anti-Carbonic Anhydrase IX (CA9) Antibodies

Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. Additionally we are shipping Carbonic Anhydrase IX Proteins (24) and Carbonic Anhydrase IX Kits (21) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
CA9 230099 Q8VHB5
CA9 313495  
CA9 768 Q16790
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Top anti-Carbonic Anhydrase IX Antibodies at antibodies-online.com

Showing 10 out of 260 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Human Rabbit Un-conjugated WB Western blot analysis of Carbonic Anhydrase 9 expression in HeLa (A), Ramos (B), Molt4 (C) whole cell lysates. 200 μL 13 to 14 Days
$487.50
Details
Human Rabbit Un-conjugated EIA, WB 0.4 mL 6 to 8 Days
$484.00
Details
Human Rabbit Un-conjugated EIA, WB 0.4 mL 6 to 8 Days
$484.00
Details
Human Mouse Un-conjugated FACS, ELISA, WB 0.1 mg 3 to 4 Days
$430.10
Details
Human Mouse Un-conjugated IHC, ELISA, WB 0.1 mg 3 to 4 Days
$430.10
Details
Human Rabbit Un-conjugated ELISA, WB 100 μL Available
$363.46
Details
Horse Mouse APC FACS, IF, IHC (f), WB 250 μL 3 to 4 Days
$441.85
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Horse Mouse PE FACS, IF, IHC (f), WB 250 μL 3 to 4 Days
$441.85
Details
Horse Mouse PerCP FACS, IF, IHC (f), WB 250 μL 3 to 4 Days
$441.85
Details
Horse Mouse Un-conjugated FACS, IF, IHC (f), WB 50 μL 3 to 4 Days
$455.38
Details

Top referenced anti-Carbonic Anhydrase IX Antibodies

  1. Dog (Canine) Polyclonal CA9 Primary Antibody for ChIP, ELISA - ABIN151877 : Kaidi, Moorghen, Williams, Paraskeva: Is the downregulation of EphB2 receptor expression during colorectal tumorigenesis due to hypoxia? in Gut 2007 (PubMed)
    Show all 179 Pubmed References

  2. Dog (Canine) Polyclonal CA9 Primary Antibody for ELISA, ICC - ABIN251625 : Bui, Seligson, Han, Pantuck, Dorey, Huang, Horvath, Leibovich, Chopra, Liao, Stanbridge, Lerman, Palotie, Figlin, Belldegrun: Carbonic anhydrase IX is an independent predictor of survival in advanced renal clear cell carcinoma: implications for prognosis and therapy. in Clinical cancer research : an official journal of the American Association for Cancer Research 2003 (PubMed)
    Show all 7 Pubmed References

  3. Polyclonal CA9 Primary Antibody for IHC (fro), IF - ABIN540761 : Yoo, Baia, Smith, McDermott, Bollen, Vandenberg, Lamborn, Lal: Expression of the hypoxia marker carbonic anhydrase 9 is associated with anaplastic phenotypes in meningiomas. in Clinical cancer research : an official journal of the American Association for Cancer Research 2007 (PubMed)
    Show all 5 Pubmed References

  4. Dog (Canine) Polyclonal CA9 Primary Antibody for ELISA, IHC (fro) - ABIN251626 : Sathornsumetee, Cao, Marcello, Herndon, McLendon, Desjardins, Friedman, Dewhirst, Vredenburgh, Rich: Tumor angiogenic and hypoxic profiles predict radiographic response and survival in malignant astrocytoma patients treated with bevacizumab and irinotecan. in Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2008 (PubMed)
    Show all 5 Pubmed References

  5. Human Monoclonal CA9 Primary Antibody for CyTOF, ELISA - ABIN4287748 : Cai, Alshehri, Choksi, Pestronk: Regional ischemic immune myopathy: a paraneoplastic dermatomyopathy. in Journal of neuropathology and experimental neurology 2014 (PubMed)
    Show all 4 Pubmed References

  6. Human Polyclonal CA9 Primary Antibody for CyTOF, FACS - ABIN4900431 : Swayampakula, McDonald, Vallejo, Coyaud, Chafe, Westerback, Venkateswaran, Shankar, Gao, Laurent, Lou, Bennewith, Supuran, Nabi, Raught, Dedhar: The interactome of metabolic enzyme carbonic anhydrase IX reveals novel roles in tumor cell migration and invadopodia/MMP14-mediated invasion. in Oncogene 2017 (PubMed)
    Show all 4 Pubmed References

