pubmed References
Human Polyclonal CA9 Primary Antibody for IF (p), IHC (p) - ABIN752773
Gogiraju, Xu, Bochenek, Steinbrecher, Lehnart, Wenzel, Kessel, Zeisberg, Dobbelstein, Schäfer: Endothelial p53 deletion improves angiogenesis and prevents cardiac fibrosis and heart failure induced by pressure overload in mice. in Journal of the American Heart Association 2015
Human Polyclonal CA9 Primary Antibody for CyTOF, FACS - ABIN4900431
Swayampakula, McDonald, Vallejo, Coyaud, Chafe, Westerback, Venkateswaran, Shankar, Gao, Laurent, Lou, Bennewith, Supuran, Nabi, Raught, Dedhar: The interactome of metabolic enzyme carbonic anhydrase IX reveals novel roles in tumor cell migration and invadopodia/MMP14-mediated invasion. in Oncogene 2017
Human Monoclonal CA9 Primary Antibody for FACS - ABIN4897691
McIntyre, Patiar, Wigfield, Li, Ledaki, Turley, Leek, Snell, Gatter, Sly, Vaughan-Jones, Swietach, Harris: Carbonic anhydrase IX promotes tumor growth and necrosis in vivo and inhibition enhances anti-VEGF therapy. in Clinical cancer research : an official journal of the American Association for Cancer Research 2012
Human Monoclonal CA9 Primary Antibody for CyTOF, ELISA (Capture) - ABIN4900432
Tan, Zhai, Chang, Hou, He, Lin, Yu, Xu, Xiao, Ma, Wang, Cao, Cao: Global analysis of metastasis-associated gene expression in primary cultures from clinical specimens of clear-cell renal-cell carcinoma. in International journal of cancer 2008
Authors demonstrate that CAIX associates with MMP14 (show MMP14 Antibodies) through potential phosphorylation residues within its intracellular domain, and that CAIX enhances MMP14 (show MMP14 Antibodies)-mediated collagen degradation by directly contributing hydrogen ions required for MMP14 (show MMP14 Antibodies) catalytic activity.
Loss of Function Screening Reveals Carbonic Anhydrase IX as a Key Modulator of Tumor Initiating Potential in Primary Pancreatic Tumors.
constitutive activation of the NF-kappaB (show NFKB1 Antibodies) pathway in CAIX-depleted cells restored G-CSF (show CSF3 Antibodies) secretion
Downregulation of carbonic anhydrase IX promotes Col10a1 (show COL10A1 Antibodies) expression in chondrocytes.
CA IX may directly or indirectly play novel functions in brain tissue.
Data show that CA9, GLUT1 (show SLC2A1 Antibodies) and LOX (show LOX Antibodies) mRNA levels were equally and strongly correlated to hypoxic extent in FaDudd, and the same profile was observed for CA9 and GLUT1 (show SLC2A1 Antibodies), but not LOX (show LOX Antibodies), in SCCVII tumors.
a novel role for CA IX in the regulation of immunologic processes and digestion
although CA IX-deficiency is not a tumor-promoting factor per se, it induces glandular atrophy in the body mucosa, a lesion which is considered to be a preneoplastic alteration in the stomach
These results suggest that the loss of function of cytosolic CA II (show CA2 Antibodies) in the stomach of Car2 (show CA2 Antibodies)-/- mice leads to up-regulation of an extracellular CA, namely CA IX, which is expressed on the cell surface of the gastric epithelium.
CA9 may regulate ion and pH homeostasis within the developing embryo.
CAIX enzyme inhibition assay showed the IC50 values in nM range. Though all the three compounds (1-3) showed a good binding with CAIX, compound 2 showed the best inhibition of CAIX activity. These compounds were non-toxic on normal cell lines (HEK (show EPHA3 Antibodies)-293) and significantly inhibit the proliferation of hypoxic cancer cells
CA9 expression was observed in normal islets, while neuroendocrine microadenomas and small (< 1 cm) pancreatic neuroendocrine neoplasms/tumors showed CA9 expression loss.
Study revealed that CA9 expression was a pivotal predictive factor for poor prognosis after radical surgery for HCC (show FAM126A Antibodies). Moreover, the CA9 regulation of the expression of EMT (show ITK Antibodies)-related molecules represented a mechanism that enhanced malignant potential.
Report weak CA9 immunoreactivity in majority of CA9 positive colorectal carcinoma cases associated with macroscopic growth pattern.
Molecular characterization of carbonic anhydrase IX catalytic domain has been presented.
Authors present evidence that enhanced autophagy does not play a role in the enhanced growth of the CA9+ cells. Our study suggests a direct in vivo functional link between hypoxic cells and CICs in primary cervix cancer xenografts.
Genetic disruption of the intracellular pH-regulating proteins Na+/H+ exchanger 1 (SLC9A1 (show SLC9A1 Antibodies)) and carbonic anhydrase 9 reduces the proliferation of colon cancer cells.
combined CA9-/CD147-capture antibodies demonstrated high efficiency for capturing circulating renal cell carcinoma (show MOK Antibodies) cells
Data show that targeting the hypoxic tumor compartment by knockdown of carbonic anhydrase IX (CAIX) using short hairpin RNA or by chemical inhibition of CAIX with acetazolamide potentiates the anti-cancer activity of mTOR (show FRAP1 Antibodies) inhibitors rapamycin.
Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA IX is a transmembrane protein and the only tumor-associated carbonic anhydrase isoenzyme known. It is expressed in all clear-cell renal cell carcinoma, but is not detected in normal kidney or most other normal tissues. It may be involved in cell proliferation and transformation. This gene was mapped to 17q21.2 by fluorescence in situ hybridization, however, radiation hybrid mapping localized it to 9p13-p12.
carbonic anhydrase IX
, carbonic anhydrase 9
, carbonate dehydratase IX
, membrane antigen MN homolog
, RCC-associated antigen G250
, RCC-associated protein G250
, carbonic dehydratase
, membrane antigen MN
, renal cell carcinoma-associated antigen G250