  7. Human Polyclonal CA9 Primary Antibody for ELISA, WB - ABIN545603 : Span, Bussink, Manders, Beex, Sweep: Carbonic anhydrase-9 expression levels and prognosis in human breast cancer: association with treatment outcome. in British journal of cancer 2003 (PubMed)
    Show all 3 Pubmed References

  8. Human Monoclonal CA9 Primary Antibody for FACS, ELISA - ABIN1724882 : Pinheiro, Sousa, Albergaria, Paredes, Dufloth, Vieira, Schmitt, Baltazar: GLUT1 and CAIX expression profiles in breast cancer correlate with adverse prognostic factors and MCT1 overexpression. in Histology and histopathology 2011 (PubMed)
    Show all 2 Pubmed References

  9. Human Monoclonal CA9 Primary Antibody for IHC, ELISA - ABIN1724883 : Neumeister, Sullivan, Lindner, Lezon-Geyda, Li, Zavada, Martel, Glazer, Tuck, Rimm, Harris: Hypoxia-induced protein CAIX is associated with somatic loss of BRCA1 protein and pathway activity in triple negative breast cancer. in Breast cancer research and treatment 2012 (PubMed)
    Show all 2 Pubmed References

  10. Human Polyclonal CA9 Primary Antibody for IF (p), IHC (p) - ABIN752773 : Gogiraju, Xu, Bochenek, Steinbrecher, Lehnart, Wenzel, Kessel, Zeisberg, Dobbelstein, Schäfer: Endothelial p53 deletion improves angiogenesis and prevents cardiac fibrosis and heart failure induced by pressure overload in mice. in Journal of the American Heart Association 2015 (PubMed)

More Antibodies against Carbonic Anhydrase IX Interaction Partners

Mouse (Murine) Carbonic Anhydrase IX (CA9) interaction partners

  1. In response to hypoxia, pancreatic ductal adenocarcinoma cells that express activated KRAS increase expression of carbonic anhydrase 9, via stabilization of HIF1A and HIF2A, to regulate pH and glycolysis.

  2. Lack of CAIX results in persistent acid backflux via claudin-18 downregulation, causing loss of parietal cells, hypergastrinaemia and foveolar hyperplasia.

  3. Authors demonstrate that CAIX associates with MMP14 through potential phosphorylation residues within its intracellular domain, and that CAIX enhances MMP14-mediated collagen degradation by directly contributing hydrogen ions required for MMP14 catalytic activity.

  4. Loss of Function Screening Reveals Carbonic Anhydrase IX as a Key Modulator of Tumor Initiating Potential in Primary Pancreatic Tumors.

  5. constitutive activation of the NF-kappaB pathway in CAIX-depleted cells restored G-CSF secretion

  6. Downregulation of carbonic anhydrase IX promotes Col10a1 expression in chondrocytes.

  7. CA IX may directly or indirectly play novel functions in brain tissue.

  8. about half the CA-dependent muscular lactate flux occurs across the surface membrane, while the other half occurs across the membranes of the T tubuli

  9. Data show that CA9, GLUT1 and LOX mRNA levels were equally and strongly correlated to hypoxic extent in FaDudd, and the same profile was observed for CA9 and GLUT1, but not LOX, in SCCVII tumors.

  10. a novel role for CA IX in the regulation of immunologic processes and digestion

  11. although CA IX-deficiency is not a tumor-promoting factor per se, it induces glandular atrophy in the body mucosa, a lesion which is considered to be a preneoplastic alteration in the stomach

  12. These results suggest that the loss of function of cytosolic CA II in the stomach of Car2-/- mice leads to up-regulation of an extracellular CA, namely CA IX, which is expressed on the cell surface of the gastric epithelium.

  13. CA9 may regulate ion and pH homeostasis within the developing embryo.

  14. CA9 has chaperone-like functions and CA9 shed from tumors may play a direct role in stimulating an adaptive immune response

  15. that expression of CA9 is regulated through both the HIF-1 and unfolded protein response hypoxia response pathways in vitro and in vivo.

Human Carbonic Anhydrase IX (CA9) interaction partners

  1. In response to hypoxia, pancreatic ductal adenocarcinoma cells that express activated KRAS increase expression of carbonic anhydrase 9, via stabilization of HIF1A and HIF2A, to regulate pH and glycolysis.

  2. CAIX acidifies the tumor microenvironment, and provides an extracellular pH control mechanism. CAIX thus acts as an extracellular pH-state, maintaining an acidic tumor extracellular pH that is tolerated by cancer cells and favors invasion and metastasis.

  3. Hypoxic stress-related adaptation - highlighted by CAIX expression - results in cellular quiescence in Hodgkin-Reed-Sternberg (HRS) cells , potentially contributing to the short-term failure of the standard chemotherapy in classical Hodgkin's lymphoma.

  4. High CA9 expression is associated with esophageal squamous cell carcinoma tumor growth.

  5. CA IX/COX-2 interplay can promote hypoxia survival and the invasion of tumor cells. These proteins may represent independent prognostic factors of colorectal cancer.

  6. Carbon anhydrase IX expression in lichen and leukoplakia epithelia shows that hypoxia plays a role in the pathogenesis of both lesions. The different distribution patterns provides further evidence of the different biological behavior of these two entities, which under certain circumstances can have similar clinical and histological features

  7. MUC5B and CA9 are highly conserved during gallbladder cance rhistological progression

  8. CA9/CAIX is an independent prognostic factor for oral squamous cell carcinoma patients.

  9. Selective inhibition of carbonic anhydrase IX over carbonic anhydrase XII in breast cancer cells using benzene sulfonamides: Disconnect between activity and growth inhibition.

  10. High membranous CA9 expression is associated with clear cell renal cell carcinoma.

  11. Results find that CAIX expression was increased in soft tissue and associated with worse disease-free survival.

  12. Positive CAIX cytoplasmic expression was significantly associated with lymph node affected and with disease-specific survival in oral squamous cell carcinoma.

  13. we identified an SNP in the CA9 3'UTR as a novel diagnostic and prognostic factor for HCC. The rs1048638-A genotype significantly affects miR-34a targeting and expression levels of CA9. The miR-34a-CA9 axis is important in controlling tumor growth and metastasis of HCC cells.

  14. CAIX and CAXII expression are diagnostic for breast cancer subtype and prognosticators of patient survival. Overall, we show that CAIX but not CAXII drives growth, migration, and metastasis consistent with its expression in more aggressive breast cancers.

  15. Our findings indicated that CA-IX may be a potential prognostic biomarker in the treatment of glioblastoma multiforme

  16. Our results do not suggest a prognostic role for CA IX overexpression in stage III non-small cell lung cancer patients who received neoadjuvant treatment.

  17. FZD1 and CAIX might be important biological markers for the carcinogenesis, metastasis, invasion, and prognosis of pancreatic ductal adenocarcinoma

  18. CAII, CAIX, and CAXII all have characteristic expression patterns in esophageal adenocarcinoma (EAC), its precursors and normal squamous epithelium. In EAC, CAII downregulation is associated with metastatic disease. CAIX expression is lost towards the more malignant lesions, but in lymph node positive disease, expression seems to be higher. CAXII is only expressed in normal esophageal epithelium.

  19. High expression of CA9 is associated with breast cancer.

  20. Data suggest that the conformational flexibility may have several important roles in tumour progression, facilitating interactions of carbonic anhydrase IX (hCA IX) with partner proteins assisting tumour spreading and progression.

Carbonic Anhydrase IX (CA9) Antigen Profile

Protein Summary

Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA IX is a transmembrane protein and the only tumor-associated carbonic anhydrase isoenzyme known. It is expressed in all clear-cell renal cell carcinoma, but is not detected in normal kidney or most other normal tissues. It may be involved in cell proliferation and transformation. This gene was mapped to 17q21.2 by fluorescence in situ hybridization, however, radiation hybrid mapping localized it to 9p13-p12.

Gene names and symbols associated with CA9

  • carbonic anhydrase 9 (CA9) antibody
  • carbonic anhydrase 9 (CAH9) antibody
  • carbonic anhydrase 9 (Car9) antibody
  • Ca9 antibody
  • CAIX antibody
  • MN antibody
  • MN/CA9 antibody

Protein level used designations for CA9

carbonic anhydrase IX , carbonic anhydrase 9 , CA-IX , carbonate dehydratase IX , membrane antigen MN homolog , P54/58N , RCC-associated antigen G250 , RCC-associated protein G250 , carbonic dehydratase , membrane antigen MN , pMW1 , renal cell carcinoma-associated antigen G250

GENE ID SPECIES
473223 Pan troglodytes
511923 Bos taurus
5726457 Chlamydomonas reinhardtii
230099 Mus musculus
313495 Rattus norvegicus
768 Homo sapiens
611933 Canis lupus familiaris
100152792 Sus scrofa
770004 Gallus gallus
100337777 Oryctolagus cuniculus
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